메뉴 건너뛰기




Volumn 39, Issue 4, 2009, Pages 355-365

HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus-specific cytotoxic T lymphocytes

Author keywords

Chronic hepatitis B; Dendritic cells; Hepatitis B virus; Polarization; T helper cell

Indexed keywords

DENDRITIC CELL VACCINE; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; HLA A24 ANTIGEN; INTERLEUKIN 4;

EID: 63649095194     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2008.00468.x     Document Type: Article
Times cited : (35)

References (46)
  • 1
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis b virus infection - Natural history and clinical consequences
    • Ganem D, Prince AM. Hepatitis b virus infection - natural history and clinical consequences. N Engl J Med 2004; 350: 1118-29.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 2
    • 0036461318 scopus 로고    scopus 로고
    • Immunology of hepatitis B infection
    • Jung MC, Pape GR. Immunology of hepatitis B infection. Lancet Infect Dis 2002; 2: 43-50.
    • (2002) Lancet Infect Dis , vol.2 , pp. 43-50
    • Jung, M.C.1    Pape, G.R.2
  • 3
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5: 215-29.
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 4
    • 0037325472 scopus 로고    scopus 로고
    • Immune responses in hepatitis B virus infection
    • Rehermann B. Immune responses in hepatitis B virus infection. Semin Liver Dis 2003; 23: 21-38.
    • (2003) Semin Liver Dis , vol.23 , pp. 21-38
    • Rehermann, B.1
  • 5
    • 0038461904 scopus 로고    scopus 로고
    • Kinetics of the immune response during HBV and HCV infection
    • Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology 2003; 38: 4-13.
    • (2003) Hepatology , vol.38 , pp. 4-13
    • Bertoletti, A.1    Ferrari, C.2
  • 6
    • 0036337681 scopus 로고    scopus 로고
    • Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: Implications for immunotherapy of persistent viral infections
    • Kakimi K, Isogawa M, Chung J, Sette A, Chisari FV. Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: Implications for immunotherapy of persistent viral infections. J Virol 2002; 76: 8609-20.
    • (2002) J Virol , vol.76 , pp. 8609-8620
    • Kakimi, K.1    Isogawa, M.2    Chung, J.3    Sette, A.4    Chisari, F.V.5
  • 7
    • 33750934617 scopus 로고    scopus 로고
    • Dendritic cells: Translating innate to adaptive immunity
    • Steinman RM, Hemmi H. Dendritic cells: Translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006; 311: 17-58.
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 17-58
    • Steinman, R.M.1    Hemmi, H.2
  • 8
    • 2442665419 scopus 로고    scopus 로고
    • Selective functional deficit in dendritic cell - T cell interaction is a crucial mechanism in chronic hepatitis B virus infection
    • Zheng BJ, Zhou J, Qu D et al. Selective functional deficit in dendritic cell - T cell interaction is a crucial mechanism in chronic hepatitis B virus infection. J Viral Hepat 2004; 11: 217-24.
    • (2004) J Viral Hepat , vol.11 , pp. 217-224
    • Zheng, B.J.1    Zhou, J.2    Qu, D.3
  • 9
    • 0043204311 scopus 로고    scopus 로고
    • Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: Mechanisms for viral immune escape
    • Beckebaum S, Cicinnati VR, Zhang X et al. Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: Mechanisms for viral immune escape. Immunology 2003; 109: 487-95.
    • (2003) Immunology , vol.109 , pp. 487-495
    • Beckebaum, S.1    Cicinnati, V.R.2    Zhang, X.3
  • 10
    • 0034882486 scopus 로고    scopus 로고
    • Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection
    • Wang FS, Xing LH, Liu MX et al. Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection. World J Gastroenterol 2001; 7: 537-41.
    • (2001) World J Gastroenterol , vol.7 , pp. 537-541
    • Wang, F.S.1    Xing, L.H.2    Liu, M.X.3
  • 11
    • 4544245140 scopus 로고    scopus 로고
    • Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B
    • van der Molen RG, Sprengers D, Binda RS et al. Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. Hepatology 2004; 40: 738-46.
    • (2004) Hepatology , vol.40 , pp. 738-746
    • van der Molen, R.G.1    Sprengers, D.2    Binda, R.S.3
  • 12
    • 6344272747 scopus 로고    scopus 로고
