Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 10, 2014, Pages 3727-3732

  Kleinboelting, Silke ^a   Diaz, Ana ^b   Moniot, Sebastien ^a   Van Den Heuvel, Joop ^c   Weyand, Michael ^a   Levin, Lonny R ^b   Buck, Jochen ^b   Steegborn, Clemens ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Activation mechanism; Bicarbonate signaling; Catalytic mechanism; Inhibition mechanism

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ADENYLATE CYCLASE; ARGININE; BICARBONATE; SOLUBLE ADENYLYL CYCLASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GENE REARRANGEMENT; PRIORITY JOURNAL; STEREOSPECIFICITY;

ACTIVATION MECHANISM; BICARBONATE SIGNALING; CATALYTIC MECHANISM; INHIBITION MECHANISM;

ADENYLATE CYCLASE; CATALYSIS; CLONING, MOLECULAR; CRYSTALLIZATION; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; SODIUM BICARBONATE;

EID: 84896301859     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322778111     Document Type: Article

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