The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery

Journal of Neurosurgical Anesthesiology

Volumn 25, Issue 1, 2013, Pages 16-24

  Bekker, Alex ^a   Haile, Michael ^b   Kline, Richard ^b   Didehvar, Sorosch ^b   Babu, Ramesh ^b   Martiniuk, Frank ^b   Urban, Michael ^c  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

C reactive protein; cortisol; cytokines; dexmedetomidine; postoperative recovery; spine surgery

Indexed keywords

DEXMEDETOMIDINE; FENTANYL; HYDROCORTISONE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; PROPOFOL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; CONVALESCENCE; FATIGUE; FEMALE; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE CARE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA; SPINE FUSION; STRESS;

ADRENERGIC ALPHA-AGONISTS; ANESTHESIA RECOVERY PERIOD; ANESTHESIA, GENERAL; ANESTHETICS, INTRAVENOUS; C-REACTIVE PROTEIN; COGNITION; CYTOKINES; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; FATIGUE; FEMALE; FENTANYL; HUMANS; HYDROCORTISONE; INFUSIONS, INTRAVENOUS; INTRAOPERATIVE CARE; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PROPOFOL; PROSPECTIVE STUDIES; QUESTIONNAIRES; SPINE;

EID: 84872409761     PISSN: 08984921     EISSN: 15371921     Source Type: Journal    
DOI: 10.1097/ANA.0b013e31826318af     Document Type: Article

References (37)

1. Homburger JA, Meiler SE. Anesthesia drugs, immunity, and longterm outcome. Curr Opin Anaesthesiol. 2006;19:423-428. (Pubitemid 44048264)
2. Kurosawa S, Kato M. Anesthetics, immune cells, and immune responses. J Anesth. 2008;22:263-277.
3. Kennedy BC, Hall GM. Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? Acta Anaesthesiol Belg. 1999;50:205-209.
4. Westaby S, Saatvedt K, White S, et al. Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass? Ann Thorac Surg. 2001;71:667-672. (Pubitemid 32173853)
5. Goldfarb Y, Sorski L, Benish M, et al. Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses. Ann Surg. 2011;253:798-810.
6. Tasdogan M, Memis D, Sut N, et al. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth. 2009;21:394-400.
7. Taniguchi T, Kidani Y, Kanakura H, et al. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxininduced shock in rats. Crit Care Med. 2004;32:1322-1326. (Pubitemid 38738587)
8. Myles PS, Hunt JO, Fletcher H. Measuring health status (quality of recovery?) after anesthesia and surgery. Anesth Analg. 2001; 92:281. (Pubitemid 32039225)
9. Myles PS, Weitkamp B, Jones K, et al. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000;84:11-15. (Pubitemid 30009299)
10. Hjollund NH, Andersen JH, Bech P. Assessment of fatigue in chronic disease: a bibliographic study of fatigue measurement scales. Health Qual Life Outcomes. 2007;5:12-17.
11. Valko PO, Bassetti CL, Bloch KE, et al. Validation of the fatigue severity scale in a Swiss cohort. Sleep. 2008;31:1601-1607.
12. Leslie K, Troedel S, Irwin K, et al. Quality of recovery from anesthesia in neurosurgical patients. Anesthesiology. 2003;99: 1158-1165. (Pubitemid 37339463)
13. Myles PS, Wengritzky R. Simplified postoperative nausea and vomiting impact scale for audit and post-discharge review. Br J Anaesth. 2012;108:423-429.
14. Genser B, Cooper PJ, Yazdanbakhsh M, et al. A guide to modern statistical analysis of immunological data. BMC Immunol. 2007; 8:27-41.
15. Kohl BA, Deutschman CS. The inflammatory response to surgery and trauma. Curr Opin Crit Care. 2006;12:325-332. (Pubitemid 44078145)
16. Christensen T, Kehlet H. Postoperative fatigue. World J Surg. 1993;17:220-225. (Pubitemid 23120852)
17. Anselmi A, Possati G, Gaudino M. Postoperative inflammatory reaction and atrial fibrillation: simple correlation or causation? Ann Thorac Surg. 2009;88:326-333.
18. van Munster BC, Korevaar JC, Zwinderman AH, et al. Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc. 2008;56:1704-1709.
19. Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet. 2003;362:1921-1928. (Pubitemid 37518512)
20. Zlotnik A, Klin Y, Gruenbaum BF, et al. b2 adrenergic-mediated reduction of blood glutamate levels and improved neurological outcome after traumatic brain injury in rats. J Neurosurg Anesthesiol. 2012;24:30-38.
21. Kehlet H. Labat lecture 2005: surgical stress and postoperative outcome-from here to where? Reg Anesth Pain Med. 2006;31: 47-52. (Pubitemid 43097406)
22. De Oliveira GS Jr, Almeida MD, Benzon HT, et al. Perioperativesingle dose systemic dexamethasone for postoperative pain: a metaanalysis of randomized controlled trials. Anesthesiology. 2011;115: 575-588.
23. Kolsen-Petersen JA, Bendtzen K, Tonnesen E. Infusion of hypertonic saline before elective hysterectomy: effects on cytokines and stress hormones. Br J Anaesth. 2008;100:478-484. (Pubitemid 351773608)
24. Kyrou I, Tsigos C. Stress hormones: physiological stress and regulation of metabolism. Curr Opin Pharmacol. 2009;9:787-793.
25. Kehlet H. Fast-track surgery-an update on physiological care principles to enhance recovery. Langenbecks Arch Surg. 2011;396: 585-590.
26. Borsook D, George E, Kussman B, et al. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010;92:601-612.
27. Lu CH, Chao PC, Borel CO, et al. Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery. Anesth Analg. 2004;99:1465-1471. (Pubitemid 39407300)
28. Schilling T, Kozian A, Senturk M, et al. Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients. Anesthesiology. 2011;115:65-74.
29. Kim MH, Hahn TH. The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy. Anesth Analg. 2000;90:1441-1444. (Pubitemid 30351354)
30. McAfoose J, Baune BT. Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev. 2009;33:355-366.
31. Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46-56. (Pubitemid 350295688)
32. Chambrier C, Chassard D, Bienvenu J, et al. Cytokine and hormonal changes after cholecystectomy. Effect of ibuprofen pretreatment. Ann Surg. 1996;224:178-182. (Pubitemid 26272064)
33. Wu CT, Jao SW, Borel CO, et al. The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery. Anesth Analg. 2004;99:502-509. (Pubitemid 38970426)
34. Nader ND, Ignatowski TA, Kurek CJ, et al. Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period. Anesth Analg. 2001;93:363-369. (Pubitemid 32701532)
35. Schneemilch CE, Ittenson A, Ansorge S, et al. Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery. J Clin Anesth. 2005;17:517-527. (Pubitemid 41627407)
36. Wichmann MW, Muller C, Meyer G, et al. Different immune responses to abdominal surgery in men and women. Langenbecks Arch Surg. 2003;387:397-401. (Pubitemid 36343033)
37. Offner PJ,MooreEE, BifflWL.Male gender is a risk factor for major infections after surgery. Arch Surg. 1999;134:935-938; discussion 938-940.