Cellular pH regulators: Potentially promising molecular targets for cancer chemotherapy

Cancer Treatment Reviews

Volumn 29, Issue 6, 2003, Pages 541-549

  Izumi, Hiroto ^a   Torigoe, Takayuki ^a   Ishiguchi, Hiroshi ^a   Uramoto, Hidetaka ^a   Yoshida, Yoichiro ^a   Tanabe, Mizuho ^a   Ise, Tomoko ^a   Murakami, Tadashi ^a   Yoshida, Takeshi ^a   Nomoto, Minoru ^a   Kohno, Kimitoshi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Apoptosis; Bicarbonate transporter; Cancer chemotherapy; Hypoxia; Monocarboxylate transporter; Proton pump; Sodium proton exchanger; V ATPase

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 1 (3,4 DIHYDRO 4 ISOPROPYL 2,2 DIMETHYL 3 OXO 2H 1,4 BENZOXAZINE 6 CARBONYL)GUANIDINE; 4 CHLORO 7 NITROBENZOFURAZAN; 6 [2 (DIMETHYLAMINO)ETHYLAMINO] 3 HYDROXY 7H INDENO[2,1 C]QUINOLIN 7 ONE; ADENOSINE TRIPHOSPHATASE INHIBITOR; AMILORIDE DERIVATIVE; ANTINEOPLASTIC AGENT; BAFILOMYCIN A1; BICARBONATE; CAMPTOTHECIN; CARIPORIDE; CISPLATIN; CONCANAMYCIN A; DAUNORUBICIN; DESTRUXIN; DICYCLOHEXYLCARBODIIMIDE; DNA FRAGMENT; ENDONUCLEASE; ETOPOSIDE; EZRIN; MOESIN; MONOCARBOXYLATE TRANSPORTER; N ETHYLMALEIMIDE; PROTON PUMP; PROTON PUMP INHIBITOR; QUERCETIN; RADIXIN; SODIUM PROTON EXCHANGE PROTEIN; UNINDEXED DRUG; VINBLASTINE;

ACIDIFICATION; ACIDOSIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CHEMOTHERAPY; CELL FUNCTION; CELL HYPOXIA; CELL INVASION; CELL PH; CELL PROLIFERATION; CELL STRUCTURE; CELL TYPE; DRUG POTENCY; DRUG RESISTANCE; DRUG TARGETING; ENZYME ACTIVATION; EXTRACELLULAR SPACE; HUMAN; INTRACELLULAR SPACE; METASTASIS; NUCLEOTIDE SEQUENCE; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW; SOLID TUMOR; TUMOR CELL; TUMOR GROWTH; UPREGULATION;

EID: 20244388917     PISSN: 03057372     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-7372(03)00106-3     Document Type: Article

References (62)

1. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumours: review. Cancer Res 1989; 49: 6449-6465.
2. Yuan J, Narayanan L, Rockwell S, et al. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 2000; 60: 4372-4376.
3. Kondo A, Safaei R, Mishima M, et al. Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair. Cancer Res 2001; 61: 7603-7607.
4. Hanahan D, Christofori G, et al. Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models: review. Eur J Cancer 1996; 32A: 2386-2393.
5. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumourigenesis: review. Cell 1996; 86: 353-364.
6. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
7. Widschwendter M, Jones PA. DNA methylation and breast carcinogenesis: review. Oncogene 2002; 21: 5462-5482.
8. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression: review. Nat Rev Cancer 2002; 2: 161-174.
9. +)-ATPases-nature's most versatile proton pumps: review. Nat Rev Mol Cell Biol 2002; 3: 94-103.
10. +-ATPae at a site important for human papillomavirus E5 and platelet-derived growth factor signaling. J Biol Chem 1999; 274: 23119-23127.
11. +-ATPase. J Biol Chem 2001; 276: 48451-48457.
12. +-ATPase E subunit. J Biol Chem 2001; 276: 46276-46283.
13. Murakami T, Shibuya I, Ise T, et al. Elevated expression of vacuolar proton pump genes and cellular pH in cisplatin resistance. Int J Cancer 2001; 93: 869-874.
14. Beck WT. The cell biology of multiple drug resistance. Biochem Pharmacol 1987; 36: 2879-2887.
15. Moriyama Y. Membrane energization by proton pumps is important for compartmentalization of drugs and toxins: a new type of active transport. J Exp Biol 1996; 199: 1447-1454.
16. Willingham MC, Cornwell MM, Cardarelli CO, et al. Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs. Cancer Res 1986; 46: 5941-5946.
17. +-adenosine triphosphatase activity in multidrug resistance in HL60 cells. J Natl Cancer Inst 1991; 83: 1098-1102.
18. +-ATPase in drug-resistant human breast carcinoma cell lines. Biochem Pharmacol 1999; 57: 1037-1046.
19. Raghunand N, Martinez-Zaguilan R, Wright SH, et al. pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol 1999; 37: 1047-1058.
20. Paglin S, Hollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439-444.
21. Long X, Crow MT, Sollott SJ, et al. Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes. J Clin Invest 1998; 101: 1453-1461.
22. +-ATPase c subunit gene (ATP6L) in response to anticancer agents. J Biol Chem 2002; 277: 36534-36543.
23. Barry MA, Reynolds JE, Eastman A. Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification. Cancer Res 1993; 53: 2349-2357.
24. Goossens JF, Henichart JP, Dassonneville L, et al. Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells. Eur J Pharm Sci 2000; 10: 125-131.
25. Sethi T, Rintoul RC, Moore SM, et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 1999; 5: 662-668.
26. Forgac M. Structure and function of the vacuolar class of ATP-driven proton pumps. Physiol Rev 1989; 69: 765-796.
27. +-ATPase. Protein Eng 1992; 5: 7-15.
28. Bowman EJ, Siebers A, Altendorf K. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci USA 1988; 85: 7972-7976.
29. +-ATPases from mammalian kidney. J Biol Chem 1992; 267: 9701-9705.
30. +-ATPases from mammalian kidney. J Biol Chem 1992; 267: 14539-14542.
31. Drose S, Bindseil KU, Bowman EJ, et al. Inhibitiory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases. Biochemistry 1993; 32: 3902-3906.
32. + exchanger, NHE1: structure, regulation, and cellular actions: review. Annu Rev Pharmacol Toxicol 2002; 42: 527-552.
33. + exchanger for tumour growth. Cancer Res 1989; 49: 205-211.
34. + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB J 2000; 14: 2185-2197.
35. Lang F, Ritter M, Gamper N, et al. Cell volume in the regulation of cell proliferation and apoptotic cell death: review. Cell Physiol Biochem 2000; 10: 417-428.
36. + -exchanger by CD95 (Fas/Apo-1)-receptor stimulation. Pflugers Arch 2000; 440: 902-907.
37. Khaled AR, Moor AN, Li A, et al. Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol 2001; 21: 7545-7557.
38. + translocation. Mol Cell 2000; 6: 1425-1436.
39. Yonemura S, Tsukita S, Tsukita S. Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins. J Cell Biol 1999; 145: 1497-1509.
40. Goodison S, Urquidi V, Tarin D. CD44 cell adhesion molecules: review. Mol Pathol 1999; 52: 189-196.
41. +-antiporter. Adv Enzyme Regul 1990; 30: 63-74.
42. + exchanger (NHE1 isoform) in response to growth factors. J Biol Chem 1997; 272: 271-279.
43. Tominaga T, Ishizaki T, Narumiya S, et al. p160ROCK mediates RhoA activation of Na-H exchange. EMBO J 1998; 17: 4712-4722.
44. Tominaga T, Barber DL. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading. Mol Biol Cell 1998; 9: 2287-2303.
45. + exchange. J Biol Chem 2001; 276: 15794-15800.
46. + exchanger NHE1. J Cell Sci 2000; 113: 3649-3662.
47. - cotransporters (NBC): cloning and characterization: review. J Membr Biol 2001; 183: 71-84.
48. + exchange activities in renal carcinoma cells. Physiol Genom 2001; 5: 119-128.
49. 3 symport in the proximal tubule. Br J Pharmacol 1994; 112: 465-470.
50. Wong P, Kleemann HW, Tannock IF. Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. Br J Cancer 2002; 87: 238-245.
51. Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation: review. Biochem J 1999; 343: 281-299.
52. Sun J, Hemler ME. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res 2001; 61: 2276-2281.
53. Walenta S, Wetterling M, Lehrke M, et al. High lactate levels predict likelihood of metastases, tumour recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000; 60: 916-921.
54. Matsuyama S, Llopis J, Deveraux QL, et al. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2000; 2: 318-325.
55. Park HJ, Lyons JC, Ohtsubo T, et al. Acidic environment causes apoptosis by increasing caspase activity. Br J Cancer 1999; 80: 1892-1897.
56. Lambert DW, Wood IS, Ellis A, et al. Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer 2002; 86: 1262-1269.
57. Laybutt DR, Sharma A, Sgroi DC, et al. Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia. J Biol Chem 2002; 277: 10912-10921.
58. Kozin SV, Gerweck LE. Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient. Br J Cancer 1998; 77: 1580-1585.
59. Gerweck LE, Seetharaman K. Cellular pH gradient in tumour versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 1996; 56: 1194-1198.
60. Lee AH, Tannock IF. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res 1998; 58: 1901-1908.
61. Simon SM. Role of organelle pH in tumour cell biology and drug resistance. Drug Discov Today 1999; 4: 32-38.
62. Raghunand N, He X, van Sluis R, et al. Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer 1999; 80: 1005-1011.