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Volumn 6, Issue 6, 2014, Pages 665-675

The mitochondrial epigenome: A role in Alzheimer's disease?

Author keywords

5 hydroxymethylcytosine; 5 methylcytosine:; Alzheimer's disease; dementia; DNA methylation; epigenetics; heteroplasmy; mitochondria

Indexed keywords

BIOLOGICAL MARKER; MITOCHONDRIAL DNA;

EID: 84919817265     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.14.50     Document Type: Review
Times cited : (37)

References (91)
  • 2
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 256(5054), 184-185 (1992
    • (1992) Science , vol.256 , Issue.5054 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 3
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580), 353-356 (2002
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 4
    • 0026570528 scopus 로고
    • Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12(2), 376-389 (1992
    • (1992) J. Neurosci , vol.12 , Issue.2 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 5
    • 33846633336 scopus 로고    scopus 로고
    • Abeta oligomerinduced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in alzheimer's disease
    • Lacor PN, Buniel MC, Furlow PW, et al. Abeta oligomerinduced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 27(4), 796-807 (2007
    • (2007) J. Neurosci , vol.27 , Issue.4 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3
  • 6
    • 19944426148 scopus 로고    scopus 로고
    • Amyloid beta induces neuronal cell death through ros-mediated ask1 activation
    • Kadowaki H, Nishitoh H, Urano F, et al. Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ. 12(1), 19-24 (2005
    • (2005) Cell Death Differ , vol.12 , Issue.1 , pp. 19-24
    • Kadowaki, H.1    Nishitoh, H.2    Urano, F.3
  • 7
    • 2342628596 scopus 로고    scopus 로고
    • Differential expression of oxidative phosphorylation genes in patients with alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
    • Manczak M, Park BS, Jung Y, Reddy PH. Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromol. Med. 5(2), 147-162 (2004
    • (2004) Neuromol. Med , vol.5 , Issue.2 , pp. 147-162
    • Manczak, M.1    Park, B.S.2    Jung, Y.3    Reddy, P.H.4
  • 8
    • 77956219269 scopus 로고    scopus 로고
    • Rethinking Alzheimer's disease therapy: Are mitochondria the key?
    • Ankarcrona M, Mangialasche F, Winblad B. Rethinking Alzheimer's disease therapy: are mitochondria the key?. J. Alzheimers Dis. 20(Suppl. 2), S579-S590 (2010
    • (2010) J. Alzheimers Dis , vol.20 , pp. S579-S590
    • Ankarcrona, M.1    Mangialasche, F.2    Winblad, B.3
  • 9
    • 84862861561 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and immune activation are detectable in early alzheimer's disease blood
    • Lunnon K, Ibrahim Z, Proitsi P, et al. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J. Alzheimers Dis. 30(3), 685-710 (2012
    • (2012) J. Alzheimers Dis , vol.30 , Issue.3 , pp. 685-710
    • Lunnon, K.1    Ibrahim, Z.2    Proitsi, P.3
  • 10
    • 84872437471 scopus 로고    scopus 로고
    • A blood gene expression marker of early alzheimer's disease
    • Lunnon K, Sattlecker M, Furney S, et al. A blood gene expression marker of early Alzheimer's disease. J. Alzheimers Dis. 33(3), 737-753 (2013
    • (2013) J. Alzheimers Dis , vol.33 , Issue.3 , pp. 737-753
    • Lunnon, K.1    Sattlecker, M.2    Furney, S.3
  • 11
    • 0019423856 scopus 로고
    • Sequence and organization of the human mitochondrial genome
    • Anderson S, Bankier AT, Barrell BG, et al. Sequence and organization of the human mitochondrial genome. Nature 290(5806), 457-465 (1981
    • (1981) Nature , vol.290 , Issue.5806 , pp. 457-465
    • Anderson, S.1    Bankier, A.T.2    Barrell, B.G.3
  • 12
    • 77951923949 scopus 로고    scopus 로고
    • Mitochondrial control of caspase-dependent and-independent cell death
    • Pradelli LA, Beneteau M, Ricci JE. Mitochondrial control of caspase-dependent and-independent cell death. Cell. Mol. Life Sci. 67(10), 1589-1597 (2010
    • (2010) Cell. Mol. Life Sci , vol.67 , Issue.10 , pp. 1589-1597
