-
2
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956;123(3191):309-14
-
(1956)
Science
, vol.123
, Issue.3191
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008;7(1):11-20
-
(2008)
Cell Metab
, vol.7
, Issue.1
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
4
-
-
84890159876
-
Cancer cell metabolism: Implications for therapeutic targets
-
Jang M, Kim SS, Lee J. Cancer cell metabolism: implications for therapeutic targets. Exp Mol Med 2013;45(10):e45
-
(2013)
Exp Mol Med
, vol.45
, Issue.10
, pp. e45
-
-
Jang, M.1
Kim, S.S.2
Lee, J.3
-
5
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005;202(3):654-62
-
(2005)
J Cell Physiol
, vol.202
, Issue.3
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
6
-
-
14644410403
-
Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin Akt and NF-kappaB: Implications for angioprevention and antiangiogenic therapy
-
Dhanalakshmi S, Singh R. Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy. Oncogene 2005;24(7):1188-202
-
(2005)
Oncogene
, vol.24
, Issue.7
, pp. 1188-1202
-
-
Dhanalakshmi, S.1
Singh, R.2
-
7
-
-
77952317006
-
A study of high-dose oral silybinphytosome followed by prostatectomy in patients with localized prostate cancer
-
Flaig TW, Glode M, Gustafson D, et al. A study of high-dose oral silybinphytosome followed by prostatectomy in patients with localized prostate cancer. Prostate 2010;70(8):848-55
-
(2010)
Prostate
, vol.70
, Issue.8
, pp. 848-855
-
-
Flaig, T.W.1
Glode, M.2
Gustafson, D.3
-
8
-
-
84892567968
-
A Phase i dose-finding study of silybin phosphatidylcholine (milk thistle) in patients with advanced hepatocellular carcinoma
-
Siegel AB, Narayan R, Rodriguez R, et al. A Phase I dose-finding study of silybin phosphatidylcholine (milk thistle) in patients with advanced hepatocellular carcinoma. Integr Cancer Ther 2014;13(1):46-53
-
(2014)
Integr Cancer Ther
, vol.13
, Issue.1
, pp. 46-53
-
-
Siegel, A.B.1
Narayan, R.2
Rodriguez, R.3
-
9
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim JW, Gao P, Liu YC, et al. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007;27(21):7381-93
-
(2007)
Mol Cell Biol
, vol.27
, Issue.21
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
-
10
-
-
33746879141
-
Glycolysis inhibition for anticancer treatment
-
Pelicano H, Martin D, Xu R, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006;25(34):4633-46
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4633-4646
-
-
Pelicano, H.1
Martin, D.2
Xu, R.3
Huang, P.4
-
11
-
-
33751091519
-
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): A potential therapeutic target for highrisk neuroblastoma
-
Fang J, Quinones QJ, Holman TL, et al. The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for highrisk neuroblastoma. Mol Pharmacol 2006;70(6):2108-15
-
(2006)
Mol Pharmacol
, vol.70
, Issue.6
, pp. 2108-2115
-
-
Fang, J.1
Quinones, Q.J.2
Holman, T.L.3
-
12
-
-
0032190467
-
Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism
-
Floridi A, Bruno T, Miccadei S, et al. Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism. Biochem Pharmacol 1998;56(7):841-9
-
(1998)
Biochem Pharmacol
, vol.56
, Issue.7
, pp. 841-849
-
-
Floridi, A.1
Bruno, T.2
Miccadei, S.3
-
13
-
-
0035123284
-
Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study
-
De Lena M, Lorusso V, Latorre A, et al. Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study. Eur J Cancer 2001;37(3):364-8
-
(2001)
Eur J Cancer
, vol.37
, Issue.3
, pp. 364-368
-
-
De Lena, M.1
Lorusso, V.2
Latorre, A.3
-
14
-
-
0032862447
-
Treatment of inoperable non-small cell lung carcinoma stage IIIb and IV with cisplatin, epidoxorubicin, vindesine and lonidamine: A phase II study
-
Portalone L, Lombardi A, Antilli A, et al. Treatment of inoperable non-small cell lung carcinoma stage IIIb and IV with cisplatin, epidoxorubicin, vindesine and lonidamine: a phase II study. Tumori 1998;85(4):239-42
-
(1998)
Tumori
, vol.85
, Issue.4
, pp. 239-242
-
-
Portalone, L.1
Lombardi, A.2
Antilli, A.3
-
15
-
-
0037108676
-
Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: Final results of a phase III study with a factorial design
-
Berruti A, Bitossi R, Gorzegno G, et al. Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design. J Clin Oncol 2002;20(20):4150-9
-
(2002)
J Clin Oncol
, vol.20
, Issue.20
, pp. 4150-4159
-
-
Berruti, A.1
Bitossi, R.2
Gorzegno, G.3
-
16
-
-
