The role of drug-polymer hydrogen bonding interactions on the molecular mobility and physical stability of nifedipine solid dispersions

Molecular Pharmaceutics

Volumn 12, Issue 1, 2015, Pages 162-170

  Kothari, Khushboo ^a,b   Ragoonanan, Vishard ^a,c   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c ALLERGAN INC   (United States)

Author keywords

crystallization; dielectric spectroscopy; FT IR spectroscopy; hydroxypropylmethyl cellulose (HPMCAS); molecular mobility; nifedipine; poly(acrylic acid) (PAA); polyvinylpyrrolidone (PVP); solid dispersion

Indexed keywords

HYDROGEN; HYDROXYPROPYLMETHYLCELLULOSE; NIFEDIPINE; POLYACRYLIC ACID; POVIDONE; ACRYLIC ACID RESIN; CARBOPOL 940; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; METHYLCELLULOSE; POLYMER; SOLVENT;

ARTICLE; COMPARATIVE STUDY; CRYSTALLIZATION; DISPERSION; DRUG ABSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG STABILITY; DRUG STRUCTURE; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; RELAXATION TIME; TEMPERATURE DEPENDENCE; THERMAL ANALYSIS; TITRIMETRY; WATER CONTENT; X RAY POWDER DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; KINETICS; TEMPERATURE; X RAY DIFFRACTION;

ACRYLIC RESINS; CRYSTALLIZATION; HYDROGEN; HYDROGEN BONDING; KINETICS; METHYLCELLULOSE; NIFEDIPINE; POLYMERS; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; X-RAY DIFFRACTION;

EID: 84920363767     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5005146     Document Type: Article

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