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Volumn , Issue , 2013, Pages 176-187

Murine models and human studies of pathogenesis of chronic hepatitis B

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EID: 84919451753     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118637272.ch13     Document Type: Chapter
Times cited : (2)

References (81)
  • 1
    • 84857358267 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity
    • Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012;30:2212-2219.
    • (2012) Vaccine , vol.30 , pp. 2212-2219
    • Ott, J.J.1    Stevens, G.A.2    Groeger, J.3    Wiersma, S.T.4
  • 2
    • 32044433759 scopus 로고    scopus 로고
    • Animal models for the study of HBV replication and its variants
    • Dandri M, Volz TK, Lutgehetmann M, Petersen J. Animal models for the study of HBV replication and its variants. J Clin Virol 2005;34(Suppl 1):S54-S62.
    • (2005) J Clin Virol , vol.34 , pp. S54-S62
    • Dandri, M.1    Volz, T.K.2    Lutgehetmann, M.3    Petersen, J.4
  • 3
    • 0022397571 scopus 로고
    • A transgenic mouse model of the chronic hepatitis B surface antigen carrier state
    • Chisari FV, Pinkert CA, Milich DR, et al. A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science 1985;230:1157-1160.
    • (1985) Science , vol.230 , pp. 1157-1160
    • Chisari, F.V.1    Pinkert, C.A.2    Milich, D.R.3
  • 4
    • 0022366887 scopus 로고
    • Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice
    • Babinet C, Farza H, Morello D, Hadchouel M, Pourcel C. Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice. Science 1985;230:1160-1163.
    • (1985) Science , vol.230 , pp. 1160-1163
    • Babinet, C.1    Farza, H.2    Morello, D.3    Hadchouel, M.4    Pourcel, C.5
  • 5
    • 0029130068 scopus 로고
    • High-level hepatitis B virus replication in transgenic mice
    • Guidotti LG, Matzke B, Schaller H, Chisari FV. High-level hepatitis B virus replication in transgenic mice. J Virol 1995;69:6158-6169.
    • (1995) J Virol , vol.69 , pp. 6158-6169
    • Guidotti, L.G.1    Matzke, B.2    Schaller, H.3    Chisari, F.V.4
  • 6
    • 4344560518 scopus 로고    scopus 로고
    • Cell culture and animal models of viral hepatitis. Part I: hepatitis B
    • Guha C, Mohan S, Roy-Chowdhury N, Roy-Chowdhury J. Cell culture and animal models of viral hepatitis. Part I: hepatitis B. Lab Anim (NY) 2004;33:37-46.
    • (2004) Lab Anim (NY) , vol.33 , pp. 37-46
    • Guha, C.1    Mohan, S.2    Roy-Chowdhury, N.3    Roy-Chowdhury, J.4
  • 7
    • 0025278341 scopus 로고
    • Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice
    • Moriyama T, Guilhot S, Klopchin K, et al. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 1990;248:361-364.
    • (1990) Science , vol.248 , pp. 361-364
    • Moriyama, T.1    Guilhot, S.2    Klopchin, K.3
  • 8
    • 0028928691 scopus 로고
    • Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice
    • Wirth S, Guidotti LG, Ando K, Schlicht HJ, Chisari FV. Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice. J Immunol 1995;154:2504-2515.
    • (1995) J Immunol , vol.154 , pp. 2504-2515
    • Wirth, S.1    Guidotti, L.G.2    Ando, K.3    Schlicht, H.J.4    Chisari, F.V.5
  • 9
    • 0032815287 scopus 로고    scopus 로고
    • Hepatitis B virus transgenic mouse model of chronic liver disease
    • Larkin J, Clayton M, Sun B, et al. Hepatitis B virus transgenic mouse model of chronic liver disease. Nat Med 1999;5:907-912.
    • (1999) Nat Med , vol.5 , pp. 907-912
    • Larkin, J.1    Clayton, M.2    Sun, B.3
  • 11
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • Isogawa M, Robek MD, Furuichi Y, Chisari FV. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 2005;79:7269-7272.
