-
1
-
-
0033842027
-
Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
-
Cavaghan MK, Ehrmann DA, Polonsky KS. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest 2000;106:329-333
-
(2000)
J Clin Invest
, vol.106
, pp. 329-333
-
-
Cavaghan, M.K.1
Ehrmann, D.A.2
Polonsky, K.S.3
-
2
-
-
79960773090
-
Preservation of b-cell function: The key to diabetes prevention
-
DeFronzo RA, Abdul-Ghani MA. Preservation of b-cell function: the key to diabetes prevention. J Clin Endocrinol Metab 2011;96:2354-2366
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 2354-2366
-
-
DeFronzo, R.A.1
Abdul-Ghani, M.A.2
-
3
-
-
33644618433
-
The biology of incretin hormones
-
Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-165
-
(2006)
Cell Metab
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
4
-
-
79952126838
-
Snapin mediates incretin action and augments glucose-dependent insulin secretion
-
Song WJ, Seshadri M, Ashraf U, et al. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab 2011;13:308- 319
-
(2011)
Cell Metab
, vol.13
, pp. 308-319
-
-
Song, W.J.1
Seshadri, M.2
Ashraf, U.3
-
5
-
-
68149136367
-
The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs
-
Zhang CL, Katoh M, Shibasaki T, et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 2009;325:607-610
-
(2009)
Science
, vol.325
, pp. 607-610
-
-
Zhang, C.L.1
Katoh, M.2
Shibasaki, T.3
-
6
-
-
77349096383
-
PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-29-O-MecAMP- AM in human islets of Langerhans
-
Chepurny OG, Kelley GG, Dzhura I, et al. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-29-O-MecAMP- AM in human islets of Langerhans. Am J Physiol Endocrinol Metab 2010;298:E622-E633
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Chepurny, O.G.1
Kelley, G.G.2
Dzhura, I.3
-
7
-
-
22144489495
-
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells
-
Kang G, Chepurny OG, Rindler MJ, et al. A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol 2005;566:173-188
-
(2005)
J Physiol
, vol.566
, pp. 173-188
-
-
Kang, G.1
Chepurny, O.G.2
Rindler, M.J.3
-
8
-
-
37649002935
-
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
-
Shibasaki T, Takahashi H, Miki T, et al. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci USA 2007;104:19333-19338
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19333-19338
-
-
Shibasaki, T.1
Takahashi, H.2
Miki, T.3
-
9
-
-
58849092285
-
Membrane fusion: Grappling with SNARE and SM proteins
-
Südhof TC, Rothman JE. Membrane fusion: grappling with SNARE and SM proteins. Science 2009;323:474-477
-
(2009)
Science
, vol.323
, pp. 474-477
-
-
Südhof, T.C.1
Rothman, J.E.2
-
10
-
-
0019197660
-
Binding proteins for cyclic AMP in mammalian tissues
-
D-skeland SO, Ogreid D. Binding proteins for cyclic AMP in mammalian tissues. Int J Biochem 1981;13:1-19
-
(1981)
Int J Biochem
, vol.13
, pp. 1-19
-
-
D-skeland, S.O.1
Ogreid, D.2
-
11
-
-
0021913482
-
The separate estimation of cAMP intracellularly bound to the regulatory subunits of protein kinase I and II in glucagon-stimulated rat hepatocytes
-
Ekanger R, Sand TE, Ogreid D, Christoffersen T, Døskeland SO. The separate estimation of cAMP intracellularly bound to the regulatory subunits of protein kinase I and II in glucagon-stimulated rat hepatocytes. J Biol Chem 1985;260:3393-3401
-
(1985)
J Biol Chem
, vol.260
, pp. 3393-3401
-
-
Ekanger, R.1
Sand, T.E.2
Ogreid, D.3
Christoffersen, T.4
D-skeland, S.O.5
-
12
-
-
27944449329
-
Free fatty acid receptor 1 (FFA(1) R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion
-
Salehi A, Flodgren E, Nilsson NE, et al. Free fatty acid receptor 1 (FFA(1) R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. Cell Tissue Res 2005;322:207-215
-
(2005)
Cell Tissue Res
, vol.322
, pp. 207-215
-
-
Salehi, A.1
Flodgren, E.2
Nilsson, N.E.3
-
13
-
-
50949128408
-
Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
-
Tan CP, Feng Y, Zhou YP, et al. Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes 2008;57:2211-2219
-
(2008)
Diabetes
, vol.57
, pp. 2211-2219
-
-
Tan, C.P.1
Feng, Y.2
Zhou, Y.P.3
-
14
-
-
82255194231
-
Treating diabetes today: A matter of selectivity of sulphonylureas
-
Seino S, Takahashi H, Takahashi T, Shibasaki T. Treating diabetes today: a matter of selectivity of sulphonylureas. Diabetes Obes Metab 2012;14 (Suppl. 1):9-13
-
(2012)
Diabetes Obes Metab
, vol.14
, Issue.SUPPL. 1
, pp. 9-13
-
-
Seino, S.1
Takahashi, H.2
Takahashi, T.3
Shibasaki, T.4
-
15
-
-
0035913986
-
