Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in Jurkat cells

Phytotherapy Research

Volumn 22, Issue 10, 2008, Pages 1336-1341

  Geethangili, Madamanchi ^a   Rao, Yerra Koteswara ^a   Fang, Shih Hua ^b   Tzeng, Yew Min ^a  

^a CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY OF SPORT   (Taiwan)

Author keywords

Acanthaceae; Andrographis paniculata; Cell cycle analysis; Cytotoxicities; Flavonoids; Labdane diterpenoids

Indexed keywords

14 DEOXY 14,15 DIDEHYDROANDROGRAPHOLIDE; 5 HYDROXY 2',7,8 TRIMETHOXYFLAVONE; 5 HYDROXY 7,8 DIMETHOXYFLAVANONE; 5 HYDROXY 7,8 DIMETHOXYFLAVONE; 5 HYDROXY 7,8,2',5' TETRAMETHOXYFLAVONE; 5,2' DIHYDROXY 7,8 DIMETHOXYFLAVANONE; ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; ISOANDROGRAPHOLIDE; UNCLASSIFIED DRUG;

ANDROGRAPHIS PANICULATA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE;

ANDROGRAPHIS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; JURKAT CELLS; PLANT EXTRACTS; SPECTRUM ANALYSIS;

ACANTHACEAE; ANDROGRAPHIS PANICULATA;

EID: 55449109861     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2493     Document Type: Article

References (34)

1. Akbarsha MA, Manivannan B, Hamid KS, Vijayan B. 1990. Antifertility effect of Andrographis paniculata (Nees) in male albino rat. Indian J Exp Biol 28: 421-426.
2. Balmain A, Connolly JD. 1973. Minor diterpenoid constituents of Andrographis paniculata Nees. J Chem Soc Perkin Trans I: 1247-1251.
3. Burgos RA, Hidalgo MA, Monsalve J, Labranche TP, Eyre P, Hancke JL. 2005. 14-Deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. Planta Med 71: 604-608.
4. Choudhury BR, Haque SJ, Poddar MK. 1987. In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolizing enzymes. Planta Med 53: 135-140.
5. Cragg GM, Newman DJ. 2005. Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79.
6. Daskiewicz JB, Depeint F, Viornery L et al. 2005. Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study. J Med Chem 48: 2790-2804.
7. Dua VK, Ojha VP, Roy R et al. 2004. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J Ethnopharmacol 95: 247-251.
8. Fang SH, Lai MY, Hwang LH et al. 2001. Ribavirin enhances interferon-gamma levels in patients with chronic hepatitis C treated with interferon-alpha. J Biomed Sci 8: 484-491.
9. Gamble JS. 1956. Flora of the Presidency of Madras. Botanical Survey of India: Calcutta, 1048-1052.
10. Garbarino JA, Chamy MC, Piovano M, Espinoza L, Belmonte E. 2004. Diterpenoids from Calceolaria inamoena. Phytochemistry 65: 903-908.
11. Gupta KK, Taneja SC, Dhar KL. 1996. Flavonoid glycoside of Andrographis paniculata. Indian J Chem 35B: 512-513.
12. Handa SS, Sharma A. 1990. Hepatoprotective activity of andrographolide against galactosamine and paracetamol intoxication in rats. Indian J Med Res 92: 284-292.
13. Husen R, Pihie AH, Nallappan M. 2004. Screening for antihyperglycaemic activity in several local herbs of Malaysia. J Ethnopharmacol 95: 205-208.
14. Ji LL, Wang Z, Dong F, Zhang WB, Wang ZT. 2005. Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-α-induced leukocytes chemotaxis. J Cell Biochem 95: 970-978.
15. Kapil A, Koul IB, Banerjee SK, Gupta BD. 1993. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol 46: 182-185.
16. Kirtikar KR, Basu BD. 1975. Indian Medicinal Plants, Vol. 3. Periodical Experts: New Delhi, 1884-1886.
17. Krishnaswamy NR, Rao GN, Omana P. 1995. Lipids and flavonoids from Sesamum laciniatum Klein. Indian J Chem 34B: 750-752.
18. Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S. 2004. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 92: 291-295.
19. Kuroyanagi M, Sato M, Ueno A, Nishi K. 1987. Flavonoids from Andrographis paniculata. Chem Pharm Bull 35: 4429-4435.
20. Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A, Nishi K. 1994. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull 42: 1216-1225.
21. Mosmann T. 1983. Rapid colorometric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
22. Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tandon JS. 1993. Immunostimulant agents from Andrographis paniculata. J Nat Prod 56: 995-999.
23. Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R. 2003. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 3: 147-158.
24. Rao YK, Fang SH, Tzeng YM. 2004a. Differential effects of synthesized 2′-oxygenated chalcone derivatives: modulation of human cell cycle phase distribution. Bioorg Med Chem 12: 2679-2686.
25. Rao YK, Fang SH, Tzeng YM. 2005. Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives. Bioorg Med Chem 13: 6850-6855.
26. Rao YK, Geethangili M, Fang SH, Tzeng YM. 2007. Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol 45: 1770-1776.
27. Rao YK, Vimalamma G, Rao CV, Tzeng YM. 2004b. Flavonoids and andrographolides from Andrographis paniculata. Phytochemistry 65: 2317-2321.
28. Shen YC, Chen CF, Chiou WF. 2002. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol 135: 399-406.
29. Siripong P, Kongkathip B, Preechanukool K, Picha P, Tunsuwan K, Taylor WC. 1992. Cytotoxic diterpenoid constituents from Andrographis paniculata Nees leaves. J Sci Soc 18: 187-194.
30. Tan ML, Kuroyanagi M, Sulaiman SF, Najimudin N, Muhammad TST. 2005. Cytotoxic activities of major diterpenoid constituents of Andrographis paniculata in a panel of human tumor cell lines. Pharm Biol 43: 501-508.
31. Zhang CY, Tan BK. 1997. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 56: 97-101.
32. Zhang CY, Tan BK. 2000. Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats. Clin Exp Pharmacol Physiol 27: 358-363.
33. Zhang YZ, Tang JZ, Zhang YJ. 1994. Study of Andrographis paniculata extracts on antiplatelet aggregation and release reaction and its mechanism. Zhongguo Zhong Xi Yi Jie He Za Zhi 14: 28-30.
34. Zhao HY, Fang WY. 1991. Antithrombotic effects of Andrographis paniculata Nees in preventing myocardial infarction. Chin Med J 104: 770-775.