Surgery Upregulates High Mobility Group Box-1 and Disrupts the Blood-Brain Barrier causing Cognitive Dysfunction in Aged Rats

CNS Neuroscience and Therapeutics

Volumn 18, Issue 12, 2012, Pages 994-1002

  He, Hui Juan ^a   Wang, Yi ^a   Le, Yuan ^a   Duan, Kai Ming ^a   Yan, Xue Bin ^a   Liao, Qin ^a   Liao, Yan ^a   Tong, Jian Bin ^a   Terrando, Niccolò ^b   Ouyang, Wen ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Aging; Blood brain barrier (BBB); High mobility group box 1 (HMGB1); Postoperative cognitive dysfunction (POCD); Surgery

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 1BETA; ISOFLURANE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; GENERAL ANESTHESIA; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LATENT PERIOD; LEARNING; MAZE TEST; MEMBRANE PERMEABILITY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSTOPERATIVE COMPLICATION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPLENECTOMY; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

AGING; ANALYSIS OF VARIANCE; ANESTHESIA; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; COGNITION DISORDERS; CYTOKINES; DISEASE MODELS, ANIMAL; ELECTRON MICROSCOPE TOMOGRAPHY; ENCEPHALITIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; HMGB1 PROTEIN; MAZE LEARNING; POSTOPERATIVE COMPLICATIONS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 84870451555     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12018     Document Type: Article

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