    • Pradelli, L.A.1    Beneteau, M.2    Ricci, J.E.3
  • 13
    • 33845985635 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletioninduced apoptosis in neural cells
    • Chan SL, Liu D, Kyriazis GA, Bagsiyao P, Ouyang X, Mattson MP. Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletioninduced apoptosis in neural cells. J. Biol. Chem. 281(49), 37391-37403 (2006
    • (2006) J. Biol. Chem , vol.281 , Issue.49 , pp. 37391-37403
    • Chan, S.L.1    Liu, D.2    Kyriazis, G.A.3    Bagsiyao, P.4    Ouyang, X.5    Mattson, M.P.6
  • 14
    • 84882951207 scopus 로고    scopus 로고
    • Activity and metabolism-related ca2+ and mitochondrial dynamics in co-cultured human fetal cortical neurons and astrocytes
    • Fu W, Ruangkittisakul A, MacTavish D, Baker GB, Ballanyi K, Jhamandas JH. Activity and metabolism-related Ca2+ and mitochondrial dynamics in co-cultured human fetal cortical neurons and astrocytes. Neuroscience 250, 520-535 (2013
    • (2013) Neuroscience , vol.250 , pp. 520-535
    • Fu, W.1    Ruangkittisakul, A.2    MacTavish, D.3    Baker, G.B.4    Ballanyi, K.5    Jhamandas, J.H.6
  • 15
    • 84881525560 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of alzheimer's disease
    • Zhao Y, Zhao B. Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid. Med. Cell. Longev. 2013, 316523 (2013
    • (2013) Oxid. Med. Cell. Longev , vol.2013 , pp. 316523
    • Zhao, Y.1    Zhao, B.2
  • 16
    • 81955164821 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved c-Terminal fragment of app in alzheimer's disease transgenic mice
    • Devi L, Ohno M. Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved C-Terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol. Dis. 45(1), 417-424 (2012
    • (2012) Neurobiol. Dis , vol.45 , Issue.1 , pp. 417-424
    • Devi, L.1    Ohno, M.2
  • 17
    • 84879881146 scopus 로고    scopus 로고
    • Mitochondrial dna damage in a mouse model of alzheimer's disease decreases amyloid beta plaque formation
    • Pinto M, Pickrell AM, Fukui H, Moraes CT. Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation. Neurobiol. Aging 34(10), 2399-2407 (2013
    • (2013) Neurobiol. Aging , vol.34 , Issue.10 , pp. 2399-2407
    • Pinto, M.1    Pickrell, A.M.2    Fukui, H.3    Moraes, C.T.4
  • 18
    • 77956224679 scopus 로고    scopus 로고
    • The alzheimer's disease mitochondrial cascade hypothesis
    • Swerdlow RH, Burns JM, Khan SM. The Alzheimer's disease mitochondrial cascade hypothesis. J. Alzheimers Dis. 20(Suppl. 2), S265-S279 (2010
    • (2010) J. Alzheimers Dis , vol.20 , pp. S265-S279
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 20
    • 13244292394 scopus 로고    scopus 로고
    • Timecourse of mitochondrial gene expressions in mice brains: Implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging
    • Manczak M, Jung Y, Park BS, Partovi D, Reddy PH. Timecourse of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging. J. Neurochem. 92(3), 494-504 (2005
    • (2005) J. Neurochem , vol.92 , Issue.3 , pp. 494-504
    • Manczak, M.1    Jung, Y.2    Park, B.S.3    Partovi, D.4    Reddy, P.H.5
  • 21
    • 3042736860 scopus 로고    scopus 로고
    • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in alzheimer's disease
    • Reddy PH, McWeeney S, Park BS, et al. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum. Mol. Genet. 13(12), 1225-1240 (2004
    • (2004) Hum. Mol. Genet , vol.13 , Issue.12 , pp. 1225-1240
    • Reddy, P.H.1    McWeeney, S.2    Park, B.S.3
  • 22
    • 84869012777 scopus 로고    scopus 로고
    • Abnormal interaction of vdac1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in alzheimer's disease
    • Manczak M, Reddy PH. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Hum. Mol. Genet. 21(23), 5131-5146 (2012
    • (2012) Hum. Mol. Genet , vol.21 , Issue.23 , pp. 5131-5146
    • Manczak, M.1    Reddy, P.H.2
  • 23
    • 53549129483 scopus 로고    scopus 로고
    • Cyclophilin d deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in alzheimer's disease
    • Du H, Guo L, Fang F, et al. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat. Med. 14(10), 1097-1105 (2008
