-
1
-
-
10744227768
-
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
-
R.J. Gum Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket J. Biol. Chem. 273 1998 15605 15610
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15605-15610
-
-
Gum, R.J.1
-
2
-
-
0033120590
-
Differential expression and activation of p38 mitogen-activated protein kinase α, β, γ and δ in inflammatory cell lineages
-
K.K. Hale D. Trollinger M. Rihanek C.L. Manthey Differential expression and activation of p38 mitogen-activated protein kinase α, β, γ and δ in inflammatory cell lineages J. Immunol. 162 1999 4246 4252
-
(1999)
J. Immunol.
, vol.162
, pp. 4246-4252
-
-
Hale, K.K.1
Trollinger, D.2
Rihanek, M.3
Manthey, C.L.4
-
3
-
-
0030868682
-
Kinetic mechanism for p38 MAP kinase
-
P.V. LoGrasso Kinetic mechanism for p38 MAP kinase Biochemistry 36 1997 10422 10427
-
(1997)
Biochemistry
, vol.36
, pp. 10422-10427
-
-
LoGrasso, P.V.1
-
4
-
-
0032519736
-
p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation
-
Y.L. Zu p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation J. Immunol. 160 1998 1982 1989
-
(1998)
J. Immunol.
, vol.160
, pp. 1982-1989
-
-
Zu, Y.L.1
-
5
-
-
0030756286
-
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
-
X.S. Wang Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase J. Biol. Chem. 272 1997 23668 23674
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23668-23674
-
-
Wang, X.S.1
-
6
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
J.C. Lee A protein kinase involved in the regulation of inflammatory cytokine biosynthesis Nature 372 1994 739 746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
-
7
-
-
0031587929
-
Novel homologs of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
-
S. Kumar Novel homologs of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles Biochem. Biophys. Res. Commun. 235 1997 533 538
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.235
, pp. 533-538
-
-
Kumar, S.1
-
8
-
-
0030702895
-
A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses
-
T. Moriguchi A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses EMBO J. 16 1997 7045 7053
-
(1997)
EMBO J.
, vol.16
, pp. 7045-7053
-
-
Moriguchi, T.1
-
9
-
-
0032575591
-
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/erk kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38
-
T. Yuasa S. Ohno J.H. Kehrl J.M. Kyriakis Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/erk kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38 J. Biol. Chem. 273 1998 22681 22692
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22681-22692
-
-
Yuasa, T.1
Ohno, S.2
Kehrl, J.H.3
Kyriakis, J.M.4
-
10
-
-
0030805915
-
p38-2, a novel mitogen-activated protein kinase with distinct properties
-
B. Stein p38-2, a novel mitogen-activated protein kinase with distinct properties J. Biol. Chem. 272 1997 19509 19517
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19509-19517
-
-
Stein, B.1
-
11
-
-
0030927106
-
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
-
M. Goedert Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases EMBO J. 16 1997 3563 3571
-
(1997)
EMBO J.
, vol.16
, pp. 3563-3571
-
-
Goedert, M.1
-
12
-
-
0032479983
-
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
-
M. Deak A.D. Clifton J.M. Lucocq D.R. Alessi Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB EMBO J. 17 1998 4426 4441
-
(1998)
EMBO J.
, vol.17
, pp. 4426-4441
-
-
Deak, M.1
Clifton, A.D.2
Lucocq, J.M.3
Alessi, D.R.4
-
13
-
-
0030588188
-
Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK
-
J. El Benna Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK Arch. Biochem. Biophys. 334 1996 395 400
-
(1996)
Arch. Biochem. Biophys.
