Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-cells

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 26435-26444

  Nie, Jia ^a,b   Sun, Chao ^b,c   Faruque, Omar ^b   Ye, Guangming ^b   Li, Jia ^b   Liang, Qiangrong ^d   Chang, Zhijie ^e   Yang, Wannian ^f   Han, Xiao ^a   Shi, Yuguang ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c NORTHWEST A F UNIVERSITY   (China)

^d UNIVERSITY OF SOUTH DAKOTA   (United States)

^e Tsinghua University   (China)

^f WEIS CENTER FOR RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING DOMAIN; CYTOSKELETAL; GLUCOSE-STIMULATED INSULIN SECRETIONS; KEY REGULATORS; KINASE ACTIVITY; KINASE DOMAINS; OVER-EXPRESSION; P-21 ACTIVATED KINASE; RHO GTPASES;

CELLS; CYTOLOGY; ENZYME ACTIVITY; GLUCOSE; PHOSPHORYLATION; PHYSIOLOGY;

INSULIN;

GLUCOSE; INSULIN; P21 ACTIVATED KINASE 1; PROTEIN SERINE THREONINE KINASE; SYNAPSES OF AMPHIDS DEFECTIVE A KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; INSULIN RELEASE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; CATALYTIC DOMAIN; ENZYME ACTIVATION; GENE EXPRESSION; GLUCOSE; HEK293 CELLS; HELA CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; P21-ACTIVATED KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; SECRETORY PATHWAY; STRESS FIBERS;

EID: 84864390450     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.378372     Document Type: Article

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