Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats

Journal of Pineal Research

Volumn 50, Issue 1, 2011, Pages 46-53

  Chen, Chao F ^a   Wang, David ^b   Reiter, Russel J ^c   Yeh, Diana Y ^b,d  

^a MING CHUAN UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

Author keywords

airway hyperreactivity; lung inflammation; melatonin; nitrosative stress; oxidative stress; pancreatic fluid

Indexed keywords

3 NITROTYROSINE; HYDROXYL RADICAL; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MELATONIN; MESSENGER RNA; METHACHOLINE; MYELOPEROXIDASE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

AIRFLOW; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL COUNT; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NEUTROPHIL COUNT; NONHUMAN; PNEUMONIA; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; BRONCHOALVEOLAR LAVAGE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; MALE; MELATONIN; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; OXIDATIVE STRESS; PANCREATIC JUICE; PNEUMONIA; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78650159113     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2010.00808.x     Document Type: Article

References (38)

1. Bhatia M,. Acute pancreatitis as a model of SIRS. Front Biosci 2009; 14: 2042-2050.
2. Beger HG, Rau BM,. Severe acute pancreatitis: clinical course and management. World J Gastroenterol 2007; 13: 5043-5051.
3. Chen CF, Wang D, Lin HI, et al. Translocation of pancreatic juice after ischemia and reperfusion of the intestines and the effects of gabexate mesilate (FOY) in rats. Transplant Proc 2007; 39: 861-863.
4. Lo HA, Sun LN, Chen CF, et al. Ischemia-reperfusion of the pancreas induced hyperresponsiveness of the airways in rats. Transplant Proc 2009; 41: 63-66.
5. Schmid-Schönbein GW,. 2008 Landis Award lecture. Inflammation and the autodigestion hypothesis. Microcirculation 2009; 16: 289-306.
6. Schmid-Schönbein GW,. Biomechanical aspects of the auto-digestion theory. Mol Cell Biomech 2008; 5: 83-95.
7. Schmid-Schönbein GW,. A journey with Tony Hugli up the inflammatory cascade towards the auto-digestion hypothesis. Int Immunopharmacol 2007; 7: 1845-1851.
8. De Campos T, Deree J, Martins JO, et al. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas 2008; 37: 42-49.
9. Liu HB, Cui NQ, Wang Q, et al. Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis. Pancreas 2008; 36: 10-15.
10. Tanaka N, Murata A, Uda K, et al. Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model. Crit Care Med 1995; 23: 901-908.
11. Kvetnoy IM,. Extrapineal melatonin: location and role within diffuse neuroendocrine system. Histochem J 1999; 31: 1-12.
12. Tan DX, Manchester LC, Reiter RJ, et al. Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. Biochim Biophys Acta 1999; 1472: 206-214.
13. Samantaray S, Sribnick EA, Das A, et al. Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats. J Pineal Res 2008; 44: 348-357.
14. Schaefer M, Hardeland R,. The melatonin metabolite N-acetyl-5- methoxykynuramine is a potent singlet oxygen scavenger. J Pineal Res 2009; 46: 49-52.
15. Hardeland R, Tan DX, Reiter RJ,. Kynunamines, metablites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47: 109-126.
16. Carrillo-Vico A, Reiter RJ, Lardone PJ, et al. The modulatory role of melatonin on immune responsiveness. Curr Opin Investig Drugs 2006; 7: 423-431.
17. Lee YD, Kim JY, Lee KH, et al. Melatonin atenuates lipopolysaccharide- induced acute lung inflammation in sleep-deprived mice. J Pineal Res 2009; 46: 53-57.
18. Gitto E, Reiter RJ, Sabatino G, et al. Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment. J Pineal Res 2005; 39: 287-293.
19. Gitto E, Karbownik M, Reiter RJ, et al. Effects of melatonin treatment in septic newborns. Pediatr Res 2001; 50: 756-760.
20. Gitto E, Pellegrino S, D'arrigo S, et al. Oxidative stress in resuscitation and in ventilation of newborns. Eur Respir J 2009; 34: 1461-1469.
21. Reynolds JS, Johnson VJ, Frazer DG,. Unrestrained acoustic plethysmograph for measuring specific airway resistance in mice. J Appl Physiol 2008; 105: 711-717.
22. Lee CC, Jiang JS, Chen ET, et al. Cytologic diagnosis of a metastatic oligodendroglioma in a pleural effusion. A case report. Acta Cytol 2006; 50: 542-544.
23. Chen CF, Wang D, Hwang CP, et al. The protective effect of niacinamide on ischemia-reperfusion-induced liver injury. J Biomed Sci 2001; 8: 446-452. (Pubitemid 33036010)
24. Yamaguchi N, Jesmin S, Zaedi S, et al. Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat. Peptides 2006; 27: 2258-2270.
25. Chu SJ, Perng WC, Hung CM, et al. Effects of various body temperatures after lipopolysaccharide-induced lung injury in rats. Chest 2005; 128: 327-336.
26. Comhair SA, Xu W, Ghosh S, et al. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Am J Pathol 2005; 166: 663-674.
27. Stevens WH, Inman MD, Wattie J, et al. Allergen-induced oxygen radical release from bronchoalveolar lavage cells and airway hyperresponsiveness in dogs. Am J Respir Crit Care Med 1995; 151: 1526-1531.
28. Gumral N, Naziroglu M, Ongel K, et al. Antioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periods. Cell Biochem Funct 2009; 27: 276-283.
29. Chuang JI, Mohan N, Meltz ML, et al. Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int 1996; 20: 687-692.
30. Wang YT, Chen SL, Xu SY,. Effect of melatonin on the expression of nuclear factor-kappa B and airway inflammation in asthmatic rats. Zhonghua Er Ke Za Zhi 2004; 42: 94-97.
31. Pablos MI, Agapito MT, Gutierrez R, et al. Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res 1995; 19: 111-115.
32. Drazen DL, Nelson RJ,. Melatonin receptor subtype MT2 (Mel 1b) and not MT1 (Mel 1a) is associated with melatonin-induced enhancement of cell-mediated and humoral immunity. Neuroendocrinology 2001; 74: 178-184.
33. Liang R, Nickkholgh A, Hoffmann K, et al. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J Pineal Res 2009; 46: 8-14.
34. Galijasevic S, Abdulhamid I, Abu-Soud HM,. Melatonin is a potent inhibitor for myeloperoxidase. Biochemistry 2008; 47: 2668-2677.
35. Gulati K, Ray A, Vijayan VK,. Free radicals and theophylline neurotoxicity: an experimental study. Cell Mol Biol 2007; 53: 42-52.
36. Lu T, Galijasevic S, Abdulhamid I, et al. Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase. Br J Pharmacol 2008; 154: 1308-1317.
37. Escames G, AcuÅa-Castroviejo D, Lopez LC, et al. Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence. J Pharm Pharmacol 2006; 58: 1153-1165.
38. Crespo E, Macías M, Pozo D, et al. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. FASEB J 1999; 13: 1537-1546.