Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

Journal of Pineal Research

Volumn 53, Issue 3, 2012, Pages 225-237

  Lim, Hyun Dae ^a   Kim, Young Suk ^b   Ko, Seok Ho ^b   Yoon, In Jong ^b   Cho, Seong Guk ^b   Chun, Yang Hyun ^b   Choi, Byeong Jun ^b   Kim, Eun Cheol ^b  

^a Wonkwang University   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

anti inflammatory effects; cytoprotection; hydrogen peroxide; melatonin; SIRT1

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 8; MELATONIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTECTIVE AGENT; PROTEIN KINASE B; SIRTINOL; SIRTUIN 1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME PHOSPHORYLATION; EXPERIMENTAL RABBIT; HUMAN; HUMAN CELL; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZAMIDES; CELL LINE; CELL SURVIVAL; CHONDROCYTES; CYCLOOXYGENASE 2; CYTOKINES; CYTOPROTECTION; FEMALE; HUMANS; HYDROGEN PEROXIDE; MELATONIN; NAPHTHOLS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; RABBITS; SIRTUIN 1;

EID: 84866264061     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2012.00991.x     Document Type: Article

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