ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy

European Journal of Pharmacology

Volumn 353, Issue 2-3, 1998, Pages 273-279

  Sakuma, Tsutomu ^a   Takahashi, Keiji ^a   Ohya, Nobuo ^a   Usuda, Katsuo ^b   Handa, Masashi ^b   Abe, Tatsuya ^c  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b Sendai Kosei Hospital   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Neutrophil; Pleural space; Proteinase inhibitor; Proteinase antiproteinase imbalance; Thoracotomy

Indexed keywords

ALPHA 1 ANTITRYPSIN; LEUKOCYTE ELASTASE; SIVELESTAT;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LOBECTOMY; NEUTROPHIL; PLEURA EFFUSION; PRIORITY JOURNAL; THORACOTOMY;

ALPHA 1-ANTITRYPSIN; GLYCINE; HUMANS; LEUKOCYTE ELASTASE; PLEURAL EFFUSION; PNEUMONECTOMY; SERINE PROTEINASE INHIBITORS; SULFONAMIDES;

EID: 0032563262     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00412-9     Document Type: Article

References (40)

1. 1-antitrypsin, C8, and factor B. Clin. Immunol. Immunopathol. 16, 84-89.
2. Baugh, R.J., Travis, J., 1976. Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 15, 836-841.
3. Bieth, J., Spiess, B., Wermuth, C.G., 1974. The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochem. Med. 11, 350-357.
4. Birrer, P., McElvaney, N.G., Rüdeberg, A., Sommer, C.W., Liechti-Gallati, S., Kraemer, R., Hubbard, R., Crystal, R.G., 1994. Protease-anti-protease imbalance in the lungs of children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 150, 207-213.
5. Campbell, E.J., Senior, R.M., McDonald, J.A., Cox, D.L., 1982. Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro. J. Clin. Invest. 70, 845-852.
6. Carrell, R.W., 1986. α1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J. Clin. Invest. 78, 1427-1431.
7. 1-protease inhibitor by human neutrophils. J. Biol. Chem. 256, 3348-3353.
8. Cochrane, C.G., Spragg, R., Revak, S.D., 1983. Pathogenesis of the adult respiratory distress syndrome: evidence of oxidant activity in bronchoalveolar lavage fluid. J. Clin. Invest. 71, 754-761.
9. Damiano, V.V., Tsang, A., Kucich, U., Abrams, W.R., Rosenbloom, J., Kimbel, P., Fallahnejad, M., Weinbaum, G., 1986. Immunolocalization of elastase in human emphysematous lungs. J. Clin. Invest. 78, 482-493.
10. Furuno, T., Mitsuyama, T., Hidaka, K., Tanaka, T., Hara, N., 1997. The role of neutrophil elastase in human pulmonary artery endothelial cell injury. Int. Arch. Allergy Immunol. 112, 262-269.
11. 2 in rats. Biochem. Biophys. Res. Commun. 231, 52-55.
12. Hastings, R.H., Grady, M., Sakuma, T., Matthay, M.A., 1992. Clearance of different-sized proteins from the alveolar space in humans and rabbits. J. Appl. Physiol. 73, 1310-1316.
13. 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Proc. Natl. Acad. Sci. USA 86, 680-684.
14. Hutchison, D.C.S., Hughes, M.D., 1997. Alpha-1-antitrypsin replacement therapy: will its efficacy ever be proved?. Eur. Respir. J. 10, 2191-2193.
15. Jochum, M., Witte, J., Duswald, K.H., Inthorn, D., Welter, H., Fritz, H., 1986. Pathobiochemistry of sepsis: role of proteinases, proteinase inhibitors and oxidizing agents. Behring. Inst. Mitt. 79, 121-130.
16. Kaneko, K., Kudoh, I., Hattori, S., Yamada, H., Ohara, M., Wiener-Kronish, J., Okumura, F., 1997. Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits. Anesthesiology 87, 635-641.
17. Katagiri, K., Ito, K., Miyaji, M., Takeuchi, T., Yoshikane, K., Sasaki, M., 1979. Succinyl trialamine p-nitroanilide-hydrolytic enzymes in human serum. An improved method for clinical diagnosis. Clin. Chim. Acta 95, 401-404.
18. Kawabata, K., Suzuki, M., Sugitani, M., Imaki, K., Toda, M., Miyamoto, T., 1991. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Commun. 177, 814-820.
