Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice

European Journal of Pharmacology

Volumn 746, Issue , 2015, Pages 206-212

  Qian, Xiao Lan ^a,b   Zhang, Wei ^c   Liu, Ming Zheng ^d   Zhou, Yu Bing ^c   Zhang, Jing Min ^a   Han, Li ^a   Peng, You Mei ^a   Jiang, Jin Hua ^a   Wang, Qing Duan ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Department of Anesthesiology The Third People's Hospital of Henan Province   (China)

^c THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^d FUWAI HOSPITAL   (China)

Author keywords

Aged; Anesthesia; Apoptosis; Dexmedetomidine; Inflammation; Postoperative cognitive dysfunction

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CASPASE 3; DEXMEDETOMIDINE; INTERLEUKIN 1BETA; PROTEIN BAX; TUMOR NECROSIS FACTOR ALPHA; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANESTHETIC AGENT; APOPTOSIS REGULATORY PROTEIN; AUTACOID; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

ANESTHESIA INDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE EXACERBATION; DRUG DOSE COMPARISON; DRUG MECHANISM; GENERAL ANESTHESIA; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAZE TEST; MOUSE; NERVE CELL NECROSIS; NONHUMAN; POSTOPERATIVE COGNITIVE DYSFUNCTION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SPLENECTOMY; TREATMENT OUTCOME; WESTERN BLOTTING; ADVERSE EFFECTS; AGING; ANIMAL; ANIMAL BEHAVIOR; APOPTOSIS; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; COGNITION DISORDERS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NERVE CELL; NEUROTOXICITY SYNDROMES; PATHOLOGY; POSTOPERATIVE COMPLICATIONS; RANDOMIZATION;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; AGING; ANESTHETICS, GENERAL; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HIPPOCAMPUS; INFLAMMATION MEDIATORS; MAZE LEARNING; MICE, INBRED BALB C; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; POSTOPERATIVE COMPLICATIONS; RANDOM ALLOCATION; SPLENECTOMY;

EID: 84919360974     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.11.017     Document Type: Article

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