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Volumn 6, Issue 10, 2014, Pages 1085-1095

Modes of action of TLR7 agonists in cancer therapy

Author keywords

cancer immunotherapy; imiquimod; innate immunity; TLR7

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; TLR7 PROTEIN, HUMAN;

EID: 84913609093     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.14.75     Document Type: Review
Times cited : (63)

References (114)
  • 1
    • 0025774776 scopus 로고
    • Drosophila Toll and IL-1 receptor
    • Gay NJ, Keith FJ. Drosophila Toll and IL-1 receptor. Nature 351 (6325), 355-356 (1991).
    • (1991) Nature , vol.351 , Issue.6325 , pp. 355-356
    • Gay, N.J.1    Keith, F.J.2
  • 2
    • 22144452520 scopus 로고    scopus 로고
    • The evolution of vertebrate Toll-like receptors
    • Roach JC, Glusman G, Rowen L. The evolution of vertebrate Toll-like receptors. Proc. Natl. Acad. Sci. USA 102 (27), 9577-9582 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.27 , pp. 9577-9582
    • Roach, J.C.1    Glusman, G.2    Rowen, L.3
  • 3
    • 33748308787 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Uematsu S, Akira S. Toll-like receptors and innate immunity. J. Mol. Med. (Berl.) 84 (9), 712-725 (2006).
    • (2006) J. Mol. Med. (Berl.) , vol.84 , Issue.9 , pp. 712-725
    • Uematsu, S.1    Akira, S.2
  • 4
    • 84885696781 scopus 로고    scopus 로고
    • Trial watch: Toll-like receptor agonists for cancer therapy
    • Vacchelli E, Eggermont A, Sautes-Fridman C. Trial watch: Toll-like receptor agonists for cancer therapy. Oncoimmunology 2 (8), e25238 (2013).
    • (2013) Oncoimmunology , vol.2 , Issue.8 , pp. e25238
    • Vacchelli, E.1    Eggermont, A.2    Sautes-Fridman, C.3
  • 5
    • 0028081705 scopus 로고
    • Coley's toxins, tumor necrosis factor and cancer research: A historical perspective
    • Wiemann B, Starnes CO. Coley's toxins, tumor necrosis factor and cancer research: a historical perspective. Pharmacol. Ther. 64 (3), 529-564 (1994).
    • (1994) Pharmacol. Ther. , vol.64 , Issue.3 , pp. 529-564
    • Wiemann, B.1    Starnes, C.O.2
  • 6
    • 0025856680 scopus 로고
    • Phase i trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients
    • Engelhardt R, Mackensen A, Galanos C. Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. Cancer Res. 51 (10), 2524-2530 (1991).
    • (1991) Cancer Res. , vol.51 , Issue.10 , pp. 2524-2530
    • Engelhardt, R.1    Mackensen, A.2    Galanos, C.3
  • 7
    • 0027420347 scopus 로고
    • Phase i trial of an oral immunomodulator and interferon inducer in cancer patients
    • Witt PL, Ritch PS, Reding D. Phase I trial of an oral immunomodulator and interferon inducer in cancer patients. Cancer Res. 53 (21), 5176-5180 (1993).
    • (1993) Cancer Res. , vol.53 , Issue.21 , pp. 5176-5180
    • Witt, P.L.1    Ritch, P.S.2    Reding, D.3
  • 8
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5 (6), 471-484 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.6 , pp. 471-484
    • Krieg, A.M.1
  • 9
    • 37249041922 scopus 로고    scopus 로고
    • First in human Phase i trial of 852A, a novel systemic Toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer
    • Dudek AZ, Yunis C, Harrison LI. First in human Phase I trial of 852A, a novel systemic Toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin. Cancer Res. 13 (23), 7119-7125 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.23 , pp. 7119-7125
    • Dudek, A.Z.1    Yunis, C.2    Harrison, L.I.3
  • 10
    • 84899555500 scopus 로고    scopus 로고
    • Toll-like receptors as therapeutic targets for cancer
    • Holldack J. Toll-like receptors as therapeutic targets for cancer. Drug Discov Today 19 (4), 379-382 (2013).
    • (2013) Drug Discov Today , vol.19 , Issue.4 , pp. 379-382
    • Holldack, J.1
  • 11
    • 79960956913 scopus 로고    scopus 로고
    • Systemic cancer therapy with a small molecule agonist of Toll-like receptor 7 can be improved by circumventing TLR tolerance
    • Bourquin C, Hotz C, Noerenberg D. Systemic cancer therapy with a small molecule agonist of Toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res. 71 (15), 5123-5133 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.15 , pp. 5123-5133
    • Bourquin, C.1    Hotz, C.2    Noerenberg, D.3
  • 12
    • 84883557025 scopus 로고    scopus 로고
    • Topical and intralesional treatment of nonmelanoma skin cancer: Efficacy and cost comparisons
    • Chitwood K, Etzkorn J, Cohen G. Topical and intralesional treatment of nonmelanoma skin cancer: efficacy and cost comparisons. Dermatol. Surg. 39 (9), 1306-1316 (2013).
    • (2013) Dermatol. Surg. , vol.39 , Issue.9 , pp. 1306-1316
    • Chitwood, K.1    Etzkorn, J.2    Cohen, G.3
  • 13
    • 84878346748 scopus 로고    scopus 로고
    • Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: A single blind, non-inferiority, randomised controlled trial
    • Arits AH, Mosterd K, Essers BA. Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. Lancet Oncol. 14 (7), 647-654 (2013).