    • (2005) J Virol , vol.79 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 12
    • 0036839012 scopus 로고    scopus 로고
    • Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice
    • Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice. J Immunol 2002;169:5188-5195.
    • (2002) J Immunol , vol.169 , pp. 5188-5195
    • Kimura, K.1    Kakimi, K.2    Wieland, S.3    Guidotti, L.G.4    Chisari, F.V.5
  • 13
    • 0030997139 scopus 로고    scopus 로고
    • Interleukin-12 inhibits hepatitis B virus replication in transgenic mice
    • Cavanaugh VJ, Guidotti LG, Chisari FV. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J Virol 1997;71:3236-3243.
    • (1997) J Virol , vol.71 , pp. 3236-3243
    • Cavanaugh, V.J.1    Guidotti, L.G.2    Chisari, F.V.3
  • 14
    • 0036839079 scopus 로고    scopus 로고
    • Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice
    • Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol 2002;76:10702-10707.
    • (2002) J Virol , vol.76 , pp. 10702-10707
    • Kimura, K.1    Kakimi, K.2    Wieland, S.3    Guidotti, L.G.4    Chisari, F.V.5
  • 15
    • 0034596944 scopus 로고    scopus 로고
    • Natural killer T cell activation inhibits hepatitis B virus replication in vivo
    • Kakimi K, Guidotti LG, Koezuka Y, Chisari FV. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exper Med 2000;192:921-930.
    • (2000) J Exper Med , vol.192 , pp. 921-930
    • Kakimi, K.1    Guidotti, L.G.2    Koezuka, Y.3    Chisari, F.V.4
  • 16
    • 79960944618 scopus 로고    scopus 로고
    • Effects of interferon-alpha/beta on HBV replication determined by viral load
    • Tian Y, Chen WL, Ou JH. Effects of interferon-alpha/beta on HBV replication determined by viral load. PLoS Pathog 2011;7:e1002159.
    • (2011) PLoS Pathog , vol.7 , pp. e1002159
    • Tian, Y.1    Chen, W.L.2    Ou, J.H.3
  • 17
    • 84868702241 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
    • Bertoletti A, Ferrari C. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut 2012;61:1754-1764.
    • (2012) Gut , vol.61 , pp. 1754-1764
    • Bertoletti, A.1    Ferrari, C.2
  • 18
    • 0036227740 scopus 로고    scopus 로고
    • Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection
    • Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 2002;16:583-594.
    • (2002) Immunity , vol.16 , pp. 583-594
    • Baron, J.L.1    Gardiner, L.2    Nishimura, S.3    Shinkai, K.4    Locksley, R.5    Ganem, D.6
  • 19
    • 36749019143 scopus 로고    scopus 로고
    • Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus
    • Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci USA 2007;104:18187-18192.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18187-18192
    • Vilarinho, S.1    Ogasawara, K.2    Nishimura, S.3    Lanier, L.L.4    Baron, J.L.5
  • 21
    • 0029589910 scopus 로고
    • Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes
    • Tsui LV, Guidotti LG, Ishikawa T, Chisari FV. Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes. Proc Natl Acad Sci USA 1995;92:12398-12402.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12398-12402
    • Tsui, L.V.1    Guidotti, L.G.2    Ishikawa, T.3    Chisari, F.V.4
  • 23
    • 0032889274 scopus 로고    scopus 로고
    • Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice
    • Heise T, Guidotti LG, Cavanaugh VJ, Chisari FV. Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice. J Virol 1999;73:474-481.
    • (1999) J Virol , vol.73 , pp. 474-481
    • Heise, T.1    Guidotti, L.G.2    Cavanaugh, V.J.3    Chisari, F.V.4
  • 24
    • 0027453541 scopus 로고
    • Mechanisms of class I restricted immunopathology: a transgenic mouse model of fulminant hepatitis
    • Ando K, Moriyama T, Guidotti LG, et al. Mechanisms of class I restricted immunopathology: a transgenic mouse model of fulminant hepatitis. J Exper Med 1993;178:1541-1554.
