Synthesis and anticancer activity of some novel indolo[3,2-b] andrographolide derivatives as apoptosis-inducing agents

European Journal of Medicinal Chemistry

Volumn 90, Issue , 2015, Pages 695-706

  Song, Yaping ^a   Xin, Zhengyuan ^a   Wan, Yumeng ^a   Li, Jiabin ^a   Ye, Boping ^a   Xue, Xiaowen ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti cancer; Apoptosis; Cell cycle arrest; Fisher indole synthesis; Indolo 3,2 b andrographolide

Indexed keywords

14 ACETYL 19 BENZOYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 14 DEOXY 19 (2,4 DICHLOROBENZOYL) 14,15 DIHYDRO INDOLO [3,2 B]ANDROGRAPHOLIDE; 14 TERT BUTYLDIMETHYL SILYL INDOLO[3,2 B] ANDROGRAPHOLIDE; 14,19 DI(TERT BUTYLDIMETHYLSILYL) INDOLO[3,2 B] ANDROGRAPHOLIDE; 14,19 DIACETYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 14,19 DIBENZOYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 ACETYL 14 (2,4 DICHLOROBENZOYL) INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 ACETYL 14 DEOXY 14,15 DIHYDRO INDOLO[3,2B]ANDROGRAPHOLIDE; 19 ACETYL 14 TERT BUTYLDIMETHYLSILYL INDOLO[3,2 B] ANDROGRAPHOLIDE; 19 ACETYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 BENZOYL 14 DEOXY 14,15 DIHYDRO INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 BENZOYL 14 TERT BUTYLDIMETHYLSILYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 BENZOYL INDOLO[3,2 B]ANDROGRAPHOLIDE; ANDROGRAPHOLIDE; BENZYL 14 (2,4 DICHLOROPHENOXYACETYL) INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; BENZYL 14 ACETYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; BENZYL 14 DEOXY 14,15 DIDEHYDRO-INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; BENZYL 14 TERT BUTYLDIMETHYLSILYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; BENZYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; BENZYLL 14 (2,4 DICHLOROBENZOYL) INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; INDOLO[3,2 B]ANDROGRAPHOLIDE; METHYL 14 (2,4 DICHLOROBENZOYL) INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; METHYL 14 (2,4 DICHLOROPHENOXYACETYL) INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; METHYL 14 ACETYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; METHYL 14 BENZOYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; METHYL 14 DEOXY 14,15 DIDEHYDRO INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; METHYL 14 TERT BUTYLDIMETHYLSILYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; METHYL INDOLO[3,2 B]ANDROGRAPHOLIDE 19 OATE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DITERPENE; INDOLO(3,2-B)ANDROGRAPHOLIDE; 14 TERT BUTYLDIMETHYL SILYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 14 TERT BUTYLDIMETHYLSILYL ANDROGRAPHOLIDE; 14 TERT BUTYLDIMETHYLSILYL ANDROGRAPHOLIDE 19 AL; 14 TERT BUTYLDIMETHYLSILYL ANDROGRAPHOLIDE 19 OATE; 14 TERT BUTYLDIMETHYLSILYL ANDROGRAPHOLIDE 19 OIC ACID; 14,19 DI(TERT BUTYLDIMETHYLSILYL) 3 OXO ANDROGRAPHOLIDE; 14,19 DI(TERT BUTYLDIMETHYLSILYL) ANDROGRAPHOLIDE; 14,19 DI(TERT BUTYLDIMETHYLSILYL) INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 ACETYL 14 DEOXY 14,15 DIHYDRO INDOLO[3,2 B]ANDROGRAPHOLIDE; 19 ACETYL 14 TERT BUTYLDIMETHYLSILYL INDOLO[3,2 B]ANDROGRAPHOLIDE; 3,19 ISOPROPYLIDENE ANDROGRAPHOLIDE; BENZYL 14 TERT BUTYL DIMETHYLSILYL 3 OXO ANDROGRAPHOLIDE 19 OATE; BENZYL 14 TERT BUTYL DIMETHYLSILYL ANDROGRAPHOLIDE 19 OATE; METHYL 14 TERT BUTYLDIMETHYLSILYL 3 OXO ANDROGRAPHOLIDE 19 OATE; METHYL 14 TERT BUTYLDIMETHYLSILYL ANDROGRAPHOLIDE 19 OATE; UNINDEXED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; PROTON NUCLEAR MAGNETIC RESONANCE; S PHASE CELL CYCLE CHECKPOINT; TUMOR GROWTH; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; BREAST CANCER; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE S PHASE; COLON CANCER; DRUG STRUCTURE; DU145 CELL LINE; HCT116 CELL LINE; IN VITRO STUDY; MALE; MCF 7 CELL LINE; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84918550944     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.017     Document Type: Article

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