    • (2013) Lancet Oncol. , vol.14 , Issue.7 , pp. 647-654
    • Arits, A.H.1    Mosterd, K.2    Essers, B.A.3
  • 14
    • 0034456693 scopus 로고    scopus 로고
    • Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
    • Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Netw. 11 (3), 362-371 (2000).
    • (2000) Eur. Cytokine Netw. , vol.11 , Issue.3 , pp. 362-371
    • Du, X.1    Poltorak, A.2    Wei, Y.3    Beutler, B.4
  • 15
    • 84871217036 scopus 로고    scopus 로고
    • Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer
    • Adams S, Kozhaya L, Martiniuk F. Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer. Clin. Cancer Res. 18 (24), 6748-6757 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.24 , pp. 6748-6757
    • Adams, S.1    Kozhaya, L.2    Martiniuk, F.3
  • 16
    • 77957659880 scopus 로고    scopus 로고
    • Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers
    • Geller MA, Cooley S, Argenta PA. Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers. Cancer Immunol. Immunother. 59 (12), 1877-1884 (2010).
    • (2010) Cancer Immunol. Immunother. , vol.59 , Issue.12 , pp. 1877-1884
    • Geller, M.A.1    Cooley, S.2    Argenta, P.A.3
  • 17
    • 84864662070 scopus 로고    scopus 로고
    • Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    • Walter S, Weinschenk T, Stenzl A. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat. Med. 18 (8), 1254-1261 (2012).
    • (2012) Nat. Med. , vol.18 , Issue.8 , pp. 1254-1261
    • Walter, S.1    Weinschenk, T.2    Stenzl, A.3
  • 18
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung V, Guenthner-Biller M, Bourquin C. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11 (3), 263-270 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.3 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3
  • 19
    • 80052184362 scopus 로고    scopus 로고
    • Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
    • Kawasaki T, Kawai T, Akira S. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol. Rev. 243 (1), 61-73 (2011).
    • (2011) Immunol. Rev. , vol.243 , Issue.1 , pp. 61-73
    • Kawasaki, T.1    Kawai, T.2    Akira, S.3
  • 20
    • 57449095648 scopus 로고    scopus 로고
    • Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications
    • Guiducci C, Coffman RL, Barrat FJ. Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications. J. Int. Med. 265 (1), 43-57 (2009).
    • (2009) J. Int. Med. , vol.265 , Issue.1 , pp. 43-57
    • Guiducci, C.1    Coffman, R.L.2    Barrat, F.J.3
  • 21
    • 79952762940 scopus 로고    scopus 로고
    • The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system
    • Engel AL, Holt GE, Lu H. The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system. Exp. Rev. Clin. Pharm. 4 (2), 275-289 (2011).
    • (2011) Exp. Rev. Clin. Pharm. , vol.4 , Issue.2 , pp. 275-289
    • Engel, A.L.1    Holt, G.E.2    Lu, H.3
  • 22
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, Kaisho T, Takeuchi O. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3 (2), 196-200 (2002).
    • (2002) Nat. Immunol. , vol.3 , Issue.2 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3
  • 23
    • 0036735155 scopus 로고    scopus 로고
    • Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
    • Applequist SE, Wallin RP, Ljunggren HG. Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int. Immunol. 14 (9), 1065-1074 (2002).
    • (2002) Int. Immunol. , vol.14 , Issue.9 , pp. 1065-1074
    • Applequist, S.E.1    Wallin, R.P.2    Ljunggren, H.G.3
  • 24
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168 (9), 4531-4537 (2002).
    • (2002) J. Immunol. , vol.168 , Issue.9 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 25
    • 0037738569 scopus 로고    scopus 로고
    • Toll-like receptor expression in murine DC subsets: Lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines
    • Edwards AD, Diebold SS, Slack EM. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33 (4), 827-833 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , Issue.4 , pp. 827-833
    • Edwards, A.D.1    Diebold, S.S.2    Slack, E.M.3
  • 26
    • 84864818532 scopus 로고    scopus 로고
    • Type i IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms
    • Poovassery JS, Bishop GA. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J. Immunol. 189 (4), 1757-1764 (2012).
    • (2012) J. Immunol. , vol.189 , Issue.4 , pp. 1757-1764
    • Poovassery, J.S.1    Bishop, G.A.2
  • 27
    • 84880087672 scopus 로고    scopus 로고
    • B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection
    • Clingan JM, Matloubian M. B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J. Immunol. 191 (2), 810-818 (2013).
    • (2013) J. Immunol. , vol.191 , Issue.2 , pp. 810-818
    • Clingan, J.M.1    Matloubian, M.2
  • 28
    • 15444364398 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type i IFN
    • Bekeredjian-Ding IB, Wagner M, Hornung V. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J. Immunol. 174 (7), 4043-4050 (2005).
    • (2005) J. Immunol. , vol.174 , Issue.7 , pp. 4043-4050
    • Bekeredjian-Ding, I.B.1    Wagner, M.2    Hornung, V.3
  • 31
    • 58049206826 scopus 로고    scopus 로고
    • Crosstalk between components of the innate immune system: Promoting anti-microbial defenses and avoiding immunopathologies
    • Crozat K, Vivier E, Dalod M. Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies. Immunol. Rev. 227 (1), 129-149 (2009).
    • (2009) Immunol. Rev. , vol.227 , Issue.1 , pp. 129-149
    • Crozat, K.1    Vivier, E.2    Dalod, M.3
  • 32
    • 67349245974 scopus 로고    scopus 로고
    • Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8
    • Janke M, Poth J, Wimmenauer V. Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. J. Allerg. Clin. Immunol. 123 (5), 1026-1033 (2009).