Induction of pancreatic differentiation by signals from blood vessels
-
Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001;294:564-567
-
(2001)
Science
, vol.294
, pp. 564-567
-
-
Lammert, E.1
Cleaver, O.2
Melton, D.3
-
16
-
-
19644364776
-
A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues
-
Kirschner LS, Kusewitt DF, Matyakhina L, et al. A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res 2005;65:4506-4514
-
(2005)
Cancer Res
, vol.65
, pp. 4506-4514
-
-
Kirschner, L.S.1
Kusewitt, D.F.2
Matyakhina, L.3
-
17
-
-
52749096469
-
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation
-
Song WJ, Schreiber WE, Zhong E, et al. Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes 2008;57:2371-2381
-
(2008)
Diabetes
, vol.57
, pp. 2371-2381
-
-
Song, W.J.1
Schreiber, W.E.2
Zhong, E.3
-
18
-
-
33749626976
-
Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation
-
Hussain MA, Porras DL, Rowe MH, et al. Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol 2006;26:7747-7759
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7747-7759
-
-
Hussain, M.A.1
Porras, D.L.2
Rowe, M.H.3
-
19
-
-
0035054129
-
Cyclic adenosine 39,59-monophosphate increases pancreatic glucokinase activity and gene expression
-
Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, et al. Cyclic adenosine 39,59-monophosphate increases pancreatic glucokinase activity and gene expression. Endocrinology 2001;142:1448-1452
-
(2001)
Endocrinology
, vol.142
, pp. 1448-1452
-
-
Fernandez-Mejia, C.1
Vega-Allende, J.2
Rojas-Ochoa, A.3
-
20
-
-
0033780046
-
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding
-
O'Doherty U, Swiggard WJ, Malim MH. Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. J Virol 2000;74:10074-10080
-
(2000)
J Virol
, vol.74
, pp. 10074-10080
-
-
O'Doherty, U.1
Swiggard, W.J.2
Malim, M.H.3
-
21
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
22
-
-
0033769693
-
CAMP-GEFII is a direct target of cAMP in regulated exocytosis
-
Ozaki N, Shibasaki T, Kashima Y, et al. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol 2000;2:805-811
-
(2000)
Nat Cell Biol
, vol.2
, pp. 805-811
-
-
Ozaki, N.1
Shibasaki, T.2
Kashima, Y.3
-
23
-
-
0032480888
-
Epac is a Rap1 guaninenucleotide- exchange factor directly activated by cyclic AMP
-
de Rooij J, Zwartkruis FJ, Verheijen MH, et al. Epac is a Rap1 guaninenucleotide- exchange factor directly activated by cyclic AMP. Nature 1998; 396:474-477
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
De Rooij, J.1
Zwartkruis, F.J.2
Verheijen, M.H.3
-
24
-
-
0032545328
-
A family of cAMP-binding proteins that directly activate Rap1
-
Kawasaki H, Springett GM, Mochizuki N, et al. A family of cAMP-binding proteins that directly activate Rap1. Science 1998;282:2275-2279
-
(1998)
Science
, vol.282
, pp. 2275-2279
-
-
Kawasaki, H.1
Springett, G.M.2
Mochizuki, N.3
-
25
-
-
0035824548
-
Critical role of cAMP-GEFII - Rim2 complex in incretin-potentiated insulin secretion
-
Kashima Y, Miki T, Shibasaki T, et al. Critical role of cAMP-GEFII - Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem 2001;276: 46046-46053
-
(2001)
J Biol Chem
, vol.276
, pp. 46046-46053
-
-
Kashima, Y.1
Miki, T.2
Shibasaki, T.3
-
26
-
-
77349114753
-
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-MecAMP- AM
-
Kelley GG, Chepurny OG, Schwede F, et al. Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-MecAMP- AM. Islets 2009;1:260-265
-
(2009)
Islets
, vol.1
, pp. 260-265
-
-
Kelley, G.G.1
Chepurny, O.G.2
Schwede, F.3
-
27
-
-
79955793555
-
Phospholipase C-́ links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
-
Dzhura I, Chepurny OG, Leech CA, et al. Phospholipase C-́ links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets 2011;3:121-128
-
(2011)
Islets
, vol.3
, pp. 121-128
-
-
Dzhura, I.1
Chepurny, O.G.2
Leech, C.A.3
-
28
-
-
33845517309
-
Fatty acid signaling in the beta-cell and insulin secretion
-
Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M. Fatty acid signaling in the beta-cell and insulin secretion. Diabetes 2006;55 (Suppl. 2):S16-S23
-
(2006)
Diabetes
, vol.55
, Issue.SUPPL. 2
-
-
Nolan, C.J.1
Madiraju, M.S.2
Delghingaro-Augusto, V.3
Peyot, M.L.4
Prentki, M.5
-
29
-
-
77956373690
-
Beta-cell failure in diet-induced obese mice stratified according to body weight gain: Secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass
-
Peyot ML, Pepin E, Lamontagne J, et al. Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes 2010;59:2178-2187
