Cyclophilin A in cardiovascular homeostasis and diseases

Tohoku Journal of Experimental Medicine

Volumn 235, Issue 1, 2014, Pages 1-15

  Satoh, Kimio ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Biomarker; Cardiovascular diseases; Cyclophilin A; Oxidative stress; Vascular smooth muscle cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; APOLIPOPROTEIN E; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CYCLOPHILIN A; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ERYTHROPOIETIN RECEPTOR; EZRIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATRIX METALLOPROTEINASE; MOESIN; MYOSIN LIGHT CHAIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PRAVASTATIN; RADIXIN; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THROMBIN; UROTENSIN; VASCULOTROPIN;

ABDOMINAL AORTA ANEURYSM; AGE; ANGIOGRAPHY; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ARTERY LIGATION; CELL MIGRATION; CELL PROLIFERATION; COHORT ANALYSIS; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; DISEASE SEVERITY; DYSLIPIDEMIA; GLOMERULUS FILTRATION RATE; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; HYPERTENSION; HYPOXIA; INFLAMMATION; NEOINTIMA; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PERCUTANEOUS CORONARY INTERVENTION; PREVALENCE; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; PULMONARY HYPERTENSION; REVIEW; SENSITIVITY ANALYSIS; SMOKING; SUDDEN DEATH; VASCULAR SMOOTH MUSCLE; ANIMAL; BLOOD; CARDIOVASCULAR SYSTEM; METABOLISM; PATHOLOGY;

ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CYCLOPHILIN A; HOMEOSTASIS; HUMANS; OXIDATIVE STRESS; RHO-ASSOCIATED KINASES;

EID: 84919785016     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.235.1     Document Type: Review

References (114)

1. Abe, K., Shimokawa, H., Morikawa, K., Uwatoku, T., Oi, K., Matsumoto, Y., Hattori, T., Nakashima, Y., Kaibuchi, K., Sueishi, K. & Takeshita, A. (2004) Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ. Res., 94, 385-393.
2. Abe, K., Tawara, S., Oi, K., Hizume, T., Uwatoku, T., Fukumoto, Y., Kaibuchi, K. & Shimokawa, H. (2006) Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J. Cardiovasc. Pharmacol., 48, 280-285.
3. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y. & Kaibuchi, K. (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem., 271, 20246-20249.
4. Anagnostou, A., Liu, Z., Steiner, M., Chin, K., Lee, E. S., Kessimian, N. & Noguchi, C. T. (1994) Erythropoietin receptor mRNA expression in human endothelial cells. Proc. Natl. Acad. Sci. USA, 91, 3974-3978.
5. Baas, A. S. & Berk, B. C. (1995) Differential activation of mitogenactivated protein kinases by H2O2 and O2-in vascular smooth muscle cells. Circ. Res., 77, 29-36.
6. Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., Robbins, J. & Molkentin, J. D. (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature, 434, 658-662.
7. Beleslin-Cokic, B. B., Cokic, V. P., Yu, X., Weksler, B. B., Schechter, A. N. & Noguchi, C. T. (2004) Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood, 104, 2073-2080.
8. Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., Berk, B. C. & Zlokovic, B. V. (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature, 485, 512-516.
9. Bergsma, D. J., Eder, C., Gross, M., Kersten, H., Sylvester, D., Appelbaum, E., Cusimano, D., Livi, G. P., McLaughlin, M. M., Kasyan, K., Porter, T. G., Silverman, C., Dunnington, D., Hand, A., Prichett, W. P., Bossard, M. J., Brandt, M. and Levy, M. A. (1991) The cyclophilin multigene family of peptidylprolyl isomerases. Characterization of three separate human isoforms. J. Biol. Chem., 266, 23204-23214.
