Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 2, 2013, Pages 187-198

  Sozio, Piera ^a   Cerasa, Laura S ^a   Laserra, Sara ^a   Cacciatore, Ivana ^a   Cornacchia, Catia ^a   Di Filippo, Ester S ^b   Fulle, Stefania ^b   Fontana, Antonella ^a   Di Crescenzo, Antonello ^a   Grilli, Massimo ^c   Marchi, Mario ^c   Di Stefano, Antonio ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b CeSI Centro Studi sull'Invecchiamento   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

A (1 42) aggregation; Alzheimer's disease; BBB permeation; Memantine conjugates

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; GLUTAMATE RECEPTOR ANTAGONIST; GLUTATHIONE; MEMANTINE; MEMANTINE ALPHA LIPOIC ACID CONJUGATE; N (3,5 DIMETHYL 1 ADAMANTYL) 5 (1,2 DITHIOLAN 3 YL)PENTANAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SCAVENGER; SULFUR; THIOCTIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; CELL LINE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTATHIONE; HIPPOCAMPUS; HUMANS; MALE; MEMANTINE; MEMBRANES, ARTIFICIAL; NEUROPROTECTIVE AGENTS; NOREPINEPHRINE; PEPTIDE FRAGMENTS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTOSOMES; THIOCTIC ACID;

EID: 84875392161     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.02.013     Document Type: Article

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