    • (2009) J. Allerg. Clin. Immunol. , vol.123 , Issue.5 , pp. 1026-1033
    • Janke, M.1    Poth, J.2    Wimmenauer, V.3
  • 33
    • 67449152234 scopus 로고    scopus 로고
    • Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes
    • Ablasser A, Poeck H, Anz D. Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes. J. Immunol. 182 (11), 6824-6833 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.11 , pp. 6824-6833
    • Ablasser, A.1    Poeck, H.2    Anz, D.3
  • 34
    • 50649093779 scopus 로고    scopus 로고
    • The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy
    • Smits EL, Ponsaerts P, Berneman ZN, Van Tendeloo VF. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 13 (8), 859-875 (2008).
    • (2008) Oncologist , vol.13 , Issue.8 , pp. 859-875
    • Smits, E.L.1    Ponsaerts, P.2    Berneman, Z.N.3    Van Tendeloo, V.F.4
  • 35
    • 74449089424 scopus 로고    scopus 로고
    • A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
    • Liu J, Xu C, Hsu LC, Luo Y, Xiang R, Chuang TH. A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition. Mol. Immunol. 47 (5), 1083-1090 (2010).
    • (2010) Mol. Immunol. , vol.47 , Issue.5 , pp. 1083-1090
    • Liu, J.1    Xu, C.2    Hsu, L.C.3    Luo, Y.4    Xiang, R.5    Chuang, T.H.6
  • 36
    • 33751565283 scopus 로고    scopus 로고
    • Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines
    • Gorden KK, Qiu X, Battiste JJ, Wightman PP, Vasilakos JP, Alkan SS. Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. J. Immunol. 177 (11), 8164-8170 (2006).
    • (2006) J. Immunol. , vol.177 , Issue.11 , pp. 8164-8170
    • Gorden, K.K.1    Qiu, X.2    Battiste, J.J.3    Wightman, P.P.4    Vasilakos, J.P.5    Alkan, S.S.6
  • 37
    • 68349131723 scopus 로고    scopus 로고
    • Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1
    • Meier A, Chang JJ, Chan ES. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat. Med. 15 (8), 955-959 (2009).
    • (2009) Nat. Med. , vol.15 , Issue.8 , pp. 955-959
    • Meier, A.1    Chang, J.J.2    Chan, E.S.3
  • 38
    • 84863090280 scopus 로고    scopus 로고
    • Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males
    • Torcia MG, Nencioni L, Clemente AM. Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males. PLoS ONE 7 (6), e39853 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.6 , pp. e39853
    • Torcia, M.G.1    Nencioni, L.2    Clemente, A.M.3
  • 40
    • 84855857588 scopus 로고    scopus 로고
    • The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling
    • Seillet C, Laffont S, Tremollieres F. The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling. Blood 119 (2), 454-464 (2012).
    • (2012) Blood , vol.119 , Issue.2 , pp. 454-464
    • Seillet, C.1    Laffont, S.2    Tremollieres, F.3
  • 41
    • 84884209596 scopus 로고    scopus 로고
    • TLR7 expression is decreased during tumour progression in transgenic adenocarcinoma of mouse prostate mice and its activation inhibits growth of prostate cancer cells
    • Han JH, Park SY, Kim JB. TLR7 expression is decreased during tumour progression in transgenic adenocarcinoma of mouse prostate mice and its activation inhibits growth of prostate cancer cells. Am. J. Reprod. Immunol. 70 (4), 317-326 (2013).
    • (2013) Am. J. Reprod. Immunol. , vol.70 , Issue.4 , pp. 317-326
    • Han, J.H.1    Park, S.Y.2    Kim, J.B.3
  • 42
    • 84905859552 scopus 로고    scopus 로고
    • Stimulation of the endosomal TLR pathway enhances autophagy-induced cell death in radiotherapy of breast cancer
    • Kang S-J, Tak J-H, Cho J-H, Lee H-J, Jung Y-J. Stimulation of the endosomal TLR pathway enhances autophagy-induced cell death in radiotherapy of breast cancer. Genes Genomics 32 (6), 599-606 (2010).
    • (2010) Genes Genomics , vol.32 , Issue.6 , pp. 599-606
    • Kang, S.-J.1    Tak, J.-H.2    Cho, J.-H.3    Lee, H.-J.4    Jung, Y.-J.5
  • 43
    • 77951196379 scopus 로고    scopus 로고
    • Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    • Cherfils-Vicini J, Platonova S, Gillard M. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J. Clin. Invest. 120 (4), 1285-1297 (2010).
    • (2010) J. Clin. Invest. , vol.120 , Issue.4 , pp. 1285-1297
    • Cherfils-Vicini, J.1    Platonova, S.2    Gillard, M.3
  • 44
    • 84868627145 scopus 로고    scopus 로고
    • Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans
    • Ochi A, Graffeo CS, Zambirinis CP. Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. J. Clin. Invest. 122 (11), 4118-4129 (2012).
    • (2012) J. Clin. Invest. , vol.122 , Issue.11 , pp. 4118-4129
    • Ochi, A.1    Graffeo, C.S.2    Zambirinis, C.P.3
  • 45
    • 34248204151 scopus 로고    scopus 로고
    • Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder
    • Smith EB, Schwartz M, Kawamoto H. Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder. J. Urol. 177 (6), 2347-2351 (2007).
