The monotopic membrane protein human oxidosqualene cyclase is active as monomer

Biochemical and Biophysical Research Communications

Volumn 315, Issue 2, 2004, Pages 247-254

  Ruf, Armin ^a   Müller, Francis ^a   D'Arcy, Brigitte ^a   Stihle, Martine ^a   Kusznir, Eric ^a   Handschin, Corinne ^a   Morand, Olivier H ^a,b   Thoma, Ralf ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

Analytical ultracentrifugation; Cholesterol; Cyclase; Detergent; Lanosterol synthase; Membrane protein; OSC; Pichia pastoris; Protein crystallization

Indexed keywords

ENZYME INHIBITOR; LANOSTEROL SYNTHASE; MONOMER; RO 488071; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTALLIZATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; ULTRACENTRIFUGATION;

MAMMALIA; PICHIA; PICHIA PASTORIS;

EID: 0842310656     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.01.052     Document Type: Article

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