10. Berk, B. C. (2001) Vascular smooth muscle growth: autocrine growth mechanisms. Physiol. Rev., 81, 999-1030.
11. Berk, B. C. (2008) Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells. Circulation, 117, 1082-1089.
12. Bierer, B. E. (1994) Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. Chem. Immunol., 59, 128-155.
13. Cassis, L. A., Rateri, D. L., Lu, H. & Daugherty, A. (2007) Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler. Thromb. Vasc. Biol., 27, 380-386.
14. Choi, K. J., Piao, Y. J., Lim, M. J., Kim, J. H., Ha, J., Choe, W. & Kim, S. S. (2007) Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia-and cisplatin-induced cell death. Cancer Res., 67, 3654-3662.
15. Cohen, R. A. & Adachi, T. (2006) Nitric-oxide-induced vasodilatation: regulation by physiologic s-glutathiolation and pathologic oxidation of the sarcoplasmic endoplasmic reticulum calcium ATPase. Trends Cardiovasc. Med., 16, 109-114.
16. Doe, Z., Fukumoto, Y., Takaki, A., Tawara, S., Ohashi, J., Nakano, M., Tada, T., Saji, K., Sugimura, K., Fujita, H., Hoshikawa, Y., Nawata, J., Kondo, T. & Shimokawa, H. (2009) Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ. J., 73, 1731-1739.
17. Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., Gunn-Moore, F. J., Vonsattel, J. P., Arancio, O., Chen, J. X. & Yan, S. D. (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat. Med., 14, 1097-1105.
18. Elias-Al-Mamun, M., Satoh, K., Tanaka, S., Shimizu, T., Nergui, S., Miyata, S., Fukumoto, Y. & Shimokawa, H. (2014) Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats. Circ. J., 78, 967-976.
19. Elrod, J. W., Wong, R., Mishra, S., Vagnozzi, R. J., Sakthievel, B., Goonasekera, S. A., Karch, J., Gabel, S., Farber, J., Force, T., Brown, J. H., Murphy, E. & Molkentin, J. D. (2010) Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J. Clin. Invest., 120, 3680-3687.
20. Enkhjargal, B., Godo, S., Sawada, A., Suvd, N., Saito, H., Noda, K., Satoh, K. & Shimokawa, H. (2014) Endothelial AMPactivated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice. Arterioscler. Thromb. Vasc. Biol., 34, 1505-1513.
21. Fukumoto, Y., Matoba, T., Ito, A., Tanaka, H., Kishi, T., Hayashidani, S., Abe, K., Takeshita, A. & Shimokawa, H. (2005) Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart, 91, 391-392.
22. Fukumoto, Y., Yamada, N., Matsubara, H., Mizoguchi, M., Uchino, K., Yao, A., Kihara, Y., Kawano, M., Watanabe, H., Takeda, Y., Adachi, T., Osanai, S., Tanabe, N., Inoue, T., Kubo, A., Ota, Y., Fukuda, K., Nakano, T. & Shimokawa, H. (2013) Doubleblind, placebo-controlled clinical trial with a rho-kinase inhibitor in pulmonary arterial hypertension. Circ. J., 77, 2619-2625.
23. Galat, A. & Metcalfe, S. M. (1995) Peptidylproline cis/trans isomerases. Prog. Biophys. Mol. Biol., 63, 67-118.
24. Gensini, G. G. (1983) A more meaningful scoring system for determining the severity of coronary heart disease. Am. J. Cardiol., 51, 606.
25. Ghezzi, P. & Brines, M. (2004) Erythropoietin as an antiapoptotic, tissue-protective cytokine. Cell Death Differ., 11 Suppl 1, S37-44.
26. Griendling, K. K. & FitzGerald, G. A. (2003) Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation, 108, 2034-2040.
27. Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D. & Alexander, R. W. (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res., 74, 1141-1148.
28. Guo, H., Majmudar, G., Jensen, T. C., Biswas, C., Toole, B. P. & Gordon, M. K. (1998) Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. Gene, 220, 99-108.
29. Handschumacher, R. E., Harding, M. W., Rice, J., Drugge, R. J. & Speicher, D. W. (1984) Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science, 226, 544-547.