    • (2007) J. Urol. , vol.177 , Issue.6 , pp. 2347-2351
    • Smith, E.B.1    Schwartz, M.2    Kawamoto, H.3
  • 46
    • 21844442818 scopus 로고    scopus 로고
    • Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod
    • Spaner DE, Miller RL, Mena J, Grossman L, Sorrenti V, Shi Y. Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod. Leuk. Lymphom. 46 (6), 935-939 (2005).
    • (2005) Leuk. Lymphom. , vol.46 , Issue.6 , pp. 935-939
    • Spaner, D.E.1    Miller, R.L.2    Mena, J.3    Grossman, L.4    Sorrenti, V.5    Shi, Y.6
  • 47
    • 70350116951 scopus 로고    scopus 로고
    • The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells
    • Smits EL, Cools N, Lion E. The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells. Cancer Immunol. Immunother. 59 (1), 35-46 (2010).
    • (2010) Cancer Immunol. Immunother. , vol.59 , Issue.1 , pp. 35-46
    • Smits, E.L.1    Cools, N.2    Lion, E.3
  • 48
    • 84872350340 scopus 로고    scopus 로고
    • Regulation of TLR7/9 signaling in plasmacytoid dendritic cells
    • Bao M, Liu YJ. Regulation of TLR7/9 signaling in plasmacytoid dendritic cells. Protein Cell 4 (1), 40-52 (2013).
    • (2013) Protein Cell , vol.4 , Issue.1 , pp. 40-52
    • Bao, M.1    Liu, Y.J.2
  • 49
    • 33847260278 scopus 로고    scopus 로고
    • Heat shock protein gp96 is a master chaperone for Toll-like receptors and is important in the innate function of macrophages
    • Yang Y, Liu B, Dai J. Heat shock protein gp96 is a master chaperone for Toll-like receptors and is important in the innate function of macrophages. Immunity 26 (2), 215-226 (2007).
    • (2007) Immunity , vol.26 , Issue.2 , pp. 215-226
    • Yang, Y.1    Liu, B.2    Dai, J.3
  • 50
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing Toll-like receptors to endolysosomes
    • Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing Toll-like receptors to endolysosomes. Nature 452 (7184), 234-238 (2008).
    • (2008) Nature , vol.452 , Issue.7184 , pp. 234-238
    • Kim, Y.M.1    Brinkmann, M.M.2    Paquet, M.E.3    Ploegh, H.L.4
  • 51
    • 79955743119 scopus 로고    scopus 로고
    • Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    • Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J. Exp. Med. 208 (4), 643-651 (2011).
    • (2011) J. Exp. Med. , vol.208 , Issue.4 , pp. 643-651
    • Ewald, S.E.1    Engel, A.2    Lee, J.3    Wang, M.4    Bogyo, M.5    Barton, G.M.6
  • 52
    • 0034725584 scopus 로고    scopus 로고
    • Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells
    • Li L, Cousart S, Hu J, McCall CE. Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J. Biol. Chem. 275 (30), 23340-23345 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.30 , pp. 23340-23345
    • Li, L.1    Cousart, S.2    Hu, J.3    McCall, C.E.4
  • 53
    • 77953714711 scopus 로고    scopus 로고
    • Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
    • Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 465 (7300), 885-890 (2010).
    • (2010) Nature , vol.465 , Issue.7300 , pp. 885-890
    • Lin, S.C.1    Lo, Y.C.2    Wu, H.3
  • 54
    • 5444274514 scopus 로고    scopus 로고
    • Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    • Kawai T, Sato S, Ishii KJ. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5 (10), 1061-1068 (2004).
    • (2004) Nat. Immunol. , vol.5 , Issue.10 , pp. 1061-1068
    • Kawai, T.1    Sato, S.2    Ishii, K.J.3
  • 55
    • 0033580466 scopus 로고    scopus 로고
    • The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
    • Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398 (6724), 252-256 (1999).
    • (1999) Nature , vol.398 , Issue.6724 , pp. 252-256
    • Ninomiya-Tsuji, J.1    Kishimoto, K.2    Hiyama, A.3    Inoue, J.4    Cao, Z.5    Matsumoto, K.6
  • 56
    • 2342629277 scopus 로고    scopus 로고
    • The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    • Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell. 14 (3), 289-301 (2004).
    • (2004) Mol. Cell. , vol.14 , Issue.3 , pp. 289-301
    • Sun, L.1    Deng, L.2    Ea, C.K.3    Xia, Z.P.4    Chen, Z.J.5
  • 57
    • 0035164415 scopus 로고    scopus 로고
    • Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity
    • Zhang G, Ghosh S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J. Clin. Invest. 107 (1), 13-19 (2001).
    • (2001) J. Clin. Invest. , vol.107 , Issue.1 , pp. 13-19
    • Zhang, G.1    Ghosh, S.2
  • 58
    • 12444341806 scopus 로고    scopus 로고
    • Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8
    • Gorden KB, Gorski KS, Gibson SJ. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J. Immunol. 174 (3), 1259-1268 (2005).
    • (2005) J. Immunol. , vol.174 , Issue.3 , pp. 1259-1268
    • Gorden, K.B.1    Gorski, K.S.2    Gibson, S.J.3
  • 59
    • 84856521363 scopus 로고    scopus 로고
    • Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
    • Drobits B, Holcmann M, Amberg N. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J. Clin. Invest. 122 (2), 575-585 (2012).