17444448833
-
FEC (5-fluorouracil, epidoxorubicin and cyclophosphamide) versus em (epidoxorubicin and mitomycin-C) with or without lonidamine as first-line treatment for advanced breast cancer. A multicentric randomised study. Final results
-
Pacini P, Rinaldini M, Algeri R, et al. FEC (5-fluorouracil, epidoxorubicin and cyclophosphamide) versus EM (epidoxorubicin and mitomycin-C) with or without lonidamine as first-line treatment for advanced breast cancer. A multicentric randomised study. Final results. Eur J Cancer 2000;36(8):966-75
-
(2000)
Eur J Cancer
, vol.36
, Issue.8
, pp. 966-975
-
-
Pacini, P.1
Rinaldini, M.2
Algeri, R.3
-
17
-
-
69849087571
-
Targeting glucose metabolism with 2-deoxy-Dglucose for improving cancer therapy
-
Dwarakanath B, Jain V. Targeting glucose metabolism with 2-deoxy-Dglucose for improving cancer therapy. Future Oncol 2009;5(5):581-5
-
(2009)
Future Oncol
, vol.5
, Issue.5
, pp. 581-585
-
-
Dwarakanath, B.1
Jain, V.2
-
18
-
-
0001422847
-
Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose
-
Landau BR, Laszlo J, Stengle J, Burk D. Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose. J Natl Cancer Inst 1958;21(3):485-94
-
(1958)
J Natl Cancer Inst
, vol.21
, Issue.3
, pp. 485-494
-
-
Landau, B.R.1
Laszlo, J.2
Stengle, J.3
Burk, D.4
-
19
-
-
0442313668
-
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-Dglucose in tumor cells treated under hypoxic vs aerobic conditions
-
Maher JC, Krishan A, Lampidis TJ. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-Dglucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother Pharmacol 2004;53(2):116-22
-
(2004)
Cancer Chemother Pharmacol
, vol.53
, Issue.2
, pp. 116-122
-
-
Maher, J.C.1
Krishan, A.2
Lampidis, T.J.3
-
20
-
-
77951221371
-
Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects
-
Dwarakanath BS, Singh D, Banerji AK, et al. Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects. J Cancer Res Ther 2009;5(Suppl 1):S21-6
-
(2009)
J Cancer Res Ther
, vol.5
, pp. S21-S26
-
-
Dwarakanath, B.S.1
Singh, D.2
Banerji, A.K.3
-
21
-
-
23044507635
-
Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme
-
Singh D, Banerji AK, Dwarakanath BS, et al. Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol 2005;181(8):507-14
-
(2005)
Strahlenther Onkol
, vol.181
, Issue.8
, pp. 507-514
-
-
Singh, D.1
Banerji, A.K.2
Dwarakanath, B.S.3
-
22
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, Vander Heiden MG, Harris MH, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008;452(7184):230-3
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
-
23
-
-
84920141937
-
Cancer metabolism and mass spectrometry-based proteomics
-
[Epub ahead of print]
-
Zhou W, Liotta LA, Petricoin EF. Cancer metabolism and mass spectrometry-based proteomics. Cancer Lett 2013. [Epub ahead of print]
-
(2013)
Cancer Lett
-
-
Zhou, W.1
Liotta, L.A.2
Petricoin, E.F.3
-
24
-
-
84874889081
-
PKM2, a central point of regulation in cancer metabolism
-
Wong N, De Melo J, Tang D. PKM2, a central point of regulation in cancer metabolism. Int J Cell Biol 2013;2013:242513
-
(2013)
Int J Cell Biol 2013
, pp. 242513
-
-
Wong, N.1
De Melo, J.2
Tang, D.3
-
25
-
-
84887045362
-
Metabolic targets for cancer therapy
-
Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov 2013;12(11):829-46
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.11
, pp. 829-846
-
-
Galluzzi, L.1
Kepp, O.2
Vander Heiden, M.G.3
Kroemer, G.4
-
26
-
-
84872548105
-
PDK1 inhibition is a novel therapeutic target in multiple myeloma
-
Fujiwara S, Kawano Y, Yuki H, et al. PDK1 inhibition is a novel therapeutic target in multiple myeloma. Br J Cancer 2013;108(1):170-8
-
(2013)
Br J Cancer
, vol.108
, Issue.1
, pp. 170-178
-
-
Fujiwara, S.1
Kawano, Y.2
Yuki, H.3
-
27
-
-
53049103850
-
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
-
Michelakis ED, Webster L, Mackey JR. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 2008;99(7):989-94
-
(2008)
Br J Cancer
, vol.99
, Issue.7
, pp. 989-994
-
-
Michelakis, E.D.1
Webster, L.2
Mackey, J.R.3
-
28
-
-
0016285850
-
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
-
Whitehouse S, Cooper RH, Randle PJ. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem J 1974;141(3):761-74
-
(1974)
Biochem J
, vol.141
, Issue.3
, pp. 761-774
-
-
Whitehouse, S.1
Cooper, R.H.2
Randle, P.J.3
-
29
-
-
84904631827
-