    • (2008) Nat. Med , vol.14 , Issue.10 , pp. 1097-1105
    • Du, H.1    Guo, L.2    Fang, F.3
  • 24
    • 32244435907 scopus 로고    scopus 로고
    • Role of genes and environments for explaining alzheimer disease
    • Gatz M, Reynolds CA, Fratiglioni L, et al. Role of genes and environments for explaining Alzheimer disease. Arch. Gen. Psychiatry 63(2), 168-174 (2006
    • (2006) Arch. Gen. Psychiatry , vol.63 , Issue.2 , pp. 168-174
    • Gatz, M.1    Reynolds, C.A.2    Fratiglioni, L.3
  • 25
    • 84887100129 scopus 로고    scopus 로고
    • Epigenetic studies in alzheimer's disease: Current findings caveats and considerations for future studies
    • Lunnon K, Mill J. Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr. Genet. 162B(8), 789-799 (2013
    • (2013) Am. J. Med. Genet. B Neuropsychiatr. Genet , vol.162 , Issue.8 , pp. 789-799
    • Lunnon, K.1    Mill, J.2
  • 26
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for alzheimer's disease
    • Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS ONE 4(8), e6617 (2009
    • (2009) PLoS ONE , vol.4 , Issue.8 , pp. e6617
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 28
    • 84878944565 scopus 로고    scopus 로고
    • Consistent decrease in global dna methylation and hydroxymethylation in the hippocampus of alzheimer's disease patients
    • Chouliaras L, Mastroeni D, Delvaux E, et al. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol. Aging 34(9), 2091-2099 (2013
    • (2013) Neurobiol. Aging , vol.34 , Issue.9 , pp. 2091-2099
    • Chouliaras, L.1    Mastroeni, D.2    Delvaux, E.3
  • 29
    • 84899943291 scopus 로고    scopus 로고
    • Cross-region reduction in 5-hydroxymethylcytosine in alzheimer's disease brain
    • Condliffe D, Wong A, Troakes C, et al. Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol. Aging 35(8), 1850-1854 (2014
    • (2014) Neurobiol. Aging , vol.35 , Issue.8 , pp. 1850-1854
    • Condliffe, D.1    Wong, A.2    Troakes, C.3
  • 30
    • 84859412462 scopus 로고    scopus 로고
    • Genome-wide dna methylation differences between late-onset alzheimer's disease and cognitively normal controls in human frontal cortex
    • Bakulski KM, Dolinoy DC, Sartor MA, et al. Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. J. Alzheimers Dis. 29(3), 571-588 (2012
    • (2012) J. Alzheimers Dis , vol.29 , Issue.3 , pp. 571-588
    • Bakulski, K.M.1    Dolinoy, D.C.2    Sartor, M.A.3
  • 31
    • 84906716826 scopus 로고    scopus 로고
    • Cross-Tissue methylomic profiling in alzheimer's disease implicates a role for cortex-specific deregulation of ank1 in neuropathology
    • Lunnon K, Smith R, Hannon EJ, et al. Cross-Tissue methylomic profiling in Alzheimer's disease implicates a role for cortex-specific deregulation of ANK1 in neuropathology. Nat. Neurosci. 17(9), 1164-1170 (2014
    • (2014) Nat. Neurosci , vol.17 , Issue.9 , pp. 1164-1170
    • Lunnon, K.1    Smith, R.2    Hannon, E.J.3
  • 32
    • 84919784465 scopus 로고    scopus 로고
    • Alzheimer'sdisease pathology is associated with early alterations in brain dna methylationat ank1
    • PL DeJager, Srivastava G, Lunnon, et al. Alzheimer'sdisease pathology is associated with early alterations in brain DNA methylationat ANK1, BIN1 and other loci. Nat. Neurosci. 17(9), 1156-1163 (2014
    • (2014) BIN1 and Other Loci. Nat. Neurosci , vol.17 , Issue.9 , pp. 1156-1163
    • Dejager, P.L.1    Srivastava, G.2    Lunnon3
  • 33
    • 0015812379 scopus 로고
    • Differential methylation of mitochondrial and nuclear dna in cultured mouse, hamster and virustransformed hamster cells in vivo and in vitro methylation
    • Nass MM. Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virustransformed hamster cells. In vivo and in vitro methylation. J. Mol. Biol. 80(1), 155-175 (1973
    • (1973) J. Mol. Biol , vol.80 , Issue.1 , pp. 155-175
    • Nass, M.M.1
  • 34
    • 0015953437 scopus 로고
    • 5-methylcytidylic acid: Absence from mitochondrial dna of frogs and hela cells
    • Dawid IB. 5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells. Science 184(4132), 80-81 (1974
    • (1974) Science , vol.184 , Issue.4132 , pp. 80-81