    • Cellular immune responses to the hepatitis B virus polymerase
    • Mizukoshi E, Sidney J, Livingston B et al. Cellular immune responses to the hepatitis B virus polymerase. J Immunol 2004; 173: 5863-71.
    • (2004) J Immunol , vol.173 , pp. 5863-5871
    • Mizukoshi, E.1    Sidney, J.2    Livingston, B.3
  • 13
    • 15244343352 scopus 로고    scopus 로고
    • Effects of IL-12 and IL-18 on HBcAg-specific cytokine production by CD4 T lymphocytes of children with chronic hepatitis B infection
    • Szkaradkiewicz A, Jopek A, Wysocki J. Effects of IL-12 and IL-18 on HBcAg-specific cytokine production by CD4 T lymphocytes of children with chronic hepatitis B infection. Antiviral Res 2005; 66: 23-7.
    • (2005) Antiviral Res , vol.66 , pp. 23-27
    • Szkaradkiewicz, A.1    Jopek, A.2    Wysocki, J.3
  • 15
    • 0037407422 scopus 로고    scopus 로고
    • HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells
    • Shimada N, Yamamoto K, Kuroda MJ et al. HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells. J Clin Immunol 2003; 23: 223-32.
    • (2003) J Clin Immunol , vol.23 , pp. 223-232
    • Shimada, N.1    Yamamoto, K.2    Kuroda, M.J.3
  • 16
    • 34047228603 scopus 로고    scopus 로고
    • Hepatitis B virus core antigen epitopes presented by HLA-A2 single-chain trimers induce functional epitope-specific CD8(+) T-cell responses in HLA-A2.1/Kb transgenic mice
    • Zhang Y, Li S, Shan M et al. Hepatitis B virus core antigen epitopes presented by HLA-A2 single-chain trimers induce functional epitope-specific CD8(+) T-cell responses in HLA-A2.1/Kb transgenic mice. Immunology 2007; 121: 105-12.
    • (2007) Immunology , vol.121 , pp. 105-112
    • Zhang, Y.1    Li, S.2    Shan, M.3
  • 17
    • 0345802996 scopus 로고    scopus 로고
    • Intrahepatic CD8 T-lymphocytes and HBV core expression in relation to response to antiviral therapy for chronic hepatitis B patients
    • Tang TJ, de Man RA, Kusters JG et al. Intrahepatic CD8 T-lymphocytes and HBV core expression in relation to response to antiviral therapy for chronic hepatitis B patients. J Med Virol 2004; 72: 215-22.
    • (2004) J Med Virol , vol.72 , pp. 215-222
    • Tang, T.J.1    de Man, R.A.2    Kusters, J.G.3
  • 18
    • 11844263890 scopus 로고    scopus 로고
    • Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery
    • Chong CS, Cao M, Wong WW et al. Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery. J Control Release 2005; 102: 85-99.
    • (2005) J Control Release , vol.102 , pp. 85-99
    • Chong, C.S.1    Cao, M.2    Wong, W.W.3
  • 19
    • 0036176535 scopus 로고    scopus 로고
    • Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen
    • Lau GK, Suri D, Liang R et al. Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen. Gastroenterology 2002; 122: 614-24.
    • (2002) Gastroenterology , vol.122 , pp. 614-624
    • Lau, G.K.1    Suri, D.2    Liang, R.3
  • 20
    • 33846241276 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV) antigen-pulsed monocyte-derived dendritic cells from HBV-associated hepatocellular carcinoma patients significantly enhance specific T cell responses in vitro
    • Shi M, Qian S, Chen WW et al. Hepatitis B virus (HBV) antigen-pulsed monocyte-derived dendritic cells from HBV-associated hepatocellular carcinoma patients significantly enhance specific T cell responses in vitro. Clin Exp Immunol 2007; 147: 277-86.
    • (2007) Clin Exp Immunol , vol.147 , pp. 277-286
    • Shi, M.1    Qian, S.2    Chen, W.W.3
  • 21
    • 13644257261 scopus 로고    scopus 로고
    • Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection
    • Xu XW, Lu MH, Tan DM. Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection. Clin Microbiol Infect 2005; 11: 52-6.
    • (2005) Clin Microbiol Infect , vol.11 , pp. 52-56
    • Xu, X.W.1    Lu, M.H.2    Tan, D.M.3
  • 22
    • 22044437114 scopus 로고    scopus 로고
    • Functional characterization of monocyte-derived dendritic cells generated under serumfree culture conditions
    • Lehner M, Morhart P, Stilper A, Holter W. Functional characterization of monocyte-derived dendritic cells generated under serumfree culture conditions. Immunol Lett 2005; 99: 209-16.
    • (2005) Immunol Lett , vol.99 , pp. 209-216
