메뉴 건너뛰기




Volumn 48, Issue 2, 2014, Pages 119-128

Melatonin suppresses nitric oxide production in glial cultures by pro-inflammatory cytokines through p38 MAPK inhibition

Author keywords

Glial cells; Inflammation; Melatonin; Nitric oxide

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84890082542     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2013.845295     Document Type: Article
Times cited : (26)

References (43)
  • 1
    • 80052827401 scopus 로고    scopus 로고
    • Infl ammation in the early stages of neurodegenerative pathology
    • Khandelwal PJ, Herman AM, Moussa CE. Infl ammation in the early stages of neurodegenerative pathology. J Neuroimmunol 2011; 238: 1-11.
    • (2011) J Neuroimmunol , vol.238 , pp. 1-11
    • Khandelwal, P.J.1    Herman, A.M.2    Moussa, C.E.3
  • 2
    • 84155162481 scopus 로고    scopus 로고
    • Role of pro-infl ammatory cytokines released from microglia in neurodegenerative diseases
    • Smith JA, Das A, Ray SK, Banik NL. Role of pro-infl ammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 2012; 87: 10-20.
    • (2012) Brain Res Bull , vol.87 , pp. 10-20
    • Smith, J.A.1    Das, A.2    Ray, S.K.3    Banik, N.L.4
  • 4
    • 84879142072 scopus 로고    scopus 로고
    • A review: Infl ammatory process in Alzheimers disease, role of cytokines
    • Rubio-Perez JM, Morillas-Ruiz JM. A review: Infl ammatory process in Alzheimers disease, role of cytokines. Scientifi c WorldJournal 2012; 75: 63-57.
    • (2012) Scientifi c WorldJournal , vol.75 , pp. 63-57
    • Rubio-Perez, J.M.1    Morillas-Ruiz, J.M.2
  • 5
    • 33947492321 scopus 로고    scopus 로고
    • Roles of glia-derived cytokines on neuronal degeneration and regeneration
    • Suzumura A, Takeuchi H, Zhang G, Kuno R, Mizuno T. Roles of glia-derived cytokines on neuronal degeneration and regeneration. Ann N Y Acad Sci 2006; 1088: 219-229.
    • (2006) Ann N Y Acad Sci , vol.1088 , pp. 219-229
    • Suzumura, A.1    Takeuchi, H.2    Zhang, G.3    Kuno, R.4    Mizuno, T.5
  • 6
    • 36749005178 scopus 로고    scopus 로고
    • Mechanisms of infl ammatory neurodegeneration: Inos and nadph oxidase
    • Brown GC. Mechanisms of infl ammatory neurodegeneration: Inos and nadph oxidase. Biochem Soc Trans 2007; 35: 1119-1121.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1119-1121
    • Brown, G.C.1
  • 7
    • 77956012154 scopus 로고    scopus 로고
    • Nitric oxide and neuronal death
    • Brown GC. Nitric oxide and neuronal death. Nitric Oxide 2010; 23: 153-165.
    • (2010) Nitric Oxide , vol.23 , pp. 153-165
    • Brown, G.C.1
  • 8
    • 61349092908 scopus 로고    scopus 로고
    • Nitric oxide as an upstream signal of p38 mediates hypoxia/ reoxygenation-induced neuronal death
    • Chen M, Sun HY, Li SJ, Das M, Kong JM, Gao TM. Nitric oxide as an upstream signal of p38 mediates hypoxia/ reoxygenation-induced neuronal death. Neurosignals 2009; 17: 162-168.
    • (2009) Neurosignals , vol.17 , pp. 162-168
    • Chen, M.1    Sun, H.Y.2    Li, S.J.3    Das, M.4    Kong, J.M.5    Gao, T.M.6
  • 9
    • 33744968899 scopus 로고    scopus 로고
    • Signals for the induction of nitric oxide synthase in astrocytes
    • Saha RN, Pahan K. Signals for the induction of nitric oxide synthase in astrocytes. Neurochem Int 2006; 49: 154-163.
    • (2006) Neurochem Int , vol.49 , pp. 154-163
    • Saha, R.N.1    Pahan, K.2
  • 10
    • 33745807628 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase gene in glial cells
    • Saha RN, Pahan K. Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid Redox Signal 2006; 8: 929-947.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 929-947
    • Saha, R.N.1    Pahan, K.2
  • 11
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signalregulated kinase and p38 subgroups of mitogen-Activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-Alpha gene expression in endotoxinstimulated primary glial cultures
    • Bhat NR, Zhang P, Lee JC, Hogan EL. Extracellular signalregulated kinase and p38 subgroups of mitogen-Activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-Alpha gene expression in endotoxinstimulated primary glial cultures. J Neurosci 1998; 18: 1633-1641.