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
-
Dunbar E, Coats B, Shroads A, et al. Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors. Invest New Drugs 2014;32(3):452-64
-
(2014)
Invest New Drugs
, vol.32
, Issue.3
, pp. 452-464
-
-
Dunbar, E.1
Coats, B.2
Shroads, A.3
-
30
-
-
84855989441
-
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate
-
Shroads AL, Langaee T, Coats BS, et al. Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate. J Clin Pharmacol 2012;52(6):837-49
-
(2012)
J Clin Pharmacol
, vol.52
, Issue.6
, pp. 837-849
-
-
Shroads, A.L.1
Langaee, T.2
Coats, B.S.3
-
31
-
-
84896706932
-
Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced nonsmall cell lung cancer
-
Garon EB, Christofk HR, Hosmer W, et al. Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced nonsmall cell lung cancer. J Cancer Res Clin Oncol 2014;140(3):443-52
-
(2014)
J Cancer Res Clin Oncol
, vol.140
, Issue.3
, pp. 443-452
-
-
Garon, E.B.1
Christofk, H.R.2
Hosmer, W.3
-
32
-
-
84895065125
-
Dichloroacetate attenuates hypoxiainduced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
-
Xuan Y, Hur H, Ham IH, et al. Dichloroacetate attenuates hypoxiainduced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism. Exp Cell Res 2014;321(2):219-30
-
(2014)
Exp Cell Res
, vol.321
, Issue.2
, pp. 219-230
-
-
Xuan, Y.1
Hur, H.2
Ham, I.H.3
-
33
-
-
84910095664
-
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
-
Stuart SD, Schauble A, Gupta S, et al. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab 2014;2(1):4
-
(2014)
Cancer Metab
, vol.2
, Issue.1
, pp. 4
-
-
Stuart, S.D.1
Schauble, A.2
Gupta, S.3
-
34
-
-
80755133485
-
Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
-
Zachar Z, Marecek J, Maturo C, et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med 2011;89(11):1137-48
-
(2011)
J Mol Med
, vol.89
, Issue.11
, pp. 1137-1148
-
-
Zachar, Z.1
Marecek, J.2
Maturo, C.3
-
35
-
-
84916596279
-
A phase i study of the safety efficacy and pharmacokinetics of the first in class pyruvate dehydrogenase complex inhibitor CPI-613 in patients with advanced hematologic malignancies
-
Pardee T, Lee K, Luddy J, et al. A phase I study of the safety, efficacy and pharmacokinetics of the first in class pyruvate dehydrogenase complex inhibitor CPI-613 in patients with advanced hematologic malignancies. Blood 2013;122(21):A486
-
(2013)
Blood
, vol.122
, Issue.21
, pp. A486
-
-
Pardee, T.1
Lee, K.2
Luddy, J.3
-
36
-
-
84879549989
-
Long-term stable disease of stage IV pancreatic neuroendocrine tumors and without significant adverse effect by CPI- 613, an investigational novel anti-cancer agent
-
Lee K, Khaira D, Rodriguez R, et al. Long-term stable disease of stage IV pancreatic neuroendocrine tumors and without significant adverse effect by CPI- 613, an investigational novel anti-cancer agent. Case Stud Case Rep 2011;1:137-45
-
(2011)
Case Stud Case Rep
, vol.1
, pp. 137-145
-
-
Lee, K.1
Khaira, D.2
Rodriguez, R.3
-
37
-
-
84916602805
-
CPI-613 an investigational novel anticancer agent provides long-term stable disease without significant adverse effects in a patient with stage IV relapsed hepatocellular carcinoma
-
Senzer N, Bedell C, Maturo C, et al. CPI-613, an investigational novel anticancer agent, provides long-term stable disease without significant adverse effects in a patient with stage IV relapsed hepatocellular carcinoma. Case Stud Case Rep 2012;2(2):38-45
-
(2012)
Case Stud Case Rep
, vol.2
, Issue.2
, pp. 38-45
-
-
Senzer, N.1
Bedell, C.2
Maturo, C.3
-
38
-
-
0034663601
-
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
-
Dimmer KS, Friedrich B, Lang F, et al. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 2000;350(Pt 1):219-27
-
(2000)
Biochem J
, vol.350
, pp. 219-227
-
-
Dimmer, K.S.1
Friedrich, B.2
Lang, F.3
-
39
-
-
75149178349
-
Tumor metabolism of lactate: The influence and therapeutic potential for MCT and CD147 regulation
-
Kennedy KM, Dewhirst MW. Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol 2010;6(1):127-48
-
(2010)
Future Oncol
, vol.6
, Issue.1
, pp. 127-148
-
-
Kennedy, K.M.1
Dewhirst, M.W.2
-
40
-
-
28544441664
-
Regulation of reactive oxygen species DNA damage, and c-Myc function by peroxiredoxin 1
-
Egler RA, Fernandes E, Rothermund K, et al. Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Oncogene 2005;24(54):8038-50
-
(2005)
Oncogene
, vol.24
, Issue.54