    • (2012) J. Clin. Invest. , vol.122 , Issue.2 , pp. 575-585
    • Drobits, B.1    Holcmann, M.2    Amberg, N.3
  • 60
    • 4143061382 scopus 로고    scopus 로고
    • Imiquimod treatment induces expression of opioid growth factor receptor: A novel tumor antigen induced by interferon-alpha? Clin
    • Urosevic M, Oberholzer PA, Maier T. Imiquimod treatment induces expression of opioid growth factor receptor: a novel tumor antigen induced by interferon-alpha? Clin. Cancer Res. 10 (15), 4959-4970 (2004).
    • (2004) Cancer Res. , vol.10 , Issue.15 , pp. 4959-4970
    • Urosevic, M.1    Oberholzer, P.A.2    Maier, T.3
  • 61
    • 84887494213 scopus 로고    scopus 로고
    • Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type i IFN secretion
    • Tel J, Sittig SP, Blom RA. Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion. J. Immunol. 191 (10), 5005-5012 (2013).
    • (2013) J. Immunol. , vol.191 , Issue.10 , pp. 5005-5012
    • Tel, J.1    Sittig, S.P.2    Blom, R.A.3
  • 62
    • 16244374662 scopus 로고    scopus 로고
    • Enhanced type i interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimod
    • Wenzel J, Uerlich M, Haller O, Bieber T, Tueting T. Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimod. J. Cut. Pathol. 32 (4), 257-262 (2005).
    • (2005) J. Cut. Pathol. , vol.32 , Issue.4 , pp. 257-262
    • Wenzel, J.1    Uerlich, M.2    Haller, O.3    Bieber, T.4    Tueting, T.5
  • 63
    • 84870249921 scopus 로고    scopus 로고
    • Intratracheal and oral administration of SM-276001: A selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer
    • Koga-Yamakawa E, Dovedi SJ, Murata M. Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer. Int. J. Cancer 132 (3), 580-590 (2013).
    • (2013) Int. J. Cancer , vol.132 , Issue.3 , pp. 580-590
    • Koga-Yamakawa, E.1    Dovedi, S.J.2    Murata, M.3
  • 64
    • 77950490375 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cell-derived type i interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists
    • Rajagopal D, Paturel C, Morel Y, Uematsu S, Akira S, Diebold SS. Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Blood 115 (10), 1949-1957 (2010).
    • (2010) Blood , vol.115 , Issue.10 , pp. 1949-1957
    • Rajagopal, D.1    Paturel, C.2    Morel, Y.3    Uematsu, S.4    Akira, S.5    Diebold, S.S.6
  • 65
    • 42549128230 scopus 로고    scopus 로고
    • TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type i IFN
    • Inglefield JR, Dumitru CD, Alkan SS. TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN. J. Interferon Cytokine Res. 28 (4), 253-263 (2008).
    • (2008) J. Interferon Cytokine Res. , vol.28 , Issue.4 , pp. 253-263
    • Inglefield, J.R.1    Dumitru, C.D.2    Alkan, S.S.3
  • 66
    • 84881401720 scopus 로고    scopus 로고
    • Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment
    • Le Mercier I, Poujol D, Sanlaville A. Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment. Cancer Res. 73 (15), 4629-4640 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.15 , pp. 4629-4640
    • Le Mercier, I.1    Poujol, D.2    Sanlaville, A.3
  • 67
    • 84893804974 scopus 로고    scopus 로고
    • Direct type i IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation
    • Pantel A, Teixeira A, Haddad E, Wood EG, Steinman RM, Longhi MP. Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 12 (1), e1001759 (2014).
    • (2014) PLoS Biol. , vol.12 , Issue.1 , pp. e1001759
    • Pantel, A.1    Teixeira, A.2    Haddad, E.3    Wood, E.G.4    Steinman, R.M.5    Longhi, M.P.6
  • 68
    • 0037013830 scopus 로고    scopus 로고
    • Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
    • Ito T, Amakawa R, Kaisho T. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195 (11), 1507-1512 (2002).
    • (2002) J. Exp. Med. , vol.195 , Issue.11 , pp. 1507-1512
    • Ito, T.1    Amakawa, R.2    Kaisho, T.3
  • 69
    • 84872469382 scopus 로고    scopus 로고
    • + T cells despite lower Ag uptake than myeloid dendritic cell subsets
    • + T cells despite lower Ag uptake than myeloid dendritic cell subsets. Blood 121 (3), 459-467 (2013).
    • (2013) Blood , vol.121 , Issue.3 , pp. 459-467
    • Tel, J.1    Schreibelt, G.2    Sittig, S.P.3
  • 70
    • 80052679448 scopus 로고    scopus 로고
    • Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission
    • Beck B, Dorfel D, Lichtenegger FS. Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission. J. Transl. Med. 9, 151 (2011).
    • (2011) J. Transl. Med. , vol.9 , pp. 151
    • Beck, B.1    Dorfel, D.2    Lichtenegger, F.S.3
  • 71
    • 0345447557 scopus 로고    scopus 로고
    • Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation
    • Nair S, McLaughlin C, Weizer A. Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation. J. Immunol. 171 (11), 6275-6282 (2003).
    • (2003) J. Immunol. , vol.171 , Issue.11 , pp. 6275-6282
    • Nair, S.1    McLaughlin, C.2    Weizer, A.3
  • 72
    • 29644446061 scopus 로고    scopus 로고
    • The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: Relation to central nervous system antitumor immunity
    • Prins RM, Craft N, Bruhn KW. The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. J. Immunol. 176 (1), 157-164 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.1 , pp. 157-164
    • Prins, R.M.1    Craft, N.2    Bruhn, K.W.3
  • 73
    • 84872609726 scopus 로고    scopus 로고
    • Synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer
    • Hong X, Dong T, Hu J. Synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer. Int. J. Col. Dis. 28 (1), 25-33 (2013).