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 12
    • 77955085839 scopus 로고    scopus 로고
    • Infl ammatory neurodegeneration and mechanisms of microglial killing of neurons
    • Brown GC, Neher JJ. Infl ammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010; 41: 242-247.
    • (2010) Mol Neurobiol , vol.41 , pp. 242-247
    • Brown, G.C.1    Neher, J.J.2
  • 13
    • 73849096467 scopus 로고    scopus 로고
    • Mapk signal transduction underlying brain infl ammation and gliosis as therapeutic target
    • Kaminska B, Gozdz A, Zawadzka M, Ellert-Miklaszewska A, Lipko M. Mapk signal transduction underlying brain infl ammation and gliosis as therapeutic target. Anat Rec (Hoboken) 2009; 292: 1902-1913.
    • (2009) Anat Rec (Hoboken) , vol.292 , pp. 1902-1913
    • Kaminska, B.1    Gozdz, A.2    Zawadzka, M.3    Ellert-Miklaszewska, A.4    Lipko, M.5
  • 14
    • 33644516288 scopus 로고    scopus 로고
    • Contribution of infl ammatory processes to Alzheimers disease: Molecular mechanisms
    • Sastre M, Klockgether T, Heneka MT. Contribution of infl ammatory processes to Alzheimers disease: Molecular mechanisms. Int J Dev Neurosci 2006; 24: 167-176.
    • (2006) Int J Dev Neurosci , vol.24 , pp. 167-176
    • Sastre, M.1    Klockgether, T.2    Heneka, M.T.3
  • 15
    • 80053175796 scopus 로고    scopus 로고
    • Pro-infl ammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of erk1/2, inos and spla(2)-iia expression in astrocytes and microglia
    • Sheng W, Zong Y, Mohammad A, Ajit D, Cui J, Han D, et al. Pro-infl ammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of erk1/2, inos and spla(2)-iia expression in astrocytes and microglia. J Neuroinfl ammation 2011; 8: 121.
    • (2011) J Neuroinfl ammation , vol.8 , pp. 121
    • Sheng, W.1    Zong, Y.2    Mohammad, A.3    Ajit, D.4    Cui, J.5    Han, D.6
  • 16
    • 84857917131 scopus 로고    scopus 로고
    • The p38 map kinase family as regulators of proinfl ammatory cytokine production in degenerative diseases of the CNS
    • Bachstetter AD, Van Eldik LJ. The p38 map kinase family as regulators of proinfl ammatory cytokine production in degenerative diseases of the CNS. Aging Dis 2010; 1: 199-211.
    • (2010) Aging Dis , vol.1 , pp. 199-211
    • Bachstetter, A.D.1    Van Eldik, L.J.2
  • 17
    • 38049119409 scopus 로고    scopus 로고
    • P38 mapk, microglial signaling, and neuropathic pain
    • Ji RR, Suter MR. P38 mapk, microglial signaling, and neuropathic pain. Mol Pain 2007; 3: 33.
    • (2007) Mol Pain , vol.3 , pp. 33
    • Ji, R.R.1    Suter, M.R.2
  • 18
    • 84860165740 scopus 로고    scopus 로고
    • Mammalian mapk signal transduction pathways activated by stress and infl ammation: A 10-year update
    • Kyriakis JM, Avruch J. Mammalian mapk signal transduction pathways activated by stress and infl ammation: A 10-year update. Physiol Rev 2012; 92: 689-737.
    • (2012) Physiol Rev , vol.92 , pp. 689-737
    • Kyriakis, J.M.1    Avruch, J.2
  • 20
    • 78651295011 scopus 로고    scopus 로고
    • Melatonin alters age-related changes in transcription factors and kinase activation
    • Bondy SC, Li H, Zhou J, Wu M, Bailey JA, Lahiri DK. Melatonin alters age-related changes in transcription factors and kinase activation. Neurochem Res 2010; 35: 2035-2042.
    • (2010) Neurochem Res , vol.35 , pp. 2035-2042
    • Bondy, S.C.1    Li, H.2    Zhou, J.3    Wu, M.4    Bailey, J.A.5    Lahiri, D.K.6
  • 21
    • 70350075810 scopus 로고    scopus 로고
    • Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents
    • Borah A, Mohanakumar KP. Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. J Pineal Res 2009; 47: 293-300.
