The mineralocorticoid receptor-p38MAPK-NFB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells

Acta Pharmacologica Sinica

Volumn 33, Issue 7, 2012, Pages 873-878

  Zhu, Chuan Jiang ^a   Wang, Qing Qing ^a   Zhou, Jun Lan ^a   Liu, Han Zhi ^a   Hua, Fang ^a   Yang, Hong Zheng ^a   Hu, Zhuo Wei ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

aldosterone; ERK1 2; fibrosis; inflammation; mineralocorticoid receptor; NF B; nongenomic effect; p38MAPK; signal transduction; Sp1; vascular smooth muscle cells

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALDOSTERONE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MINERALOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SPIRONOLACTONE; TOSYLLYSYL CHLOROMETHYL KETONE; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR FIBROSIS; VASCULAR SMOOTH MUSCLE; VASCULITIS; WESTERN BLOTTING;

ALDOSTERONE; ANIMALS; CELL LINE; CELL NUCLEOLUS; CYCLOOXYGENASE 2; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASES; RATS; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84863658156     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.36     Document Type: Article

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