30. Harding, M. W., Handschumacher, R. E. & Speicher, D. W. (1986) Isolation and amino acid sequence of cyclophilin. J. Biol. Chem., 261, 8547-8555.
31. Haug, C., Lenz, C., Diaz, F. & Bachem, M. G. (2004) Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 24, 1823-1829.
32. Higashi, M., Shimokawa, H., Hattori, T., Hiroki, J., Mukai, Y., Morikawa, K., Ichiki, T., Takahashi, S. & Takeshita, A. (2003) Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ. Res., 93, 767-775.
33. Ikeda, S., Satoh, K., Kikuchi, N., Miyata, S., Suzuki, K., Omura, J., Shimizu, T., Kobayashi, K., Kobayashi, K., Fukumoto, Y., Sakata, Y. & Shimokawa, H. (2014) Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice. Arterioscler. Thromb. Vasc. Biol., 34, 1260-1271.
34. Jin, Z. G., Lungu, A. O., Xie, L., Wang, M., Wong, C. & Berk, B. C. (2004) Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler. Thromb. Vasc. Biol., 24, 1186-1191.
35. Jin, Z. G., Melaragno, M. G., Liao, D. F., Yan, C., Haendeler, J., Suh, Y. A., Lambeth, J. D. & Berk, B. C. (2000) Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ. Res., 87, 789-796.
36. Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Eto, Y., Morishige, K., Matsumoto, Y., Obara, K., Nakayama, K., Takahashi, S. & Takeshita, A. (2003) Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm. Arterioscler. Thromb. Vasc. Biol., 23, 2209-2214.
37. Kandabashi, T., Shimokawa, H., Mukai, Y., Matoba, T., Kunihiro, I., Morikawa, K., Ito, M., Takahashi, S., Kaibuchi, K. & Takeshita, A. (2002) Involvement of Rho-kinase in agonistsinduced contractions of arteriosclerotic human arteries. Arterioscler. Thromb. Vasc. Biol., 22, 243-248.
38. Kesarwani, P., Murali, A. K., Al-Khami, A. A. & Mehrotra, S. (2013) Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. Antioxid. Redox Signal., 18, 1497-1534.
39. Khromykh, L. M., Kulikova, N. L., Anfalova, T. V., Muranova, T. A., Abramov, V. M., Vasiliev, A. M., Khlebnikov, V. S. & Kazansky, D. B. (2007) Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells. Cell. Immunol., 249, 46-53.
40. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A. & Kaibuchi, K. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science, 273, 245-248.
41. Lassegue, B., San Martin, A. & Griendling, K. K. (2012) Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ. Res., 110, 1364-1390.
42. Liao, D. F., Jin, Z. G., Baas, A. S., Daum, G., Gygi, S. P., Aebersold, R. & Berk, B. C. (2000) Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J. Biol. Chem., 275, 189-196.
43. Mackay, D. J. & Hall, A. (1998) Rho GTPases. J. Biol. Chem., 273, 20685-20688.
44. Marks, A. R. (1996) Cellular functions of immunophilins. Physiol. Rev., 76, 631-649.
45. Matoba, T., Shimokawa, H., Nakashima, M., Hirakawa, Y., Mukai, Y., Hirano, K., Kanaide, H. & Takeshita, A. (2000) Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J. Clin. Invest., 106, 1521-1530.
46. Matsubara, J., Sugiyama, S., Sugamura, K., Nakamura, T., Fujiwara, Y., Akiyama, E., Kurokawa, H., Nozaki, T., Ohba, K., Konishi, M., Maeda, H., Izumiya, Y., Kaikita, K., Sumida, H., Jinnouchi, H., Matsui, K., Kim-Mitsuyama, S., Takeya, M. & Ogawa, H. (2012) A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J. Am. Coll. Cardiol., 59, 265-276.
47. Miller, L. H., Ackerman, H. C., Su, X. Z. & Wellems, T. E. (2013) Malaria biology and disease pathogenesis: insights for new treatments. Nat. Med., 19, 156-167.