    • (2009) J Pineal Res , vol.47 , pp. 293-300
    • Borah, A.1    Mohanakumar, K.P.2
  • 23
    • 0037372980 scopus 로고    scopus 로고
    • Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition
    • Chung SY, Han SH. Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition. J Pineal Res 2003; 34: 95-102.
    • (2003) J Pineal Res , vol.34 , pp. 95-102
    • Chung, S.Y.1    Han, S.H.2
  • 24
    • 7444246751 scopus 로고    scopus 로고
    • Protective effect of melatonin on beta-Amyloid-induced apoptosis in rat astroglioma c6 cells and its mechanism
    • Feng Z, Zhang JT. Protective effect of melatonin on beta-Amyloid-induced apoptosis in rat astroglioma c6 cells and its mechanism. Free Radic Biol Med 2004; 37: 1790-1801.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1790-1801
    • Feng, Z.1    Zhang, J.T.2
  • 25
    • 79953193013 scopus 로고    scopus 로고
    • Mechanism of neuroprotection of melatonin against betaamyloid neurotoxicity
    • Ionov M, Burchell V, Klajnert B, Bryszewska M, Abramov AY. Mechanism of neuroprotection of melatonin against betaamyloid neurotoxicity. Neuroscience 2011; 180: 229-237.
    • (2011) Neuroscience , vol.180 , pp. 229-237
    • Ionov, M.1    Burchell, V.2    Klajnert, B.3    Bryszewska, M.4    Abramov, A.Y.5
  • 26
    • 84864988984 scopus 로고    scopus 로고
    • Melatonininduced autophagy protects against human prion proteinmediated neurotoxicity
    • Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY. Melatonininduced autophagy protects against human prion proteinmediated neurotoxicity. J Pineal Res 2012; 53: 138-146.
    • (2012) J Pineal Res , vol.53 , pp. 138-146
    • Jeong, J.K.1    Moon, M.H.2    Lee, Y.J.3    Seol, J.W.4    Park, S.Y.5
  • 27
    • 0037119464 scopus 로고    scopus 로고
    • P38 mapk-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa b, camp response element-binding protein, ccaat/enhancerbinding protein-beta, and activating transcription factor-2
    • Bhat NR, Feinstein DL, Shen Q, Bhat AN. P38 mapk-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa b, camp response element-binding protein, ccaat/enhancerbinding protein-beta, and activating transcription factor-2. J Biol Chem 2002; 277: 29584-29592.
    • (2002) J Biol Chem , vol.277 , pp. 29584-29592
    • Bhat, N.R.1    Feinstein, D.L.2    Shen, Q.3    Bhat, A.N.4
  • 28
    • 0032900218 scopus 로고    scopus 로고
    • Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: Role of p38 mitogen-Activated protein kinase activation
    • Bhat NR, Zhang P, Bhat AN. Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: Role of p38 mitogen-Activated protein kinase activation. J Neurochem 1999; 72: 472-478.
    • (1999) J Neurochem , vol.72 , pp. 472-478
    • Bhat, N.R.1    Zhang, P.2    Bhat, A.N.3
  • 29
    • 77956226827 scopus 로고    scopus 로고
    • Physiology of neuronal-glial networking
    • Verkhratsky A. Physiology of neuronal-glial networking. Neurochem Int 2010; 57: 332-343.
    • (2010) Neurochem Int , vol.57 , pp. 332-343
    • Verkhratsky, A.1
  • 30
    • 34249776663 scopus 로고    scopus 로고
    • Glutamate-mediated neuronalglial transmission
    • Verkhratsky A, KirchHoffF. Glutamate-mediated neuronalglial transmission. J Anat 2007; 210: 651-660.
    • (2007) J Anat , vol.210 , pp. 651-660
    • Verkhratsky, A.1    Kirchhoff, F.2
  • 31
    • 81755173570 scopus 로고    scopus 로고
    • Role of microglia in cns infl ammation
    • Graeber MB, Li W, Rodriguez ML. Role of microglia in cns infl ammation. FEBS Lett 2011; 585: 3798-3805.
    • (2011) FEBS Lett , vol.585 , pp. 3798-3805
    • Graeber, M.B.1    Li, W.2    Rodriguez, M.L.3
  • 32
    • 84866561135 scopus 로고    scopus 로고
    • Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats
    • Lee IC, Kim SH, Lee SM, Baek HS, Moon C, Park SC, et al. Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats. Arch Toxicol 2012; 86: 1527-1536.
