메뉴 건너뛰기




Volumn 31, Issue 3, 2012, Pages 257-266

Multiplexed high content screening reveals that cigarette smoke condensate-altered cell signaling pathways are accentuated through FAK inhibition in human bronchial cells

Author keywords

F actin; focal adhesion kinase; human bronchial cells; MAPKs; paxillin

Indexed keywords

CIGARETTE SMOKE CONDENSATE; F ACTIN; FOCAL ADHESION KINASE; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE; PAXILLIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

EID: 84862017568     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581812440890     Document Type: Article
Times cited : (5)

References (38)
  • 1
    • 67349242950 scopus 로고    scopus 로고
    • Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells
    • Carter CA, Hamm JT. Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells. Toxicology. 2009; 261(3):89-102.
    • (2009) Toxicology , vol.261 , Issue.3 , pp. 89-102
    • Carter, C.A.1    Hamm, J.T.2
  • 2
    • 48249107981 scopus 로고    scopus 로고
    • A role for actin in regulating apoptosis/programmed cell death: Evidence spanning yeast, plants and animals
    • Franklin-Tong VE, Gourlay CW. A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals. Biochem J. 2008;413(3):389-404.
    • (2008) Biochem J , vol.413 , Issue.3 , pp. 389-404
    • Franklin-Tong, V.E.1    Gourlay, C.W.2
  • 3
    • 39249084530 scopus 로고    scopus 로고
    • Disruption of FAK signaling: A side mechanism in cytotoxicity
    • Chatzizacharias NA, Kouraklis GP, Theocharis SE. Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008;245(1-2):1-10.
    • (2008) Toxicology , vol.245 , Issue.1-2 , pp. 1-10
    • Chatzizacharias, N.A.1    Kouraklis, G.P.2    Theocharis, S.E.3
  • 4
    • 67650588774 scopus 로고    scopus 로고
    • Characterisation of fibronectinmediated FAK signalling pathways in lung cancer cell migration and invasion
    • Meng XN, Jin Y, Yu Y, et al. Characterisation of fibronectinmediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer. 2009;101(2):327-334.
    • (2009) Br J Cancer , vol.101 , Issue.2 , pp. 327-334
    • Meng, X.N.1    Jin, Y.2    Yu, Y.3
  • 6
    • 34548085454 scopus 로고    scopus 로고
    • Focal Adhesion Kinase and p53 Signaling in Cancer Cells
    • DOI 10.1016/S0074-7696(07)63003-4, PII S0074769607630034, A Survey of Cell Biology
    • Golubovskaya VM, Cance WG. Focal adhesion kinase and p53 signaling in cancer cells. Int Rev Cytol. 2007;263:103-153. (Pubitemid 47296394)
    • (2007) International Review of Cytology , vol.263 , pp. 103-153
    • Golubovskaya, V.M.1    Cance, W.G.2
  • 7
    • 27644543932 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation
    • Sawai H, Okada Y, Funahashi H, et al. Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol Cancer. 2005;4:37.
    • (2005) Mol Cancer , vol.4 , pp. 37
    • Sawai, H.1    Okada, Y.2    Funahashi, H.3
  • 8
    • 0028986116 scopus 로고
    • Pp125FAK-Dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk
    • Schaller MD, Parsons JT. pp125FAK-Dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol. 1995;15(5):2635-2645.
    • (1995) Mol Cell Biol , vol.15 , Issue.5 , pp. 2635-2645
    • Schaller, M.D.1    Parsons, J.T.2
  • 9
    • 4644328892 scopus 로고    scopus 로고
    • Paxillin: Adapting to change
    • DOI 10.1152/physrev.00002.2004
    • Brown MC, Turner CE. Paxillin: adapting to change. Physiol Rev. 2004;84(4):1315-1339. (Pubitemid 39287952)
    • (2004) Physiological Reviews , vol.84 , Issue.4 , pp. 1315-1339
    • Brown, M.C.1    Turner, C.E.2
  • 10
    • 82955171096 scopus 로고    scopus 로고
    • Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database
    • Surati M, Robinson M, Nandi S, et al. Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database. J Clin Bioinforma. 2011;1(8):1-11.
    • (2011) J Clin Bioinforma , vol.1 , Issue.8 , pp. 1-11
    • Surati, M.1    Robinson, M.2    Nandi, S.3
  • 11
    • 68449092818 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
    • Hochwald SN, Nyberg C, Zheng M, et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 2009;8(15):2435-2443.
    • (2009) Cell Cycle , vol.8 , Issue.15 , pp. 2435-2443
    • Hochwald, S.N.1    Nyberg, C.2    Zheng, M.3
  • 12
    • 44549085698 scopus 로고    scopus 로고
    • HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression
    • Lee JW, Kwak HJ, Lee JJ, et al. HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression. Eur J Cell Biol. 2008;87(6):377-387.
    • (2008) Eur J Cell Biol , vol.87 , Issue.6 , pp. 377-387
    • Lee, J.W.1    Kwak, H.J.2    Lee, J.J.3
  • 14
    • 77952471937 scopus 로고    scopus 로고
    • Effects of short-term cigarette smoke exposure on Fischer 344 rats and on selected lung proteins
    • Carter CA, Misra M. Effects of short-term cigarette smoke exposure on Fischer 344 rats and on selected lung proteins. Toxicol Pathol. 2010;38(3):402-415.
    • (2010) Toxicol Pathol , vol.38 , Issue.3 , pp. 402-415
    • Carter, C.A.1    Misra, M.2
  • 15
    • 66649114486 scopus 로고    scopus 로고
    • Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1/2 pathway
    • Petecchia L, Sabatini F, Varesio L, et al. Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1/2 pathway. Chest. 2009;135(6):1502-1512.
    • (2009) Chest , vol.135 , Issue.6 , pp. 1502-1512
    • Petecchia, L.1    Sabatini, F.2    Varesio, L.3
  • 16
    • 34547198361 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase mediates sidestream cigarette smoke-induced endothelial permeability
    • DOI 10.1254/jphs.FP0070385
    • Low B, Liang M, Fu J. p38 mitogen-activated protein kinase mediates sidestream cigarette smoke-induced endothelial permeability. J Pharmacol Sci. 2007;104(3):225-231. (Pubitemid 47122470)
    • (2007) Journal of Pharmacological Sciences , vol.104 , Issue.3 , pp. 225-231
    • Low, B.1    Liang, M.2    Fu, J.3
  • 17
    • 53949087155 scopus 로고    scopus 로고
    • Cigarette smoke-induced left ventricular remodelling is associated with activation of mitogen-activated protein kinases
    • Gu L, Pandey V, Geenen DL, Chowdhury SA, Piano MR. Cigarette smoke-induced left ventricular remodelling is associated with activation of mitogen-activated protein kinases. Eur J Heart Fail. 2008;10(11):1057-1064.
    • (2008) Eur J Heart Fail , vol.10 , Issue.11 , pp. 1057-1064
    • Gu, L.1    Pandey, V.2    Geenen, D.L.3    Chowdhury, S.A.4    Piano, M.R.5
  • 18
    • 77952521005 scopus 로고    scopus 로고
    • Reversal of second-hand cigarettesmoke-induced impairment of cornealwound healing by thymosin beta4 combined with anti-inflammatory agents
    • Yuan H, Ma C, Moinet L, Sato N, Martins-Green M. Reversal of second-hand cigarettesmoke-induced impairment of cornealwound healing by thymosin beta4 combined with anti-inflammatory agents. Invest Ophthalmol Vis Sci. 2010;51(5):2424-2435.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.5 , pp. 2424-2435
    • Yuan, H.1    Ma, C.2    Moinet, L.3    Sato, N.4    Martins-Green, M.5
  • 20
    • 65249089049 scopus 로고    scopus 로고
    • FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: Differential roles for paxillin and p130Cas
    • Zouq NK, Keeble JA, Lindsay J, et al. FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci. 2009;122(pt 3): 357-367.
