GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Chou, Chia Hua ^a,b   Lin, Ching Chih ^a   Yang, Ming Chang ^a,b,c   Wei, Chih Chang ^a   Liao, Huei De ^a   Lin, Run Chin ^a   Tu, Wen Yu ^a   Kao, Tsung Chieh ^a   Hsu, Ching Mei ^b   Cheng, Jiin Tsuey ^b   Chou, An Kuo ^d,e   Lee, Chu I ^f   Loh, Joon Khim ^d,g   Howng, Shen Long ^d,g   Hong, Yi Ren ^a,b,d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c KAOHSIUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^f FOOYIN UNIVERSITY   (Taiwan)

^g KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 3; CASPASE 7; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; DYNAMIN RELATED PROTEIN 1; GLYCOGEN SYNTHASE KINASE 3BETA; GUANOSINE TRIPHOSPHATASE; HISTIDINE; HYDROGEN PEROXIDE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN LC3B; SERINE; THREONINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; MORPHOLOGY; NERVE CELL; OXIDATIVE STRESS; PHENOTYPE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; APOPTOSIS; AUTOPHAGY; DYNAMINS; GLYCOGEN SYNTHASE KINASE 3; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; HYDROLYSIS; LYSINE; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; OXIDATIVE STRESS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84869856304     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049112     Document Type: Article

References (41)

1. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA, (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
2. Jope RS, Johnson GV, (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29: 95-102.
3. Cho J, Rameshwar P, Sadoshima J, (2009) Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. J Biol Chem 284: 36647-36658.
4. Hooper C, Killick R, Lovestone S, (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104: 1433-1439.
5. Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC, (1998) Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. Biochem Biophys Res Commun 249: 697-703.
6. Chen CH, Hwang SL, Howng SL, Chou CK, Hong YR, (2000) Three rat brain alternative splicing dynamin-like protein variants: interaction with the glycogen synthase kinase 3beta and action as a substrate. Biochem Biophys Res Commun 268: 893-898.
7. Figueroa-Romero C, Iniguez-Lluhi JA, Stadler J, Chang CR, Arnoult D, et al. (2009) SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J 23: 3917-3927.
8. Reddy PH, Manczak M, Mao P, Calkins MJ, Reddy AP, et al. (2010) Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline. J Alzheimers Dis 20 Suppl 2: S499-512.
9. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA, (2003) Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol 15: 706-716.
10. Suen DF, Norris KL, Youle RJ, (2008) Mitochondrial dynamics and apoptosis. Genes Dev 22: 1577-1590.
11. Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, et al. (2010) Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. J Cell Biol 191: 1127-1139.
12. Santel A, Frank S, (2008) Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1. IUBMB Life 60: 448-455.
13. Chang CR, Blackstone C, (2010) Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann N Y Acad Sci 1201: 34-39.
14. Chang CR, Blackstone C, (2007) Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 282: 21583-21587.
15. Cribbs JT, Strack S, (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 8: 939-944.
16. Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, et al. (2008) Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A 105: 15803-15808.
17. Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, et al. (2008) CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol 182: 573-585.
18. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, et al. (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 191: 1141-1158.
19. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K, (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282: 11521-11529.
20. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E, (2008) Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9: 505-518.
21. Lin CC, Chou CH, Howng SL, Hsu CY, Hwang CC, et al. (2009) GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells. J Cell Biochem 108: 1325-1336.
22. Sever S, Muhlberg AB, Schmid SL, (1999) Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature 398: 481-486.
23. Zhu PP, Patterson A, Stadler J, Seeburg DP, Sheng M, et al. (2004) Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1. J Biol Chem 279: 35967-35974.
24. Howng SL, Hwang CC, Hsu CY, Hsu MY, Teng CY, et al. (2010) Involvement of the residues of GSKIP, AxinGID, and FRATtide in their binding with GSK3beta to unravel a novel C-terminal scaffold-binding region. Mol Cell Biochem 339: 23-33.
25. Chappie JS, Acharya S, Liu YW, Leonard M, Pucadyil TJ, et al. (2009) An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell 20: 3561-3571.
26. Liesa M, Palacin M, Zorzano A, (2009) Mitochondrial dynamics in mammalian health and disease. Physiol Rev 89: 799-845.
27. Gao S, von der Malsburg A, Paeschke S, Behlke J, Haller O, et al. (2010) Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature 465: 502-506.
28. Wasilewski M, Scorrano L, (2009) The changing shape of mitochondrial apoptosis. Trends Endocrinol Metab 20: 287-294.
29. Parone PA, Da Cruz S, Tondera D, Mattenberger Y, James DI, et al. (2008) Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One 3: e3257.
30. Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J, (2011) Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A 108: 10190-10195.
31. Rambold AS, Kostelecky B, Lippincott-Schwartz J, (2011) Fuse or die: Shaping mitochondrial fate during starvation. Commun Integr Biol 4: 752-754.
32. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, et al. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160: 189-200.
33. Chen H, Chan DC, (2005) Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 14 Spec No. 2: R283-289.
34. Yen WL, Klionsky DJ, (2008) How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) 23: 248-262.
35. Gomes LC, Di Benedetto G, Scorrano L, (2011) During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 13: 589-598.
36. Chen CH, Howng SL, Hwang SL, Chou CK, Liao CH, et al. (2000) Differential expression of four human dynamin-like protein variants in brain tumors. DNA Cell Biol 19: 189-194.
37. Wang S, Song J, Tan M, Albers KM, Jia J, (2012) Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease. Eur J Neurol 19: 1015-1022.
38. Wilson TJ, Slupe AM, Strack S, (2012) Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease. Neurobiol Dis.
39. Merrill RA, Dagda RK, Dickey AS, Cribbs JT, Green SH, et al. (2011) Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. PLoS Biol 9: e1000612.
40. Skroblin P, Grossmann S, Schafer G, Rosenthal W, Klussmann E, (2010) Mechanisms of protein kinase A anchoring. Int Rev Cell Mol Biol 283: 235-330.
41. Ingerman E, Nunnari J, (2005) A continuous, regenerative coupled GTPase assay for dynamin-related proteins. Methods Enzymol 404: 611-619.