-
(2010)
Diabetes
, vol.59
, pp. 2178-2187
-
-
Peyot, M.L.1
Pepin, E.2
Lamontagne, J.3
-
30
-
-
84857032603
-
GPR40-induced insulin secretion by the novel agonist TAK-875: First clinical findings in patients with type 2 diabetes
-
Araki T, Hirayama M, Hiroi S, Kaku K. GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes. Diabetes Obes Metab 2012;14:271-278
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 271-278
-
-
Araki, T.1
Hirayama, M.2
Hiroi, S.3
Kaku, K.4
-
31
-
-
84866129127
-
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
-
Ferdaoussi M, Bergeron V, Zarrouki B, et al. G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia 2012;55:2682-2692
-
(2012)
Diabetologia
, vol.55
, pp. 2682-2692
-
-
Ferdaoussi, M.1
Bergeron, V.2
Zarrouki, B.3
-
32
-
-
58249117850
-
Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines
-
Islam D, Zhang N, Wang P, et al. Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines. Am J Physiol Endocrinol Metab 2009;296:E174-E181
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Islam, D.1
Zhang, N.2
Wang, P.3
-
33
-
-
84873670723
-
Regulation of insulin secretion in human pancreatic islets
-
Rorsman P, Braun M. Regulation of Insulin Secretion in Human Pancreatic Islets. Annu Rev Physiol 2013;75:155-179
-
(2013)
Annu Rev Physiol
, vol.75
, pp. 155-179
-
-
Rorsman, P.1
Braun, M.2
-
34
-
-
77953466435
-
Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac
-
Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG, Holz GG. Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac. Islets 2010;2:72-81
-
(2010)
Islets
, vol.2
, pp. 72-81
-
-
Leech, C.A.1
Dzhura, I.2
Chepurny, O.G.3
Schwede, F.4
Genieser, H.G.5
Holz, G.G.6
-
35
-
-
82455210942
-
Molecular physiology of glucagon- like peptide-1 insulin secretagogue action in pancreatic b cells
-
Leech CA, Dzhura I, Chepurny OG, et al. Molecular physiology of glucagon- like peptide-1 insulin secretagogue action in pancreatic b cells. Prog Biophys Mol Biol 2011;107:236-247
-
(2011)
Prog Biophys Mol Biol
, vol.107
, pp. 236-247
-
-
Leech, C.A.1
Dzhura, I.2
Chepurny, O.G.3
-
36
-
-
84866370709
-
Cell signalling in insulin secretion: The molecular targets of ATP, cAMP and sulfonylurea
-
Seino S. Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea. Diabetologia 2012;55:2096-2108
-
(2012)
Diabetologia
, vol.55
, pp. 2096-2108
-
-
Seino, S.1
-
37
-
-
77955120393
-
Pancreatic beta-cell signaling: Toward better understanding of diabetes and its treatment
-
Seino S, Shibasaki T, Minami K. Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment. Proc Jpn Acad, Ser B, Phys Biol Sci 2010;86:563-577
-
(2010)
Proc Jpn Acad, Ser B, Phys Biol Sci
, vol.86
, pp. 563-577
-
-
Seino, S.1
Shibasaki, T.2
Minami, K.3
-
38
-
-
0027473729
-
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)
-
Holz GG 4th, Kühtreiber WM, Habener JF. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 1993;361:362-365
-
(1993)
Nature
, vol.361
, pp. 362-365
-
-
Holz IV, G.G.1
Kühtreiber, W.M.2
Habener, J.F.3
-
39
-
-
33744939752
-
CAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells
-
Kang G, Chepurny OG, Malester B, et al. cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J Physiol 2006;573:595-609
-
(2006)
J Physiol
, vol.573
, pp. 595-609
-
-
Kang, G.1
Chepurny, O.G.2
Malester, B.3
-
40
-
-
40049101849
-
Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells
-
Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG. Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol 2008;586:1307-1319
-
(2008)
J Physiol
, vol.586
, pp. 1307-1319
-
-
Kang, G.1
Leech, C.A.2
Chepurny, O.G.3
Coetzee, W.A.4
Holz, G.G.5
-
41
-
-
33750730215
-
Cell physiology of cAMP sensor Epac
-
Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG. Cell physiology of cAMP sensor Epac. J Physiol 2006;577:5-15
-
(2006)
J Physiol
, vol.577
, pp. 5-15
-
-
Holz, G.G.1
Kang, G.2
Harbeck, M.3
Roe, M.W.4
Chepurny, O.G.5
-
42
-
-
0035971143
-
Ca2+-induced Ca2+ release from the endoplasmic reticulum amplifies the Ca2+ signal mediated by activation of voltage-gated L-type Ca2+ channels in pancreatic betacells
-
Lemmens R, Larsson O, Berggren PO, Islam MS. Ca2+-induced Ca2+ release from the endoplasmic reticulum amplifies the Ca2+ signal mediated by activation of voltage-gated L-type Ca2+ channels in pancreatic betacells. J Biol Chem 2001;276:9971-9977
-
(2001)
J Biol Chem
, vol.276
, pp. 9971-9977
-
-
Lemmens, R.1
Larsson, O.2
Berggren, P.O.3
Islam, M.S.4
|