    • Dawid, I.B.1
  • 36
    • 0018802805 scopus 로고
    • Mitochondrial dna from various organisms does not contain internally methylated cytosine in-ccgg-sequences
    • Groot GS Kroon AM. Mitochondrial DNA from various organisms does not contain internally methylated cytosine in-CCGG-sequences. Biochim. Biophys. Acta 564(2), 355-357 (1979
    • (1979) Biochim. Biophys. Acta , vol.564 , Issue.2 , pp. 355-357
    • Groot, G.S.1    Kroon, A.M.2
  • 37
    • 79952749156 scopus 로고    scopus 로고
    • Dna methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
    • Shock LS, Thakkar PV, Peterson EJ, Moran RG, Taylor SM. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc. Natl Acad. Sci. USA 108(9), 3630-3635 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.9 , pp. 3630-3635
    • Shock, L.S.1    Thakkar, P.V.2    Peterson, E.J.3    Moran, R.G.4    Taylor, S.M.5
  • 38
    • 79551612072 scopus 로고    scopus 로고
    • Fluorescent in situ hybridization of mitochondrial dna and rna
    • Alan L, Zelenka J, Jezek J, Dlaskova A, Jezek P. Fluorescent in situ hybridization of mitochondrial DNA and RNA. Acta Biochim. Pol. 57(4), 403-408 (2010
    • (2010) Acta Biochim. Pol , vol.57 , Issue.4 , pp. 403-408
    • Alan, L.1    Zelenka, J.2    Jezek, J.3    Dlaskova, A.4    Jezek, P.5
  • 39
    • 84873339236 scopus 로고    scopus 로고
    • Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in hepg2 cells
    • Tauber J, Dlaskova A, Santorova J, et al. Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells. Int. J. Biochem. Cell Biol. 45(3), 593-603 (2013
    • (2013) Int. J. Biochem. Cell Biol , vol.45 , Issue.3 , pp. 593-603
    • Tauber, J.1    Dlaskova, A.2    Santorova, J.3
  • 40
    • 34548495323 scopus 로고    scopus 로고
    • The mitochondrial transcription factor tfam coordinates the assembly of multiple dna molecules into nucleoid-like structures
    • Kaufman BA, Durisic N, Mativetsky JM, et al. The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. Mol. Biol. Cell 18(9), 3225-3236 (2007
    • (2007) Mol. Biol. Cell , vol.18 , Issue.9 , pp. 3225-3236
    • Kaufman, B.A.1    Durisic, N.2    Mativetsky, J.M.3
  • 41
    • 84864459466 scopus 로고    scopus 로고
    • Mitochondrial dna: A blind spot in neuroepigenetics
    • Manev H, Dzitoyeva S, Chen H. Mitochondrial DNA: a blind spot in neuroepigenetics. Biomol. Concepts 3(2), 107-115 (2012
    • (2012) Biomol. Concepts , vol.3 , Issue.2 , pp. 107-115
    • Manev, H.1    Dzitoyeva, S.2    Chen, H.3
  • 42
    • 73349116629 scopus 로고    scopus 로고
    • In vivo methylation of mtdna reveals the dynamics of protein-mtdna interactions
    • Rebelo AP, Williams SL, Moraes CT. In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions. Nucleic Acids Res. 37(20), 6701-6715 (2009
    • (2009) Nucleic Acids Res , vol.37 , Issue.20 , pp. 6701-6715
    • Rebelo, A.P.1    Williams, S.L.2    Moraes, C.T.3
  • 43
    • 81255143014 scopus 로고    scopus 로고
    • Epigenetic regulation of motor neuron cell death through dna methylation
    • Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, Martin LJ. Epigenetic regulation of motor neuron cell death through DNA methylation. J. Neurosci. 31(46), 16619-16636 (2011
    • (2011) J. Neurosci , vol.31 , Issue.46 , pp. 16619-16636
    • Chestnut, B.A.1    Chang, Q.2    Price, A.3    Lesuisse, C.4    Wong, M.5    Martin, L.J.6
  • 44
    • 84882889657 scopus 로고    scopus 로고
    • The control region of mitochondrial dna shows an unusual cpg and non-cpg methylation pattern
    • Bellizzi D, D'Aquila P, Scafone T, et al. The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern. DNA Res. 20(6), 537-547 (2013
    • (2013) DNA Res , vol.20 , Issue.6 , pp. 537-547
    • Bellizzi, D.1    D'aquila, P.2    Scafone, T.3
  • 45
    • 45449114804 scopus 로고    scopus 로고
    • The colorful history of active dna demethylation
    • Ooi SK, Bestor TH. The colorful history of active DNA demethylation. Cell 133(7), 1145-1148 (2008
    • (2008) Cell , vol.133 , Issue.7 , pp. 1145-1148
    • Ooi, S.K.1    Bestor, T.H.2
  • 46
    • 77956189495 scopus 로고    scopus 로고
