B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: A mechanism of antigen-triggering plasma cell differentiation

Journal of Immunology

Volumn 188, Issue 12, 2012, Pages 6127-6134

  Yasuda, Takahiko ^a   Hayakawa, Fumihiko ^a   Kurahashi, Shingo ^a   Sugimoto, Keiki ^a,b   Minami, Yosuke ^a   Tomita, Akihiro ^a   Naoe, Tomoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; B LYMPHOCYTE RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR PAX5;

ANIMAL CELL; ARTICLE; BLIMP1 GENE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOSTIMULATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION TERMINATION;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; CELL DIFFERENTIATION; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; LYMPHOMA; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; PHOSPHORYLATION; PLASMA CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, B-CELL; REPRESSOR PROTEINS; TRANSFECTION;

EID: 84862603761     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103039     Document Type: Article

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