, pp. 8038-8050
-
-
Egler, R.A.1
Fernandes, E.2
Rothermund, K.3
-
41
-
-
0029984062
-
Antioxidant and redox regulation of gene transcription
-
Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 1996;10(7):709-20
-
(1996)
FASEB J
, vol.10
, Issue.7
, pp. 709-720
-
-
Sen, C.K.1
Packer, L.2
-
42
-
-
33144466181
-
Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity
-
Doroshow JH. Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity. J Natl Cancer Inst 2006;98(4):223-5
-
(2006)
J Natl Cancer Inst
, vol.98
, Issue.4
, pp. 223-225
-
-
Doroshow, J.H.1
-
43
-
-
77952856438
-
A phase II study of ARQ 501 in patients with advanced squamous cell carcinoma of the head and neck
-
Kawecki A, Adkins D, Cunningham C, et al. A phase II study of ARQ 501 in patients with advanced squamous cell carcinoma of the head and neck. J Clin Oncol 2007;25:16509
-
(2007)
J Clin Oncol
, vol.25
, pp. 16509
-
-
Kawecki, A.1
Adkins, D.2
Cunningham, C.3
-
44
-
-
33646438024
-
Phase i trial of ARQ 501, an activated checkpoint therapy (ACT) agent, in patients with advanced solid tumors
-
Shapiro G, Supko J, Ryan D, et al. Phase I trial of ARQ 501, an activated checkpoint therapy (ACT) agent, in patients with advanced solid tumors. J Clin Oncol 2005;23:3042
-
(2005)
J Clin Oncol
, vol.23
, pp. 3042
-
-
Shapiro, G.1
Supko, J.2
Ryan, D.3
-
45
-
-
44949193380
-
A phase 2 study of ARQ 501 in combination with gemcitabine in adult patients with treatment naive, unresectable pancreatic adenocarcinoma
-
Khong H, Dreisbach L, Kindler H, et al. A phase 2 study of ARQ 501 in combination with gemcitabine in adult patients with treatment naive, unresectable pancreatic adenocarcinoma. J Clin Oncol 2007;25:15017
-
(2007)
J Clin Oncol
, vol.25
, pp. 15017
-
-
Khong, H.1
Dreisbach, L.2
Kindler, H.3
-
46
-
-
84861172244
-
The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells
-
Nagai M, Vo NH, Shin Ogawa L, et al. The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells. Free Radic Biol Med 2012;52(10):2142-50
-
(2012)
Free Radic Biol Med
, vol.52
, Issue.10
, pp. 2142-2150
-
-
Nagai, M.1
Vo, N.H.2
Shin Ogawa, L.3
-
47
-
-
73949153317
-
Phase II, randomized, controlled, doubleblinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma
-
ODay S, Gonzalez R, Lawson D, et al. Phase II, randomized, controlled, doubleblinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma. J Clin Oncol 2009;27(32):5452-8
-
(2009)
J Clin Oncol
, vol.27
, Issue.32
, pp. 5452-5458
-
-
Oday, S.1
Gonzalez, R.2
Lawson, D.3
-
48
-
-
84875980910
-
Final results of phase III SYMMETRY study: Randomized, double-blind trial of elesclomol plus paclitaxel versus paclitaxel alone as treatment for chemotherapynaive patients with advanced melanoma
-
ODay SJ, Eggermont AM, Chiarion-Sileni V, et al. Final results of phase III SYMMETRY study: randomized, double-blind trial of elesclomol plus paclitaxel versus paclitaxel alone as treatment for chemotherapynaive patients with advanced melanoma. J Clin Oncol 2013;31(9):1211-18
-
(2013)
J Clin Oncol
, vol.31
, Issue.9
, pp. 1211-1218
-
-
Oday, S.J.1
Eggermont, A.M.2
Chiarion-Sileni, V.3
-
49
-
-
67649610311
-
Copper chelation in cancer therapy using tetrathiomolybdate: An evolving paradigm
-
Khan G, Merajver S. Copper chelation in cancer therapy using tetrathiomolybdate: an evolving paradigm. Expert Opin Investig Drugs 2009;18(4):541-8
-
(2009)
Expert Opin Investig Drugs
, vol.18
, Issue.4
, pp. 541-548
-
-
Khan, G.1
Merajver, S.2
-
50
-
-
58149359314
-
Phase i study of copper-binding agent ATN-224 in patients with advanced solid tumors
-
Lowndes SA, Adams A, Timms A, et al. Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors. Clin Cancer Res 2008;14(22):7526-34
-
(2008)
Clin Cancer Res
, vol.14
, Issue.22
, pp. 7526-7534
-
-
Lowndes, S.A.1
Adams, A.2
Timms, A.3
-
51
-
-
0037652214
-
Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
-
Redman BG, Esper P, Pan Q, et al. Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer. Clin Cancer Res 2003;2003:9(5):1666-72
-
(2003)
Clin Cancer Res 2003
, vol.9
, Issue.5
, pp. 1666-1672
-
-
Redman, B.G.1
Esper, P.2
Pan, Q.3
-
52
-
-
34548083741
-
Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormonerefractory prostate cancer
-
Henry NL, Dunn R, Merjaver S, et al. Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormonerefractory prostate cancer. Oncology 2007;71(3-4):168-75
