Meloxicam improves object recognition memory and modulates glial activation after splenectomy in mice

European Journal of Anaesthesiology

Volumn 29, Issue 7, 2012, Pages 332-337

  Kamer, Angela R ^a   Galoyan, Samuel M ^b   Haile, Michael ^b   Kline, Richard ^b   Boutajangout, Allal ^b   Li, Yong Sheng ^b   Bekker, Alex ^b  

^a NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxygenase 2; Glial activation; Meloxicam; Neuroinflammation; Postoperative cognitive dysfunction

Indexed keywords

MELOXICAM; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HISTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NEUROPSYCHOLOGICAL TEST; NONHUMAN; OBJECT RECOGNITION TEST; POSTOPERATIVE COGNITIVE DYSFUNCTION; RECOGNITION; SPLENECTOMY; TREATMENT OUTCOME; WORKING MEMORY;

ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; INFLAMMATION; MALE; MEMORY; MEMORY, SHORT-TERM; MICE; NEUROGLIA; RECOGNITION (PSYCHOLOGY); SPLENECTOMY; THIAZINES; THIAZOLES; TIME FACTORS;

EID: 84863609399     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e3283534f56     Document Type: Article

References (35)

1. Newman S, Stygall J, Hirani S, et al. Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology 2007; 106:572-590. (Pubitemid 46662224)
2. Rohan D, Buggy DJ, Crowley S, et al. Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly. Can J Anaesth 2005; 52:137-142. (Pubitemid 40480957)
3. Rudolph JL, Schreiber KA, Culley DJ, et al. Measurement of postoperative cognitive dysfunction after cardiac surgery: a systematic review. Acta Anaesthesiol Scand 2010; 54:663-677.
4. Rosczyk HA, Sparkman NL, Johnson RW. Neuroinflammation and cognitive function in aged mice following minor surgery. Exp Gerontol 2008; 43:840-846.
5. Abildstrom H, Rasmussen LS, Rentowl P, et al. Cognitive dysfunction 1-2 years after noncardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiol Scand 2000; 44:1246-1251.
6. Kadoi Y, Goto F. Factors associated with postoperative cognitive dysfunction in patients undergoing cardiac surgery. Surg Today 2006; 36:1053-1057. (Pubitemid 44819447)
7. Gao L, Taha R, Gauvin D, et al. Postoperative cognitive dysfunction after cardiac surgery. Chest 2005; 128:3664-3670. (Pubitemid 41698708)
8. Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 2008; 15:323-330.
9. Wan Y, Xu J, Ma D, et al. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology 2007; 106:436-443. (Pubitemid 46662208)
10. Cao XZ, Ma H, Wang JK, et al. Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34:1426-1432.
11. Quan N, Banks WA. Brain-immune communication pathways. Brain Behav Immun 2007; 21:727-735. (Pubitemid 47002217)
12. Watkins LR, Goehler LE, Relton JK, et al. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett 1995; 183:27-31.
13. Nathan N, Denizot Y, Cornu E, et al. Cytokine and lipid mediator blood concentrations after coronary artery surgery. Anesth Analg 1997; 85:1240-1246. (Pubitemid 28130518)
14. Hein AM, O'Banion MK. Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol 2009; 40:15-32.
15. Garcia E, Forrester L, Kamer A, Bekker, A. Meloxicam prevents transient cognitive dysfunction in mice after nitroglycerin induced hypotension (2009). http://www.asaabstracts.com/strands/asaabstracts/abstract. htm;jsessionid= 0EBD5C32A9D96C52C6CCC04272E7DB00? year=2009&index=10&absnum=1264. [accessed April 4, 2012]
16. Acarin L, Vela JM, Gonzalez B, Castellano B. Demonstration of poly-Nacetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding. J Histochem Cytochem 1994; 42:1033-1041. (Pubitemid 24226330)
17. Cibelli M, Fidalgo AR, Terrando N, et al. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol 2010; 68:360-368.
18. Terrando N, Monaco C, Ma D, et al. Tumor necrosis factor- alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci USA 2010; 107:20518-20522.
19. Garcia E, D'Urso J, Quartermain D, et al. Time course expression of plasma cytokine levels following acute hypotension and associated cognitive dysfunction in mice. Anesth Analg 2010; 109:S432.
20. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001; 2:734-744. (Pubitemid 33674819)
21. Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 1998; 38:97-120. (Pubitemid 28231490)
22. Goncalves MB, Williams EJ, Yip P, et al. The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain. Br J Pharmacol 2010; 159:1118-1125.
23. Yirmiya R, Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 2011; 25:181-213.
24. Bazan NG. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol 2005; 32:89-103. (Pubitemid 41113211)
25. Bastos GN, Moriya T, Inui F, et al. Involvement of cyclooxygenase-2 in lipopolysaccharide-induced impairment of the newborn cell survival in the adult mouse dentate gyrus. Neuroscience 2008; 155:454-462.
26. Kis B, Snipes JA, Busija DW. Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. J Pharmacol Exp Ther 2005; 315:1-7. (Pubitemid 41380491)
27. Funk CD, FitzGerald GA. COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol 2007; 50:470-479. (Pubitemid 350146448)
28. Desborough JP. The stress response to trauma and surgery. Br J Anaesth 2000; 85:109-117. (Pubitemid 30417226)
29. Deak T. From classic aspects of the stress response to neuroinflammation and sickness: implications for individuals and offspring. Int J Compar Psychol 2007; 20:96-110.
30. Jolliet P, Simon N, Bree F, et al. Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery. Pharm Res 1997; 14:650-656. (Pubitemid 27220285)
31. Pakrasi PL, Jain AK. Cyclooxygenase-2 derived PGE2 and PGI2 play an important role via EP2 and PPARdelta receptors in early steps of oil induced decidualization in mice. Placenta 2008; 29:523-530.
32. Knorr C, Marks D, Gerstberger R, et al. Peripheral and central cyclooxygenase (COX) products may contribute to the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-activating lipopeptide-2 (MALP-2). Neurosci Lett 2010; 479:107-111.
33. Bekker A, Haile M, Gingrich K, et al. Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice. Anesth Analg 2007; 105:739-743. (Pubitemid 47300854)
34. Rinder HM, Tracey JB, Souhrada M, et al. Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial. J Clin Pharmacol 2002; 42:881-886. (Pubitemid 34803851)
35. Hawkey C, Kahan A, Steinbruck K, et al. Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study GROUP. Meloxicam Large-scale International Study Safety Assessment. Br J Rheumatol 1998; 37:937-945.