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Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 19, 2004, Pages 4979-4982

Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate

(5) Troutman, Jerry M a Chehade, Kareem A H a Kiegiel, Katarzyna a Andres, Douglas A a,b Spielmann, H Peter a,b

a UNIVERSITY OF KENTUCKY (United States)

b UNIVERSITY OF KENTUCKY (United States)

Author keywords

Bisphosphonates; Farnesylation; Prodrugs

Indexed keywords

ESTER DERIVATIVE; FARNESYL DIPHOSPHATE; ISOPRENOID; MEDRONIC ACID; PRODRUG; PROTEIN FARNESYLTRANSFERASE; PYROPHOSPHORIC ACID DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; ENZYME SUBSTRATE; LIPOPHILICITY; STATISTICAL SIGNIFICANCE;

ALKYL AND ARYL TRANSFERASES; FARNESYLTRANSTRANSFERASE; POLYISOPRENYL PHOSPHATES; PRODRUGS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

EID: 4444292598 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2004.07.017 Document Type: Article

Times cited : (18)

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