Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo

Molecular Cancer Therapeutics

Volumn 11, Issue 11, 2012, Pages 2342-2351

  Lee, Inkyoung ^a   Lee, Sook Ja ^a   Kang, Won Ki ^a   Park, Chaehwa ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BAFILOMYCIN; CHLOROQUINE; DOXORUBICIN; FLUOROURACIL; MONOCARBOXYLATE TRANSPORTER 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL GROWTH; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; GROWTH DISORDER; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; TUMOR GROWTH;

ANIMALS; AUTOPHAGY; CELL AGING; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DNA DAMAGE; DOXORUBICIN; FLUOROURACIL; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MICE; MICE, NUDE; MITOCHONDRIA; MONOCARBOXYLIC ACID TRANSPORTERS; PHENOTYPE; REACTIVE OXYGEN SPECIES; TUMOR MARKERS, BIOLOGICAL;

EID: 84869217303     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0488     Document Type: Article

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