    • Role of tet proteins in 5mc to 5hmc conversion es-cell self-renewal and inner cell mass specification
    • Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466(7310), 1129-1133 (2010
    • (2010) Nature , vol.466 , Issue.7310 , pp. 1129-1133
    • Ito, S.1    D'alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 47
    • 84874267510 scopus 로고    scopus 로고
    • High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells
    • Sun Z, Terragni J, Borgaro JG, et al. High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep. 3(2), 567-576 (2013
    • (2013) Cell Rep , vol.3 , Issue.2 , pp. 567-576
    • Sun, Z.1    Terragni, J.2    Borgaro, J.G.3
  • 48
    • 84861627818 scopus 로고    scopus 로고
    • Correlation between increased nd2 expression and demethylated displacement loop of mtdna in colorectal cancer
    • Feng S, Xiong L, Ji Z, Cheng W, Yang H. Correlation between increased ND2 expression and demethylated displacement loop of mtDNA in colorectal cancer. Mol. Med. Rep. 6(1), 125-130 (2012
    • (2012) Mol. Med. Rep , vol.6 , Issue.1 , pp. 125-130
    • Feng, S.1    Xiong, L.2    Ji, Z.3    Cheng, W.4    Yang, H.5
  • 49
    • 84894156694 scopus 로고    scopus 로고
    • Defective mitochondrial function in vivo in skeletal muscle in adults with down's syndrome: A 31p-mrs study
    • Phillips AC, Sleigh A, McAllister CJ, et al. Defective mitochondrial function in vivo in skeletal muscle in adults with Down's syndrome: a 31P-MRS study. PLoS ONE 8(12), e84031 (2013
    • (2013) PLoS ONE , vol.8 , Issue.12 , pp. e84031
    • Phillips, A.C.1    Sleigh, A.2    McAllister, C.J.3
  • 51
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of alzheimer's disease in down's syndrome
    • Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17(3), 278-282 (1985
    • (1985) Ann. Neurol , vol.17 , Issue.3 , pp. 278-282
    • Wisniewski, K.E.1    Wisniewski, H.M.2    Wen, G.Y.3
  • 52
    • 84878097979 scopus 로고    scopus 로고
    • Effects of airborne pollutants on mitochondrial dna methylation
    • Byun HM, Panni T, Motta V, et al. Effects of airborne pollutants on mitochondrial DNA methylation. Part. Fibre Toxicol. 10, 18 (2013
    • (2013) Part. Fibre Toxicol , vol.10 , Issue.18
    • Byun, H.M.1    Panni, T.2    Motta, V.3
  • 53
    • 84881546730 scopus 로고    scopus 로고
    • Epigenetic modification of liver mitochondrial dna is associated with histological severity of nonalcoholic fatty liver disease
    • Pirola CJ, Gianotti TF, Burgueno AL, et al. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut 62(9), 1356-1363 (2013
    • (2013) Gut , vol.62 , Issue.9 , pp. 1356-1363
    • Pirola, C.J.1    Gianotti, T.F.2    Burgueno, A.L.3
  • 54
    • 79851512298 scopus 로고    scopus 로고
    • Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in down's syndrome
    • Infantino V, Castegna A, Iacobazzi F, et al. Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome. Mol. Genet. Metab. 102(3), 378-382 (2011
    • (2011) Mol. Genet. Metab , vol.102 , Issue.3 , pp. 378-382
    • Infantino, V.1    Castegna, A.2    Iacobazzi, F.3
  • 55
    • 84891533924 scopus 로고    scopus 로고
    • Mitochondrial dnmt3a and dna methylation in skeletal muscle and cns of transgenic mouse models of als
    • Wong M, Gertz B, Chestnut BA, Martin LJ. Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Front. Cell. Neurosci. 7, 279 (2013
    • (2013) Front. Cell. Neurosci , vol.7 , Issue.279
    • Wong, M.1    Gertz, B.2    Chestnut, B.A.3    Martin, L.J.4
  • 56
    • 84881604162 scopus 로고    scopus 로고
    • Decreased copy number of mitochondrial dna: A potential diagnostic criterion for gastric cancer
    • Wen SL, Zhang F, Feng S. Decreased copy number of mitochondrial DNA: a potential diagnostic criterion for gastric cancer. Oncol. Lett. 6(4), 1098-1102 (2013
    • (2013) Oncol. Lett , vol.6 , Issue.4 , pp. 1098-1102
    • Wen, S.L.1    Zhang, F.2    Feng, S.3
  • 57
    • 84888133742 scopus 로고    scopus 로고
    • Epigenetic changes in the progression of alzheimer's disease