-
(2007)
Oncology
, vol.71
, Issue.3-4
, pp. 168-175
-
-
Henry, N.L.1
Dunn, R.2
Merjaver, S.3
-
53
-
-
84879460993
-
A non-comparative randomized phase II study of 2 doses of ATN-224 a copper/zinc superoxide dismutase inhibitor in patients with biochemically recurrent hormone-naive prostate cancer
-
Lin J, Zahurak M, Beer TM, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naive prostate cancer. Urol Oncol 2013;31(5):581-8
-
(2013)
Urol Oncol
, vol.31
, Issue.5
, pp. 581-588
-
-
Lin, J.1
Zahurak, M.2
Beer, T.M.3
-
54
-
-
84879551228
-
Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate a novel copper chelator for patients with resectable esophageal cancer
-
Schneider BJ, Lee JS-J, Hayman JA, et al. Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate, a novel copper chelator, for patients with resectable esophageal cancer. Invest New Drugs 2013;31(2):435-42
-
(2013)
Invest New Drugs
, vol.31
, Issue.2
, pp. 435-442
-
-
Schneider, B.J.1
Js-J, L.2
Hayman, J.A.3
-
55
-
-
84860241870
-
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate
-
Bruce JY, Eickhoff J, Pili R, et al. A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate. Invest New Drugs 2012;30(2):794-802
-
(2012)
Invest New Drugs
, vol.30
, Issue.2
, pp. 794-802
-
-
Bruce, J.Y.1
Eickhoff, J.2
Pili, R.3
-
56
-
-
79960900243
-
A prospective phase II study of 2- methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors
-
Kulke MH, Chan JA, Meyerhardt JA, et al. A prospective phase II study of 2- methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors. Cancer Chemother Pharmacol 2011;68(2):293-300
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, Issue.2
, pp. 293-300
-
-
Kulke, M.H.1
Chan, J.A.2
Meyerhardt, J.A.3
-
57
-
-
79955986877
-
A phase i dose-escalation safety and pharmacokinetic study of the 2- methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
-
Zhou Q, Gustafson D, Nallapareddy S, et al. A phase I dose-escalation, safety and pharmacokinetic study of the 2- methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer. Invest New Drugs 2011;29(2):340-6
-
(2011)
Invest New Drugs
, vol.29
, Issue.2
, pp. 340-346
-
-
Zhou, Q.1
Gustafson, D.2
Nallapareddy, S.3
-
58
-
-
61549104698
-
Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: Results of a phase III trial
-
Mehta MP, Shapiro WR, Phan SC, et al. Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial. Int J Radiat Oncol Biol Phys 2009;73(4):1069-76
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.73
, Issue.4
, pp. 1069-1076
-
-
Mehta, M.P.1
Shapiro, W.R.2
Phan, S.C.3
-
59
-
-
3042787102
-
Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial
-
Meyers CA, Smith JA, Bezjak A, et al. Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial. J Clin Oncol 2004;22(1):157-65
-
(2004)
J Clin Oncol
, vol.22
, Issue.1
, pp. 157-165
-
-
Meyers, C.A.1
Smith, J.A.2
Bezjak, A.3
-
60
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROSmediated mechanism by beta-phenylethyl isothiocyanate
-
Trachootham D, Zhou Y, Zhang H, et al. Selective killing of oncogenically transformed cells through a ROSmediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 2006;10(3):241-52
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
-
61
-
-
33947309495
-
Phase i trial of imexon in patients with advanced malignancy
-
Dragovich T, Gordon M, Mendelson D, et al. Phase I trial of imexon in patients with advanced malignancy. J Clin Oncol 2007;25(13):1779-84
-
(2007)
J Clin Oncol
, vol.25
, Issue.13
, pp. 1779-1784
-
-
Dragovich, T.1
Gordon, M.2
Mendelson, D.3
-
62
-
-
0030658870
-
Phase i study of continuous-infusion L-S, R-buthionine sulfoximine with intravenous melphalan
-
Bailey HH, Ripple G, Tutsch KD, et al. Phase I study of continuous-infusion L-S, R-buthionine sulfoximine with intravenous melphalan. J Natl Cancer Inst 1997;89(23):1789-96
-
(1997)
J Natl Cancer Inst
, vol.89
, Issue.23
, pp. 1789-1796
-
-
Bailey, H.H.1
Ripple, G.2
Tutsch, K.D.3
-
63
-
-
84892945267
-
Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir
-
Coriat R, Alexandre J, Nicco C, et al. Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir. J Clin Invest 2014;124(1):262-72
-
(2014)
J Clin Invest
, vol.124
, Issue.1
, pp. 262-272
-
-
Coriat, R.1
Alexandre, J.2
Nicco, C.3
-
64
-
-
84871687310
-
Superior therapeutic index of calmangafodipir in comparison to mangafodipir as a chemotherapy adjunct