    • (2013) Int. J. Col. Dis. , vol.28 , Issue.1 , pp. 25-33
    • Hong, X.1    Dong, T.2    Hu, J.3
  • 74
    • 84899073975 scopus 로고    scopus 로고
    • Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205
    • Dhodapkar MV, Sznol M, Zhao B. Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Sci. Transl. Med. 6 (232), 232ra251 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , Issue.232 , pp. 232ra251
    • Dhodapkar, M.V.1    Sznol, M.2    Zhao, B.3
  • 75
    • 84906078348 scopus 로고    scopus 로고
    • Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8 T-cell cross-priming
    • Fehres CM, Bruijns SC, Van Beelen AJ. Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8 T-cell cross-priming. Eur. J. Immunol. 44 (8), 2145-2124 (2014).
    • (2014) Eur. J. Immunol. , vol.44 , Issue.8 , pp. 2145-2124
    • Fehres, C.M.1    Bruijns, S.C.2    Van Beelen, A.J.3
  • 76
    • 34250324345 scopus 로고    scopus 로고
    • Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
    • Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J. Exp. Med. 204 (6), 1441-1451 (2007).
    • (2007) J. Exp. Med. , vol.204 , Issue.6 , pp. 1441-1451
    • Stary, G.1    Bangert, C.2    Tauber, M.3    Strohal, R.4    Kopp, T.5    Stingl, G.6
  • 77
    • 84856939962 scopus 로고    scopus 로고
    • TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: Mechanisms of imiquimod-and IFN-alpha-mediated antitumor reactivity
    • Kalb ML, Glaser A, Stary G, Koszik F, Stingl G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod-and IFN-alpha-mediated antitumor reactivity. J. Immunol. 188 (4), 1583-1591 (2012).
    • (2012) J. Immunol. , vol.188 , Issue.4 , pp. 1583-1591
    • Kalb, M.L.1    Glaser, A.2    Stary, G.3    Koszik, F.4    Stingl, G.5
  • 78
    • 77954229780 scopus 로고    scopus 로고
    • Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7
    • Bourquin C, Schmidt L, Lanz AL. Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7. J. Immunol. 183 (10), 6078-6086 (2009).
    • (2009) J. Immunol. , vol.183 , Issue.10 , pp. 6078-6086
    • Bourquin, C.1    Schmidt, L.2    Lanz, A.L.3
  • 79
    • 77951603998 scopus 로고    scopus 로고
    • Treatment with imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination
    • Chuang CM, Monie A, Hung CF, Wu TC. Treatment with imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination. J. Biomed. Sci. 17, 32 (2010).
    • (2010) J. Biomed. Sci. , vol.17 , pp. 32
    • Chuang, C.M.1    Monie, A.2    Hung, C.F.3    Wu, T.C.4
  • 80
    • 59449092855 scopus 로고    scopus 로고
    • NK1.1+ cells mediate the antitumor effects of a dual Toll-like receptor 7/8 agonist in the disseminated B16-F10 melanoma model
    • Dumitru CD, Antonysamy MA, Gorski KS. NK1.1+ cells mediate the antitumor effects of a dual Toll-like receptor 7/8 agonist in the disseminated B16-F10 melanoma model. Cancer Immunol. Immunother. 58 (4), 575-587 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , Issue.4 , pp. 575-587
    • Dumitru, C.D.1    Antonysamy, M.A.2    Gorski, K.S.3
  • 81
    • 70450200218 scopus 로고    scopus 로고
    • Cancer immunotherapeutic potential of novel small molecule TLR7 and TLR8 agonists
    • Hamm S, Rath S, Michel S, Baumgartner R. Cancer immunotherapeutic potential of novel small molecule TLR7 and TLR8 agonists. J. Immunotoxicol. 6 (4), 257-265 (2009).
    • (2009) J. Immunotoxicol. , vol.6 , Issue.4 , pp. 257-265
    • Hamm, S.1    Rath, S.2    Michel, S.3    Baumgartner, R.4
  • 82
    • 35748972931 scopus 로고    scopus 로고
    • Synthetic imidazoquinolines potently and broadly activate the cellular immune response of patients with cutaneous T-cell lymphoma: Synergy with interferon-gamma enhances production of interleukin-12
    • Wysocka M, Newton S, Benoit BM. Synthetic imidazoquinolines potently and broadly activate the cellular immune response of patients with cutaneous T-cell lymphoma: synergy with interferon-gamma enhances production of interleukin-12. Clin. Lymphoma Myeloma 7 (8), 524-534 (2007).
    • (2007) Clin. Lymphoma Myeloma , vol.7 , Issue.8 , pp. 524-534
    • Wysocka, M.1    Newton, S.2    Benoit, B.M.3
  • 83
    • 79251554653 scopus 로고    scopus 로고
    • The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma
    • Grela F, Aumeunier A, Bardel E. The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma. J. Immunol. 186 (1), 284-290 (2011).
    • (2011) J. Immunol. , vol.186 , Issue.1 , pp. 284-290
    • Grela, F.1    Aumeunier, A.2    Bardel, E.3
  • 84
    • 38949100471 scopus 로고    scopus 로고
    • An exploratory study of systemic administration of the Toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
    • Dummer R, Hauschild A, Becker JC. An exploratory study of systemic administration of the Toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin. Cancer Res. 14 (3), 856-864 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.3 , pp. 856-864
    • Dummer, R.1    Hauschild, A.2    Becker, J.C.3
  • 85
    • 79959545223 scopus 로고    scopus 로고
    • Phase i study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients
    • Morse MA, Chapman R, Powderly J. Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients. Clin. Cancer Res. 17 (14), 4844-4853 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.14 , pp. 4844-4853
    • Morse, M.A.1    Chapman, R.2    Powderly, J.3
  • 86
    • 70350068545 scopus 로고    scopus 로고
    • Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin
    • Huang SJ, Hijnen D, Murphy GF. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J. Invest. Dermatol. 129 (11), 2676-2685 (2009).