48. Miyata, K., Shimokawa, H., Kandabashi, T., Higo, T., Morishige, K., Eto, Y., Egashira, K., Kaibuchi, K. & Takeshita, A. (2000) Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler. Thromb. Vasc. Biol., 20, 2351-2358.
49. Morikawa, K., Shimokawa, H., Matoba, T., Kubota, H., Akaike, T., Talukder, M. A., Hatanaka, M., Fujiki, T., Maeda, H., Takahashi, S. & Takeshita, A. (2003) Pivotal role of Cu, Znsuperoxide dismutase in endothelium-dependent hyperpolarization. J. Clin. Invest., 112, 1871-1879.
50. Nakano, M., Satoh, K., Fukumoto, Y., Ito, Y., Kagaya, Y., Ishii, N., Sugamura, K. & Shimokawa, H. (2007) Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ. Res., 100, 662-669.
51. Neco, P., Giner, D., Viniegra, S., Borges, R., Villarroel, A. & Gutierrez, L. M. (2004) New roles of myosin II during vesicle transport and fusion in chromaffin cells. J. Biol. Chem., 279, 27450-27457.
52. Nigro, P., Satoh, K., O'Dell, M. R., Soe, N. N., Cui, Z., Mohan, A., Abe, J., Alexis, J. D., Sparks, J. D. & Berk, B. C. (2011) Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J. Exp. Med., 208, 53-66.
53. Nishihara, M., Miura, T., Miki, T., Tanno, M., Yano, T., Naitoh, K., Ohori, K., Hotta, H., Terashima, Y. & Shimamoto, K. (2007) Modulation of the mitochondrial permeability transition pore complex in GSK-3β-mediated myocardial protection. J. Mol. Cell. Cardiol., 43, 564-570.
54. Noguchi, C. T., Wang, L., Rogers, H. M., Teng, R. & Jia, Y. (2008) Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev. Mol. Med., 10, e36.
55. Pan, H., Luo, C., Li, R., Qiao, A., Zhang, L., Mines, M., Nyanda, A. M., Zhang, J. & Fan, G. H. (2008) Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration. J. Biol. Chem., 283, 623-637.
56. Petit, R. D., Warburton, R. R., Ou, L. C., Brinck-Johnson, T. & Hill, N. S. (1993) Exogenous erythropoietin fails to augment hypoxic pulmonary hypertension in rats. Respir. Physiol., 91, 271-282.
57. Price, E. R., Zydowsky, L. D., Jin, M. J., Baker, C. H., McKeon, F. D. & Walsh, C. T. (1991) Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proc. Natl. Acad. Sci. USA, 88, 1903-1907.
58. Pushkarsky, T., Zybarth, G., Dubrovsky, L., Yurchenko, V., Tang, H., Guo, H., Toole, B., Sherry, B. & Bukrinsky, M. (2001) CD147 facilitates HIV-1 infection by interacting with virusassociated cyclophilin A. Proc. Natl. Acad. Sci. USA, 98, 6360-6365.
59. Rabinovitch, M. (2012) Molecular pathogenesis of pulmonary arterial hypertension. J. Clin. Invest., 122, 4306-4313.
60. Rao, G. N. & Berk, B. C. (1992) Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ. Res., 70, 593-599.
61. Ridker, P. M. (2004) High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. Am. Heart J., 148, S19-26.
62. Sandow, S. L. (2004) Factors, fiction and endothelium-derived hyperpolarizing factor. Clin. Exp. Pharmacol. Physiol., 31, 563-570.
63. Satoh, K. (2013a) Dipeptidyl peptidase-4 inhibitors: emerging player for vascular protection. Circ. J., 77, 1156-1157.
64. Satoh, K. (2013b) Linoleic acid. A novel mechanism of endothelial cell dysfunction. Circ. J., 77, 2702-2703.
65. Satoh, K. (2014) Globotriaosylceramide induces endothelial dysfunction in fabry disease. Arterioscler. Thromb. Vasc. Biol., 34, 2-4.