-
Karlsson JOG, Kurz T, Flechsig S, et al. Superior therapeutic index of calmangafodipir in comparison to mangafodipir as a chemotherapy adjunct. Transl Oncol 2012;5(6):492
-
(2012)
Transl Oncol
, vol.5
, Issue.6
, pp. 492
-
-
Jog, K.1
Kurz, T.2
Flechsig, S.3
-
65
-
-
0001068795
-
The effect of arginase on the retardation of tumour growth
-
Bach SJ, Swaine D. The effect of arginase on the retardation of tumour growth. Br J Cancer 1965;19:379-86
-
(1965)
Br J Cancer
, vol.19
, pp. 379-386
-
-
Bach, S.J.1
Swaine, D.2
-
66
-
-
79954775922
-
Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
-
Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget 2010;1(4):246-51
-
(2010)
Oncotarget
, vol.1
, Issue.4
, pp. 246-251
-
-
Kuo, M.T.1
Savaraj, N.2
Feun, L.G.3
-
67
-
-
0027193797
-
L-asparaginase kills lymphoma cells by apoptosis
-
Story MD, Voehringer DW, Stephens LC, Meyn RE. L-asparaginase kills lymphoma cells by apoptosis. Cancer Chemother Pharmacol 1993;32(2):129-33
-
(1993)
Cancer Chemother Pharmacol
, vol.32
, Issue.2
, pp. 129-133
-
-
Story, M.D.1
Voehringer, D.W.2
Stephens, L.C.3
Meyn, R.E.4
-
68
-
-
0028911354
-
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia
-
Ettinger LJ, Kurtzberg J, Voute P, et al. An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia. Cancer 1995;75:1176-6
-
(1995)
Cancer
, vol.75
, pp. 1176-1186
-
-
Ettinger, L.J.1
Kurtzberg, J.2
Voute, P.3
-
69
-
-
84906788870
-
A phase II clinical trial of polyethylene glycol-conjugated L-asparaginase in patients with advanced ovarian cancer: Early closure for safety
-
Hays JL, Kim G, Walker A, et al. A phase II clinical trial of polyethylene glycol-conjugated L-asparaginase in patients with advanced ovarian cancer: early closure for safety. Mol Clin Oncol 2013;1(3):565-9
-
(2013)
Mol Clin Oncol
, vol.1
, Issue.3
, pp. 565-569
-
-
Hays, J.L.1
Kim, G.2
Walker, A.3
-
70
-
-
84879550695
-
Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma
-
Ott PA, Carvajal RD, Pandit-Taskar N, et al. Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma. Invest New Drugs 2013;31(2):425-34
-
(2013)
Invest New Drugs
, vol.31
, Issue.2
, pp. 425-434
-
-
Ott, P.A.1
Carvajal, R.D.2
Pandit-Taskar, N.3
-
71
-
-
84916625890
-
Phase i trial of ADI-peg 20 plus docetaxel (DOC) in patients (pts) with advanced solid tumors
-
Abstract 2569
-
Tomlinson BK, Bomalaski JS, Diaz M, et al. Phase I trial of ADI-peg 20 plus docetaxel (DOC) in patients (pts) with advanced solid tumors. J Clin Oncol 2013;31(Suppl):abstract 2569
-
(2013)
J Clin Oncol
, pp. 31
-
-
Tomlinson, B.K.1
Bomalaski, J.S.2
Diaz, M.3
-
72
-
-
77957245576
-
A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
-
Yang T, Lu S, Chao Y, et al. A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients. Br J Cancer 2010;103(7):954-60
-
(2010)
Br J Cancer
, vol.103
, Issue.7
, pp. 954-960
-
-
Yang, T.1
Lu, S.2
Chao, Y.3
-
73
-
-
0021466891
-
Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
-
Ookhtens M, Kannan R, Lyon I, Baker N. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am J Physiol 1984;247(1 Pt 2):R146-53
-
(1984)
Am J Physiol
, vol.247
, Issue.1
, pp. R146-R153
-
-
Ookhtens, M.1
Kannan, R.2
Lyon, I.3
Baker, N.4
-
74
-
-
77950605484
-
Fatty acid synthase as a potential therapeutic target in cancer
-
Flavin R, Peluso S, Nguyen PL, Loda M. Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol 2010;6(4):551-62
-
(2010)
Future Oncol
, vol.6
, Issue.4
, pp. 551-562
-
-
Flavin, R.1
Peluso, S.2
Nguyen, P.L.3
Loda, M.4
-
75
-
-
79952148424
-
Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker
-
Liu H, Liu JY, Wu X, Zhang JT. Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. Int J Biochem Mol Biol 2010;1(1):69-89
-
(2010)
Int J Biochem Mol Biol
, vol.1
, Issue.1
, pp. 69-89
-
-
Liu, H.1
Liu, J.Y.2
Wu, X.3
Zhang, J.T.4
-
76
-
-
84872058507
-
Phase 2 trial of daily oral polyphenon e in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia
-
Shanafelt TD, Call TG, Zent CS, et al. Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer 2013;119(2):363-70
-
(2013)
Cancer
, vol.119
, Issue.2
, pp. 363-370
-
-
Shanafelt, T.D.1
Call, T.G.2
Zent, C.S.3
-
77
-
-
77956265489
-
IDH mutations in glioma and acute myeloid leukemia
-
Dang L, Jin S, Su SM. IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med 2010;16(9):387-97
-
(2010)
Trends Mol Med
, vol.16
, Issue.9