    • (2009) J Cell Sci , vol.122 , Issue.PART 3 , pp. 357-367
    • Zouq, N.K.1    Keeble, J.A.2    Lindsay, J.3
  • 21
    • 2442606429 scopus 로고    scopus 로고
    • Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility
    • DOI 10.1083/jcb.200308011
    • SubausteMC,Pertz O,AdamsonED, Turner CE, JungerS,HahnKM. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol. 2004;165(3):371-381. (Pubitemid 38649912)
    • (2004) Journal of Cell Biology , vol.165 , Issue.3 , pp. 371-381
    • Subauste, M.C.1    Pertz, O.2    Adamson, E.D.3    Turner, C.E.4    Junger, S.5    Hahn, K.M.6
  • 22
    • 77953709612 scopus 로고    scopus 로고
    • PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
    • Tanjoni I, Walsh C, Uryu S, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010;9(10):764-777.
    • (2010) Cancer Biol Ther , vol.9 , Issue.10 , pp. 764-777
    • Tanjoni, I.1    Walsh, C.2    Uryu, S.3
  • 23
    • 51049105997 scopus 로고    scopus 로고
    • Tumor growth inhibition by synthetic and expressed small interfering RNA targeting focal adhesion kinase
    • Tsutsumi K, Kasaoka T, Park HM, Nishiyama H, Nakajima M, Honda T. Tumor growth inhibition by synthetic and expressed small interfering RNA targeting focal adhesion kinase. Int J Oncol. 2008;33(1):215-224.
    • (2008) Int J Oncol , vol.33 , Issue.1 , pp. 215-224
    • Tsutsumi, K.1    Kasaoka, T.2    Park, H.M.3    Nishiyama, H.4    Nakajima, M.5    Honda, T.6
  • 24
    • 0034717285 scopus 로고    scopus 로고
    • Anti-apoptotic role of focal adhesion kinase (FAK): Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60
    • DOI 10.1074/jbc.275.21.16309
    • Sonoda Y, Matsumoto Y, Funakoshi M, Yamamoto D, Hanks SK, Kasahara T. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem. 2000;275(21):16309- 16315. (Pubitemid 30366946)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.21 , pp. 16309-16315
    • Sonoda, Y.1    Matsumoto, Y.2    Funakoshi, M.3    Yamamoto, D.4    Hanks, S.K.5    Kasahara, T.6
  • 25
    • 3342910234 scopus 로고    scopus 로고
    • FAK and paxillin: Regulators of N-cadherin adhesion and inhibitors of cell migration?
    • DOI 10.1083/jcb.200406151
    • Schaller MD. FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration? J Cell Biol. 2004;166(2): 157-159. (Pubitemid 38988767)
    • (2004) Journal of Cell Biology , vol.166 , Issue.2 , pp. 157-159
    • Schaller, M.D.1
  • 26
    • 72749121087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients
    • Singh D, Smyth L, Borrill Z, Sweeney L, Tal-Singer R. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010;50(1):94-100.
    • (2010) J Clin Pharmacol , vol.50 , Issue.1 , pp. 94-100
    • Singh, D.1    Smyth, L.2    Borrill, Z.3    Sweeney, L.4    Tal-Singer, R.5
  • 27
    • 79952825166 scopus 로고    scopus 로고
    • Chemoresistance of lung cancer stem-like cells depends on activation of Hsp27
    • Hsu HS, Lin JH, Huang WC, et al. Chemoresistance of lung cancer stem-like cells depends on activation of Hsp27. Cancer. 2011;117(7):1516-1528.
    • (2011) Cancer , vol.117 , Issue.7 , pp. 1516-1528
    • Hsu, H.S.1    Lin, J.H.2    Huang, W.C.3
  • 28
    • 0028015872 scopus 로고
    • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
    • DOI 10.1016/0092-8674(94)90278-X
    • Freshney NW, Rawlinson L, Guesdon F, et al. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell. 1994;78(6):1039-1049. (Pubitemid 24292331)
    • (1994) Cell , vol.78 , Issue.6 , pp. 1039-1049
    • Freshney, N.W.1    Rawlinson, L.2    Guesdon, F.3    Jones, E.4    Cowley, S.5    Hsuan, J.6    Saklatvala, J.7
  • 29
