Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death

Cancer Research

Volumn 67, Issue 8, 2007, Pages 3654-3662

  Kyu, Jin Choi ^a   Yu, Ji Piao ^a   Min, Jin Lim ^a   Jin, Hwan Kim ^a   Ha, Joohun ^a   Choe, Wonchae ^a   Sung, Soo Kim ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLOPHILIN A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; GENE ACTIVATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; HYPOXIA; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN DNA BINDING; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL GROWTH PROCESSES; CELL HYPOXIA; CELL LINE, TUMOR; CISPLATIN; CYCLOPHILIN A; DRUG RESISTANCE, NEOPLASM; HCT116 CELLS; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NEOPLASMS; NIH 3T3 CELLS; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 34248562291     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1759     Document Type: Article

References (36)

1. Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984;226:544-7.
2. Harding MW, Handschumacher RE, Speicher DW. Isolation and amino acid sequence of cyclophilin. J Biol Chem 1986;261:8547-55.
3. Andreeva L, Heads R, Green CJ. Cyclophilins and their possible role in the stress response. Int J Exp Pathol 1999;80:305-15.
4. Caroni P, Rothenfluh A, McGlynn E, Schneider C. S- cyclophilin. New member of the cyclophilin family associated with the secretory pathway. J Biol Chem 1991;266:10739-42.
5. Halestrap AP, Connern CP, Griffiths EJ, Kerr PM. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol Cell Biochem 1997;174:167-72.
6. Connern CP, Halestrap AP. Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem J 1994;302:321-4.
7. Bourquin JP, Stagljar I, Meier P, et al. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. Nucleic Acids Res 1997;25:2055-61.
8. Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q. Effect of cyclophilin A on gene expression in human pancreatic cancer cells. Am J Surg 2005;190:739-45.
9. Shen J, Person MD, Zhu J, Abbruzzese JL, Li D. Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res 2004;64:9018-26.
10. Fillies T, Werkmeister R, van Diest PJ, Brandt B, Joos U, Buerger H. HIF1-α overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. BMC Cancer 2005;5:84.
11. Rey O, Baluda MA, Park NH. Differential gene expression in neoplastic and human papillomavirus-immortalized oral keratinocytes. Oncogene 1999;18: 827-31.
12. Howard BA, Furumai R, Campa MJ, et al. Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. Cancer Res 2005;65:8853-60.
13. Howard BA, Zheng Z, Campa MJ, et al. Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. Lung Cancer 2004;46:313-23.
14. Cui Y, Mirkia K, Florence FY, Zhu L, Yokoyama KK, Chiu R. Interaction of the retinoblastoma gene product, RB, with cyclophilin A negatively affects cyclosporin-inhibited NFAT signaling. J Cell Biochem 2002;86:630-41.
15. Seko Y, Fujimura T, Taka H, Mineki R, Murayama K, Nagai R. Hypoxia followed by reoxygenation induces secretion of cyclophilin A from cultured rat cardiac myocytes. Biochem Biophys Res Commun 2004;317: 162-8.
16. Doyle V, Virji S, Crompton M. Evidence that cyclophilin-A protects cells against oxidative stress. Biochem J 1999;341:127-32.
17. Hong F, Lee J, Song JW, et al. Cyclosporin A blocks muscle differentiation by inducing oxidative stress and inhibiting the peptidyl-prolyl-cis-trans isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporin A-induced cytotoxicity. FASEB J 2002; 16:1633-5.
18. Haque M, Davis DA, Wang V, Widmer I, Yarchoan R. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia. J Virol 2003;77: 6761-8.
19. Shibanuma M, Kuroki T, Nose K. Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells. Oncogene 1990;5: 1025-32.
20. Semenza GL, Wang SL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12: 5447-54.
21. Semenza GL, Jiang BH, Leung SW, et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996;20, 271:32529-37.
22. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999;15:551-78.
23. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α. in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-90.
24. Mizuno T, Nagao M, Yamada Y, et al. Small interfering RNA expression vector targeting hypoxia-inducible factor 1α inhibits tumor growth in hepatobiliary and pancreatic cancers. Cancer Gene Ther 2006; 13:131-40.
25. Satoh M, Kashihara N, Fujimoto S, et al. A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharmacol Exp Ther 2003;305:1183-90.
26. Schweyer S, Soruri A, Heintze A, Radzun HJ, Fayyazi A. The role of reactive oxygen species in cisplatin-induced apoptosis in human malignant testicular germ cell lines. Int J Oncol 2004;25:1671-6.
27. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003;22:7265-79.
28. Lin HL, Liu TY, Chau GY, Lui WY, Chi CW. Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species. Cancer 2000;89:983-94.
29. Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, Safa AR. Taxol induces caspase-10-dependent apoptosis. J Biol Chem 2004;279:51057-67.
30. Sawicki G, Dakour J, Morrish DW. Functional proteomics of neurokinin B in the placenta indicates a novel role in regulating cytotrophoblast antioxidant defences. Proteomics 2003;3:2044-51.
31. Lee JP, Palfrey HC, Bindokas VP, et al. The role of immunophilins in mutant superoxide dismutase-linked familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 1999;96:3251-6.
32. Lee SP, Hwang YS, Kim YJ, et al. Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. J Biol Chem 2001;276:29826-32.
33. Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC. Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circ Res 2006;98:811-7.
34. Ross HJ, Cho J, Osann K, et al. Phase I/II trial of low dose cyclosporin A with EP for advanced non-small cell lung cancer. Lung Cancer 1997;18:189-98.
35. Larsson R, Bergh J, Nygren P. Combination of cyclosporin A and buthionine sulfoximine (BSO) as a pharmacological strategy for circumvention of multidrug resistance in small cell lung cancer cell lines selected for resistance to doxorubicin. Anticancer Res 1991;11:455-9.
36. Colgan J, Asmal M, Luban J. Isolation, characterization and targeted disruption of mouse ppia: cyclophilin A is not essential for mammalian cell viability. Genomics 2000;68:167-78.