, pp. 387-397
-
-
Dang, L.1
Jin, S.2
Su, S.M.3
-
78
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008;321(5897):1807-12
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
79
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360(8):765-73
-
(2009)
N Engl J Med
, vol.360
, Issue.8
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
80
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009;462(7274):739-44
-
(2009)
Nature
, vol.462
, Issue.7274
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
81
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype disrupt TET2 function and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010;18(6):553-67
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
82
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012;483(7390):474-8
-
(2012)
Nature
, vol.483
, Issue.7390
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
-
83
-
-
84888265282
-
Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
-
Chaturvedi A, Cruz MMA, Jyotsana N, et al. Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML. Blood 2013;122(16):2877-87
-
(2013)
Blood
, vol.122
, Issue.16
, pp. 2877-2887
-
-
Chaturvedi, A.1
Mma, C.2
Jyotsana, N.3
-
84
-
-
84907980918
-
Clinical safety and activity in a phase i trial of AG-221 a first in class potent inhibitor of the IDH2-mutant protein in patients with IDH2 mutant positive advanced hematologic malignancies
-
Stein E, Tallman M, Pollyea D, et al. Clinical safety and activity in a phase I trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies. Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014. p. 5-9
-
(2014)
Proceedings of the 105th Annual Meeting of the American Association for Cancer Research
, pp. 5-9
-
-
Stein, E.1
Tallman, M.2
Pollyea, D.3
-
85
-
-
78650308850
-
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
-
Swietach P, Hulikova A, Vaughan-Jones RD, Harris AL. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene 2010;29(50):6509-21
-
(2010)
Oncogene
, vol.29
, Issue.50
, pp. 6509-6521
-
-
Swietach, P.1
Hulikova, A.2
Vaughan-Jones, R.D.3
Harris, A.L.4
-
86
-
-
78751650361
-
A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX-) and interferon-alpha-2a in metastatic renal cell carcinoma patients
-
Siebels M, Rohrmann K, Oberneder R, et al. A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX-) and interferon-alpha-2a in metastatic renal cell carcinoma patients. World J Urol 2011;29(1):121-6
-
World J Urol 2011
, vol.29
, Issue.1
, pp. 121-126
-
-
Siebels, M.1
Rohrmann, K.2
Oberneder, R.3
-
87
-
-
84888227525
-
ARISER: A randomized double blind phase III study to evaluate adjuvant cG250 treatment versus placebo in patients with high-risk ccRCC - results and implications for adjuvant clinical trials
-
abstract 4507
-
Belldegrun A, Kloepfer P, Fall B, et al. ARISER: a randomized double blind phase III study to evaluate adjuvant cG250 treatment versus placebo in patients with high-risk ccRCC - results and implications for adjuvant clinical trials. J Clin Oncol 2013;31(Suppl):abstract 4507
-
(2013)
J Clin Oncol
, vol.31
-
-
Belldegrun, A.1
Kloepfer, P.2
Fall, B.3
-
88
-
-
33847182737
-
A phase i and pharmacokinetic study of indisulam in combination with carboplatin
-
Dittrich C, Zandvliet A, Gneist M, et al. A phase I and pharmacokinetic study of indisulam in combination with carboplatin. Br J Cancer 2007;96(4):559-66
-
(2007)
Br J Cancer
, vol.96
, Issue.4
, pp. 559-566
-
-
Dittrich, C.1
Zandvliet, A.2
Gneist, M.3
-
89
-
-
42149111544
-
A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours
-
Siegel-Lakhai W, Zandvliet A, Huitema A, et al. A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours. Br J Cancer 2008;98(8):1320-6
-
(2008)
Br J Cancer
, vol.98
, Issue.8
, pp. 1320-1326
-
-
Siegel-Lakhai, W.1
Zandvliet, A.2
Huitema, A.3
-
90
-
-
33644512888
-
A phase II multicenter study of the cyclin-dependent kinase inhibitor indisulam in patients with progressive inoperable and/or metastatic renal cell carcinoma (RCC
-
Raftopoulos H, Escudier B, Renshaw G, et al. A phase II multicenter study of the cyclin-dependent kinase inhibitor indisulam in patients with progressive inoperable and/or metastatic renal cell carcinoma (RCC). J Clin Oncol 2004;22:4629
-
(2004)
J Clin Oncol
, vol.22
, pp. 4629
-
-
Raftopoulos, H.1
Escudier, B.2
Renshaw, G.3
-
91
-
-
34250167232
-
