-
1
-
-
79957900616
-
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
-
Seino S., Shibasaki T., Minami K. Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J. Clin. Invest. 2011, 121:2118-2125.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2118-2125
-
-
Seino, S.1
Shibasaki, T.2
Minami, K.3
-
3
-
-
84896495719
-
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
-
Kahn S.E., Cooper M.E., Del Prato S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 2014, 383:1068-1083.
-
(2014)
Lancet
, vol.383
, pp. 1068-1083
-
-
Kahn, S.E.1
Cooper, M.E.2
Del Prato, S.3
-
4
-
-
0036314864
-
Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
-
Gerich J.E. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?. Diabetes 2002, 51(Suppl. 1):S117-S121.
-
(2002)
Diabetes
, vol.51
, pp. S117-S121
-
-
Gerich, J.E.1
-
5
-
-
0033760442
-
Triggering and amplifying pathways of regulation of insulin secretion by glucose
-
Henquin J.C. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000, 49:1751-1760.
-
(2000)
Diabetes
, vol.49
, pp. 1751-1760
-
-
Henquin, J.C.1
-
6
-
-
84860400102
-
The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells
-
Henquin J.C. The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells. Diabetes Res. Clin. Pract. 2011, 93(Suppl. 1):S27-S31.
-
(2011)
Diabetes Res. Clin. Pract.
, vol.93
, pp. S27-S31
-
-
Henquin, J.C.1
-
7
-
-
0023692118
-
Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells
-
Thorens B., Sarkar H.K., Kaback H.R., Lodish H.F. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells. Cell 1988, 55:281-290.
-
(1988)
Cell
, vol.55
, pp. 281-290
-
-
Thorens, B.1
Sarkar, H.K.2
Kaback, H.R.3
Lodish, H.F.4
-
8
-
-
0028859374
-
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression
-
De Vos A., Heimberg H., Quartier E., Huypens P., Bouwens L., Pipeleers D., Schuit F. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J. Clin. Invest. 1995, 96:2489-2495.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 2489-2495
-
-
De Vos, A.1
Heimberg, H.2
Quartier, E.3
Huypens, P.4
Bouwens, L.5
Pipeleers, D.6
Schuit, F.7
-
9
-
-
0026636552
-
Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA
-
Koranyi L.I., Tanizawa Y., Welling C.M., Rabin D.U., Permutt M.A. Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA. Diabetes 1992, 41:807-811.
-
(1992)
Diabetes
, vol.41
, pp. 807-811
-
-
Koranyi, L.I.1
Tanizawa, Y.2
Welling, C.M.3
Rabin, D.U.4
Permutt, M.A.5
-
10
-
-
0036896635
-
Regulation of pancreatic β-cell glucokinase: from basics to therapeutics
-
Matschinsky F.M. Regulation of pancreatic β-cell glucokinase: from basics to therapeutics. Diabetes 2002, 51(Suppl. 3):S394-S404.
-
(2002)
Diabetes
, vol.51
, pp. S394-S404
-
-
Matschinsky, F.M.1
-
12
-
-
34248219593
-
Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
-
Wang Z., Oh E., Thurmond D.C. Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion. J. Biol. Chem. 2007, 282:9536-9546.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9536-9546
-
-
Wang, Z.1
Oh, E.2
Thurmond, D.C.3
-
13
-
-
66849115296
-
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins
-
Wang Z., Thurmond D.C. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. J. Cell Sci. 2009, 122:893-903.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 893-903
-
-
Wang, Z.1
Thurmond, D.C.2
-
14
-
-
77955879987
-
Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments
-
Mourad N.I., Nenquin M., Henquin J.C. Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments. Am. J. Physiol. Cell Physiol. 2010, 299:C389-C398.
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.299
, pp. C389-C398
-
-
Mourad, N.I.1
Nenquin, M.2
Henquin, J.C.3
-
15
-
-
79952141408
-
Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules
-
Mourad N.I., Nenquin M., Henquin J.C. Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules. Am. J. Physiol. Cell Physiol. 2011, 300:C697-C706.
-
(2011)
Am. J. Physiol. Cell Physiol.
, vol.300
, pp. C697-C706
-
-
Mourad, N.I.1
Nenquin, M.2
Henquin, J.C.3
-
16
-
-
84866749128
-
CAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments
-
Mourad N.I., Nenquin M., Henquin J.C. cAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments. Endocrinology 2012, 153:4644-4654.
-
(2012)
Endocrinology
, vol.153
, pp. 4644-4654
-
-
Mourad, N.I.1
Nenquin, M.2
Henquin, J.C.3
-
17
-
-
0042879951
-
Insulin granule dynamics in pancreatic beta cells
-
Rorsman P., Renström E. Insulin granule dynamics in pancreatic beta cells. Diabetologia 2003, 46:1029-1045.
-
(2003)
Diabetologia
, vol.46
, pp. 1029-1045
-
-
Rorsman, P.1
Renström, E.2
-
18
-
-
37649002935
-
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
-
Shibasaki T., Takahashi H., Miki T., Sunaga Y., Matsumura K., Yamanaka M., Zhang C., Tamamoto A., Satoh T., Miyazaki J., Seino S. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:19333-19338.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 19333-19338
-
-
Shibasaki, T.1
Takahashi, H.2
Miki, T.3
Sunaga, Y.4
Matsumura, K.5
Yamanaka, M.6
Zhang, C.7
Tamamoto, A.8
Satoh, T.9
Miyazaki, J.10
Seino, S.11
-
19
-
-
44949196953
-
Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic β-cell
-
Wiederkehr A., Wollheim C.B. Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic β-cell. Cell Calcium 2008, 44:64-76.
-
(2008)
Cell Calcium
, vol.44
, pp. 64-76
-
-
Wiederkehr, A.1
Wollheim, C.B.2
-
20
-
-
57749185452
-
Mitochondrial dysfunction in pancreatic β-cells in type 2 diabetes
-
Mudler H., Ling C. Mitochondrial dysfunction in pancreatic β-cells in type 2 diabetes. Mol. Cell. Endocrinol. 2009, 297:34-40.
-
(2009)
Mol. Cell. Endocrinol.
, vol.297
, pp. 34-40
-
-
Mudler, H.1
Ling, C.2
-
22
-
-
84901941969
-
Incretin-modulated beta cell energetics in intact islets of Langerhans
-
Hodson D.J., Tarasov A.I., Gimeno Brias S., Mitchell R.K., Johnston N.R., Haghollahi S., Cane M.C., Bugliani M., Marchetti P., Bosco D., Johnson P.R., Hughes S.J., Rutter G.A. Incretin-modulated beta cell energetics in intact islets of Langerhans. Mol. Endocrinol. 2014, 28:860-871.
-
(2014)
Mol. Endocrinol.