    • Bradley-Whitman MA, Lovell MA. Epigenetic changes in the progression of Alzheimer's disease. Mech. Ageing Dev. 134(10), 486-495 (2013
    • (2013) Mech. Ageing Dev , vol.134 , Issue.10 , pp. 486-495
    • Bradley-Whitman, M.A.1    Lovell, M.A.2
  • 58
    • 84866755324 scopus 로고    scopus 로고
    • Effect of aging on 5-hydroxymethylcytosine in brain mitochondria
    • Dzitoyeva S, Chen H, Manev H. Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol. Aging 33(12), 2881-2891 (2012
    • (2012) Neurobiol. Aging , vol.33 , Issue.12 , pp. 2881-2891
    • Dzitoyeva, S.1    Chen, H.2    Manev, H.3
  • 59
    • 49749121841 scopus 로고    scopus 로고
    • A novel role for mitochondria in regulating epigenetic modification in the nucleus
    • Smiraglia DJ, Kulawiec M, Bistulfi GL, Gupta SG, Singh KK. A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol. Ther. 7(8), 1182-1190 (2008
    • (2008) Cancer Biol. Ther , vol.7 , Issue.8 , pp. 1182-1190
    • Smiraglia, D.J.1    Kulawiec, M.2    Bistulfi, G.L.3    Gupta, S.G.4    Singh, K.K.5
  • 60
  • 61
    • 77955670048 scopus 로고    scopus 로고
    • Dna methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions
    • Takasugi M, Yagi S, Hirabayashi K, Shiota K. DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions. BMC Genomics 11, 481 (2010
    • (2010) BMC Genomics , vol.11 , Issue.481
    • Takasugi, M.1    Yagi, S.2    Hirabayashi, K.3    Shiota, K.4
  • 62
    • 51649110939 scopus 로고    scopus 로고
    • Many species in one: Dna barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified
    • Song H, Buhay JE, Whiting MF, Crandall KA. Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified. Proc. Natl Acad. Sci. USA 105(36), 13486-13491 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.36 , pp. 13486-13491
    • Song, H.1    Buhay, J.E.2    Whiting, M.F.3    Crandall, K.A.4
  • 63
    • 84885012678 scopus 로고    scopus 로고
    • Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine
    • Booth MJ, Ost TW, Beraldi D, et al. Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat. Protoc. 8(10), 1841-1851 (2013
    • (2013) Nat. Protoc , vol.8 , Issue.10 , pp. 1841-1851
    • Booth, M.J.1    Ost, T.W.2    Beraldi, D.3
  • 64
    • 0033367329 scopus 로고    scopus 로고
    • Mitochondrial genome evolution and the origin of eukaryotes
    • Lang BF, Gray MW, Burger G. Mitochondrial genome evolution and the origin of eukaryotes. Annu. Rev. Genet. 33, 351-397 (1999
    • (1999) Annu. Rev. Genet , vol.33 , pp. 351-397
    • Lang, B.F.1    Gray, M.W.2    Burger, G.3
  • 65
    • 34548399778 scopus 로고    scopus 로고
    • Mitochondrial introgressions into the nuclear genome of the domestic cat
    • Antunes A, Pontius J, Ramos MJ, O'Brien SJ, Johnson WE. Mitochondrial introgressions into the nuclear genome of the domestic cat. J. Hered. 98(5), 414-420 (2007
    • (2007) J. Hered , vol.98 , Issue.5 , pp. 414-420
    • Antunes, A.1    Pontius, J.2    Ramos, M.J.3    O'brien, S.J.4    Johnson, W.E.5
  • 66
    • 84864934013 scopus 로고    scopus 로고
    • Primates and mouse numts in the ucsc genome browser
    • Calabrese FM, Simone D, Attimonelli M. Primates and mouse NumtS in the UCSC Genome Browser. BMC Bioinform. 13(Suppl. 4), S15 (2012
    • (2012) BMC Bioinform , vol.13 , pp. S15
    • Calabrese, F.M.1    Simone, D.2    Attimonelli, M.3
  • 67
    • 84880870813 scopus 로고    scopus 로고
    • Hominin evolution and gene flow in the pleistocene africa
    • Ovchinnikov IV. Hominin evolution and gene flow in the Pleistocene Africa. Anthropol. Anz. 70(2), 221-227 (2013
    • (2013) Anthropol. Anz , vol.70 , Issue.2 , pp. 221-227
    • Ovchinnikov, I.V.1
  • 68
    • 19344368527 scopus 로고    scopus 로고
    • Continued colonization of the human genome by mitochondrial dna
    • Ricchetti M, Tekaia F, Dujon B. Continued colonization of the human genome by mitochondrial DNA. PLoS Biol. 2(9), E273 (2004
    • (2004) PLoS Biol , vol.2 , Issue.9 , pp. E273
    • Ricchetti, M.1    Tekaia, F.2    Dujon, B.3
  • 69
    • 36448952310 scopus 로고    scopus 로고
    • Molecular analyses of mitochondrial pseudogenes within the nuclear genome of arvicoline rodents
