A transcriptional profile of aging in the human kidney

PLoS Biology

Volumn 2, Issue 12, 2004, Pages

  Rodwell, Graham E J ^a   Sonu, Rebecca ^b   Zahn, Jacob M ^b   Lund, James ^b   Wilhelmy, Julie ^b   Wang, Lingli ^a   Xiao, Wenzhong ^b   Mindrinos, Michael ^b   Crane, Emily ^b   Segal, Eran ^b   Myers, Bryan D ^a   Brooks, James D ^b   Davis, Ronald W ^b   Higgins, John ^a   Owen, Art B ^b   Kim, Stuart K ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; INFLAMMATION; KIDNEY; PHYSIOLOGY; REGULATORY MECHANISM; ADULT; AGE; AGED; ANIMAL; BIOPSY; DNA MICROARRAY; FEMALE; GENE EXPRESSION REGULATION; GLOMERULUS; IMMUNE SYSTEM; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; METABOLISM; MIDDLE AGED; MUSCLE; PATHOLOGY; REGRESSION ANALYSIS; SEX DIFFERENCE; STATISTICAL MODEL; TIME;

RNA;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANIMALS; BIOPSY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM; INFLAMMATION; KIDNEY; KIDNEY CORTEX; KIDNEY GLOMERULUS; KIDNEY MEDULLA; MALE; MIDDLE AGED; MODELS, STATISTICAL; MUSCLES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REGRESSION ANALYSIS; RNA; SEX FACTORS; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 20044394182     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0020427     Document Type: Article

References (25)

1. Droge W (2003) Oxidative stress and aging. Adv Exp Med Biol 543: 191-200.
2. Guarente L, Kenyon C (2000) Genetic pathways that regulate ageing in model organisms. Nature 408: 255-262.
3. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (2003) Aging and genome maintenance: Lessons from the mouse? Science 299: 1355-1359.
4. Hekimi S, Guarente L (2003) Genetics and the specificity of the aging process. Science 299: 1351-1354.
5. Higgins JP, Shinghal R, Gill H, Reese JH, Terris M, et al. (2003) Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol 162: 925-932.
6. Higgins JP, Wang L, Kambham N, Montgomery K, Mason V, et al. (2004) Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell 15: 649-656.
7. Hill AA, Hunter CP, Tsung BT, Tucker-Kellogg G, Brown EL (2000) Genomic analysis of gene expression in C. elegans. Science 290: 809-812.
8. Hoang K, Tan JC, Derby G, Blouch KL, Masek M, et al. (2003) Determinants of glomerular hypofiltration in aging humans. Kidney Int 64: 1417-1424.
9. Kaul SC, Yaguchi T, Taira K, Reddel RR, Wadhwa R (2003) Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res 286: 96-101.
10. Kirkwood TB, Austad SN (2000) Why do we age? Nature 408: 233-238.
11. Lee CK, Klopp RG, Weindruch R, Prolla TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390-1393.
12. Lee CK, Weindruch R, Prolla TA (2000) Gene-expression profile of the ageing brain in mice. Nat Genet 25: 294-297.
13. Lund J, Tedesco P, Duke K, Wang J, Kim SK, et al. (2002) Transcriptional profile of aging in C. elegans. Curr Biol 12: 1566-1573.
14. Ly DH, Lockhart DJ, Lerner RA, Schultz PG (2000) Mitotic misregulation and human aging. Science 287: 2486-2492.
15. McCarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, et al. (2004) Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet 36: 197-204.
16. Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, et al. (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
17. Pletcher SD, Macdonald SJ, Marguerie R, Certa U, Stearns SC, et al. (2002) Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol 12: 712-723.
18. Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, et al. (2002) Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A 99: 4465-4470.
19. Tissenbaum HA, Guarente L (2002) Model organisms as a guide to mammalian aging. Dev Cell 2: 9-19.
20. Weindruch R (2003) Caloric restriction, gene expression, and aging. Alzheimer Dis Assoc Disord 17 (Suppl 2) S58-S59.
21. Welle S, Brooks AI, Delehanty JM, Needler N, Thornton CA (2003) Gene expression profile of aging in human muscle. Physiol Genomics 14: 149-159.
22. Welle S, Brooks AI, Delehanty JM, Needler N, Bhatt K, et al. (2004) Skelet al.muscle gene expression profiles in 20-29 year old and 65-71 year old women. Exp Gerontol 39: 369-377.
23. Yoshida S, Yashar BM, Hiriyanna S, Swaroop A (2002) Microarray analysis of gene expression in the aging human retina. Invest Ophthalmol Vis Sci 43: 2554-2560.
24. Zhong S, Li C, Wong WH (2003) ChipInfo: Software for extracting gene annotation and gene ontology information for microarray analysis. Nucleic Acids Res 31: 3483-3486.
25. Zou S, Meadows S, Sharp L, Jan LY, Jan YN (2000) Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A 97: 13726-13731.