    • Lehner, M.1    Morhart, P.2    Stilper, A.3    Holter, W.4
  • 23
    • 33846370510 scopus 로고    scopus 로고
    • Terminal complement complex C5b-9-treated human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization
    • Chen Y, Yang C, Jin N et al. Terminal complement complex C5b-9-treated human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization. Eur J Immunol 2007; 37: 167-76.
    • (2007) Eur J Immunol , vol.37 , pp. 167-176
    • Chen, Y.1    Yang, C.2    Jin, N.3
  • 25
    • 0035400281 scopus 로고    scopus 로고
    • A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity
    • Lecoeur H, Février M, Garcia S, Rivière Y, Gougeon ML. A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity. J Immunol Methods 2001; 253: 177-87.
    • (2001) J Immunol Methods , vol.253 , pp. 177-187
    • Lecoeur, H.1    Février, M.2    Garcia, S.3    Rivière, Y.4    Gougeon, M.L.5
  • 26
    • 0037261447 scopus 로고    scopus 로고
    • Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: Tetramer assay and therapeutic implications
    • Tsai SL, Sheen IS, Chien RN et al. Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: Tetramer assay and therapeutic implications. J Biomed Sci 2003; 10: 120-35.
    • (2003) J Biomed Sci , vol.10 , pp. 120-135
    • Tsai, S.L.1    Sheen, I.S.2    Chien, R.N.3
  • 27
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • Boni C, Bertoletti A, Penna A et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest 1998; 102: 968-75.
    • (1998) J Clin Invest , vol.102 , pp. 968-975
    • Boni, C.1    Bertoletti, A.2    Penna, A.3
  • 28
    • 0242329812 scopus 로고    scopus 로고
    • HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B
    • Szkaradkiewicz A, Jopek A, Wysocki J, Grzymislawski M, Malecka I, Wozniak A. HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B. Virus Res 2003; 97: 127-33.
    • (2003) Virus Res , vol.97 , pp. 127-133
    • Szkaradkiewicz, A.1    Jopek, A.2    Wysocki, J.3    Grzymislawski, M.4    Malecka, I.5    Wozniak, A.6
  • 29
    • 0033027690 scopus 로고    scopus 로고
    • Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection
    • Lin SM, Sheen IS, Chien RN, Chu CM, Liaw YF. Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. Hepatology 1999; 29: 971-5.
    • (1999) Hepatology , vol.29 , pp. 971-975
    • Lin, S.M.1    Sheen, I.S.2    Chien, R.N.3    Chu, C.M.4    Liaw, Y.F.5
  • 30
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group
    • Liaw YF, Leung NW, Chang TT et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. Gastroenterology 2000; 119: 172-80.
    • (2000) Gastroenterology , vol.119 , pp. 172-180
    • Liaw, Y.F.1    Leung, N.W.2    Chang, T.T.3
  • 31
    • 0028960040 scopus 로고
    • Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th 2 cytokines
    • Sad S, Marcotte R, Mosmann TR. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th 2 cytokines. Immunity 1995; 2: 271-9.
    • (1995) Immunity , vol.2 , pp. 271-279
    • Sad, S.1    Marcotte, R.2    Mosmann, T.R.3
  • 32
    • 0030175602 scopus 로고    scopus 로고
    • Type 1 and type 2: A fundamental dichotomy for all T-cell subsets
    • Carter LL, Dutton RW. Type 1 and type 2: A fundamental dichotomy for all T-cell subsets. Curr Opin Immunol 1996; 8: 336-42.
    • (1996) Curr Opin Immunol , vol.8 , pp. 336-342
    • Carter, L.L.1    Dutton, R.W.2
  • 33
    • 0034745646 scopus 로고    scopus 로고
    • TH1/TH2 and TC1/TC2 profiles in peripheral blood and bronchoalveolar lavage fluid cells in pulmonary sarcoidosis
    • Inui N, Chida K, Suda T, Nakamura H. TH1/TH2 and TC1/TC2 profiles in peripheral blood and bronchoalveolar lavage fluid cells in pulmonary sarcoidosis. J Allergy Clin Immunol 2001; 107: 337-44.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 337-344
    • Inui, N.1    Chida, K.2    Suda, T.3    Nakamura, H.4
  • 34
    • 0037083298 scopus 로고    scopus 로고
    • Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals
    • de Jong EC, Vieira PL, Kalinski P et al. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol 2002; 168: 1704-9.
    • (2002) J Immunol , vol.168 , pp. 1704-1709
    • de Jong, E.C.1    Vieira, P.L.2    Kalinski, P.3
  • 35
    • 0034658107 scopus 로고    scopus 로고
    • Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo
    • d'Ostiani CF, Del Sero G, Bacci A et al. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med 2000; 191: 1661-74.
    • (2000) J Exp Med , vol.191 , pp. 1661-1674
    • d'Ostiani, C.F.1    Del Sero, G.2    Bacci, A.3
  • 36
    • 0034193991 scopus 로고    scopus 로고
    • Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    • Vieira PL, de Jong EC, Wierenga EA et al. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol 2000; 164(9): 4507-12.
    • (2000) J Immunol , vol.164 , Issue.9 , pp. 4507-4512
    • Vieira, P.L.1    de Jong, E.C.2    Wierenga, E.A.3
  • 37
    • 0348135024 scopus 로고    scopus 로고
    • Dendritic-cell control of pathogen-driven T-cell polarization
    • Kapsenberg ML. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003; 3: 984-93.
    • (2003) Nat Rev Immunol , vol.3 , pp. 984-993
    • Kapsenberg, M.L.1
  • 38
    • 33745712871 scopus 로고    scopus 로고
    • Dendritic cells in a mature age
    • Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006; 6: 476-83.
    • (2006) Nat Rev Immunol , vol.6 , pp. 476-483
    • Reis e Sousa, C.1
  • 39
    • 0032211129 scopus 로고    scopus 로고
    • Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice
    • Shimizu Y, Guidotti LG, Fowler P, Chisari FV. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. J Immunol 1998; 161: 4520-9.
    • (1998) J Immunol , vol.161 , pp. 4520-4529
    • Shimizu, Y.1    Guidotti, L.G.2    Fowler, P.3    Chisari, F.V.4
  • 40
    • 0035014396 scopus 로고    scopus 로고
    • Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice
    • Oka Y, Akbar SM, Horiike N, Joko K, Onji M. Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunology 2001; 103: 90-7.
    • (2001) Immunology , vol.103 , pp. 90-97
    • Oka, Y.1    Akbar, S.M.2    Horiike, N.3    Joko, K.4    Onji, M.5
  • 41
    • 33646425837 scopus 로고    scopus 로고
    • Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HBsAg
    • Huang Y, Chen Z, Jia H et al. Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HBsAg. Clin Immunol 2006; 119: 280-90.
    • (2006) Clin Immunol , vol.119 , pp. 280-290
    • Huang, Y.1    Chen, Z.2    Jia, H.3
  • 42
    • 2942652414 scopus 로고    scopus 로고
    • Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers
    • Fazle Akbar SM, Furukawa S, Onji M et al. Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers. Hepatol Res 2004; 29: 136-41.
    • (2004) Hepatol Res , vol.29 , pp. 136-141
    • Fazle Akbar, S.M.1    Furukawa, S.2    Onji, M.3
  • 43
    • 11244276289 scopus 로고    scopus 로고
    • Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrierer
    • Akbar SM, Furukawa S, Hasebe A, Horiike N, Michitaka K, Onji M. Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrierer. Int J Mol Med 2004; 14: 295-9.
    • (2004) Int J Mol Med , vol.14 , pp. 295-299
    • Akbar, S.M.1    Furukawa, S.2    Hasebe, A.3    Horiike, N.4    Michitaka, K.5    Onji, M.6
  • 44
    • 1842375707 scopus 로고    scopus 로고
    • The hepatitis B virus core and e antigens elicit different Th cell subsets: Antigen structure can affect Th cell phenotype
    • Milich DR, Schödel F, Hughes JL, Jones JE, Peterson DLL. The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J Virol 1997; 71: 2192-201.
    • (1997) J Virol , vol.71 , pp. 2192-2201
    • Milich, D.R.1    Schödel, F.2    Hughes, J.L.3    Jones, J.E.4    Peterson, D.L.L.5
  • 45
    • 12644276399 scopus 로고    scopus 로고
    • Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor
    • Bertoletti A, Southwood S, Chesnut R et al. Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor. Hepatology 1997; 26: 1027-34.
    • (1997) Hepatology , vol.26 , pp. 1027-1034
    • Bertoletti, A.1    Southwood, S.2    Chesnut, R.3
  • 46
    • 0032752883 scopus 로고    scopus 로고
    • Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules
    • Livingston BD, Crimi C, Fikes J, Chesnut RW, Sidney J, Sette A. Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules. Hum Immunol 1999; 60: 1013-17.
    • (1999) Hum Immunol , vol.60 , pp. 1013-1017
    • Livingston, B.D.1    Crimi, C.2    Fikes, J.3    Chesnut, R.W.4    Sidney, J.5    Sette, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.