Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 3, 2012, Pages 630-637

  Borde, A S ^a   Karlsson, E M ^a   Andersson, K ^a   Bjorhall K ^a   Lennernas H ^b   Abrahamsson, B ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Enzymatic stability; FaSSIF; Human intestinal fluid; Pancreatin; Prodrug; SDS PAGE gel

Indexed keywords

CANDESARTAN; CANDESARTAN HEXETIL; CHLORAMPHENICOL HEMISUCCINATE; ENALAPRIL; ESTERASE INHIBITOR; PANCREATIN; PRODRUG;

ADULT; ARTICLE; DEGRADATION KINETICS; DOG; DRUG DEGRADATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROPHORESIS; ENZYMATIC DEGRADATION; ENZYME INHIBITION; HUMAN; INTESTINE FLUID; JEJUNUM; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; NORMAL HUMAN; PH; PROTEIN CONTENT; SIMULATION; SMALL INTESTINE;

ADOLESCENT; ADULT; ANIMALS; BENZIMIDAZOLES; BIOPHARMACEUTICS; BIPHENYL COMPOUNDS; BODY FLUIDS; CHLORAMPHENICOL; DOGS; DRUG STABILITY; ENALAPRIL; ENZYME INHIBITORS; HUMANS; INTESTINAL SECRETIONS; INTESTINE, SMALL; MALE; PANCREATIN; PRODRUGS; TETRAZOLES; YOUNG ADULT;

EID: 84858155589     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.11.011     Document Type: Article

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