    • (1993) J Exper Med , vol.178 , pp. 1541-1554
    • Ando, K.1    Moriyama, T.2    Guidotti, L.G.3
  • 25
    • 0028274539 scopus 로고
    • Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo
    • Ando K, Guidotti LG, Wirth S, et al. Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. J Immunol 1994;152:3245-3253.
    • (1994) J Immunol , vol.152 , pp. 3245-3253
    • Ando, K.1    Guidotti, L.G.2    Wirth, S.3
  • 26
    • 0035905411 scopus 로고    scopus 로고
    • Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    • Kakimi K, Lane TE, Wieland S, et al. Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J Exper Med 2001;194:1755-1766.
    • (2001) J Exper Med , vol.194 , pp. 1755-1766
    • Kakimi, K.1    Lane, T.E.2    Wieland, S.3
  • 27
    • 0037108755 scopus 로고    scopus 로고
    • Depletion of neutrophils blocks the recruitment of antigen- nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes
    • Sitia G, Isogawa M, Kakimi K, Wieland SF, Chisari FV, Guidotti LG. Depletion of neutrophils blocks the recruitment of antigen- nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes. Proc Natl Acad Sci USA 2002;99:13717-13722.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13717-13722
    • Sitia, G.1    Isogawa, M.2    Kakimi, K.3    Wieland, S.F.4    Chisari, F.V.5    Guidotti, L.G.6
  • 28
    • 2142763034 scopus 로고    scopus 로고
    • MMPs are required for recruitment of antigen- nonspecific mononuclear cells into the liver by CTLs
    • Sitia G, Isogawa M, Iannacone M, Campbell IL, Chisari FV, Guidotti LG. MMPs are required for recruitment of antigen- nonspecific mononuclear cells into the liver by CTLs. J Clin Invest 2004;113:1158-1167.
    • (2004) J Clin Invest , vol.113 , pp. 1158-1167
    • Sitia, G.1    Isogawa, M.2    Iannacone, M.3    Campbell, I.L.4    Chisari, F.V.5    Guidotti, L.G.6
  • 29
    • 30744437415 scopus 로고    scopus 로고
    • Platelets mediate cytotoxic T lymphocyte-induced liver damage
    • Iannacone M, Sitia G, Isogawa M, et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med 2005;11:1167-1169.
    • (2005) Nat Med , vol.11 , pp. 1167-1169
    • Iannacone, M.1    Sitia, G.2    Isogawa, M.3
  • 30
    • 79959851182 scopus 로고    scopus 로고
    • Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis
    • Sitia G, Iannacone M, Aiolfi R, et al. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog 2011;7:e1002061.
    • (2011) PLoS Pathog , vol.7 , pp. e1002061
    • Sitia, G.1    Iannacone, M.2    Aiolfi, R.3
  • 31
    • 0031571320 scopus 로고    scopus 로고
    • Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice
    • Franco A, Guidotti LG, Hobbs MV, Pasquetto V, Chisari FV. Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J Immunol 1997;159:2001-2008.
    • (1997) J Immunol , vol.159 , pp. 2001-2008
    • Franco, A.1    Guidotti, L.G.2    Hobbs, M.V.3    Pasquetto, V.4    Chisari, F.V.5
  • 32
    • 80054847781 scopus 로고    scopus 로고
    • A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus
    • Zhang Y, Cobleigh MA, Lian JQ, et al. A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology 2011;141:1897-1906.
    • (2011) Gastroenterology , vol.141 , pp. 1897-1906
    • Zhang, Y.1    Cobleigh, M.A.2    Lian, J.Q.3
  • 34
    • 79952220107 scopus 로고    scopus 로고
    • IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B
    • Publicover J, Goodsell A, Nishimura S, et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest 2011;121:1154-1162.
    • (2011) J Clin Invest , vol.121 , pp. 1154-1162
    • Publicover, J.1    Goodsell, A.2    Nishimura, S.3
  • 35
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999;6:1258-1266.
