Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 439-448

  Pandeti, Sukanya ^a   Sonkar, Ravi ^a   Shukla, Astha ^a   Bhatia, Gitika ^a   Tadigoppula, Narender ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Andographis paniculata; Andrographolide derivatives; Anti oxidant activity; Antidyslipidemic activity; LDL oxidation; LPL activity

Indexed keywords

3 [2 [6 HYDROXY 5 (HYDROXYMETHYL) 5,8A DIMETHYL 2 METHYLENEDECAHYDRONAPHTHALEN 1 YL]ETHYLIDENE]FURAN 2(3H) ONE; 3 [2 [6 HYDROXYL 5 (HYDROXYMETHYL) 5,8A DIMETHYL 2 METHYLENEDECAHYDRONAPHTHALEN 1 YL]ETHYL]FURAN 2(5H) ONE; 4 [2 [6 HYDROXY 5 (HYDROXYMETHYL) 5,8A DIMETHYL 2 METHYLENE DECAHYDRONAPHTHALEN 1 YL]ETHYLIDENE] 5 OXOTETRAHYDROFURAN 3 YL ACETATE; 4 [2 [6 HYDROXYL 5 [(MESITYLSULFONYLOXY)METHYL] 5,8A DIMETHYL 2 METHYLENE DECAHYDRONAPHTHALEN 1 YL]ETHYLIDENE] 5 OXOTETRAHYDROFURAN 3 YL ACETATE; 4 HYDROXY 3 [2 (3,3,6A,10B TETRAMETHYL 8 METHYLENEDECAHYDRO 1H NAPHTHO[2,1 D] [1,3] DIOXIN 7 YL)ETHYLIDENE]DIHYDROFURAN 2(3H) ONE; 4 HYDROXY 3 [2 [6 HYDROXY 5 (HYDROXYMETHYL) 2,5,8A TRIMETHYLDECAHYDRONAPHTHALEN 1 YL]ETHYL]DIHYDROFURAN 2(3H) ONE; 4 HYDROXY 3 [2 [6 HYDROXY 5 (HYDROXYMETHYL) 2,5,8A TRIMETHYLDECAHYDRONAPHTHALEN 1 YL]ETHYLIDENE]DIHYDROFURAN 2(3H) ONE; 4 HYDROXY 3 [2 [6 HYDROXY 5 (HYDROXYMETHYL) 5,8A DIMETHYLOCTAHYDRO 1H SPIRO (NAPHTHALENE 2,2' OXIRANE) 1 YL]ETHYLIDENE]DIHYDROFURAN 2(3H) ONE; 4 HYDROXY 3 [2 [6 HYDROXYL 5 (HYDROXYMETHYL) 5,8A DIMETHYL 2 METHYLENEDECAHYDRONAPHTHALEN 1 YL]ETHYL]DIHYDROFURAN 2(3H) ONE; 5 [2 (4 ACETOXY 2 OXODIHYDROFURAN (2H) YLIDENE)ETHYL] 1 (ACETOXYMETHYL) 1,4A DIMETHYL 6 METHYLENEDECAHYDRONAPHTAHALEN 2 YL ACETATE; 5 [2 (4 HYDROXY 2 OXODIHYDROFURAN 3(2H) YLIDENE)ETHYL] 1,4A DIMETHYL 6 METHYLENE 2 OXODECAHYDRONAPHTHALENE 1 CARBALDEHYDE; 5 OXO 4 [2 (3,3,6A,10B TETRAMETHYL 8 METHYLENEDECAHYDRO 1H NAPHTHO[2,1 D] [1,3] DIOXIN 7 YL)ETHYLIDENE]TETRAHYDROFURAN 3 YL ACETATE; [2 HYDROXYL 5 [2 (4 HYDROXYL 2 OXODIHYDROFURAN 3 (2H) YLIDENE)ETHYL] 1,4 ALPHA DIMETHYL 6 METHYLENEDECAHYDRONAPHTHALEN 1 YL] METHYL 2,4,6 TRIMETHYLBENZENESULFONATE; [2 HYDROXYL 5 [2 (4 HYDROXYL 2 OXODIHYDROFURAN 3 (2H) YLIDENE)ETHYL] 1,4 ALPHA DIMETHYL 6 METHYLENEDECAHYDRONAPHTHALEN 1 YL] METHYL 4 METHYLBENZENESULFONATE; ANDROGRAPHOLIDE; ANTILIPEMIC AGENT; ANTIOXIDANT; EXOCYCLIC DOUBLE BOND; HIGH DENSITY LIPOPROTEIN; HYDROXYL RADICAL; LOW DENSITY LIPOPROTEIN; SUPEROXIDE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANDROGRAPHIS PANICULATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; EPOXIDATION; HERB; HYDROGENATION; HYPERLIPIDEMIA; LIPID PEROXIDATION; LIPOLYSIS; LIPOPROTEIN METABOLISM; MALE; NONHUMAN; OXIDATION; RAT;

ANDOGRAPHIS PANICULATA; ANDROGRAPHOLIDE DERIVATIVES; ANTI OXIDANT ACTIVITY; ANTIDYSLIPIDEMIC ACTIVITY; LDL OXIDATION; LPL ACTIVITY;

ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DITERPENES; HUMANS; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; LIPOPROTEINS, LDL; MALE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; RATS, INBRED STRAINS;

EID: 84884692577     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.002     Document Type: Article

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