, vol.28
, pp. 860-871
-
-
Hodson, D.J.1
Tarasov, A.I.2
Gimeno Brias, S.3
Mitchell, R.K.4
Johnston, N.R.5
Haghollahi, S.6
Cane, M.C.7
Bugliani, M.8
Marchetti, P.9
Bosco, D.10
Johnson, P.R.11
Hughes, S.J.12
Rutter, G.A.13
-
23
-
-
0027018241
-
Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37)
-
Holz G.G., Habener J.F. Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37). Trans. Assoc. Am. Phys. 1992, 105:260-267.
-
(1992)
Trans. Assoc. Am. Phys.
, vol.105
, pp. 260-267
-
-
Holz, G.G.1
Habener, J.F.2
-
24
-
-
0026645809
-
Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept
-
Holz G.G., Habener J.F. Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem. Sci. 1992, 17:388-393.
-
(1992)
Trends Biochem. Sci.
, vol.17
, pp. 388-393
-
-
Holz, G.G.1
Habener, J.F.2
-
25
-
-
0027473729
-
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)
-
Holz G.G., Kühtreiber W.M., Habener J.F. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 1993, 361:362-365.
-
(1993)
Nature
, vol.361
, pp. 362-365
-
-
Holz, G.G.1
Kühtreiber, W.M.2
Habener, J.F.3
-
26
-
-
12244305595
-
New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic β-cells
-
Holz G.G. New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic β-cells. Horm. Metab. Res. 2004, 36:787-794.
-
(2004)
Horm. Metab. Res.
, vol.36
, pp. 787-794
-
-
Holz, G.G.1
-
27
-
-
0037219411
-
β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
28
-
-
58549083162
-
Rescuing the subprime meltdown in insulin exocytosis in diabetes
-
Kwan E.P., Gaisano H.Y. Rescuing the subprime meltdown in insulin exocytosis in diabetes. Ann. N. Y. Acad. Sci. 2009, 1152:154-164.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1152
, pp. 154-164
-
-
Kwan, E.P.1
Gaisano, H.Y.2
-
29
-
-
84891675212
-
Age-dependent labeling and imaging of insulin secretory granules
-
Ivanova A., Kalaidzidis Y., Dirkx R., Sarov M., Gerlach M., Schroth-Diez B., Müller A., Liu Y., Andree C., Mulligan B., Münster C., Kurth T., Bickle M., Speier S., Anastassiadis K., Solimena M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 2013, 62:3687-3696.
-
(2013)
Diabetes
, vol.62
, pp. 3687-3696
-
-
Ivanova, A.1
Kalaidzidis, Y.2
Dirkx, R.3
Sarov, M.4
Gerlach, M.5
Schroth-Diez, B.6
Müller, A.7
Liu, Y.8
Andree, C.9
Mulligan, B.10
Münster, C.11
Kurth, T.12
Bickle, M.13
Speier, S.14
Anastassiadis, K.15
Solimena, M.16
-
30
-
-
84863207933
-
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes
-
Rosengren A.H., Braun M., Mahdi T., Andersson S.A., Travers M.E., Shigeto M., Zhang E., Almgren P., Ladenvall C., Axelsson A.S., Edlund A., Pedersen M.G., Jonsson A., Ramracheya R., Tang Y., Walker J.N., Barrett A., Johnson P.R., Lyssenko V., McCarthy M.I., Groop L., Salehi A., Gloyn A.L., Renström E., Rorsman P., Eliasson L. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes 2012, 61:1726-1733.
-
(2012)
Diabetes
, vol.61
, pp. 1726-1733
-
-
Rosengren, A.H.1
Braun, M.2
Mahdi, T.3
Andersson, S.A.4
Travers, M.E.5
Shigeto, M.6
Zhang, E.7
Almgren, P.8
Ladenvall, C.9
Axelsson, A.S.10
Edlund, A.11
Pedersen, M.G.12
Jonsson, A.13
Ramracheya, R.14
Tang, Y.15
Walker, J.N.16
Barrett, A.17
Johnson, P.R.18
Lyssenko, V.19
McCarthy, M.I.20
Groop, L.21
Salehi, A.22
Gloyn, A.L.23
Renström, E.24
Rorsman, P.25
Eliasson, L.26
more..
-
31
-
-
1842579441
-
Type 2 diabetes mellitus: not quite exciting enough?
-
Spec No 1
-
Ashcroft F., Rorsman P. Type 2 diabetes mellitus: not quite exciting enough?. Hum. Mol. Genet. 2004, 13(Spec No 1):R21-R31.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. R21-R31
-
-
Ashcroft, F.1
Rorsman, P.2
-
32
-
-
33645322386
-
ATP channels as molecular sensors of cellular metabolism
-
ATP channels as molecular sensors of cellular metabolism. Nature 2006, 440:470-476.
-
(2006)
Nature
, vol.440
, pp. 470-476
-
-
Nichols, C.G.1
-
33
-
-
0026659006
-
Sulfonylureas in NIDDM
-
Groop L.C. Sulfonylureas in NIDDM. Diabetes Care 1992, 15:737-754.
-
(1992)
Diabetes Care
, vol.15
, pp. 737-754
-
-
Groop, L.C.1
-
34
-
-
0141953908
-
Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus
-
Holz G.G., Chepurny O.G. Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr. Med. Chem. 2003, 10:2471-2483.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 2471-2483
-
-
Holz, G.G.1
Chepurny, O.G.2
-
37
-
-
84901593760
-
Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities
-
Lund A., Knop F.K., Vilsbøll T. Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities. Eur. J. Intern. Med. 2014, 25:407-414.
-
(2014)
Eur. J. Intern. Med.
, vol.25
, pp. 407-414
-
-
Lund, A.1
Knop, F.K.2
Vilsbøll, T.3
-
38
-
-
67349176115
-
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
-
Ahrén B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat. Rev. Drug Discov. 2009, 8:369-385.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 369-385
-
-
Ahrén, B.1
-
39
-
-
0034725748
-
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
-
Chen Y., Cann M.J., Litvin T.N., Iourgenko V., Sinclair M.L., Levin L.R., Buck J. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 2000, 289:625-628.
-
(2000)
Science
, vol.289
, pp. 625-628
-
-
Chen, Y.1
Cann, M.J.2
Litvin, T.N.3
Iourgenko, V.4
Sinclair, M.L.5
Levin, L.R.6
Buck, J.7
-
41
-
-
0037844844
-
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate
-
Litvin T.N., Kamenetsky M., Zarifyan A., Buck J., Levin L.R. Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J. Biol. Chem. 2003, 278:15922-15926.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15922-15926
-
-
Litvin, T.N.1
Kamenetsky, M.2
Zarifyan, A.3
Buck, J.4
Levin, L.R.5
-
42
-
-
11444256177
-
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
-
Steegborn C., Litvin T.N., Levi L.R., Buck J., Wu H. Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat. Struct. Mol. Biol. 2005, 12:32-37.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 32-37
-
-
Steegborn, C.1
Litvin, T.N.2
Levi, L.R.3
Buck, J.4
Wu, H.5
-
43
-
-
84889670858
-
PH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC)
-
Rahman N., Buck J., Levin L.R. pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC). Front. Physiol. 2013, 4:343.
