Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and blimp-1 expression for epigenetic modulation of antibody and autoantibody responses

Journal of Immunology

Volumn 193, Issue 12, 2014, Pages 5933-5950

  White, Clayton A ^a,b,c   Pone, Egest J ^b   Lam, Tonika ^a,b   Tat, Connie ^a,b   Hayama, Ken L ^b   Li, Guideng ^a,b,d   Zan, Hong ^a,b   Casali, Paolo ^a,b  

^a University of Texas Health Science Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALLERGAN INC   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ANTIBODY; AUTOANTIBODY; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BUTYRIC ACID; MICRORNA; MICRORNA 125B; MICRORNA 155; MICRORNA 181B; MICRORNA 23B; MICRORNA 30A; MICRORNA 361; PROTEIN BACH2; PROTEIN BCL 6; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG; VALPROIC ACID; X BOX BINDING PROTEIN 1; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; DNA BINDING PROTEIN; HISTONE DEACETYLASE INHIBITOR; PRDM1 PROTEIN, HUMAN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; C57BL 6 MOUSE; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CLASS SWITCH DNA RECOMBINATION; CONTROLLED STUDY; DNA RECOMBINATION; DOWN REGULATION; DRUG EFFECT; EPIGENETICS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION; SURVIVAL; UPREGULATION; ANIMAL; ANTIBODY PRODUCTION; BIOSYNTHESIS; CELL SURVIVAL; CYTOLOGY; DNA METHYLATION; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE REARRANGEMENT; GENE SILENCING; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; PHYSIOLOGY;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; AUTOANTIBODIES; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SURVIVAL; CYTIDINE DEAMINASE; DNA METHYLATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GENE SILENCING; HISTONE DEACETYLASE INHIBITORS; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED MRL LPR; MICRORNAS; PLASMA CELLS; REPRESSOR PROTEINS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTION FACTORS;

EID: 84916910420     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401702     Document Type: Article

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