    • (1999) Gene Ther , vol.6 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 36
    • 84983721048 scopus 로고    scopus 로고
    • An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection
    • Huang LR, Wu HL, Chen PJ, Chen DS. An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection. Proc Natl Acad Sci USA 2006;103:17862-17867.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17862-17867
    • Huang, L.R.1    Wu, H.L.2    Chen, P.J.3    Chen, D.S.4
  • 37
    • 0037108818 scopus 로고    scopus 로고
    • Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection
    • Yang PL, Althage A, Chung J, Chisari FV. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 2002;99:13825-13830.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13825-13830
    • Yang, P.L.1    Althage, A.2    Chung, J.3    Chisari, F.V.4
  • 38
    • 76249097154 scopus 로고    scopus 로고
    • Immune effectors required for hepatitis B virus clearance
    • Yang PL, Althage A, Chung J, et al. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci USA 2010;107:798-802.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 798-802
    • Yang, P.L.1    Althage, A.2    Chung, J.3
  • 39
    • 84983727018 scopus 로고    scopus 로고
    • Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model
    • Lin YJ, Huang LR, Yang HC, et al. Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model. Proc Natl Acad Sci USA 2010;107:9340-9345.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9340-9345
    • Lin, Y.J.1    Huang, L.R.2    Yang, H.C.3
  • 41
    • 34547730702 scopus 로고    scopus 로고
    • Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice
    • Azuma H, Paulk N, Ranade A, et al. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nature Biotechnol 2007;25:903-910.
    • (2007) Nature Biotechnol , vol.25 , pp. 903-910
    • Azuma, H.1    Paulk, N.2    Ranade, A.3
  • 42
    • 78049374383 scopus 로고    scopus 로고
    • Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity
    • Strom SC, Davila J, Grompe M. Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol 2010;640:491-509.
    • (2010) Methods Mol Biol , vol.640 , pp. 491-509
    • Strom, S.C.1    Davila, J.2    Grompe, M.3
  • 43
    • 77949725830 scopus 로고    scopus 로고
    • Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
    • Bissig KD, Wieland SF, Tran P, et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest 2010;120:924-930.
    • (2010) J Clin Invest , vol.120 , pp. 924-930
    • Bissig, K.D.1    Wieland, S.F.2    Tran, P.3
  • 44
    • 17744378552 scopus 로고    scopus 로고
    • Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
    • Dandri M, Burda MR, Torok E, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology 2001;33:981-988.
    • (2001) Hepatology , vol.33 , pp. 981-988
    • Dandri, M.1    Burda, M.R.2    Torok, E.3
  • 46
    • 22544481160 scopus 로고    scopus 로고
    • Stealth and cunning: hepatitis B and hepatitis C viruses
    • Wieland SF, Chisari FV. Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol 2005;79:9369-9380.
    • (2005) J Virol , vol.79 , pp. 9369-9380
    • Wieland, S.F.1    Chisari, F.V.2
  • 47
    • 70349435373 scopus 로고    scopus 로고
    • Temporal analysis of early immune responses in patients with acute hepatitis B virus infection
    • Dunn C, Peppa D, Khanna P, et al. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 2009;137:1289-1300.
    • (2009) Gastroenterology , vol.137 , pp. 1289-1300
    • Dunn, C.1    Peppa, D.2    Khanna, P.3
  • 48
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro P, Valdatta C, Boni C, et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 2009;58:974-982.
    • (2009) Gut , vol.58 , pp. 974-982
    • Fisicaro, P.1    Valdatta, C.2    Boni, C.3
  • 49
    • 79958127932 scopus 로고    scopus 로고
    • Hepatitis B virus limits response of human hepatocytes to interferon-alpha in chimeric mice
    • Lutgehetmann M, Bornscheuer T, Volz T, et al. Hepatitis B virus limits response of human hepatocytes to interferon-alpha in chimeric mice. Gastroenterology 2011;140:2074-2083, 83 e1-e2.