-
(2013)
Front. Physiol.
, vol.4
, pp. 343
-
-
Rahman, N.1
Buck, J.2
Levin, L.R.3
-
44
-
-
84887851869
-
-- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor
-
-- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J. Biol. Chem. 2013, 288:33283-33291.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 33283-33291
-
-
Zippin, J.H.1
Chen, Y.2
Straub, S.G.3
Hess, K.C.4
Diaz, A.5
Lee, D.6
Tso, P.7
Holz, G.G.8
Sharp, G.W.9
Levin, L.R.10
Buck, J.11
-
45
-
-
84896301859
-
-
Kleinboelting S., Diaz A., Moniot S., van den Heuvel J., Weyand M., Levin L.R., Buck J., Steegborn C. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:3727-3732.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 3727-3732
-
-
Kleinboelting, S.1
Diaz, A.2
Moniot, S.3
van den Heuvel, J.4
Weyand, M.5
Levin, L.R.6
Buck, J.7
Steegborn, C.8
-
46
-
-
0141703301
-
Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa
-
Jaiswal B.S., Conti M. Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:10676-10681.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10676-10681
-
-
Jaiswal, B.S.1
Conti, M.2
-
47
-
-
0029071517
-
Metabolic coupling factors in pancreatic β-cell signal transduction
-
Newgard C.B., McGarry J.D. Metabolic coupling factors in pancreatic β-cell signal transduction. Annu. Rev. Biochem. 1995, 64:689-719.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 689-719
-
-
Newgard, C.B.1
McGarry, J.D.2
-
48
-
-
0016609879
-
Extracellular bicarbonate ions and insulin secretion
-
Henquin J.C., Lambert A.E. Extracellular bicarbonate ions and insulin secretion. Biochim. Biophys. Acta 1975, 381:437-442.
-
(1975)
Biochim. Biophys. Acta
, vol.381
, pp. 437-442
-
-
Henquin, J.C.1
Lambert, A.E.2
-
49
-
-
0017093534
-
Bicarbonate modulation of glucose-induced biphasic insulin release by rat islets
-
Henquin J.C., Lambert A.E. Bicarbonate modulation of glucose-induced biphasic insulin release by rat islets. Am. J. Physiol. 1976, 231:713-721.
-
(1976)
Am. J. Physiol.
, vol.231
, pp. 713-721
-
-
Henquin, J.C.1
Lambert, A.E.2
-
50
-
-
0032544429
-
Expression of carbonic anhydrase V in pancreatic beta cells suggests role for mitochondrial carbonic anhydrase in insulin secretion
-
Parkkila A.K., Scarim A.L., Parkkila S., Waheed A., Corbett J.A., Sly W.S. Expression of carbonic anhydrase V in pancreatic beta cells suggests role for mitochondrial carbonic anhydrase in insulin secretion. J. Biol. Chem. 1998, 273:24620-24623.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24620-24623
-
-
Parkkila, A.K.1
Scarim, A.L.2
Parkkila, S.3
Waheed, A.4
Corbett, J.A.5
Sly, W.S.6
-
51
-
-
34447554567
-
Possible role of carbonic anhydrase in rat pancreatic islets: enzymatic, secretory, metabolic, ionic, and electrical aspects
-
Sener A., Jijakli H., Zahedi Asl S., Courtois P., Yates A.P., Meuris S., Best L.C., Malaisse W.J. Possible role of carbonic anhydrase in rat pancreatic islets: enzymatic, secretory, metabolic, ionic, and electrical aspects. Am. J. Physiol. Endocrinol. Metab. 2007, 292:E1624-E1630.
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.292
, pp. E1624-E1630
-
-
Sener, A.1
Jijakli, H.2
Zahedi Asl, S.3
Courtois, P.4
Yates, A.P.5
Meuris, S.6
Best, L.C.7
Malaisse, W.J.8
-
52
-
-
0028933903
-
Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells
-
Leech C.A., Holz G.G., Habener J.F. Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells. Endocrinology 1995, 136:1530-1536.
-
(1995)
Endocrinology
, vol.136
, pp. 1530-1536
-
-
Leech, C.A.1
Holz, G.G.2
Habener, J.F.3
-
53
-
-
0028978243
-
2+-signaling pathway in pancreatic β-cells by the insulinotropic hormone glucagon-like peptide-1
-
2+-signaling pathway in pancreatic β-cells by the insulinotropic hormone glucagon-like peptide-1. J. Biol. Chem. 1995, 270:17749-17757.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 17749-17757
-
-
Holz, G.G.1
Leech, C.A.2
Habener, J.F.3
-
54
-
-
0030475718
-
Signal transduction of PACAP and GLP-1 in pancreatic β cells
-
Leech C.A., Holz G.G., Habener J.F. Signal transduction of PACAP and GLP-1 in pancreatic β cells. Ann. N. Y. Acad. Sci. 1996, 805:81-92.
-
(1996)
Ann. N. Y. Acad. Sci.
, vol.805
, pp. 81-92
-
-
Leech, C.A.1
Holz, G.G.2
Habener, J.F.3
-
55
-
-
82455210942
-
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells
-
Leech C.A., Dzhura I., Chepurny O.G., Kang G., Schwede F., Genieser H.G., Holz G.G. Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells. Prog. Biophys. Mol. Biol. 2011, 107:236-247.
-
(2011)
Prog. Biophys. Mol. Biol.
, vol.107
, pp. 236-247
-
-
Leech, C.A.1
Dzhura, I.2
Chepurny, O.G.3
Kang, G.4
Schwede, F.5
Genieser, H.G.6
Holz, G.G.7
-
56
-
-
0037264053
-
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains
-
Zippin J.H., Chen Y., Nahirney P., Kamenetsky M., Wuttke M.S., Fischman D.A., Levin L.R., Buck J. Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J. 2003, 17:82-84.
-
(2003)
FASEB J.
, vol.17
, pp. 82-84
-
-
Zippin, J.H.1
Chen, Y.2
Nahirney, P.3
Kamenetsky, M.4
Wuttke, M.S.5
Fischman, D.A.6
Levin, L.R.7
Buck, J.8
-
57
-
-
60649095658
-
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation
-
Acin-Perez R., Salazar E., Kamenetsky M., Buck J., Levin L.R., Manfredi G. Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab. 2009, 9:265-276.
-
(2009)
Cell Metab.
, vol.9
, pp. 265-276
-
-
Acin-Perez, R.1
Salazar, E.2
Kamenetsky, M.3
Buck, J.4
Levin, L.R.5
Manfredi, G.6
-
58
-
-
84878531701
-
CAMP and mitochondria
-
Valsecchi F., Ramos-Espiritu L.S., Buck J., Levin L.R., Manfredi G. cAMP and mitochondria. Physiology (Bethesda) 2013, 28:199-209.