19. Kawabata, K., Moore, A.R., Willoughby, D.A., 1996. Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage. Ann. Rheum. Dis. 55, 248-252.
20. 1-antitrypsin in transgenic mice revealed by in situ hybridization. Genes Dev. 3, 16-25.
21. Kubo, K., Kobayashi, T., Hayano, T., Koizumi, T., Honda, T., Sekiguchi, M., Sakai, A., 1994. Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep. J. Appl. Physiol. 77, 1333-1340.
22. Kushimoto, S., Okajima, K., Okabe, H., Binder, B.R., 1996. Role of granulocyte elastase in the formation of hemorrhagic shock-induced gastric mucosal lesions in the rat. Crit. Care. Med. 24, 1041-1046.
23. Lee, C.T., Fein, A.M., Lippmann, M., Holtzman, H., Kimbel, P., Weinbaum, G., 1981. Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory distress syndrome. New Engl. J. Med. 304, 192-196.
24. Matheson, N.R., Wong, P.S., Travis, J., 1979. Enzymatic inactivation of human alpha-1-proteinase inhibitor by neutrophil myeloperoxidase. Biochem. Biophys. Res. Commun. 88, 402-409.
25. McGuire, W.W., Spragg, R.G., Cohen, A.B., Cochrane, C.G., 1982. Studies on the pathogenesis of the adult respiratory distress syndrome. J. Clin. Invest. 69, 543-553.
26. Murakami, K., Okajima, K., Uchiba, M., Harada, N., Johno, M., Okabe, H., Takatsuki, K., 1997. Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats. Dig. Dis. Sci. 42, 319-325.
27. 1-proteinase inhibitor. J. Clin. Chem. Clin. Biochem. 22, 693-697.
28. Ohlsson, K., Olsson, I., 1974. The neutral proteases of human granulocytes. Isolation and partial characterization of granulocyte elastases. Eur. J. Biochem. 42, 519-527.
29. Ossanna, P.J., Test, S.T., Matheson, N.R., Regiani, S., Weiss, S.J., 1986. Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions. J. Clin. Invest. 77, 1939-1951.
30. Sakuma, T., Kubo, H., Tanita, T., Koike, K., Fujimura, S., 1992. Migration of neutrophils from the lung into the pleural space after lung resection in humans and rabbits. Chest 102, 812-818.
31. Salahuddin, P., 1991. Isolation and characterization of alpha-1-proteinase inhibitor from goat plasma. Biochem. Int. 24, 321-338.
32. Schalkwijk, J., Van den Berg, W.B., Van de Putte, L.B., Joosten, L.A., 1987. Elastase secreted by activated polymorphonuclear leucocytes causes chondrocyte damage and matrix degradation in intact articular cartilage: escape from inactivation by alpha-1-proteinase inhibitor. Br. J. Exp. Pathol. 68, 81-88.
33. Shulman, G., 1979. Comparison of specific protein assays in biological fluids by radial immunodiffusion and laser nephelometer. Clin. Biochem. 12, 123-125.
34. Travis, J., Salvesen, G.S., 1983. Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52, 655-709.
35. Uchiba, M., Okajima, K., Murakami, K., Okabe, H., Takatsuki, K., 1996. Attenuation of endotoxin-induced pulmonary vascular injury by anti-thrombin III. Am. J. Physiol. 270, L921-L930.
36. Weiss, S.J., 1989. Tissue destruction by neutrophils. New Engl. J. Med. 320, 365-376.
37. Weissmann, G., Korchak, H., 1984. Rheumatoid arthritis. The role of neutrophil activation. Inflammation 8, S3-S14.
38. Wewers, M.D., Casolaro, A.M., Sellers, S.E., Swayze, S.C., McPhaul, K.M., Wittes, J.T., Crystal, R.G., 1987. Replacement therapy for alphal-antitrypsin deficiency associated with emphysema. New Engl. J. Med. 316, 1055-1062.
39. Yamaguchi, Y., Akizuki, E., Ichiguchi, O., Matsumura, F., Goto, M., Miyanari, N., Mori, K., Yamada, S., Ogawa, M., 1997. Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver. Gastroenterology 112, 551-560.
40. 4-induced lung injury in rabbit. J. Appl. Physiol. 76, 91-96.