Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 10, 2014, Pages 2353-2359

  Chen, Hao ^a,b   Ma, Yun Bao ^a   Huang, Xiao Yan ^a   Geng, Chang An ^a   Zhao, Yong ^a,b   Wang, Li Jun ^a   Guo, Rui Hua ^a   Liang, Wen Juan ^a,b   Zhang, Xue Mei ^a   Chen, Ji Jun ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anti HBV activity; Dehydroandrographolide and andrographolide derivatives; Octanol water partition coefficients; Structure activity relationships

Indexed keywords

ANDROGRAPHOLIDE DERIVATIVE; ANTIVIRUS AGENT; CARBOXYL GROUP; DEHYDROANDROGRAPHOLIDE DERIVATIVE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; HYDROXYL GROUP; TENOFOVIR; UNCLASSIFIED DRUG; VIRUS DNA; ANDROGRAPHOLIDE; BIOLOGICAL PRODUCT; DEHYDROANDROGRAPHOLIDE; DITERPENE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPLICATION; DRUG SYNTHESIS; HEPATITIS B VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENETICS; PHYSIOLOGY; SYNTHESIS; VIRUS REPLICATION;

ANDROGRAPHIS PANICULATA; HEPATITIS B VIRUS;

ANTIVIRAL AGENTS; BIOLOGICAL PRODUCTS; DITERPENES; DNA REPLICATION; DNA, VIRAL; HEPATITIS B VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84899651898     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.060     Document Type: Article

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