Synthesis of a novel cyclic prodrug of S -allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells

Molecular Pharmaceutics

Volumn 12, Issue 1, 2015, Pages 66-74

  Patruno, Antonia ^a   Fornasari, Erika ^a   Di Stefano, Antonio ^a   Cerasa, Laura S ^a   Marinelli, Lisa ^a   Baldassarre, Leonardo ^a   Sozio, Piera ^a   Turkez, Hasan ^b   Franceschelli, Sara ^a   Ferrone, Alessio ^a   Di Giacomo, Viviana ^a   Speranza, Lorenza ^a   Felaco, Mario ^a   Cacciatore, Ivana ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b ERZURUM TECHNICAL UNIVERSITY   (Turkey)

Author keywords

acyloxy alkoxy linker; cyclic prodrug; glutathione; MAPK pathway

Indexed keywords

ANTIINFLAMMATORY AGENT; GLUTATHIONE DERIVATIVE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; S ALLYL GLUTATHIONE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GLUTATHIONE; PRODRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; ENZYMATIC DEGRADATION; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; LIPOPHILICITY; MONOCYTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; SIGNAL TRANSDUCTION; SYNTHESIS; CELL MEMBRANE PERMEABILITY; CHEMICAL MODEL; CHEMISTRY; CYTOLOGY; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; METABOLISM; PERMEABILITY; TEMPERATURE; U937 CELL LINE;

CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLUTATHIONE; HUMANS; HYDROGEN-ION CONCENTRATION; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MODELS, CHEMICAL; MONOCYTES; PERMEABILITY; PRODRUGS; REACTIVE OXYGEN SPECIES; TEMPERATURE; U937 CELLS;

EID: 84920440295     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500431r     Document Type: Article

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