-
(2013)
Physiology (Bethesda)
, vol.28
, pp. 199-209
-
-
Valsecchi, F.1
Ramos-Espiritu, L.S.2
Buck, J.3
Levin, L.R.4
Manfredi, G.5
-
59
-
-
84857785686
-
Mitochondrial signals drive insulin secretion in the pancreatic β-cell
-
Wiederkehr A., Wollheim C.B. Mitochondrial signals drive insulin secretion in the pancreatic β-cell. Mol. Cell. Endocrinol. 2012, 353:128-137.
-
(2012)
Mol. Cell. Endocrinol.
, vol.353
, pp. 128-137
-
-
Wiederkehr, A.1
Wollheim, C.B.2
-
60
-
-
79959390543
-
Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets
-
Tian G., Sandler S., Gylfe E., Tengholm A. Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets. Diabetes 2011, 60:1535-1543.
-
(2011)
Diabetes
, vol.60
, pp. 1535-1543
-
-
Tian, G.1
Sandler, S.2
Gylfe, E.3
Tengholm, A.4
-
62
-
-
50449094096
-
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells
-
Ramos L.S., Zippin J.H., Kamenetsky M., Buck J., Levin L.R. Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J. Gen. Physiol. 2008, 132:329-338.
-
(2008)
J. Gen. Physiol.
, vol.132
, pp. 329-338
-
-
Ramos, L.S.1
Zippin, J.H.2
Kamenetsky, M.3
Buck, J.4
Levin, L.R.5
-
64
-
-
0142125207
-
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
-
Delmeire D., Flamez D., Hinke S.A., Cali J.J., Pipeleers D., Schuit F. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia 2003, 46:1383-1393.
-
(2003)
Diabetologia
, vol.46
, pp. 1383-1393
-
-
Delmeire, D.1
Flamez, D.2
Hinke, S.A.3
Cali, J.J.4
Pipeleers, D.5
Schuit, F.6
-
65
-
-
78951478947
-
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells
-
Roger B., Papin J., Vacher P., Raoux M., Mulot A., Dubois M., Kerr-Conte J., Voy B.H., Pattou F., Charpentier G., Jonas J.C., Moustaïd-Moussa N., Lang J. Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Diabetologia 2011, 54:390-402.
-
(2011)
Diabetologia
, vol.54
, pp. 390-402
-
-
Roger, B.1
Papin, J.2
Vacher, P.3
Raoux, M.4
Mulot, A.5
Dubois, M.6
Kerr-Conte, J.7
Voy, B.H.8
Pattou, F.9
Charpentier, G.10
Jonas, J.C.11
Moustaïd-Moussa, N.12
Lang, J.13
-
66
-
-
33644538464
-
Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets
-
Hatakeyama H., Kishimoto T., Nemoto T., Kasai H., Takahashi N. Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets. J. Physiol. 2006, 570:271-282.
-
(2006)
J. Physiol.
, vol.570
, pp. 271-282
-
-
Hatakeyama, H.1
Kishimoto, T.2
Nemoto, T.3
Kasai, H.4
Takahashi, N.5
-
67
-
-
79952126838
-
Snapin mediates incretin action and augments glucose-dependent insulin secretion
-
Song W.J., Seshadri M., Ashraf U., Mdluli T., Mondal P., Keil M., Azevedo M., Kirschner L.S., Stratakis C.A., Hussain M.A. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab. 2011, 13:308-319.
-
(2011)
Cell Metab.
, vol.13
, pp. 308-319
-
-
Song, W.J.1
Seshadri, M.2
Ashraf, U.3
Mdluli, T.4
Mondal, P.5
Keil, M.6
Azevedo, M.7
Kirschner, L.S.8
Stratakis, C.A.9
Hussain, M.A.10
-
68
-
-
79952040814
-
2+ primarily through protein kinase A in mouse pancreatic beta cells
-
2+ primarily through protein kinase A in mouse pancreatic beta cells. Cell Calcium 2011, 49:89-99.
-
(2011)
Cell Calcium
, vol.49
, pp. 89-99
-
-
Skelin, M.1
Rupnik, M.2
-
69
-
-
84864390450
-
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-cells
-
Nie J., Sun C., Faruque O., Ye G., Li J., Liang Q., Chang Z., Yang W., Han X., Shi Y. Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-cells. J. Biol. Chem. 2012, 287:26435-26444.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 26435-26444
-
-
Nie, J.1
Sun, C.2
Faruque, O.3
Ye, G.4
Li, J.5
Liang, Q.6
Chang, Z.7
Yang, W.8
Han, X.9
Shi, Y.10
-
70
-
-
84880783742
-
SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells
-
Nie J., Lilley B.N., Pan Y.A., Faruque O., Liu X., Zhang W., Sanes J.R., Han X., Shi Y. SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells. Mol. Cell. Biol. 2013, 33:2527-2534.
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 2527-2534
-
-
Nie, J.1
Lilley, B.N.2
Pan, Y.A.3
Faruque, O.4
Liu, X.5
Zhang, W.6
Sanes, J.R.7
Han, X.8
Shi, Y.9
-
71
-
-
1242285150
-
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain
-
Zippin J.H., Farrell J., Huron D., Kamenetsky M., Hess K.C., Fischman D.A., Levin L.R., Buck J. Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J. Cell Biol. 2004, 164:527-534.
-
(2004)
J. Cell Biol.
, vol.164
, pp. 527-534
-
-
Zippin, J.H.1
Farrell, J.2
Huron, D.3
Kamenetsky, M.4
Hess, K.C.5
Fischman, D.A.6
Levin, L.R.7
Buck, J.8
-
72
-
-
33745215639
-
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1
-
Stessin A.M., Zippin J.H., Kamenetsky M., Hess K.C., Buck J., Levin L.R. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J. Biol. Chem. 2006, 281:17253-17258.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17253-17258
-
-
Stessin, A.M.1
Zippin, J.H.2
Kamenetsky, M.3
Hess, K.C.4
Buck, J.5
Levin, L.R.6
-
73
-
-
0347990624
-
Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic β-cell
-
Holz G.G. Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic β-cell. Diabetes 2004, 53:5-13.
-
(2004)
Diabetes
, vol.53
, pp. 5-13
-
-
Holz, G.G.1
-
74
-
-
33750730215
-
Cell physiology of cAMP sensor Epac
-
Holz G.G., Kang G., Harbeck M., Roe M.W., Chepurny O.G. Cell physiology of cAMP sensor Epac. J. Physiol. 2006, 577:5-15.
-
(2006)
J. Physiol.
, vol.577
, pp. 5-15
-
-
Holz, G.G.1
Kang, G.2
Harbeck, M.3
Roe, M.W.4
Chepurny, O.G.5
-
75
-
-
0035824548
-
Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion
-
Kashima Y., Miki T., Shibasaki T., Ozaki N., Miyazaki M., Yano H., Seino S. Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 2001, 276:46046-46053.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46046-46053
-
-
Kashima, Y.1
Miki, T.2
Shibasaki, T.3
Ozaki, N.4
Miyazaki, M.5
Yano, H.6
Seino, S.7
-
76
-
-
0037337832
-
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells
-
Eliasson L., Ma X., Renström E., Barg S., Berggren P.O., Galvanovskis J., Gromada J., Jing X., Lundquist I., Salehi A., Sewing S., Rorsman P. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J. Gen. Physiol. 2003, 121:181-197.