66. Satoh, K. & Berk, B. C. (2008) Circulating smooth muscle progenitor cells: novel players in plaque stability. Cardiovasc. Res., 77, 445-447.
67. Satoh, K., Berk, B. C. & Shimokawa, H. (2011a) Vascular-derived reactive oxygen species for homeostasis and diseases. Nitric Oxide, 25, 211-215.
68. Satoh, K., Fukumoto, Y., Nakano, M., Kagaya, Y. & Shimokawa, H. (2011b) Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular therapeutic target. J. Cardiovasc. Pharmacol., 58, 570-574.
69. Satoh, K., Fukumoto, Y., Nakano, M., Sugimura, K., Nawata, J., Demachi, J., Karibe, A., Kagaya, Y., Ishii, N., Sugamura, K. & Shimokawa, H. (2009a) Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. Cardiovasc. Res., 81, 226-234.
70. Satoh, K., Fukumoto, Y. & Shimokawa, H. (2011c) Rho-kinase: important new therapeutic target in cardiovascular diseases. Am. J. Physiol. Heart Circ. Physiol., 301, H287-296.
71. Satoh, K., Fukumoto, Y., Sugimura, K., Miura, Y., Aoki, T., Nochioka, K., Tatebe, S., Miyamichi-Yamamoto, S., Shimizu, T., Osaki, S., Takagi, Y., Tsuburaya, R., Ito, Y., Matsumoto, Y., Nakayama, M., Takeda, M., Takahashi, J., Ito, K., Yasuda, S. & Shimokawa, H. (2013) Plasma cyclophilin A is a novel biomarker for coronary artery disease. Circ. J., 77, 447-455.
72. Satoh, K., Godo, S., Saito, H., Enkhjargal, B. & Shimokawa, H. (2014a) Dual roles of vascular-derived reactive oxygen species: with a special reference to hydrogen peroxide and cyclophilin A. J. Mol. Cell. Cardiol., 73, 50-56.
73. Satoh, K., Kagaya, Y., Nakano, M., Ito, Y., Ohta, J., Tada, H., Karibe, A., Minegishi, N., Suzuki, N., Yamamoto, M., Ono, M., Watanabe, J., Shirato, K., Ishii, N., Sugamura, K. & Shimokawa, H. (2006) Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation, 113, 1442-1450.
74. Satoh, K., Matoba, T., Suzuki, J., O'Dell, M. R., Nigro, P., Cui, Z., Mohan, A., Pan, S., Li, L., Jin, Z. G., Yan, C., Abe, J. & Berk, B. C. (2008) Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation, 117, 3088-3098.
75. Satoh, K., Nigro, P. & Berk, B. C. (2010a) Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid. Redox Signal., 12, 675-682.
76. Satoh, K., Nigro, P., Matoba, T., O'Dell, M. R., Cui, Z., Shi, X., Mohan, A., Yan, C., Abe, J., Illig, K. A. & Berk, B. C. (2009b) Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat. Med., 15, 649-656.
77. Satoh, K., Nigro, P., Zeidan, A., Soe, N. N., Jaffre, F., Oikawa, M., O'Dell, M. R., Cui, Z., Menon, P., Lu, Y., Mohan, A., Yan, C., Blaxall, B. C. & Berk, B. C. (2011d) Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 31, 1116-1123.
78. Satoh, K., Satoh, T., Kikuchi, N., Omura, J., Kurosawa, R., Suzuki, K., Sugimura, K., Aoki, T., Nochioka, K., Tatebe, S., Miyamichi-Yamamoto, S., Miura, M., Shimizu, T., Ikeda, S., Yaoita, N., Fukumoto, Y., Minami, T., Miyata, S., Nakamura, K., Ito, H., Kadomatsu, K. & Shimokawa, H. (2014b) Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Circ. Res., 115, 738-750.
79. Satoh, K. & Shimokawa, H. (2014) High-sensitivity C-reactive protein: still need for next-generation biomarkers for remote future cardiovascular events. Eur. Heart J., 35, 1776-1778.
