MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4

FEBS Letters

Volumn 585, Issue 6, 2011, Pages 854-860

  Yang, Ke ^a   He, Yu Song ^a   Wang, Xiao Qun ^a   Lu, Lin ^a   Chen, Qiu Jing ^a   Liu, Jing ^a   Sun, Zhen ^a   Shen, Wei Feng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Atherosclerosis; Lipoprotein; Macrophage; MicroRNA; Toll like receptor 4

Indexed keywords

GELATINASE B; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MICRORNA; MICRORNA 132; MICRORNA 146A; MICRORNA 1826; MICRORNA 19B; MICRORNA 923; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOSKELETON; DOWN REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; LIPID STORAGE; LIPID TRANSPORT; MACROPHAGE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; CELL LINE; CHEMOKINE CCL2; CHOLESTEROL, LDL; CYTOKINES; CYTOSKELETON; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPROTEINS, LDL; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICRORNAS; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 79952575527     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.02.009     Document Type: Article

References (33)

1. Li, A.C. and Glass, C.K. (2002) The macrophage foam cell as a target for therapeutic intervention. Nat. Med. 8, 1235-1242.
2. Kuchibhotla, S., Vanegas, D., Kennedy, D.J., Guy, E., Nimako, G., Morton, R.E. and Febbraio, M. (2008) Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II. Cardiovasc. Res. 78, 185-196.
3. Stoletov, K., Fang, L., Choi, S.H., Hartvigsen, K., Hansen, L.F., Hall, C., Pattison, J., Juliano, J., Miller, E.R., Almazan, F., Crosier, P., Witztum, J.L., Klemke, R.L. and Miller, Y.I. (2009) Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ. Res. 104, 952-960.
4. Choi, S.H., Harkewicz, R., Lee, J.H., Boullier, A., Almazan, F., Li, A.C., Witztum, J.L., Bae, Y.S. and Miller, Y.I. (2009) Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ. Res. 104, 1355-1363.
5. Akira, S. (2003) Toll-like receptor signaling. J. Biol. Chem. 278, 38105-38108.
6. Urbich, C., Kuehbacher, A. and Dimmeler, S. (2008) Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc. Res. 79, 581-588.
7. Fichtlscherer, S., De Rosa, S., Fox, H., Schwietz, T., Fischer, A., Liebetrau, C., Weber, M., Hamm, C.W., Röxe, T., Müller-Ardogan, M., Bonauer, A., Zeiher, A.M. and Dimmeler, S. (2010) Circulating microRNAs in patients with coronary artery disease. Circ. Res. 107, 677-684.
8. O'Connell, R.M., Taganov, K.D., Boldin, M.P., Cheng, G. and Baltimore, D. (2007) MicroRNA-155 is induced during the macrophage inflammatory response. Proc. Natl. Acad. Sci. USA 104, 1604-1609.
9. Taganov, K.D., Boldin, M.P., Chang, K.J. and Baltimore, D. (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103, 12481-12486.
10. Nahid, M.A., Satoh, M. and Chan, E.K. (2011) Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling. J. Immunol. 186, 1723-1734.
11. Chen, T., Huang, Z., Wang, L., Wang, Y., Wu, F., Meng, S. and Wang, C. (2009) MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. Cardiovasc. Res. 83, 131-139.
12. Sucharov, C., Bristow, M.R. and Port, J.D. (2008) MiRNA expression in the failing human heart: functional correlates. J. Mol. Cell. Cardiol. 45, 185-192.
13. Krek, A., Grün, D., Poy, M.N., Wolf, R., Rosenberg, L., Epstein, E.J., MacMenamin, P., da Piedade, I., Gunsalus, K.C., Stoffel, M. and Rajewsky, N. (2005) Combinatorial microRNA target predictions. Nat. Genet. 37, 495-500.