, vol.334
, pp. 395-400
-
-
El Benna, J.1
-
15
-
-
0030661712
-
Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils
-
K.I. Hidari A.S. Weyrich G.A. Zimmerman R.P. McEver Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils J. Biol. Chem. 272 1997 28750 28756
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28750-28756
-
-
Hidari, K.I.1
Weyrich, A.S.2
Zimmerman, G.A.3
McEver, R.P.4
-
16
-
-
0031018424
-
Tumor necrosis factor α-induced E-selectin expression is activated by the nuclear factor-κB and c-jun N-terminal kinase/p38 mitogen-activated protein kinase pathways
-
M.A. Read Tumor necrosis factor α-induced E-selectin expression is activated by the nuclear factor-κB and c-jun N-terminal kinase/p38 mitogen-activated protein kinase pathways J. Biol. Chem. 272 1997 2753 2761
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2753-2761
-
-
Read, M.A.1
-
17
-
-
0033559424
-
Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
-
J.A. Nick Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils J. Clin. Invest. 103 1999 851 858
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 851-858
-
-
Nick, J.A.1
-
18
-
-
85119798345
-
Activation of stress-activated protein kinase is a mechanism of priming in macrophages
-
G.J. Bauer I. Garcia R.V. Maier Activation of stress-activated protein kinase is a mechanism of priming in macrophages Surg. Forum 48 1997 43 45
-
(1997)
Surg. Forum
, vol.48
, pp. 43-45
-
-
Bauer, G.J.1
Garcia, I.2
Maier, R.V.3
-
19
-
-
0031114081
-
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase. Regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels
-
S.H. Ridley Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase. Regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels J. Immunol. 158 1997 3165 3173
-
(1997)
J. Immunol.
, vol.158
, pp. 3165-3173
-
-
Ridley, S.H.1
-
20
-
-
0030048490
-
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils
-
C. Knall Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils J. Biol. Chem. 271 1996 2832 2838
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2832-2838
-
-
Knall, C.1
-
21
-
-
0032529398
-
Role of stress-activated mitogen-activated protein kinase (p38) in β2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst
-
P.A. Detmers Role of stress-activated mitogen-activated protein kinase (p38) in β2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst J. Immunol. 161 1998 1921 1929
-
(1998)
J. Immunol.
, vol.161
, pp. 1921-1929
-
-
Detmers, P.A.1
-
22
-
-
0032562605
-
Two signaling mechanisms for activation of αMβ2 avidity in polymorphonuclear neutrophils
-
2 avidity in polymorphonuclear neutrophils J. Biol. Chem. 273 1998 10556 10566
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10556-10566
-
-
Jones, S.L.1
-
23
-
-
0031550222
-
p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level
-
A. Pietersma p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level Biochem. Biophys. Res. Commun. 230 1997 44 48
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.230
, pp. 44-48
-
-
Pietersma, A.1
-
24
-
-
0030903025
-
Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases
-
C. Knall G.S. Worthen G.L. Johnson Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases Proc. Natl. Acad. Sci. U. S. A. 94 1997 3052 3057
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 3052-3057
-
-
Knall, C.1
Worthen, G.S.2
Johnson, G.L.3
-
25
-
-
0032495987
-
The role of p38 MAP kinase in TGF-β1-induced signal transduction in human neutrophils
-
M. Hannigan L. Zhan Y. Ai C.K. Huang The role of p38 MAP kinase in TGF-β1-induced signal transduction in human neutrophils Biochem. Biophys. Res. Commun. 246 1998 55 58
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.246
, pp. 55-58
-
-
Hannigan, M.1
Zhan, L.2
Ai, Y.3
Huang, C.K.4
-
27
-
-
0030937347
-
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
-
J.A. Nick Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP J. Clin. Invest. 99 1997 975 986
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 975-986
-
-
Nick, J.A.1
-
28
-
-
85119793615
-
Role of p38 MAP kinase in human neutrophil priming for superoxide production and elastase release
-
D.A. Partrick Role of p38 MAP kinase in human neutrophil priming for superoxide production and elastase release Surg. Forum 48 1997 48 50
-
(1997)
Surg. Forum
, vol.48
, pp. 48-50
-
-
Partrick, D.A.1
-
29
-
-
0030827057
-
Tumor necrosis factor α and interleukin 1 signalling: do MAPKK kinases connect it all?
