Evaluating tumor metastatic potential by imaging intratumoral acidosis via pH-Activatable near-Infrared fluorescent probe

International Journal of Cancer

Volumn 136, Issue 4, 2015, Pages E107-E116

  Wang, Lu ^a   Fan, Zhichao ^b   Zhang, Jingye ^a   Changyi, Yinzhi ^a   Huang, Cuiyun ^a   Gu, Yanjuan ^c   Xu, Ziyao ^a   Tang, Zhijia ^a   Lu, Weiyue ^a   Wei, Xunbin ^b   Li, Cong ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Acidic tumor microenvironment; Metastatic potential; Near infrared fluorescence; Optical imaging; PH responsive probe

Indexed keywords

DIIRB C; DIIRB S; FLUORESCENT DYE; PH ACTIVATABLE NEAR INFRARED FLUORESCENT PROBE; UNCLASSIFIED DRUG; DIIRB-S COMPOUND; HYDRAZONE DERIVATIVE; INDOLE DERIVATIVE;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PH; CELL VIABILITY; CHEMICAL BINDING; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRATUMORAL ACIDOSIS; MALE; METASTASIS POTENTIAL; MOUSE; NEAR INFRARED FLUORESCENCE IMAGING; NONHUMAN; TARGET TO BACKGROUND SIGNAL RATIO; TOXICITY TESTING; TUMOR MICROENVIRONMENT; ACIDOSIS; ANIMAL; CANCER TRANSPLANTATION; CELL SURVIVAL; DIAGNOSTIC USE; DRUG EFFECTS; HEPG2 CELL LINE; LIVER NEOPLASMS; LUNG NEOPLASMS; METABOLISM; NEAR INFRARED SPECTROSCOPY; NUDE MOUSE; PATHOLOGY; PH; PHYSIOLOGY; SECONDARY; TOXICITY; UMBILICAL VEIN ENDOTHELIAL CELL;

ACIDOSIS; ANIMALS; CELL SURVIVAL; FLUORESCENT DYES; HEP G2 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; INDOLES; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OPTICAL IMAGING; SPECTROSCOPY, NEAR-INFRARED; TUMOR MICROENVIRONMENT;

EID: 84918816342     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29153     Document Type: Article

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