-
(2003)
J. Gen. Physiol.
, vol.121
, pp. 181-197
-
-
Eliasson, L.1
Ma, X.2
Renström, E.3
Barg, S.4
Berggren, P.O.5
Galvanovskis, J.6
Gromada, J.7
Jing, X.8
Lundquist, I.9
Salehi, A.10
Sewing, S.11
Rorsman, P.12
-
78
-
-
25444520038
-
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis
-
Seino S., Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol. Rev. 2005, 85:1303-1342.
-
(2005)
Physiol. Rev.
, vol.85
, pp. 1303-1342
-
-
Seino, S.1
Shibasaki, T.2
-
79
-
-
33745260129
-
Differential modulation of Cav1.2 and Cav1.3-mediated glucose-stimulated insulin secretion by cAMP in INS-1 cells: distinct roles for exchange protein directly activated by cAMP 2 (Epac2) and protein kinase A
-
Liu G., Jacobo S.M., Hilliard N., Hockerman G.H. Differential modulation of Cav1.2 and Cav1.3-mediated glucose-stimulated insulin secretion by cAMP in INS-1 cells: distinct roles for exchange protein directly activated by cAMP 2 (Epac2) and protein kinase A. J. Pharmacol. Exp. Ther. 2006, 318:152-160.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.318
, pp. 152-160
-
-
Liu, G.1
Jacobo, S.M.2
Hilliard, N.3
Hockerman, G.H.4
-
80
-
-
34948822833
-
Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells
-
Kwan E.P., Xie L., Sheu L., Ohtsuka T., Gaisano H.Y. Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes 2007, 56:2579-2588.
-
(2007)
Diabetes
, vol.56
, pp. 2579-2588
-
-
Kwan, E.P.1
Xie, L.2
Sheu, L.3
Ohtsuka, T.4
Gaisano, H.Y.5
-
81
-
-
70350310990
-
Roles of cAMP signalling in insulin granule exocytosis
-
Seino S., Takahashi H., Fujimoto W., Shibasaki T. Roles of cAMP signalling in insulin granule exocytosis. Diabetes Obes. Metab. 2009, 11(Suppl. 4):180-188.
-
(2009)
Diabetes Obes. Metab.
, vol.11
, pp. 180-188
-
-
Seino, S.1
Takahashi, H.2
Fujimoto, W.3
Shibasaki, T.4
-
82
-
-
68049096966
-
Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells
-
Vikman J., Svensson H., Huang Y.C., Kang Y., Andersson S.A., Gaisano H.Y., Eliasson L. Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E452-E461.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
, pp. E452-E461
-
-
Vikman, J.1
Svensson, H.2
Huang, Y.C.3
Kang, Y.4
Andersson, S.A.5
Gaisano, H.Y.6
Eliasson, L.7
-
83
-
-
84862945912
-
Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A
-
Park J.H., Kim S.J., Park S.H., Son D.G., Bae J.H., Kim H.K., Han J., Song D.K. Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A. Endocrinology 2012, 153:574-582.
-
(2012)
Endocrinology
, vol.153
, pp. 574-582
-
-
Park, J.H.1
Kim, S.J.2
Park, S.H.3
Son, D.G.4
Bae, J.H.5
Kim, H.K.6
Han, J.7
Song, D.K.8
-
84
-
-
84885160578
-
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome
-
Kai A.K., Lam A.K., Chen Y., Tai A.C., Zhang X., Lai A.K., Yeung P.K., Tam S., Wang J., Lam K.S., Vanhoutte P.M., Bos J.L., Chung S.S., Xu A., Chung S.K. Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB J. 2013, 27:4122-4135.
-
(2013)
FASEB J.
, vol.27
, pp. 4122-4135
-
-
Kai, A.K.1
Lam, A.K.2
Chen, Y.3
Tai, A.C.4
Zhang, X.5
Lai, A.K.6
Yeung, P.K.7
Tam, S.8
Wang, J.9
Lam, K.S.10
Vanhoutte, P.M.11
Bos, J.L.12
Chung, S.S.13
Xu, A.14
Chung, S.K.15
-
85
-
-
84891698714
-
Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A
-
Song W.J., Mondal P., Li Y., Lee S.E., Hussain M.A. Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A. Diabetes 2013, 62:2796-2807.
-
(2013)
Diabetes
, vol.62
, pp. 2796-2807
-
-
Song, W.J.1
Mondal, P.2
Li, Y.3
Lee, S.E.4
Hussain, M.A.5
-
86
-
-
84891669356
-
Epac2A makes a new impact in β-cell biology
-
Holz G.G., Chepurny O.G., Leech C.A. Epac2A makes a new impact in β-cell biology. Diabetes 2013, 62:2665-2666.
-
(2013)
Diabetes
, vol.62
, pp. 2665-2666
-
-
Holz, G.G.1
Chepurny, O.G.2
Leech, C.A.3
-
87
-
-
84868570315
-
Isoform-specific antagonists of exchange proteins directly activated by cAMP
-
Tsalkova T., Mei F.C., Li S., Chepurny O.G., Leech C.A., Liu T., Holz G.G., Woods V.L., Cheng X. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:18613-18618.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 18613-18618
-
-
Tsalkova, T.1
Mei, F.C.2
Li, S.3
Chepurny, O.G.4
Leech, C.A.5
Liu, T.6
Holz, G.G.7
Woods, V.L.8
Cheng, X.9
-
88
-
-
84873887299
-
Identification and characterization of small molecules as potent and specific EPAC2 antagonists
-
Chen H., Tsalkova T., Chepurny O.G., Mei F.C., Holz G.G., Cheng X., Zhou J. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J. Med. Chem. 2013, 56:952-962.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 952-962
-
-
Chen, H.1
Tsalkova, T.2
Chepurny, O.G.3
Mei, F.C.4
Holz, G.G.5
Cheng, X.6
Zhou, J.7
-
89
-
-
84871729159
-
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac
-
Courilleau D., Bisserier M., Jullian J.C., Lucas A., Bouyssou P., Fischmeister R., Blondeau J.P., Lezoualc'h F. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J. Biol. Chem. 2012, 287:44192-44202.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 44192-44202
-
-
Courilleau, D.1
Bisserier, M.2
Jullian, J.C.3
Lucas, A.4
Bouyssou, P.5
Fischmeister, R.6
Blondeau, J.P.7
Lezoualc'h, F.8
-
91
-
-
33644872121
-
2+ signals through the modulation of Ras signaling
-
2+ signals through the modulation of Ras signaling. Curr. Opin. Cell Biol. 2006, 18:157-161.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 157-161
-
-
Cullen, P.J.1
-
92
-
-
77349096383
-
PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans
-
Chepurny O.G., Kelley G.G., Dzhura I., Leech C.A., Roe M.W., Dzhura E., Li X., Schwede F., Genieser H.G., Holz G.G. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans. Am. J. Physiol. Endocrinol. Metab. 2010, 298:E622-E633.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
, pp. E622-E633
-
-
Chepurny, O.G.1
Kelley, G.G.2
Dzhura, I.3
Leech, C.A.4
Roe, M.W.5
Dzhura, E.6
Li, X.7
Schwede, F.8
Genieser, H.G.9
Holz, G.G.10
-
93
-
-
0029859599
-
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP
-
Dachicourt N., Serradas P., Giroix M.H., Gangnerau M.N., Portha B. Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP. Am. J. Physiol. 1996, 271:E725-E732.