14. Rehmsmeier, M., Steffen, P., Hochsmann, M. and Giegerich, R. (2004) Fast and effective prediction of microRNA/target duplexes. RNA 10, 1507-1517. (Pubitemid 39288185)
15. Sharma, A., Kumar, M., Aich, J., Hariharan, M., Brahmachari, S.K., Agrawal, A. and Ghosh, B. (2009) Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc. Natl. Acad. Sci. USA 106, 5761-5766.
16. Kazemi, M.R., McDonald, C.M., Shigenaga, J.K., Grunfeld, C. and Feingold, K.R. (2005) Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists. Arterioscler. Thromb. Vasc. Biol. 25, 1220-1224.
17. Yang, H., Wei, J., Zhang, H., Lin, L., Zhang, W. and He, S. (2009) Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF. BMC Cell Biol. 10, 37.
18. Lee, K.H., Chen, Y.L., Yeh, S.D., Hsiao, M., Lin, J.T., Goan, Y.G. and Lu, P.J. (2009) MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene 28, 3360-3370.
19. Edfeldt, K., Swedenborg, J., Hansson, G.K. and Yan, Z.Q. (2002) Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105, 1158-1161. (Pubitemid 34225814)
20. Björkbacka, H. (2006) Multiple roles of Toll-like receptor signaling in atherosclerosis. Curr. Opin. Lipidol. 17, 527-533.
21. Michelsen, K.S., Wong, M.H., Shah, P.K., Zhang, W., Yano, J., Doherty, T.M., Akira, S., Rajavashisth, T.B. and Arditi, M. (2004) Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl. Acad. Sci. USA 101, 10679-10684.
22. Xu, X.H., Shah, P.K., Faure, E., Equils, O., Thomas, L., Fishbein, M.C., Luthringer, D., Xu, X.P., Rajavashisth, T.B., Yano, J., Kaul, S. and Arditi, M. (2001) Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation 104, 3103-3108. (Pubitemid 34014065)
23. Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z. and Cao, X. (2009) MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183, 2150-2158.
24. Maa, M.C., Chang, M.Y., Li, J., Li, Y.Y., Hsieh, M.Y., Yang, C.J., Chen, Y.J., Li, Y., Chen, H.C., Cheng, W.E., Hsieh, C.Y., Cheng, C.W. and Leu, T.H. (2010) The iNOS/ Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages. Biochim. Biophys. Acta.
25. Collins, R.F., Touret, N., Kuwata, H., Tandon, N.N., Grinstein, S. and Trimble, W.S. (2009) Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis. J. Biol. Chem. 284, 30288-30297.
26. Fitzer-Attas, C.J., Lowry, M., Crowley, M.T., Finn, A.J., Meng, F., DeFranco, A.L. and Lowell, C.A. (2000) Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J. Exp. Med. 191, 669-681.
27. Hazeki, K., Masuda, N., Funami, K., Sukenobu, N., Matsumoto, M., Akira, S., Takeda, K., Seya, T. and Hazeki, O. (2003) Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. Eur. J. Immunol. 33, 740-747.
28. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K. and Akira, S. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643. (Pubitemid 36927946)
29. Lee, J.Y., Ye, J., Gao, Z., Youn, H.S., Lee, W.H., Zhao, L., Sizemore, N. and Hwang, D.H. (2003) Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J. Biol. Chem. 278, 37041-37051.
30. Verstak, B., Nagpal, K., Bottomley, S.P., Golenbock, D.T., Hertzog, P.J. and Mansell, A. (2010) MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J. Biol. Chem. 284, 24192-24203.
31. Lee, J.Y., Sohn, K.H., Rhee, S.H. and Hwang, D. (2001) Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276, 16683-16689.
32. Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H. and Mitchell, T.C. (2009) Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J. Biol. Chem. 284, 31982-31991.
33. Lin, Y.C., Huang, D.Y., Chu, C.L. and Lin, W.W. (2010) Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway. Mol. Immunol. 47, 1569-1578.