A randomized phase ii pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer
-
Talbot DC, von Pawel J, Cattell E, et al. A randomized phase ii pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer. Clin Cancer Res 2007;13(6):1816-22
-
(2007)
Clin Cancer Res
, vol.13
, Issue.6
, pp. 1816-1822
-
-
Talbot, D.C.1
Von Pawel, J.2
Cattell, E.3
-
92
-
-
84902991536
-
HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc
-
Zhong C, Fan L, Yao F, et al. HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc. Tumor Biol 2014;35:4123-9
-
(2014)
Tumor Biol
, vol.35
, pp. 4123-4129
-
-
Zhong, C.1
Fan, L.2
Yao, F.3
-
93
-
-
79955486467
-
A phase 2 study of irinotecan cisplatin and simvastatin for untreated extensivedisease small cell lung cancer
-
Han JY, Lim KY, Yu SY, et al. A phase 2 study of irinotecan, cisplatin, and simvastatin for untreated extensivedisease small cell lung cancer. Cancer 2011;117(10):2178-85
-
(2011)
Cancer
, vol.117
, Issue.10
, pp. 2178-2185
-
-
Han, J.Y.1
Lim, K.Y.2
Yu, S.Y.3
-
94
-
-
84892789527
-
Randomized double-blinded placebocontrolled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients
-
Hong JY, Nam EM, Lee J, et al. Randomized double-blinded, placebocontrolled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients. Cancer Chemother Pharmacol 2014;73(1):125-30
-
(2014)
Cancer Chemother Pharmacol
, vol.73
, Issue.1
, pp. 125-130
-
-
Hong, J.Y.1
Nam, E.M.2
Lee, J.3
-
95
-
-
79952714380
-
A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer
-
Han J-Y, Lee S-H, Yoo NJ, et al. A randomized phase II. study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer. Clin Cancer Res 2011;17(6):1553-60
-
(2011)
Clin Cancer Res
, vol.17
, Issue.6
, pp. 1553-1560
-
-
Han, J.-Y.1
Lee, S.-H.2
Yoo, N.J.3
-
96
-
-
84908511175
-
SWOG0919: A Phase 2 study of idarubicin and cytarabine in combination with pravastatin for relapsed acute myeloid leukaemia
-
[Epub ahead of print]
-
Advani AS, McDonough S, Copelan E, et al. SWOG0919: a Phase 2 study of idarubicin and cytarabine in combination with pravastatin for relapsed acute myeloid leukaemia. Br J Haematol 2014. [Epub ahead of print]
-
(2014)
Br J Haematol
-
-
Advani, A.S.1
McDonough, S.2
Copelan, E.3
-
97
-
-
84877251996
-
Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
-
Karnevi E, Said K, Andersson R, Rosendahl AH. Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. BMC Cancer 2013;13:235
-
(2013)
BMC Cancer
, vol.13
, pp. 235
-
-
Karnevi, E.1
Said, K.2
Andersson, R.3
Rosendahl, A.H.4
-
98
-
-
84864371674
-
Metformin and cancer: New applications for an old drug
-
Kourelis TV, Siegel RD. Metformin and cancer: new applications for an old drug. Med Oncol 2012;29(2):1314-27
-
(2012)
Med Oncol
, vol.29
, Issue.2
, pp. 1314-1327
-
-
Kourelis, T.V.1
Siegel, R.D.2
-
99
-
-
85027954141
-
Metformin and cancer therapy
-
Bost F, Sahra IB, Le Marchand-Brustel Y, Tanti JF. Metformin and cancer therapy. Curr Opin Oncol 2012;24(1):103-8
-
(2012)
Curr Opin Oncol
, vol.24
, Issue.1
, pp. 103-108
-
-
Bost, F.1
Sahra, I.B.2
Le Marchand-Brustel, Y.3
Tanti, J.F.4
-
100
-
-
84905757105
-
Metformin-mode of action and clinical implications for diabetes and cancer
-
Pernicova I, Korbonits M. Metformin-mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014;10(3):143-56
-
(2014)
Nat Rev Endocrinol
, vol.10
, Issue.3
, pp. 143-156
-
-
Pernicova, I.1
Korbonits, M.2
-
101
-
-
84894041491
-
Metformin is associated with improved survival in endometrial cancer
-
Ko EM, Walter P, Jackson A, et al. Metformin is associated with improved survival in endometrial cancer. Gynecol Oncol 2014;132(2):438-42
-
(2014)
Gynecol Oncol
, vol.132
, Issue.2
, pp. 438-442
-
-
Ko, E.M.1
Walter, P.2
Jackson, A.3
-
102
-
-
84901060319
-
Molecular pathways: Preclinical models and clinical trials with metformin in breast cancer
-
Thompson AM. Molecular pathways: preclinical models and clinical trials with metformin in breast cancer. Clin Cancer Res 2014;20(10):2508-15
-
(2014)
Clin Cancer Res
, vol.20
, Issue.10
, pp. 2508-2515
-
-
Thompson, A.M.1
-
103
-
-
84911888868
-
Modification in the diet can induce beneficial effects against breast cancer
-
Aragón F, Perdigón G, de LeBlanc A. Modification in the diet can induce beneficial effects against breast cancer. World J Clin Oncol 2014;5(3):455
-
(2014)
World J Clin Oncol
, vol.5
, Issue.3
, pp. 455
-
-
Aragón, F.1
Perdigón, G.2
De Leblanc, A.3
|