Membrane permeability related physicochemical properties of a novel γ-secretase inhibitor

International Journal of Pharmaceutics

Volumn 280, Issue 1-2, 2004, Pages 47-55

  El Gendy, Ahmed M ^a   Adejare, Adeboye ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

IAM partitioning chromatography; log P; Pharmaceutical profiling; Physicochemical characterizations; pKa; Solubility

Indexed keywords

GAMMA SECRETASE INHIBITOR; OCTANOL; SULFONAMIDE; WATER;

ARTICLE; ARTIFICIAL MEMBRANE; CALCULATION; DISSOCIATION CONSTANT; DRUG ABSORPTION; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEMBRANE PERMEABILITY; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ABSORPTION; ADAMANTANE; ADMINISTRATION, ORAL; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL MEMBRANE PERMEABILITY; ENDOPEPTIDASES; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; PROTEASE INHIBITORS; SOLUBILITY; SULFONAMIDES;

EID: 3242723046     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.04.019     Document Type: Article

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