80. Satoh, K., Shimokawa, H. & Berk, B. C. (2010b) Cyclophilin A: promising new target in cardiovascular therapy. Circ. J., 74, 2249-2256.
81. Schneider, H., Charara, N., Schmitz, R., Wehrli, S., Mikol, V., Zurini, M. G., Quesniaux, V. F. & Movva, N. R. (1994) Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. Biochemistry, 33, 8218-8224.
82. Seizer, P., Geisler, T., Bigalke, B., Schneider, M., Klingel, K., Kandolf, R., Stellos, K., Schreieck, J., Gawaz, M. & May, A. E. (2013) EMMPRIN and its ligand Cyclophilin A as novel diagnostic markers in inflammatory cardiomyopathy. Int. J. Cardiol., 163, 299-304.
83. Seizer, P., Klingel, K., Sauter, M., Westermann, D., Ochmann, C., Schonberger, T., Schleicher, R., Stellos, K., Schmidt, E. M., Borst, O., Bigalke, B., Kandolf, R., Langer, H., Gawaz, M. & May, A. E. (2012) Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. J. Mol. Cell. Cardiol., 53, 6-14.
84. Seizer, P., Ochmann, C., Schonberger, T., Zach, S., Rose, M., Borst, O., Klingel, K., Kandolf, R., MacDonald, H. R., Nowak, R. A., Engelhardt, S., Lang, F., Gawaz, M. & May, A. E. (2011) Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. Arterioscler. Thromb. Vasc. Biol., 31, 1377-1386.
85. Seizer, P., Schonberger, T., Schott, M., Lang, M. R., Langer, H. F., Bigalke, B., Kramer, B. F., Borst, O., Daub, K., Heidenreich, O., Schmidt, R., Lindemann, S., Herouy, Y., Gawaz, M. & May, A. E. (2010) EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis, 209, 51-57.
86. Semenza, G. L. (2004) O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J. Appl. Physiol., 96, 1173-1177; discussion 1170-1172.
87. Shao, D., Oka, S., Brady, C. D., Haendeler, J., Eaton, P. & Sadoshima, J. (2012) Redox modification of cell signaling in the cardiovascular system. J. Mol. Cell. Cardiol., 52, 550-558.
88. Shimizu, T., Fukumoto, Y., Tanaka, S., Satoh, K., Ikeda, S. & Shimokawa, H. (2013) Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice. Arterioscler. Thromb. Vasc. Biol., 33, 2780-2791.
89. Shimokawa, H. (1999) Primary endothelial dysfunction: atherosclerosis. J. Mol. Cell. Cardiol., 31, 23-37.
90. Shimokawa, H. (2002) Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases. J. Cardiovasc. Pharmacol., 39, 319-327.
91. Shimokawa, H. (2010) Hydrogen peroxide as an endotheliumderived hyperpolarizing factor. Pflugers. Archiv., 459, 915-922.
92. Shimokawa, H. & Satoh, K. (2014a) Light and dark of reactive oxygen species for vascular function. J. Cardiovasc. Pharmacol., [Epub ahead of print].
93. Shimokawa, H. & Satoh, K. (2014b) Vascular function. Arterioscler. Thromb. Vasc. Biol., 34, 2359-2362.
94. Shimokawa, H. & Takeshita, A. (2005) Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler. Thromb. Vasc. Biol., 25, 1767-1775.
95. Shimokawa, H., Tomoike, H., Nabeyama, S., Yamamoto, H., Araki, H., Nakamura, M., Ishii, Y. & Tanaka, K. (1983) Coronary artery spasm induced in atherosclerotic miniature swine. Science, 221, 560-562.
96. Siekierka, J. J., Hung, S. H., Poe, M., Lin, C. S. & Sigal, N. H. (1989) A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature, 341, 755-757.
97. Soe, N. N., Sowden, M., Baskaran, P., Smolock, E. M., Kim, Y., Nigro, P. & Berk, B. C. (2013) Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 33, 2147-2153.
