Novel aminobenzyl-acetamidine derivative modulate the differential regulation of NOSs in LPS induced inflammatory response: Role of PI3K/Akt pathway

Biochimica et Biophysica Acta - General Subjects

Volumn 1820, Issue 12, 2012, Pages 2095-2104

  Patruno, Antonia ^a   Franceschelli, Sara ^a   Pesce, Mirko ^a   MacCallini, Cristina ^a   Fantacuzzi, Marialuigia ^a   Speranza, Lorenza ^a   Ferrone, Alessio ^a   De Lutiis, Maria Anna ^a   Ricciotti, Emanuela ^b   Amoroso, Rosa ^a   Felaco, Mario ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aminobenzyl acetamidine derivative; H9c2; Inflammation; NF B; NO synthases

Indexed keywords

ACETAMIDINE DERIVATIVE; AMINOBENZYLACETAMIDINE DERIVATIVE; ANTIINFLAMMATORY AGENT; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME REGULATION; INFLAMMATION; INTRACELLULAR TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; SEPTIC SHOCK;

AMIDINES; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; I-KAPPA B KINASE; INFLAMMATION; LIPOPOLYSACCHARIDES; MYOBLASTS, CARDIAC; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; OXIDATION-REDUCTION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84867431362     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.08.014     Document Type: Article

References (48)