    • (2011) Gastroenterology , vol.140
    • Lutgehetmann, M.1    Bornscheuer, T.2    Volz, T.3
  • 50
    • 79951796190 scopus 로고    scopus 로고
    • Experimental models to study the immunobiology of hepatitis C virus
    • Jo J, Lohmann V, Bartenschlager R, Thimme R. Experimental models to study the immunobiology of hepatitis C virus. J Gen Virol 2011;92:477-493.
    • (2011) J Gen Virol , vol.92 , pp. 477-493
    • Jo, J.1    Lohmann, V.2    Bartenschlager, R.3    Thimme, R.4
  • 51
    • 33646425837 scopus 로고    scopus 로고
    • Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HBsAg
    • Huang Y, Chen Z, Jia H, Wu W, Zhong S, Zhou C. Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HBsAg. Clin Immunol 2006;119:280-290.
    • (2006) Clin Immunol , vol.119 , pp. 280-290
    • Huang, Y.1    Chen, Z.2    Jia, H.3    Wu, W.4    Zhong, S.5    Zhou, C.6
  • 52
    • 0035014396 scopus 로고    scopus 로고
    • Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice
    • Oka Y, Akbar SM, Horiike N, Joko K, Onji M. Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunology 2001;103:90-97.
    • (2001) Immunology , vol.103 , pp. 90-97
    • Oka, Y.1    Akbar, S.M.2    Horiike, N.3    Joko, K.4    Onji, M.5
  • 53
    • 0032211129 scopus 로고    scopus 로고
    • Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice
    • Shimizu Y, Guidotti LG, Fowler P, Chisari FV. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. J Immunol 1998;161:4520-4529.
    • (1998) J Immunol , vol.161 , pp. 4520-4529
    • Shimizu, Y.1    Guidotti, L.G.2    Fowler, P.3    Chisari, F.V.4
  • 54
    • 77957336889 scopus 로고    scopus 로고
    • Immune modulator and antiviral potential of dendritic cells pulsed with both hepatitis B surface antigen and core antigen for treating chronic HBV infection
    • Akbar SM, Yoshida O, Chen S, et al. Immune modulator and antiviral potential of dendritic cells pulsed with both hepatitis B surface antigen and core antigen for treating chronic HBV infection. Antivir Ther 2010;15:887-895.
    • (2010) Antivir Ther , vol.15 , pp. 887-895
    • Akbar, S.M.1    Yoshida, O.2    Chen, S.3
  • 55
    • 63649095194 scopus 로고    scopus 로고
    • HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus- specific cytotoxic T lymphocytes
    • Chen W, Shi M, Shi F, et al. HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus- specific cytotoxic T lymphocytes. Hepatol Res 2009;39:355-365.
    • (2009) Hepatol Res , vol.39 , pp. 355-365
    • Chen, W.1    Shi, M.2    Shi, F.3
  • 56
    • 40449096921 scopus 로고    scopus 로고
    • Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
    • Petersen J, Dandri M, Mier W, et al. Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nature Biotech 2008;26:335-341.
    • (2008) Nature Biotech , vol.26 , pp. 335-341
    • Petersen, J.1    Dandri, M.2    Mier, W.3
  • 57
    • 84856514985 scopus 로고    scopus 로고
    • IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • Belloni L, Allweiss L, Guerrieri F, et al. IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J Clin Invest 2012;122:529-537.
    • (2012) J Clin Invest , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3
  • 58
    • 0033754682 scopus 로고    scopus 로고
    • Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms
    • Webster GJ, Reignat S, Maini MK, et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000;32:1117-1124.
    • (2000) Hepatology , vol.32 , pp. 1117-1124
    • Webster, G.J.1    Reignat, S.2    Maini, M.K.3
  • 59
    • 72049133156 scopus 로고    scopus 로고
    • Alpha- galactosylceramide in chronic hepatitis B infection: results from a randomized placebo-controlled Phase I/II trial
    • Woltman AM, Ter Borg MJ, Binda RS, et al. Alpha- galactosylceramide in chronic hepatitis B infection: results from a randomized placebo-controlled Phase I/II trial. Antivir Ther 2009;14:809-818.