98. Steudel, W., Scherrer-Crosbie, M., Bloch, K. D., Weimann, J., Huang, P. L., Jones, R. C., Picard, M. H. & Zapol, W. M. (1998) Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J. Clin. Invest., 101, 2468-2477.
99. Suzuki, J., Jin, Z. G., Meoli, D. F., Matoba, T. & Berk, B. C. (2006) Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circ. Res., 98, 811-817.
100. Suzuki, N., Ohneda, O., Takahashi, S., Higuchi, M., Mukai, H. Y., Nakahata, T., Imagawa, S. & Yamamoto, M. (2002) Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality. Blood, 100, 2279-2288.
101. Tada, H., Kagaya, Y., Takeda, M., Ohta, J., Asaumi, Y., Satoh, K., Ito, K., Karibe, A., Shirato, K., Minegishi, N. & Shimokawa, H. (2006) Endogenous erythropoietin system in non-hematopoietic lineage cells plays a protective role in myocardial ischemia/reperfusion. Cardiovasc. Res., 71, 466-477.
102. Takaki, A., Morikawa, K., Tsutsui, M., Murayama, Y., Tekes, E., Yamagishi, H., Ohashi, J., Yada, T., Yanagihara, N. & Shimokawa, H. (2008) Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. J. Exp. Med., 205, 2053-2063.
103. Takemoto, M., Sun, J., Hiroki, J., Shimokawa, H. & Liao, J. K. (2002) Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation, 106, 57-62.
104. Taniyama, Y. & Griendling, K. K. (2003) Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension, 42, 1075-1081.
105. Theuerkorn, M., Fischer, G. & Schiene-Fischer, C. (2011) Prolyl cis/trans isomerase signalling pathways in cancer. Curr. Opin. Pharmacol., 11, 281-287.
106. Vanhoutte, P. M. (2001) Endothelium-derived free radicals: for worse and for better. J. Clin. Invest., 107, 23-25.
107. Vanhoutte, P. M., Shimokawa, H., Tang, E. H. & Feletou, M. (2009) Endothelial dysfunction and vascular disease. Acta Physiol., 196, 193-222.
108. Vannucchi, A. M., Grossi, A., Bosi, A., Rafanelli, D., Statello, M., Guidi, S., Saccardi, R. & Rossi-Ferrini, P. (1993) Effects of cyclosporin A on erythropoietin production by the human Hep3B hepatoma cell line. Blood, 82, 978-984.
109. Voelkel, N. F. & Tuder, R. M. (2000) Hypoxia-induced pulmonary vascular remodeling: a model for what human disease? J. Clin. Invest., 106, 733-738.
110. Wang, Y. X., Martin-McNulty, B., da Cunha, V., Vincelette, J., Lu, X., Feng, Q., Halks-Miller, M., Mahmoudi, M., Schroeder, M., Subramanyam, B., Tseng, J. L., Deng, G. D., Schirm, S., Johns, A., Kauser, K., Dole, W. P. & Light, D. R. (2005) Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation, 111, 2219-2226.
111. Weintraub, N. L. (2009) Understanding abdominal aortic aneurysm. N. Engl. J. Med., 361, 1114-1116.
112. Yamakawa, T., Tanaka, S., Numaguchi, K., Yamakawa, Y., Motley, E. D., Ichihara, S. & Inagami, T. (2000) Involvement of Rhokinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension, 35, 313-318.
113. Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W. W., Franchin, G., Hao, T., Guo, H., Hung, H. C., Toole, B., Gallay, P., Sherry, B. & Bukrinsky, M. (2002) Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J. Biol. Chem., 277, 22959-22965.
114. Zhu, C., Wang, X., Deinum, J., Huang, Z., Gao, J., Modjtahedi, N., Neagu, M. R., Nilsson, M., Eriksson, P. S., Hagberg, H., Luban, J., Kroemer, G. & Blomgren, K. (2007) Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J. Exp. Med., 204, 1741-1748.