    • 71049178599 scopus 로고    scopus 로고
    • Urban particulate matter causes ER stress and the unfolded protein response in human lung cells
    • Watterson TL, Hamilton B, Martin R, Coulombe RA, Jr. Urban particulate matter causes ER stress and the unfolded protein response in human lung cells. Toxicol Sci. 2009;112(1):111-122.
    • (2009) Toxicol Sci , vol.112 , Issue.1 , pp. 111-122
    • Watterson, T.L.1    Hamilton, B.2    Martin, R.3    Coulombe Jr., R.A.4
  • 30
    • 78649542823 scopus 로고    scopus 로고
    • Cigarette smoke extracts promote vascular smooth muscle cell proliferation and enhances contractile responses in the vasculature and airway
    • Xu CB, Lei Y, Chen Q, Pehrson C, Larsson L, Edvinsson L. Cigarette smoke extracts promote vascular smooth muscle cell proliferation and enhances contractile responses in the vasculature and airway. Basic Clin Pharmacol Toxicol. 107(6):940-948.
    • Basic Clin Pharmacol Toxicol , vol.107 , Issue.6 , pp. 940-948
    • Xu, C.B.1    Lei, Y.2    Chen, Q.3    Pehrson, C.4    Larsson, L.5    Edvinsson, L.6
  • 31
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • DOI 10.1016/j.ceb.2007.02.001, PII S0955067407000154
    • Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol. 2007;19(2):142-149. (Pubitemid 46386399)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.2 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 32
    • 28344453450 scopus 로고    scopus 로고
    • Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: Role of glutathione
    • Luppi F, Aarbiou J, van Wetering S, et al. Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respir Res. 2005;6(1):140.
    • (2005) Respir Res , vol.6 , Issue.1 , pp. 140
    • Luppi, F.1    Aarbiou, J.2    Van Wetering, S.3
  • 34
    • 4744341925 scopus 로고    scopus 로고
    • Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins
    • Liu C, Russell RM, Wang XD. Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins. J Nutr. 2004;134(10): 2705-2710. (Pubitemid 39315276)
    • (2004) Journal of Nutrition , vol.134 , Issue.10 , pp. 2705-2710
    • Liu, C.1    Russell, R.M.2    Wang, X.-D.3
  • 35
    • 0029166094 scopus 로고
    • Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase
    • Bellis SL, Miller JT, Turner CE. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem. 1995;270(29):17437-17441.
    • (1995) J Biol Chem , vol.270 , Issue.29 , pp. 17437-17441
    • Bellis, S.L.1    Miller, J.T.2    Turner, C.E.3
  • 36
    • 0030793696 scopus 로고    scopus 로고
    • Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin
    • Bellis SL, Perrotta JA, Curtis MS, Turner CE. Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin. Biochem J. 1997;325(pt 2):375-381. (Pubitemid 27338716)
    • (1997) Biochemical Journal , vol.325 , Issue.2 , pp. 375-381
    • Bellis, S.L.1    Perrotta, J.A.2    Curtis, M.S.3    Turner, C.E.4
  • 37
    • 0029827130 scopus 로고    scopus 로고
    • Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
    • Brown MC, Perrotta JA, Turner CE. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol. 1996;135(4): 1109-1123. (Pubitemid 26403782)
    • (1996) Journal of Cell Biology , vol.135 , Issue.4 , pp. 1109-1123
    • Brown, M.C.1    Perrotta, J.A.2    Turner, C.E.3
  • 38
    • 0029741102 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
    • Gilmore AP, Romer LH. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol cell. 1996;7(8):1209-1224. (Pubitemid 26260738)
    • (1996) Molecular Biology of the Cell , vol.7 , Issue.8 , pp. 1209-1224
    • Gilmore, A.P.1    Romer, L.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.