    • (2009) J. Invest. Dermatol. , vol.129 , Issue.11 , pp. 2676-2685
    • Huang, S.J.1    Hijnen, D.2    Murphy, G.F.3
  • 87
    • 77954514970 scopus 로고    scopus 로고
    • Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade
    • Lu H, Wagner WM, Gad E. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J. Immunol. 184 (9), 5360-5367 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.9 , pp. 5360-5367
    • Lu, H.1    Wagner, W.M.2    Gad, E.3
  • 88
    • 84856080674 scopus 로고    scopus 로고
    • Immunomodulation by imiquimod in patients with high-risk primary melanoma
    • Narayan R, Nguyen H, Bentow JJ. Immunomodulation by imiquimod in patients with high-risk primary melanoma. J. Invest. Dermatol. 132 (1), 163-169 (2012).
    • (2012) J. Invest. Dermatol. , vol.132 , Issue.1 , pp. 163-169
    • Narayan, R.1    Nguyen, H.2    Bentow, J.J.3
  • 89
    • 79953065996 scopus 로고    scopus 로고
    • Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors
    • Xiong Z, Ohlfest JR. Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors. J. Immunother. 34 (3), 264-269 (2011).
    • (2011) J. Immunother. , vol.34 , Issue.3 , pp. 264-269
    • Xiong, Z.1    Ohlfest, J.R.2
  • 90
    • 78149281913 scopus 로고    scopus 로고
    • Delivery of immunostimulatory RNA oligonucleotides by gelatin nanoparticles triggers an efficient antitumoral response
    • Bourquin C, Wurzenberger C, Heidegger S. Delivery of immunostimulatory RNA oligonucleotides by gelatin nanoparticles triggers an efficient antitumoral response. J. Immunother. 33 (9), 935-944 (2010).
    • (2010) J. Immunother. , vol.33 , Issue.9 , pp. 935-944
    • Bourquin, C.1    Wurzenberger, C.2    Heidegger, S.3
  • 91
    • 84861787202 scopus 로고    scopus 로고
    • Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immunosuppressive cells
    • Dang Y, Wagner WM, Gad E. Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immunosuppressive cells. Clin. Cancer Res. 18 (11), 3122-3131 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.11 , pp. 3122-3131
    • Dang, Y.1    Wagner, W.M.2    Gad, E.3
  • 92
    • 33947607799 scopus 로고    scopus 로고
    • Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response
    • Bourquin C, Schmidt L, Hornung V. Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response. Blood 109 (7), 2953-2960 (2007).
    • (2007) Blood , vol.109 , Issue.7 , pp. 2953-2960
    • Bourquin, C.1    Schmidt, L.2    Hornung, V.3
  • 94
    • 66949170320 scopus 로고    scopus 로고
    • Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy
    • Broomfield SA, Van Der Most RG, Prosser AC. Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy. J. Immunol. 182 (9), 5217-5224 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.9 , pp. 5217-5224
    • Broomfield, S.A.1    Van Der Most, R.G.2    Prosser, A.C.3
  • 95
    • 77957680668 scopus 로고    scopus 로고
    • The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice
    • Ma F, Zhang J, Zhang J, Zhang C. The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cell. Mol. Immunol. 7 (5), 381-388 (2010).
    • (2010) Cell. Mol. Immunol. , vol.7 , Issue.5 , pp. 381-388
    • Ma, F.1    Zhang, J.2    Zhang, J.3    Zhang, C.4
  • 96
    • 84871121537 scopus 로고    scopus 로고
    • A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin
    • Fiorenza S, Kenna TJ, Comerford I. A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin. J. Immunol. 189 (12), 5622-5631 (2012).
    • (2012) J. Immunol. , vol.189 , Issue.12 , pp. 5622-5631
    • Fiorenza, S.1    Kenna, T.J.2    Comerford, I.3
  • 97
    • 53349153303 scopus 로고    scopus 로고
    • Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    • Clark RA, Huang SJ, Murphy GF. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J. Exp. Med. 205 (10), 2221-2234 (2008).
    • (2008) J. Exp. Med. , vol.205 , Issue.10 , pp. 2221-2234
    • Clark, R.A.1    Huang, S.J.2    Murphy, G.F.3
  • 98
    • 79955488983 scopus 로고    scopus 로고
    • Adjuvant combination and antigen targeting as a strategy to induce polyfunctional and high-avidity T-cell responses against poorly immunogenic tumors
    • Aranda F, Llopiz D, Diaz-Valdes N. Adjuvant combination and antigen targeting as a strategy to induce polyfunctional and high-avidity T-cell responses against poorly immunogenic tumors. Cancer Res. 71 (9), 3214-3224 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.9 , pp. 3214-3224
    • Aranda, F.1    Llopiz, D.2    Diaz-Valdes, N.3
  • 99
    • 34247139249 scopus 로고    scopus 로고
    • Transcutaneous immunization with imiquimod is amplified by CD40 ligation and results in sustained cytotoxic T-lymphocyte activation and tumor protection
    • Warger T, Rechtsteiner G, Schmid B, Osterloh P, Schild H, Radsak MP. Transcutaneous immunization with imiquimod is amplified by CD40 ligation and results in sustained cytotoxic T-lymphocyte activation and tumor protection. Clin. Rev. Allerg. Immunol. 32 (1), 57-66 (2007).