    • Triant DA, DeWoody JA. Molecular analyses of mitochondrial pseudogenes within the nuclear genome of arvicoline rodents. Genetica 132(1), 21-33 (2008
    • (2008) Genetica , vol.132 , Issue.1 , pp. 21-33
    • Triant, D.A.1    Dewoody, J.A.2
  • 70
    • 0034882969 scopus 로고    scopus 로고
    • The human genome project reveals a continuous transfer of large mitochondrial fragments to the nucleus
    • Mourier T, Hansen AJ, Willerslev E, Arctander P. The Human Genome Project reveals a continuous transfer of large mitochondrial fragments to the nucleus. Mol. Biol. Evol. 18(9), 1833-1837 (2001
    • (2001) Mol. Biol. Evol , vol.18 , Issue.9 , pp. 1833-1837
    • Mourier, T.1    Hansen, A.J.2    Willerslev, E.3    Arctander, P.4
  • 71
    • 70450253232 scopus 로고    scopus 로고
    • Ancient mitogenomics
    • Ho SY, Gilbert MT. Ancient mitogenomics. Mitochondrion 10(1), 1-11 (2010
    • (2010) Mitochondrion , vol.10 , Issue.1 , pp. 1-11
    • Ho, S.Y.1    Gilbert, M.T.2
  • 72
    • 0242634301 scopus 로고    scopus 로고
    • Sperm mitochondrial mutations as a cause of low sperm motility
    • Thangaraj K, Joshi MB, Reddy AG, Rasalkar AA, Singh L. Sperm mitochondrial mutations as a cause of low sperm motility. J. Androl. 24(3), 388-392 (2003
    • (2003) J. Androl , vol.24 , Issue.3 , pp. 388-392
    • Thangaraj, K.1    Joshi, M.B.2    Reddy, A.G.3    Rasalkar, A.A.4    Singh, L.5
  • 73
    • 56649112226 scopus 로고    scopus 로고
    • Pseudomitochondrial genome haunts disease studies
    • Yao YG, Kong QP, Salas A, Bandelt HJ. Pseudomitochondrial genome haunts disease studies. J. Med. Genet. 45(12), 769-772 (2008
    • (2008) J. Med. Genet , vol.45 , Issue.12 , pp. 769-772
    • Yao, Y.G.1    Kong, Q.P.2    Salas, A.3    Bandelt, H.J.4
  • 74
    • 0031449003 scopus 로고    scopus 로고
    • Apparent mtdna heteroplasmy in alzheimer's disease patients and in normals due to pcr amplification of nucleus-embedded mtdna pseudogenes
    • Hirano M, Shtilbans A, Mayeux R, et al. Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc. Natl Acad. Sci. USA 94(26), 14894-14899 (1997
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.26 , pp. 14894-14899
    • Hirano, M.1    Shtilbans, A.2    Mayeux, R.3
  • 75
    • 12644257598 scopus 로고    scopus 로고
    • Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset alzheimer disease
    • Davis RE, Miller S, Herrnstadt C, et al. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc. Natl Acad. Sci. USA 94(9), 4526-4531 (1997
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.9 , pp. 4526-4531
    • Davis, R.E.1    Miller, S.2    Herrnstadt, C.3
  • 76
    • 84882847104 scopus 로고    scopus 로고
    • Mitochondrial dna methylation as a next-generation biomarker and diagnostic tool
    • Iacobazzi V, Castegna A, Infantino V, Andria G. Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. Mol. Genet. Metab. 110(1-2), 25-34 (2013
    • (2013) Mol. Genet. Metab , vol.110 , Issue.1-2 , pp. 25-34
    • Iacobazzi, V.1    Castegna, A.2    Infantino, V.3    Andria, G.4
  • 77
    • 77956870508 scopus 로고    scopus 로고
    • Method to purify mitochondrial dna directly from yeast total dna
    • Zhou J, Liu L, Chen J. Method to purify mitochondrial DNA directly from yeast total DNA. Plasmid 64(3), 196-199 (2010
    • (2010) Plasmid , vol.64 , Issue.3 , pp. 196-199
    • Zhou, J.1    Liu, L.2    Chen, J.3
  • 78
    • 84901382660 scopus 로고    scopus 로고
    • Mitochondrial dna genetics and the heteroplasmy conundrum in evolution and disease
    • Wallace DC, Chalkia D. Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease. Cold Spring Harb. Perspect. Biol. 5(11), a021220 (2013
    • (2013) Cold Spring Harb. Perspect. Biol , vol.5 , Issue.11 , pp. a021220
    • Wallace, D.C.1    Chalkia, D.2
  • 79
    • 84863239514 scopus 로고    scopus 로고
    • High levels of mitochondrial heteroplasmy modify the development of ovine-bovine interspecies nuclear transferred embryos
    • Hua S, Lu C, Song Y, et al. High levels of mitochondrial heteroplasmy modify the development of ovine-bovine interspecies nuclear transferred embryos. Reprod. Fertil. Dev. 24(3), 501-509 (2012
