Molecular targets underlying general anaesthesia

British Journal of Pharmacology

Volumn 147, Issue SUPPL. 1, 2006, Pages

  Franks, Nicholas P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Anaesthetic mechanisms; Ion channels; Receptors

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; DEXMEDETOMIDINE; ETOMIDATE; GLYCINE RECEPTOR; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; LIPID; NITROUS OXIDE; PENTOBARBITAL; POTASSIUM CHANNEL; PROPOFOL; SEVOFLURANE; THIOPENTAL; VOLATILE AGENT; XENON;

DRUG MECHANISM; GENERAL ANESTHESIA; HUMAN; NERVE MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW;

ANESTHESIA, GENERAL; ANESTHETICS, GENERAL; ANESTHETICS, INHALATION; ANIMALS; BINDING SITES; ETOMIDATE; GABA-A RECEPTOR AGONISTS; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; LIPIDS; MODELS, MOLECULAR; POTASSIUM CHANNELS; PROPOFOL; PROTEIN CONFORMATION; RECEPTORS, GABA-A; RECEPTORS, GLYCINE;

EID: 30444459043     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706441     Document Type: Review

References (36)

1. A receptors in hippocampal neurons. Mol. Pharmacol., 59, 814-824.
2. A receptor. Mol. Pharmacol., 65, 68-76.
3. A receptor is influenced by a single amino acid. Proc. Natl. Acad. Sci. U.S.A., 94, 11031-11036.
4. BHATTACHARYA, A.A., CURRY, S. & FRANKS, N.P. (2000). Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J. Biol. Chem., 275, 38731-38738.
5. CAMPAGNA, J.A., MILLER, K.W. & FORMAN, S.A. (2003). Mechanisms of actions of inhaled anesthetics. N. Engl. J. Med., 348, 2110-2124.
6. CHEN, X., SIROIS, J.E., LEI, Q., TALLEY, E.M., LYNCH III, C. & BAYLISS, D.A. (2005). HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents. J. Neurosci., 25, 5803-5814.
7. CORREA-SALES, C., RABIN, B.C. & MAZE, M. (1992). A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology, 76, 948-952.
8. DOWNIE, D.L., HALL, A.C., LIEB, W.R. & FRANKS, N.P. (1996). Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes. Br. J. Pharmacol., 118, 493-502.
9. FRANKS, N.P. & LIEB, W.R. (1982). Molecular mechanisms of general anaesthesia. Nature, 300, 487-493.
10. FRANKS, N.P. & LIEB, W.R. (1984). Do general anaesthetics act by competitive binding to specific receptors? Nature, 310, 599-601.
11. + current. Nature, 333, 662-664.
12. FRANKS, N.P. & LIEB, W.R. (1994). Molecular and cellular mechanisms of general anaesthesia. Nature, 367, 607-614.
13. HALES, T.G. & LAMBERT, J.J. (1991). The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br. J. Pharmacol., 104, 619-628.
14. A and glycine receptors by the inhalation anesthetic isoflurane. Mol. Pharmacol., 44, 628-632.
15. + channel involved in neuroprotection and general anesthesia. EMBO J., 23, 2684-2695.
16. A receptor. Br. J. Pharmacol., 120, 749-756.
17. HUSAIN, S.S., ZIEBELL, M.R., RUESCH, D., HONG, F., AREVALO, E., KOSTERLITZ, J.A., OLSEN, R.W., FORMAN, S.A., COHEN, J.B. & MILLER, K.W. (2003). 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5- carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J. Med. Chem., 46, 1257-1265.
18. A receptor. J. Neurosci., 21, RC136.
19. JURD, R., ARRAS, M., LAMBERT, S., DREXLER, B., SIEGWART, R., CRESTANI, F., ZAUGG, M., VOGT, K.E., LEDERMANN, B., ANTKOWIAK, B. & RUDOLPH, U. (2003). General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J., 17, 250-252.
20. A receptors. Eur. J. Pharmacol., 516, 23-27.
21. LEEB-LUNDBERG, F., SNOWMAN, A. & OLSEN, R.W. (1980). Barbiturate receptor sites are coupled to benzodiazepine receptors. Proc. Natl. Acad. Sci. U.S.A., 77, 7468-7472.
22. MACDONALD, R.L. & BARKER, J.L. (1978). Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons. Science, 200, 775-777.
23. MASCIA, M.P., MACHU, T.K. & HARRIS, R.A. (1996). Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br. J. Pharmacol., 119, 1331-1336.
24. MASCIA, M.P., TRUDELL, J.R. & HARRIS, R.A. (2000). Specific binding sites for alcohols and anesthetics on ligandated ion channels. Proc. Natl. Acad. Sci. U.S.A., 97, 9305-9310.
25. A and glycine receptors. Nature, 389, 385-389.
26. A receptors in an endogenous sleep pathway. Nat. Neurosci., 5, 979-984.
27. NICOLL, R.A. (1978). Pentobarbital: differential postsynaptic actions on sympathetic ganglion cells. Science, 199, 451-452.
28. A receptors: contrasting effects of alpha1(S270) and beta2(N265) point mutations. Neuropharmacology, 42, 337-345.
29. + channels. Anesthesiology, 95, 1013-1021.
30. PROCTOR, W.R., MYNLIEFF, M. & DUNWIDDIE, T.V. (1986). Facilitatory action of etomidate and pentobarbital on recurrent inhibition in rat hippocampal pyramidal neurons. J. Neurosci., 6, 3161-3168.
31. A receptor isoforms. J. Neurosci., 23, 8608-8617.
32. A receptors. J. Neurochem., 80, 140-148.
33. + channel is a molecular substrate for neuronal effects of inhalation anesthetics. J. Neurosci., 20, 6347-6354.
34. SONNER, J.M., ANTOGNINI, J.F., DUTTON, R.C., FLOOD, P., GRAY, A.T., HARRIS, R.A., HOMANICS, G.E., KENDIG, J., ORSER, B., RAINES, D.E., RAMPIL, I.J., TRUDELL, J., VISSEL, B. & EGER II, E.I. (2003). Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth. Analg., 97, 718-740.
35. A receptors and animals. Anesthesiology, 88, 708-717.
36. WU, X.S., SUN, J.Y., EVERS, A.S., CROWDER, M. & WU, L.G. (2004). Isoflurane inhibits transmitter release and the presynaptic action potential. Anesthesiology, 100, 663-670.