-
(1996)
Am. J. Physiol.
, vol.271
, pp. E725-E732
-
-
Dachicourt, N.1
Serradas, P.2
Giroix, M.H.3
Gangnerau, M.N.4
Portha, B.5
-
94
-
-
80054965549
-
CAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1
-
Dolz M., Movassat J., Bailbé D., Le Stunff H., Giroix M.H., Fradet M., Kergoat M., Portha B. cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1. Am. J. Physiol. Endocrinol. Metab. 2011, 301:E797-E806.
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.301
, pp. E797-E806
-
-
Dolz, M.1
Movassat, J.2
Bailbé, D.3
Le Stunff, H.4
Giroix, M.H.5
Fradet, M.6
Kergoat, M.7
Portha, B.8
-
95
-
-
33744939752
-
CAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cells
-
Kang G., Chepurny O.G., Malester B., Rindler M.J., Rehmann H., Bos J.L., Schwede F., Coetzee W.A., Holz G.G. cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cells. J. Physiol. 2006, 573:595-609.
-
(2006)
J. Physiol.
, vol.573
, pp. 595-609
-
-
Kang, G.1
Chepurny, O.G.2
Malester, B.3
Rindler, M.J.4
Rehmann, H.5
Bos, J.L.6
Schwede, F.7
Coetzee, W.A.8
Holz, G.G.9
-
99
-
-
0037232658
-
2+ release in INS-1 pancreatic β cells
-
2+ release in INS-1 pancreatic β cells. J. Physiol. 2003, 546:175-189.
-
(2003)
J. Physiol.
, vol.546
, pp. 175-189
-
-
Kang, G.1
Holz, G.G.2
-
100
-
-
0037424363
-
2+ release and exocytosis in pancreatic β-cells
-
2+ release and exocytosis in pancreatic β-cells. J. Biol. Chem. 2003, 278:8279-8285.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8279-8285
-
-
Kang, G.1
Joseph, J.W.2
Chepurny, O.G.3
Monaco, M.4
Wheeler, M.B.5
Bos, J.L.6
Schwede, F.7
Genieser, H.G.8
Holz, G.G.9
-
101
-
-
22144489495
-
2+ release in mouse pancreatic β cells
-
2+ release in mouse pancreatic β cells. J. Physiol. 2005, 566:173-188.
-
(2005)
J. Physiol.
, vol.566
, pp. 173-188
-
-
Kang, G.1
Chepurny, O.G.2
Rindler, M.J.3
Collis, L.4
Chepurny, Z.5
Li, W.H.6
Harbeck, M.7
Roe, M.W.8
Holz, G.G.9
-
102
-
-
78650090455
-
2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice
-
2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. J. Physiol. 2010, 588:4871-4889.
-
(2010)
J. Physiol.
, vol.588
, pp. 4871-4889
-
-
Dzhura, I.1
Chepurny, O.G.2
Kelley, G.G.3
Leech, C.A.4
Roe, M.W.5
Dzhura, E.6
Afshari, P.7
Malik, S.8
Rindler, M.J.9
Xu, X.10
Lu, Y.11
Smrcka, A.V.12
Holz, G.G.13
-
103
-
-
33749626976
-
Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation
-
Hussain M.A., Porras D.L., Rowe M.H., West J.R., Song W.J., Schreiber W.E., Wondisford F.E. Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol. Cell. Biol. 2006, 26:7747-7759.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7747-7759
-
-
Hussain, M.A.1
Porras, D.L.2
Rowe, M.H.3
West, J.R.4
Song, W.J.5
Schreiber, W.E.6
Wondisford, F.E.7
-
104
-
-
52749096469
-
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation
-
Song W.J., Schreiber W.E., Zhong E., Liu F.F., Kornfeld B.D., Wondisford F.E., Hussain M.A. Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes 2008, 57:2371-2381.
-
(2008)
Diabetes
, vol.57
, pp. 2371-2381
-
-
Song, W.J.1
Schreiber, W.E.2
Zhong, E.3
Liu, F.F.4
Kornfeld, B.D.5
Wondisford, F.E.6
Hussain, M.A.7
-
105
-
-
77951246517
-
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression
-
Cornu M., Modi H., Kawamori D., Kulkarni R.N., Joffraud M., Thorens B. Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J. Biol. Chem. 2010, 285:10538-10545.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 10538-10545
-
-
Cornu, M.1
Modi, H.2
Kawamori, D.3
Kulkarni, R.N.4
Joffraud, M.5
Thorens, B.6
-
106
-
-
0038339191
-
CAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
-
Jhala U.S., Canettieri G., Screaton R.A., Kulkarni R.N., Krajewski S., Reed J., Walker J., Lin X., White M., Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003, 17:1575-1580.
-
(2003)
Genes Dev.
, vol.17
, pp. 1575-1580
-
-
Jhala, U.S.1
Canettieri, G.2
Screaton, R.A.3
Kulkarni, R.N.4
Krajewski, S.5
Reed, J.6
Walker, J.7
Lin, X.8
White, M.9
Montminy, M.10
-
107
-
-
0032429466
-
Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones
-
Holz G.G., Habener J.F. Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 1998, 121:177-184.
-
(1998)
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
, vol.121
, pp. 177-184
-
-
Holz, G.G.1
Habener, J.F.2
-
108
-
-
84902278779
-
The role of beta-cell glucagon-like peptide-1 signaling in glucose regulation and responses to diabetes drugs
-
Smith E.P., An Z., Wagner C., Lewis A.G., Cohen E.B., Bailing L., Parinaz M., Sandoval D., Perez-Tilve D., Tamarina N., Philipson L.H., Stoffers D.A., Seeley R.J., D'Alessio D.A. The role of beta-cell glucagon-like peptide-1 signaling in glucose regulation and responses to diabetes drugs. Cell Metab. 2014, 19:1050-1057.
-
(2014)
Cell Metab.
, vol.19
, pp. 1050-1057
-
-
Smith, E.P.1
An, Z.2
Wagner, C.3
Lewis, A.G.4
Cohen, E.B.5
Bailing, L.6
Parinaz, M.7
Sandoval, D.8
Perez-Tilve, D.9
Tamarina, N.10
Philipson, L.H.11
Stoffers, D.A.12
Seeley, R.J.13
D'Alessio, D.A.14
-
110
-
-
38349134789
-
2+ and G protein-coupled receptors in the pancreatic β-cell: a computational approach"
-
2+ and G protein-coupled receptors in the pancreatic β-cell: a computational approach". Am. J. Physiol. Cell Physiol. 2008, 294:C4-C6.