    • (2012) Reprod. Fertil. Dev , vol.24 , Issue.3 , pp. 501-509
    • Hua, S.1    Lu, C.2    Song, Y.3
  • 80
    • 17744397107 scopus 로고    scopus 로고
    • Mitochondrial dna haplogroups and apoe4 allele are non-independent variables in sporadic alzheimer's disease
    • Carrieri G, Bonafe M, De Luca M, et al. Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease. Hum. Genet. 108(3), 194-198 (2001
    • (2001) Hum. Genet , vol.108 , Issue.3 , pp. 194-198
    • Carrieri, G.1    Bonafe, M.2    De Luca, M.3
  • 81
    • 70049112960 scopus 로고    scopus 로고
    • Mitochondrial haplogroup H and Alzheimer's disease: Is there a connection?. Neurobiol
    • Maruszak A, Canter JA, Styczynska M, Zekanowski C, Barcikowska M. Mitochondrial haplogroup H and Alzheimer's disease: is there a connection?. Neurobiol. Aging 30(11), 1749-1755 (2009
    • (2009) Aging , vol.30 , Issue.11 , pp. 1749-1755
    • Maruszak, A.1    Canter, J.A.2    Styczynska, M.3    Zekanowski, C.4    Barcikowska, M.5
  • 82
    • 84862210732 scopus 로고    scopus 로고
    • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    • Davies MN, Volta M, Pidsley R, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 13(6), R43 (2012
    • (2012) Genome Biol , vol.13 , Issue.6 , pp. R43
    • Davies, M.N.1    Volta, M.2    Pidsley, R.3
  • 83
    • 84884853033 scopus 로고    scopus 로고
    • Dna methylation map of mouse and human brain identifies target genes in alzheimer's disease
    • Sanchez-Mut JV, Aso E, Panayotis N, et al. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain 136(Pt 10), 3018-3027 (2013
    • (2013) Brain , vol.136 , pp. 3018-3027
    • Sanchez-Mut, J.V.1    Aso, E.2    Panayotis, N.3
  • 85
    • 84885426338 scopus 로고    scopus 로고
    • Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells
    • Park J, Choi H, Min JS, et al. Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells. J. Neurochem. 127(2), 221-232 (2013
    • (2013) J. Neurochem , vol.127 , Issue.2 , pp. 221-232
    • Park, J.1    Choi, H.2    Min, J.S.3
  • 86
    • 77954061853 scopus 로고    scopus 로고
    • Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in dna
    • Nestor C, Ruzov A, Meehan R, Dunican D. Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA. Biotechniques 48(4), 317-319 (2010
    • (2010) Biotechniques , vol.48 , Issue.4 , pp. 317-319
    • Nestor, C.1    Ruzov, A.2    Meehan, R.3    Dunican, D.4
  • 87
    • 84870525593 scopus 로고    scopus 로고
    • A comparison of the whole genome approach of medip-seq to the targeted approach of the infinium humanmethylation 450 bead chip ((r)) for methylome profiling
    • Clark C, Palta P, Joyce CJ, et al. A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation 450 Bead Chip ((R)) for methylome profiling. PLoS ONE 7(11), e50233 (2012
    • (2012) PLoS ONE , vol.7 , Issue.11 , pp. e50233
    • Clark, C.1    Palta, P.2    Joyce, C.J.3
  • 88
    • 84867400649 scopus 로고    scopus 로고
    • Dna methylation based biomarkers: Practical considerations and applications
    • How Kit A, Nielsen HM, Tost J. DNA methylation based biomarkers: practical considerations and applications. Biochimie 94(11), 2314-2337 (2012
    • (2012) Biochimie , vol.94 , Issue.11 , pp. 2314-2337
    • How Kit, A.1    Nielsen, H.M.2    Tost, J.3
  • 89
    • 84877336241 scopus 로고    scopus 로고
    • Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of tet1
    • Liu C, Liu L, Chen X, et al Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. PLoS ONE 8(5), e62828 (2013
    • (2013) PLoS ONE , vol.8 , Issue.5 , pp. e62828
    • Liu, C.1    Liu, L.2    Chen, X.3
  • 90
    • 84891801684 scopus 로고    scopus 로고
    • A prognostic dna methylation signature for stage i non-small-cell lung cancer
    • Sandoval J, Mendez-Gonzalez J, Nadal E, et al. A prognostic DNA methylation signature for stage I non-small-cell lung cancer. J. Clin. Oncol. 31(32), 4140-4147 (2013
    • (2013) J. Clin. Oncol , vol.31 , Issue.32 , pp. 4140-4147
    • Sandoval, J.1    Mendez-Gonzalez, J.2    Nadal, E.3


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