Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6421-6426

  Wu, Zhen Wei ^a   Xu, Hai Wei ^a   Dai, Gui Fu ^a   Liu, Meng Jiao ^a   Zhu, Li Ping ^a   Wu, Jian ^a   Wang, Ya Nan ^a   Wu, Feng Juan ^a   Zhao, Dan ^a   Gao, Ming Fu ^a   Nie, Shan Shan ^a   Han, Wei ^a   Song, Jing Hui ^a   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Andrographolide; Derivative; Invasion; Migration; MMP 9

Indexed keywords

15 BENZYLIDENE DERIVATIVE; ANDROGRAPHOLIDE; ANDROGRAPHOLIDE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE; GELATINASE A; GELATINASE B; MATRILYSIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL STRAIN HT29; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG POTENCY; DRUG SCREENING; ENZYME INACTIVATION; HUMAN; IC 50; NONHUMAN; PROTEIN EXPRESSION; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANDROGRAPHOLIDE; DERIVATIVE; INVASION; MIGRATION; MMP-9;

CELL MOVEMENT; CELL PROLIFERATION; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886950000     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.049     Document Type: Article

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