    • (2012) Arch Toxicol , vol.86 , pp. 1527-1536
    • Lee, I.C.1    Kim, S.H.2    Lee, S.M.3    Baek, H.S.4    Moon, C.5    Park, S.C.6
  • 33
    • 77957943337 scopus 로고    scopus 로고
    • The mechanism of action of MPTP-induced neuroinfl ammation and its modulation by melatonin in rat astrocytoma cells, c6
    • Niranjan R, Nath C, Shukla R. The mechanism of action of MPTP-induced neuroinfl ammation and its modulation by melatonin in rat astrocytoma cells, c6. Free Radic Res 2010; 44: 1304-1316.
    • (2010) Free Radic Res , vol.44 , pp. 1304-1316
    • Niranjan, R.1    Nath, C.2    Shukla, R.3
  • 36
    • 44649122048 scopus 로고    scopus 로고
    • Melatonin inhibits amphetamine-induced nitric oxide synthase mrna overexpression in microglial cell lines
    • Tocharus J, Chongthammakun S, Govitrapong P. Melatonin inhibits amphetamine-induced nitric oxide synthase mrna overexpression in microglial cell lines. Neurosci Lett 2008; 439: 134-137.
    • (2008) Neurosci Lett , vol.439 , pp. 134-137
    • Tocharus, J.1    Chongthammakun, S.2    Govitrapong, P.3
  • 37
    • 77951932919 scopus 로고    scopus 로고
    • Cdk5 is a major regulator of p38 cascade: Relevance to neurotoxicity in Alzheimers disease
    • Chang KH, de Pablo Y, Lee HP, Lee HG, Smith MA, Shah K. Cdk5 is a major regulator of p38 cascade: Relevance to neurotoxicity in Alzheimers disease. J Neurochem 2010; 113: 1221-1229.
    • (2010) J Neurochem , vol.113 , pp. 1221-1229
    • Chang, K.H.1    De Pablo, Y.2    Lee, H.P.3    Lee, H.G.4    Smith, M.A.5    Shah, K.6
  • 38
    • 84860347826 scopus 로고    scopus 로고
    • Erk and p38 inhibitors attenuate memory defi cits and increase creb phosphorylation and pgc-1alpha levels in abeta-injected rats
    • Ashabi G, Ramin M, Azizi P, Taslimi Z, Alamdary SZ, Haghparast A, et al. Erk and p38 inhibitors attenuate memory defi cits and increase creb phosphorylation and pgc-1alpha levels in abeta-injected rats. Behav Brain Res 2012; 232: 165-173.
    • (2012) Behav Brain Res , vol.232 , pp. 165-173
    • Ashabi, G.1    Ramin, M.2    Azizi, P.3    Taslimi, Z.4    Alamdary, S.Z.5    Haghparast, A.6
  • 39
  • 40
    • 68249127673 scopus 로고    scopus 로고
    • Melatonin and its brain metabolite n (1)-Acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice
    • Tapias V, Escames G, Lopez LC, Lopez A, Camacho E, Carrion MD, et al. Melatonin and its brain metabolite n(1)-Acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. J Neurosci Res 2009; 87: 3002-3010.
    • (2009) J Neurosci Res , vol.87 , pp. 3002-3010
    • Tapias, V.1    Escames, G.2    Lopez, L.C.3    Lopez, A.4    Camacho, E.5    Carrion, M.D.6
  • 41
    • 84864672251 scopus 로고    scopus 로고
    • Melatonin attenuated mediators of neuroinfl ammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells
    • Niranjan R, Nath C, Shukla R. Melatonin attenuated mediators of neuroinfl ammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6. Free Radic Res 2012; 46: 1167-1177.
    • (2012) C6. Free Radic Res , vol.46 , pp. 1167-1177
    • Niranjan, R.1    Nath, C.2    Shukla, R.3
  • 42
    • 84867745074 scopus 로고    scopus 로고
    • Melatonin modulates TLR4-mediated infl ammatory genes through MyD88- And TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells
    • Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, et al. Melatonin modulates TLR4-mediated infl ammatory genes through MyD88- And TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. J Pineal Res 2012; 53: 325-334.
    • (2012) J Pineal Res , vol.53 , pp. 325-334
    • Xia, M.Z.1    Liang, Y.L.2    Wang, H.3    Chen, X.4    Huang, Y.Y.5    Zhang, Z.H.6
  • 43
    • 84858752720 scopus 로고    scopus 로고
    • Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of B and STAT/GAS activity
    • Akt-induced NF-
    • Min KJ, Jang JH, Kwon TK. Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of B and STAT/GAS activity. J Pineal Res 2012; 52: 296-304. Akt-induced NF-
    • (2012) J Pineal Res , vol.52 , pp. 296-304
    • Min, K.J.1    Jang, J.H.2    Kwon, T.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.