-
(2008)
Am. J. Physiol. Cell Physiol.
, vol.294
, pp. C4-C6
-
-
Holz, G.G.1
Heart, E.2
Leech, C.A.3
-
112
-
-
24744455039
-
2+ and cAMP signaling in the insulin-secreting MIN6 β-cell line
-
2+ and cAMP signaling in the insulin-secreting MIN6 β-cell line. J. Biol. Chem. 2005, 280:31294-31302.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31294-31302
-
-
Landa, L.R.1
Harbeck, M.2
Kaihara, K.3
Chepurny, O.4
Kitiphongspattana, K.5
Graf, O.6
Nikolaev, V.O.7
Lohse, M.J.8
Holz, G.G.9
Roe, M.W.10
-
113
-
-
45549098329
-
Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
-
Dyachok O., Idevall-Hagren O., Sågetorp J., Tian G., Wuttke A., Arrieumerlou C., Akusjärvi G., Gylfe E., Tengholm A. Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion. Cell Metab. 2008, 8:26-37.
-
(2008)
Cell Metab.
, vol.8
, pp. 26-37
-
-
Dyachok, O.1
Idevall-Hagren, O.2
Sågetorp, J.3
Tian, G.4
Wuttke, A.5
Arrieumerlou, C.6
Akusjärvi, G.7
Gylfe, E.8
Tengholm, A.9
-
114
-
-
77954925625
-
CAMP mediators of pulsatile insulin secretion from glucose-stimulated single β-cells
-
Idevall-Hagren O., Barg S., Gylfe E., Tengholm A. cAMP mediators of pulsatile insulin secretion from glucose-stimulated single β-cells. J. Biol. Chem. 2010, 285:23007-23018.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 23007-23018
-
-
Idevall-Hagren, O.1
Barg, S.2
Gylfe, E.3
Tengholm, A.4
-
115
-
-
78650510151
-
2+-cAMP-PKA oscillatory circuit
-
2+-cAMP-PKA oscillatory circuit. Nat. Chem. Biol. 2011, 7:34-40.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 34-40
-
-
Ni, Q.1
Ganesan, A.2
Aye-Han, N.N.3
Gao, X.4
Allen, M.D.5
Levchenko, A.6
Zhang, J.7
-
116
-
-
80053180108
-
Systems analysis of GLP-1 receptor signaling in pancreatic β-cells
-
Takeda Y., Amano A., Noma A., Nakamura Y., Fujimoto S., Inagaki N. Systems analysis of GLP-1 receptor signaling in pancreatic β-cells. Am. J. Physiol. Cell Physiol. 2011, 301:C792-C803.
-
(2011)
Am. J. Physiol. Cell Physiol.
, vol.301
, pp. C792-C803
-
-
Takeda, Y.1
Amano, A.2
Noma, A.3
Nakamura, Y.4
Fujimoto, S.5
Inagaki, N.6
-
117
-
-
84906672321
-
ADCY5 couples glucose to insulin secretion in human islets
-
([Epub ahead of print] PubMed PMID: 24740569)
-
Hodson D.J., Mitchell R.K., Marselli L., Pullen T.J., Brias S.G., Semplici F., Everett K.L., Cooper D.M., Bugliani M., Marchetti P., Lavallard V., Bosco D., Piemonti L., Johnson P.R., Hughes S.J., Li D., Li W.H., Shapiro A.M., Rutter G.A. ADCY5 couples glucose to insulin secretion in human islets. Diabetes 2014, ([Epub ahead of print] PubMed PMID: 24740569).
-
(2014)
Diabetes
-
-
Hodson, D.J.1
Mitchell, R.K.2
Marselli, L.3
Pullen, T.J.4
Brias, S.G.5
Semplici, F.6
Everett, K.L.7
Cooper, D.M.8
Bugliani, M.9
Marchetti, P.10
Lavallard, V.11
Bosco, D.12
Piemonti, L.13
Johnson, P.R.14
Hughes, S.J.15
Li, D.16
Li, W.H.17
Shapiro, A.M.18
Rutter, G.A.19
-
120
-
-
0015800525
-
Activation by glucose of adenyl cyclase in pancreatic islets of the rat
-
Grill V., Cerasi E. Activation by glucose of adenyl cyclase in pancreatic islets of the rat. FEBS Lett. 1973, 33:311-314.
-
(1973)
FEBS Lett.
, vol.33
, pp. 311-314
-
-
Grill, V.1
Cerasi, E.2
-
121
-
-
0015918106
-
Adenosine 3',5'-monophosphate in pancreatic islets: glucose-induced insulin release
-
Charles M.A., Fanska R., Schmid F.G., Forsham P.H., Grodsky G.M. Adenosine 3',5'-monophosphate in pancreatic islets: glucose-induced insulin release. Science 1973, 179:569-571.
-
(1973)
Science
, vol.179
, pp. 569-571
-
-
Charles, M.A.1
Fanska, R.2
Schmid, F.G.3
Forsham, P.H.4
Grodsky, G.M.5
-
122
-
-
0016245969
-
Stimulation by d-glucose of cyclic adenosine 3':5'-monophosphate accumulation and insulin release in isolated pancreatic islets of the rat
-
Grill V., Cerasi E. Stimulation by d-glucose of cyclic adenosine 3':5'-monophosphate accumulation and insulin release in isolated pancreatic islets of the rat. J. Biol. Chem. 1974, 249:4196-4201.
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 4196-4201
-
-
Grill, V.1
Cerasi, E.2
-
123
-
-
0016707104
-
Glucose-induced cyclic AMP accumulation in rat islets of Langerhans: preferential effect of the alpha anomer
-
Grill V., Cerasi E. Glucose-induced cyclic AMP accumulation in rat islets of Langerhans: preferential effect of the alpha anomer. FEBS Lett. 1975, 54:80-83.
-
(1975)
FEBS Lett.
, vol.54
, pp. 80-83
-
-
Grill, V.1
Cerasi, E.2
-
124
-
-
0016683393
-
Decreased cyclic AMP and insulin response to glucose in isolated islets of neonatal rats
-
Grill V., Asplund K., Hellerström C., Cerasi E. Decreased cyclic AMP and insulin response to glucose in isolated islets of neonatal rats. Diabetes 1975, 24:746-752.
-
(1975)
Diabetes
, vol.24
, pp. 746-752
-
-
Grill, V.1
Asplund, K.2
Hellerström, C.3
Cerasi, E.4
-
125
-
-
0016783039
-
Effect of glucose on adenosine 3', 5'-monophosphate levels in rat pancreatic islets
-
Suzuki S., Oka H., Yasuda H., Yamashita K., Kaneko T., Oda T. Effect of glucose on adenosine 3', 5'-monophosphate levels in rat pancreatic islets. Endocrinol. Jpn. 1975, 22:479-482.