    • (2009) Antivir Ther , vol.14 , pp. 809-818
    • Woltman, A.M.1    Ter Borg, M.J.2    Binda, R.S.3
  • 60
    • 33748163913 scopus 로고    scopus 로고
    • CD1d- and MR1-restricted invariant T cells: of mice and men
    • Treiner E, Lantz O. CD1d- and MR1-restricted invariant T cells: of mice and men. Curr Opin Immunol 2006;18:519-526.
    • (2006) Curr Opin Immunol , vol.18 , pp. 519-526
    • Treiner, E.1    Lantz, O.2
  • 62
    • 0035742828 scopus 로고    scopus 로고
    • Non-cytolytic inhibition of hepatitis B virus replication in human hepatocytes
    • Suri D, Schilling R, Lopes AR, et al. Non-cytolytic inhibition of hepatitis B virus replication in human hepatocytes. J Hepatol 2001;35:790-797.
    • (2001) J Hepatol , vol.35 , pp. 790-797
    • Suri, D.1    Schilling, R.2    Lopes, A.R.3
  • 63
    • 0025916176 scopus 로고
    • A randomised controlled trial of recombinant interferon-gamma in Chinese patients with chronic hepatitis B virus infection
    • Lau JY, Lai CL, Wu PC, Chung HT, Lok AS, Lin HJ. A randomised controlled trial of recombinant interferon-gamma in Chinese patients with chronic hepatitis B virus infection. J Med Virol 1991;34:184-187.
    • (1991) J Med Virol , vol.34 , pp. 184-187
    • Lau, J.Y.1    Lai, C.L.2    Wu, P.C.3    Chung, H.T.4    Lok, A.S.5    Lin, H.J.6
  • 64
    • 0025942053 scopus 로고
    • Treatment with human gamma interferon of chronic hepatitis B: comparative study with alpha interferon
    • Kakumu S, Ishikawa T, Mizokami M, et al. Treatment with human gamma interferon of chronic hepatitis B: comparative study with alpha interferon. J Med Virol 1991;35:32-37.
    • (1991) J Med Virol , vol.35 , pp. 32-37
    • Kakumu, S.1    Ishikawa, T.2    Mizokami, M.3
  • 65
    • 33744808242 scopus 로고    scopus 로고
    • The immune response during hepatitis B virus infection
    • Bertoletti A, Gehring AJ. The immune response during hepatitis B virus infection. J Gen Virol 2006;87:1439-1449.
    • (2006) J Gen Virol , vol.87 , pp. 1439-1449
    • Bertoletti, A.1    Gehring, A.J.2
  • 66
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • Boni C, Fisicaro P, Valdatta C, et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007;81:4215-4225.
    • (2007) J Virol , vol.81 , pp. 4215-4225
    • Boni, C.1    Fisicaro, P.2    Valdatta, C.3
  • 67
    • 55549116694 scopus 로고    scopus 로고
    • Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire
    • Tan AT, Loggi E, Boni C, et al. Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire. J Virol 2008;82:10986-10997.
    • (2008) J Virol , vol.82 , pp. 10986-10997
    • Tan, A.T.1    Loggi, E.2    Boni, C.3
  • 68
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy
    • Webster GJ, Reignat S, Brown D, et al. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 2004;78:5707-5719.
    • (2004) J Virol , vol.78 , pp. 5707-5719
    • Webster, G.J.1    Reignat, S.2    Brown, D.3
  • 69
    • 0037213545 scopus 로고    scopus 로고
    • CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • Thimme R, Wieland S, Steiger C, et al. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003;77:68-76.
    • (2003) J Virol , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3
  • 70
    • 70349298402 scopus 로고    scopus 로고
    • The size of the viral inoculum contributes to the outcome of hepatitis B virus infection
    • Asabe S, Wieland SF, Chattopadhyay PK, et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 2009;83:9652-9662.
