Biochemical characterization of the water-soluble squalene synthase from Methylococcus capsulatus and the functional analyses of its two DXXD(E)D motifs and the highly conserved aromatic amino acid residues

FEBS Journal

Volumn 281, Issue 24, 2014, Pages 5479-5497

  Ohtake, Kana ^a   Saito, Naoki ^a   Shibuya, Satoshi ^a   Kobayashi, Wakako ^a   Amano, Ryosuke ^a   Hirai, Takumi ^a   Sasaki, Shinji ^a   Nakano, Chiaki ^a   Hoshino, Tsutomu ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Farnesyl diphosphate; Methylococcus capsulatus; NADPH; Squalene; Squalene synthase

Indexed keywords

AROMATIC AMINO ACID; CATION; FARNESYL DIPHOSPHATE; FARNESYL METHYLENEDIPHOSPHONATE; MAGNESIUM ION; MEDRONIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SQUALENE SYNTHASE; UNCLASSIFIED DRUG; WATER;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; BIOCHEMISTRY; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; METHYLOCOCCUS CAPSULATUS; NONHUMAN; PROTEIN MOTIF; SOLUBILITY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS;

METHYLOCOCCUS CAPSULATUS;

AMINO ACID MOTIFS; CONSERVED SEQUENCE; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; KINETICS; METHYLOCOCCUS CAPSULATUS; MUTAGENESIS, SITE-DIRECTED;

EID: 84916620411     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13090     Document Type: Article

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