1. S. Moncada, and E.A. Higgs Endogenous nitric oxide: physiology, pathology and clinical relevance Eur. J. Clin. Invest. 21 1991 361 374
2. S. Mariotto, M. Menegazzi, and H. Suzuki Biochemical aspects of nitric oxide Curr. Pharm. Des. 10 2004 1627 1645
3. A.M. Shah, and P.A. MacCarthy Paracrine and autocrine effects of nitric oxide on myocardial function Pharmacol. Ther. 86 2000 49 86
4. A. Berdeaux Nitric oxide: an ubiquitous messenger Fundam. Clin. Pharmacol. 7 1993 401 411
5. S. Moncada The 1991 Ulf von Euler Lecture. The l-arginine: nitric oxide pathway Acta Physiol. Scand. 145 1992 201 227
6. J.E. Parrillo, C. Burch, J.H. Shelhamer, M.M. Parker, C. Natanson, and W. Schuette A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance J. Clin. Invest. 76 1985 1539 1553
7. M.A. Freudenberg, T. Merlin, M. Gumenscheimer, C. Kalis, R. Landmann, and C. Galanos Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria Microbes Infect. 3 2001 1213 1222
8. A. Aderem, and R.J. Ulevitch Toll-like receptors in the induction of the innate immune response Nature 406 2000 782 787
9. Y. Geng, B. Zhang, and M. Lotz Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes J. Immunol. 151 1993 6692 6700
10. T.D. Geppert, C.E. Whitehurst, P. Thompson, and B. Beutler Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway Mol. Med. 1 1994 93 103
11. J. Hambleton, S.L. Weinstein, L. Lem, and A.L. De Franco Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages Proc. Natl. Acad. Sci. U. S. A. 93 1996 2774 2778
12. J. Han, J.D. Lee, L. Bibbs, and R.J. Ulevitch A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells Science 265 1994 808 811
13. G. Zhang, and S. Ghosh Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity J. Clin. Invest. 107 2001 13 19
14. E.N. Hatada, D. Krappmann, and C. Scheiderit NF-kappaB and the innate immune response Curr. Opin. Immunol. 12 2000 52 58
15. M. Fantacuzzi, C. Maccallini, F. Lannutti, A. Patruno, S. Masella, M. Pesce, L. Speranza, A. Ammazzalorso, B. De Filippis, L. Giampietro, N. Re, and R. Amoroso Selective inhibition of iNOS by benzyl- and dibenzyl derivatives of N-(3-aminobenzyl)acetamidine ChemMedChem 6 2011 1203 1206
16. S. Gorfien, A. Spector, D. DeLuca, and S. Weiss Growth and physiological functions of vascular endothelial cells in a new serum-free medium (SFM) Exp. Cell Res. 206 1993 291 301
17. M.A. Titheradge The enzymatic measurement of nitrate and nitrite Methods Mol. Biol. 100 1998 83 91
18. J.M. Hevel, and M.A. Marletta Nitric oxide synthase assays Methods Enzymol. 133 1994 250 258
19. A. Patruno, P. Amerio, M. Pesce, G. Vianale, S. Di Luzio, A. Tulli, S. Franceschelli, A. Grilli, R. Muraro, and M. Reale Extremely low frequency electromagnetic fields modulate expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and cyclooxygenase-2 in the human keratinocyte cell line HaCat: potential therapeutic effects in wound healing Br. J. Dermatol. 162 2010 258 266
20. A.M. Wang, M.V. Doyle, and D.F. Mark Quantification of mRNA by the polymerase chain reaction Proc. Natl. Acad. Sci. U. S. A. 86 1989 9717 9721
21. W.A. Pryor, and G.L. Squadrito The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide Am. J. Physiol. 268 1995 699 722
22. G. Hall, I.S. Singh, L. Hester, J.D. Hasday, and T.B. Rogers Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation Am. J. Physiol. Heart Circ. Physiol. 289 2005 2103 2111
23. B.M. Marte, and J. Downward PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond Trends Biochem. Sci. 22 1997 355 358
24. J. Downward Lipid-regulated kinases: some common themes at last Science 279 1998 673 674
25. O.N. Ozes, L.D. Mayo, J.A. Gustin, S.R. Pfeffer, L.M. Pfeffer, and D.B. Donner NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase Nature 401 1999 82 85
26. H.O. Jin, S. An, H.C. Lee, S.H. Woo, S.K. Seo, T.B. Choe, D.H. Yoo, S.B. Lee, H.D. Um, S.J. Lee, M.J. Park, J.I. Kim, S.I. Hong, C.H. Rhee, and I.C. Park Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway Cell. Signal. 19 7 2007 1393 1403
27. G. Bonizzi, and M. Karin The two NF-kappaB activation pathways and their role in innate and adaptive immunity Trends Immunol. 25 2004 280 288
28. S.C. Sun Non-canonical NF-κB signaling pathway Cell Res. 21 2011 71 85
29. P. Ramakrishnan, W. Wang, and D. Wallach Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB inducing kinase Immunity 21 2004 477 489
30. M.P. Glauser, G. Zanetti, J.D. Baumgartner, and J. Cohen Septic shock: pathogenesis Lancet 338 1991 732 736
31. D.G. Remick, and P.A. Ward Evaluation of endotoxin models for the study of sepsis Shock 1 2005 7 11
32. M. Satoh, M. Nakamura, T. Akatsu, J. Iwasaka, Y. Shimoda, I. Segawa, and K. Hiramori Expression of Toll-like receptor 4 is associated with enteroviral replication in human myocarditis Clin. Sci. (Lond.) 104 2003 577 584
33. L. Comini, A. Boraso, T. Bachetti, P. Bernocchi, E. Pasini, D. Bastianon, S. Curello, C.M. Terracciano, C. Ceconi, and R. Ferrari Effects of endotoxic shock on neuronal NOS and calcium transients in rat cardiac myocytes Pharmacol. Res. 51 2005 409 417
34. A. Papapetropoulos, R.D. Rudic, and W.C. Sessa Molecular control of nitric oxide synthases in the cardiovascular system Cardiovasc. Res. 43 1999 509 520
35. R. Madonna, P. Di Napoli, M. Massaro, A. Grilli, M. Felaco, A. De Caterina, D. Tang, R. De Caterina, and Y.J. Geng Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts J. Biol. Chem. 280 2005 13503 13511
36. K. Pomerantz, L. Casey, J.R. Fletcher, and P.W. Ramwell Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment Adv. Shock. Res. 7 1982 191 198
37. A. Lopez, J.A. Lorente, J. Steingrub, J. Bakker, A. McLuckie, S. Willatts, M. Brockway, A. Anzueto, L. Holzapfel, D. Breen, M.S. Silverman, J. Takala, J. Donaldson, C. Arneson, G. Grove, S. Grossman, and R. Grover Multiple- center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock Crit. Care Med. 32 2004 21 30
38. M. Colasanti, and H. Suzuki The dual personality of NO Trends Pharmacol. Sci. 21 2000 249 252
39. M. Colasanti, T. Persichini, M. Menegazzi, S. Mariotto, E. Giordano, C.M. Caldarera, V. Sogos, G.M. Lauro, and H. Suzuki Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide J. Biol. Chem. 270 1995 26731 26733
40. S. Akira, and K. Takeda Functions of toll-like receptors: lessons from KO mice C. R. Biol. 327 2004 581 589
41. K.V. Ramana, M.S. Willis, M.D. White, J.W. Horton, J.M. Di Maio, D. Srivastava, A. Bhatnagar, and S.K. Srivastava Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition Circulation 114 2006 1838 1846
42. D. Rudolph, W.C. Yeh, A. Wakeham, B. Rudolph, D. Nallainathan, J. Potter, A.J. Elia, and T.W. Mak Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice Genes Dev. 14 2000 854 862
43. L. Ling, Z. Cao, and D.V. Goeddel NF-B-inducing kinase activates IKK-a by phosphorylation of Ser-176 Proc. Natl. Acad. Sci. U. S. A. 95 1998 3792 3797
44. D.L. Williams, T. Ozment-Skelton, and C. Li Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury Shock 25 2006 432 439
45. M.V. Rajaram, L.P. Ganesan, K.V. Parsa, J.P. Butchar, J.S. Gunn, and S. Tridandapani Akt/protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice J. Immunol. 177 2006 6317 6324
46. B.J. Michell, J.E. Griffiths, K.I. Mitchelhill, I. Rodriguez-Crespo, T. Tiganis, S. Bozinovski, P.R. de Montellano, B.E. Kemp, and R.B. Pearson The Akt kinase signals directly to endothelial nitric oxide synthase Curr. Biol. 9 1999 845 848
47. H. Li, T. Wallerath, and U. Forstermann Physiological mechanisms regulating the expression of endothelial-type NO synthase Nitric Oxide 7 2002 132 147
48. K.L. Wright, and S.G. Ward Interactions between phosphatidylinositol 3-kinase and nitric oxide: explaining the paradox Mol. Cell Biol. Res. Commun. 4 2000 137 143