    • (2009) J Virol , vol.83 , pp. 9652-9662
    • Asabe, S.1    Wieland, S.F.2    Chattopadhyay, P.K.3
  • 71
    • 0034678435 scopus 로고    scopus 로고
    • The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection
    • Maini MK, Boni C, Lee CK, et al. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exper Med 2000;191:1269-1280.
    • (2000) J Exper Med , vol.191 , pp. 1269-1280
    • Maini, M.K.1    Boni, C.2    Lee, C.K.3
  • 72
    • 77249098281 scopus 로고    scopus 로고
    • A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B
    • Tan AT, Koh S, Goh W, et al. A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B. J Hepatol 2010;52:330-339.
    • (2010) J Hepatol , vol.52 , pp. 330-339
    • Tan, A.T.1    Koh, S.2    Goh, W.3
  • 73
    • 73449125874 scopus 로고    scopus 로고
    • Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B
    • Zhang JY, Zhang Z, Lin F, et al. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2010;51:81-91.
    • (2010) Hepatology , vol.51 , pp. 81-91
    • Zhang, J.Y.1    Zhang, Z.2    Lin, F.3
  • 74
    • 79958822254 scopus 로고    scopus 로고
    • Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections
    • Oliviero B, Cerino A, Varchetta S, et al. Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections. J Hepatol 2011;55:53-60.
    • (2011) J Hepatol , vol.55 , pp. 53-60
    • Oliviero, B.1    Cerino, A.2    Varchetta, S.3
  • 76
    • 0016693477 scopus 로고
    • Vertical transmission of hepatitis B antigen in Taiwan
    • Stevens CE, Beasley RP, Tsui J, Lee WC. Vertical transmission of hepatitis B antigen in Taiwan. NEJM 1975;292:771-774.
    • (1975) NEJM , vol.292 , pp. 771-774
    • Stevens, C.E.1    Beasley, R.P.2    Tsui, J.3    Lee, W.C.4
  • 77
    • 0017066968 scopus 로고
    • e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants
    • Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. NEJM 1976;294:746-749.
    • (1976) NEJM , vol.294 , pp. 746-749
    • Okada, K.1    Kamiyama, I.2    Inomata, M.3    Imai, M.4    Miyakawa, Y.5
  • 78
    • 0020074156 scopus 로고
    • Maternofetal transmission of IgG-bound hepatitis B e antigen
    • Arakawa K, Tsuda F, Takahashi K, et al. Maternofetal transmission of IgG-bound hepatitis B e antigen. Pediatr Res 1982;16: 247-250.
    • (1982) Pediatr Res , vol.16 , pp. 247-250
    • Arakawa, K.1    Tsuda, F.2    Takahashi, K.3
  • 79
    • 0022471034 scopus 로고
    • Prevention of maternal-infant hepatitis B virus transmission by immunization: the role of serum hepatitis B virus DNA
    • Lee SD, Lo KJ, Wu JC, et al. Prevention of maternal-infant hepatitis B virus transmission by immunization: the role of serum hepatitis B virus DNA. Hepatology 1986;6:369-373.
    • (1986) Hepatology , vol.6 , pp. 369-373
    • Lee, S.D.1    Lo, K.J.2    Wu, J.C.3
  • 80
    • 0026552494 scopus 로고
    • Cellular immune response to HBcAg in mother-to-infant transmission of hepatitis B virus
    • Hsu HY, Chang MH, Hsieh KH, et al. Cellular immune response to HBcAg in mother-to-infant transmission of hepatitis B virus. Hepatology 1992;15:770-776.
    • (1992) Hepatology , vol.15 , pp. 770-776
    • Hsu, H.Y.1    Chang, M.H.2    Hsieh, K.H.3
  • 81
    • 84862801307 scopus 로고    scopus 로고
    • High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B
    • Apr
    • Ma SW, Huang X, Li YY, et al. High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B. J Hepatol 2012 Apr;66:775-781.
    • (2012) J Hepatol , vol.66 , pp. 775-781
    • Ma, S.W.1    Huang, X.2    Li, Y.Y.3


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