-
(1975)
Endocrinol. Jpn.
, vol.22
, pp. 479-482
-
-
Suzuki, S.1
Oka, H.2
Yasuda, H.3
Yamashita, K.4
Kaneko, T.5
Oda, T.6
-
126
-
-
0016800280
-
Factors governing glucose induced elevation of cyclic 3'5' AMP levels in pancreatic islets
-
Zawalich W.S., Karl R.C., Ferrendelli J.A., Matschinsky F.M. Factors governing glucose induced elevation of cyclic 3'5' AMP levels in pancreatic islets. Diabetologia 1975, 11:231-235.
-
(1975)
Diabetologia
, vol.11
, pp. 231-235
-
-
Zawalich, W.S.1
Karl, R.C.2
Ferrendelli, J.A.3
Matschinsky, F.M.4
-
127
-
-
0016791349
-
Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium
-
Charles M.A., Lawecki J., Pictet R., Grodsky G.M. Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium. J. Biol. Chem. 1975, 250:6134-6140.
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 6134-6140
-
-
Charles, M.A.1
Lawecki, J.2
Pictet, R.3
Grodsky, G.M.4
-
128
-
-
0017103668
-
2O of glucose-induced cyclic AMP accumulation in rat islets of Langerhans
-
2O of glucose-induced cyclic AMP accumulation in rat islets of Langerhans. FEBS Lett. 1976, 68:165-169.
-
(1976)
FEBS Lett.
, vol.68
, pp. 165-169
-
-
Grill, V.1
Cerasi, E.2
-
129
-
-
0017107975
-
Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats
-
Rabinovitch A., Grill V., Renold A.E., Cerasi E. Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats. J. Clin. Invest. 1976, 58:1209-1216.
-
(1976)
J. Clin. Invest.
, vol.58
, pp. 1209-1216
-
-
Rabinovitch, A.1
Grill, V.2
Renold, A.E.3
Cerasi, E.4
-
130
-
-
0017618375
-
Permissive effect of glucose on the glucagon-induced accumulation of cAMP in isolated rat pancreatic islets
-
Schauder P., Arends J., Schindler B., Ebert R., Frerichs H. Permissive effect of glucose on the glucagon-induced accumulation of cAMP in isolated rat pancreatic islets. Diabetologia 1977, 13:171-175.
-
(1977)
Diabetologia
, vol.13
, pp. 171-175
-
-
Schauder, P.1
Arends, J.2
Schindler, B.3
Ebert, R.4
Frerichs, H.5
-
131
-
-
0018776563
-
Dynamics of insulin and cyclic adenosine 3',5'-monophosphate release from the perifused rat islets of Langerhans under a slow-rise stimulation with d-glucose and its anomers
-
Tsumura Y., Kobayashi K., Yoshida K., Kagawa S., Matsuoka A. Dynamics of insulin and cyclic adenosine 3',5'-monophosphate release from the perifused rat islets of Langerhans under a slow-rise stimulation with d-glucose and its anomers. Endocrinol. Jpn. 1979, 26:245-253.
-
(1979)
Endocrinol. Jpn.
, vol.26
, pp. 245-253
-
-
Tsumura, Y.1
Kobayashi, K.2
Yoshida, K.3
Kagawa, S.4
Matsuoka, A.5
-
132
-
-
47749094308
-
Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice
-
Kim J.W., Roberts C.D., Berg S.A., Caicedo A., Roper S.D., Chaudhari N. Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice. PLoS One 2008, 3:e2127.
-
(2008)
PLoS One
, vol.3
, pp. e2127
-
-
Kim, J.W.1
Roberts, C.D.2
Berg, S.A.3
Caicedo, A.4
Roper, S.D.5
Chaudhari, N.6
-
133
-
-
34247623456
-
2+ and cAMP in single cells
-
2+ and cAMP in single cells. Sci. STKE 2006, 2006(353):pl6.
-
(2006)
Sci. STKE
, vol.2006
, Issue.353
, pp. pl6
-
-
Harbeck, M.C.1
Chepurny, O.2
Nikolaev, V.O.3
Lohse, M.J.4
Holz, G.G.5
Roe, M.W.6
-
134
-
-
84882534093
-
CAMP sensor Epac and gastrointestinal function
-
Elsevier, L. Johnson, F. Ghishan, J.M. Kaunitz, H. Said, J. Wood (Eds.)
-
Chepurny O.G., Leech C.A., Cheng X., Holz G.G. cAMP sensor Epac and gastrointestinal function. Physiology of the Gastrointestinal Tract 2012, 1849-1861. Elsevier. 5th ed. L. Johnson, F. Ghishan, J.M. Kaunitz, H. Said, J. Wood (Eds.).
-
(2012)
Physiology of the Gastrointestinal Tract
, pp. 1849-1861
-
-
Chepurny, O.G.1
Leech, C.A.2
Cheng, X.3
Holz, G.G.4
-
135
-
-
0027235323
-
Calcium-independent potentiation of insulin release by cyclic AMP in single beta cells
-
Ammälä C., Ashcroft F.M., Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single beta cells. Nature 1993, 363:356-358.
-
(1993)
Nature
, vol.363
, pp. 356-358
-
-
Ammälä, C.1
Ashcroft, F.M.2
Rorsman, P.3
-
136
-
-
0033524477
-
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
-
Buck J., Sinclair M.L., Schapal L., Cann M.J., Levin L.R. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:79-84.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 79-84
-
-
Buck, J.1
Sinclair, M.L.2
Schapal, L.3
Cann, M.J.4
Levin, L.R.5
-
137
-
-
78649358628
-
Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1
-
Leech C.A., Chepurny O.G., Holz G.G. Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. Vitam. Horm. 2010, 84:279-302.
-
(2010)
Vitam. Horm.
, vol.84
, pp. 279-302
-
-
Leech, C.A.1
Chepurny, O.G.2
Holz, G.G.3
-
138
-
-
79955793555
-
Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
-
Dzhura I., Chepurny O.G., Leech C.A., Roe M.W., Dzhura E., Xu X., Lu Y., Schwede F., Genieser H.G., Smrcka A.V., Holz G.G. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets 2011, 3:121-128.
-
(2011)
Islets
, vol.3
, pp. 121-128
-
-
Dzhura, I.1
Chepurny, O.G.2
Leech, C.A.3
Roe, M.W.4
Dzhura, E.5
Xu, X.6
Lu, Y.7
Schwede, F.8
Genieser, H.G.9
Smrcka, A.V.10
Holz, G.G.11
-
139
-
-
84862778234
-
Role of phospholipase Cε in physiological phosphoinositide signaling networks
-
Smrcka A.V., Brown J.H., Holz G.G. Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell. Signal. 2012, 24:1333-1343.
-
(2012)
Cell. Signal.
, vol.24
, pp. 1333-1343
-
-
Smrcka, A.V.1
Brown, J.H.2
Holz, G.G.3
|