Miniaturized screening of polymers for amorphous drug stabilization (SPADS): Rapid assessment of solid dispersion systems

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 84, Issue 3, 2013, Pages 583-598

  Wyttenbach, Nicole ^a   Janas, Christine ^a,d   Siam, Monira ^b   Lauer, Matthias Eckhard ^b   Jacob, Laurence ^a   Scheubel, Emmanuel ^c   Page, Susanne ^a  

^a PRED Hoffmann La Roche   (Switzerland)

^b Discovery Technologies   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

Amorphous solid dispersions; Dissolution; Screening; Stability prediction; Supersaturation

Indexed keywords

EUDRAGIT; POLYMER;

ARTICLE; ATOMIC FORCE MICROSCOPY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; MINIATURIZED SCREENING OF POLYMERS FOR AMORPHOUS DRUG STABILIZATION IMAGING ASSAY; MISCIBILITY; SOLID STATE; SPRAY DRYING;

ADMINISTRATION, ORAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG CARRIERS; DRUG STABILITY; MICROSCOPY, ATOMIC FORCE; PARTICLE SIZE; POLYMERS; POWDERS; PROBABILITY; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; THERMOGRAVIMETRY; TIME FACTORS; X-RAY DIFFRACTION;

EID: 84879119113     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.01.009     Document Type: Article

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