-
J. Eder Tumor necrosis factor α and interleukin 1 signalling: do MAPKK kinases connect it all? Trends Pharmacol. Sci. 18 1997 319 322
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 319-322
-
-
Eder, J.1
-
30
-
-
0032549174
-
IκBα degradation and nuclear factor κB DNA binding are insufficient for interleukin-1β and tumor necrosis factor-α-induced κB-dependent transcription. Requirement for an additional activation pathway
-
M. Bergmann IκBα degradation and nuclear factor κB DNA binding are insufficient for interleukin-1β and tumor necrosis factor-α-induced κB-dependent transcription. Requirement for an additional activation pathway J. Biol. Chem. 273 1998 6607 6610
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 6607-6610
-
-
Bergmann, M.1
-
31
-
-
0030911732
-
Activation of transcription factor NFκB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways
-
S. Wesselborg Activation of transcription factor NFκB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways J. Biol. Chem. 272 1997 12422 12429
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12422-12429
-
-
Wesselborg, S.1
-
32
-
-
0030426902
-
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
-
A.M. Badger Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function J. Pharmacol. Exp. Ther. 279 1996 1453 1461
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 1453-1461
-
-
Badger, A.M.1
-
33
-
-
12644277392
-
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
-
K.P. Wilson The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase Chem. Biol. 4 1997 423 431
-
(1997)
Chem. Biol.
, vol.4
, pp. 423-431
-
-
Wilson, K.P.1
-
34
-
-
0030954172
-
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
-
L. Tong A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket Nat. Struct. Biol. 4 1997 311 316
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 311-316
-
-
Tong, L.1
-
35
-
-
0032530336
-
Structural basis of inhibitor selectivity in MAP kinases
-
Z. Wang Structural basis of inhibitor selectivity in MAP kinases Structure 6 1998 1117 1128
-
(1998)
Structure
, vol.6
, pp. 1117-1128
-
-
Wang, Z.1
-
36
-
-
0032578559
-
The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding
-
B. Frantz The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding Biochemistry 37 1998 13846 13853
-
(1998)
Biochemistry
, vol.37
, pp. 13846-13853
-
-
Frantz, B.1
-
37
-
-
0030924833
-
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
-
P.R. Young Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site J. Biol. Chem. 272 1997 12116 12121
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12116-12121
-
-
Young, P.R.1
-
38
-
-
0032564311
-
Molecular basis for p38 protein kinase inhibitor specificity
-
J.M. Lisnock Molecular basis for p38 protein kinase inhibitor specificity Biochemistry 37 1998 16573 16581
-
(1998)
Biochemistry
, vol.37
, pp. 16573-16581
-
-
Lisnock, J.M.1
-
39
-
-
0031934170
-
Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
-
J.R. Jackson Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models J. Pharmacol. Exp. Ther. 284 1998 687 692
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.284
, pp. 687-692
-
-
Jackson, J.R.1
-
40
-
-
0031765795
-
Conquering airway inflammation in the 21st century
-
D.F. Rogers M.A. Giembycz Conquering airway inflammation in the 21st century Drug Discov. Today 3 1998 532 535
-
(1998)
Drug Discov. Today
, vol.3
, pp. 532-535
-
-
Rogers, D.F.1
Giembycz, M.A.2
-
41
-
-
0028907221
-
Molecular cloning of human p38 MAP kinase
-
J. Han Molecular cloning of human p38 MAP kinase Biochim. Biophys. Acta 1265 1995 224 227
-
(1995)
Biochim. Biophys. Acta
, vol.1265
, pp. 224-227
-
-
Han, J.1
-
43
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38β)
-
Y. Jiang Characterization of the structure and function of a new mitogen-activated protein kinase (p38β) J. Biol. Chem. 271 1996 17920 17926
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
|