    • (2007) Clin. Rev. Allerg. Immunol. , vol.32 , Issue.1 , pp. 57-66
    • Warger, T.1    Rechtsteiner, G.2    Schmid, B.3    Osterloh, P.4    Schild, H.5    Radsak, M.P.6
  • 100
    • 78650640612 scopus 로고    scopus 로고
    • Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity
    • Fotin-Mleczek M, Duchardt KM, Lorenz C. Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J. Immunother. 34 (1), 1-15 (2011).
    • (2011) J. Immunother. , vol.34 , Issue.1 , pp. 1-15
    • Fotin-Mleczek, M.1    Duchardt, K.M.2    Lorenz, C.3
  • 101
    • 47949129948 scopus 로고    scopus 로고
    • Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
    • Adams S, O'Neill DW, Nonaka D. Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J. Immunol. 181 (1), 776-784 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.1 , pp. 776-784
    • Adams, S.1    O'Neill, D.W.2    Nonaka, D.3
  • 102
    • 0034669965 scopus 로고    scopus 로고
    • Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848
    • Bishop GA, Hsing Y, Hostager BS, Jalukar SV, Ramirez LM, Tomai MA. Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848. J. Immunol. 165 (10), 5552-5557 (2000).
    • (2000) J. Immunol. , vol.165 , Issue.10 , pp. 5552-5557
    • Bishop, G.A.1    Hsing, Y.2    Hostager, B.S.3    Jalukar, S.V.4    Ramirez, L.M.5    Tomai, M.A.6
  • 103
  • 104
    • 68149126174 scopus 로고    scopus 로고
    • Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop
    • Green NM, Laws A, Kiefer K. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J. Immunol. 183 (3), 1569-1576 (2009).
    • (2009) J. Immunol. , vol.183 , Issue.3 , pp. 1569-1576
    • Green, N.M.1    Laws, A.2    Kiefer, K.3
  • 105
    • 33847702017 scopus 로고    scopus 로고
    • Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents
    • Shi Y, White D, He L, Miller RL, Spaner DE. Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents. Cancer Res. 67 (4), 1823-1831 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.4 , pp. 1823-1831
    • Shi, Y.1    White, D.2    He, L.3    Miller, R.L.4    Spaner, D.E.5
  • 106
    • 84877766547 scopus 로고    scopus 로고
    • Effects of Toll-like receptor 7 and Toll-like receptor 9 signaling stimulators and inhibitors on chronic lymphocytic leukemia cells ex vivo and their interactions with cladribine
    • Wolska A, Cebula-Obrzut B, Smolewski P, Robak T. Effects of Toll-like receptor 7 and Toll-like receptor 9 signaling stimulators and inhibitors on chronic lymphocytic leukemia cells ex vivo and their interactions with cladribine. Leuk. Lymph. 54 (6), 1268-1278 (2013).
    • (2013) Leuk. Lymph. , vol.54 , Issue.6 , pp. 1268-1278
    • Wolska, A.1    Cebula-Obrzut, B.2    Smolewski, P.3    Robak, T.4
  • 107
    • 31444457097 scopus 로고    scopus 로고
    • Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells
    • Spaner DE, Shi Y, White D. Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells. Leukemia 20 (2), 286-295 (2006).
    • (2006) Leukemia , vol.20 , Issue.2 , pp. 286-295
    • Spaner, D.E.1    Shi, Y.2    White, D.3
  • 108
    • 77953435969 scopus 로고    scopus 로고
    • Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8
    • Wang D, Precopio M, Lan T. Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8. Mol. Cancer Ther. 9 (6), 1788-1797 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.6 , pp. 1788-1797
    • Wang, D.1    Precopio, M.2    Lan, T.3
  • 109
    • 72249091840 scopus 로고    scopus 로고
    • Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells
    • Shojaei H, Oberg HH, Juricke M. Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells. Cancer Res. 69 (22), 8710-8717 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.22 , pp. 8710-8717
    • Shojaei, H.1    Oberg, H.H.2    Juricke, M.3
  • 110
    • 84902270524 scopus 로고    scopus 로고
    • A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models
    • Adlard AL, Dovedi SJ, Telfer BA. A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int. J. Cancer 135 (4), 820-829 (2014).
    • (2014) Int. J. Cancer , vol.135 , Issue.4 , pp. 820-829
    • Adlard, A.L.1    Dovedi, S.J.2    Telfer, B.A.3
  • 111
    • 84871230007 scopus 로고    scopus 로고
    • Synergy of topical Toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
    • Dewan MZ, Vanpouille-Box C, Kawashima N. Synergy of topical Toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer. Clin. Cancer Res. 18 (24), 6668-6678 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.24 , pp. 6668-6678
    • Dewan, M.Z.1    Vanpouille-Box, C.2    Kawashima, N.3
  • 112
    • 84872328340 scopus 로고    scopus 로고
    • Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma
    • Dovedi SJ, Melis MH, Wilkinson RW. Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma. Blood 121 (2), 251-259 (2013).
    • (2013) Blood , vol.121 , Issue.2 , pp. 251-259
    • Dovedi, S.J.1    Melis, M.H.2    Wilkinson, R.W.3
  • 114
    • 84878276077 scopus 로고    scopus 로고
    • GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
    • 1517.e1-10
    • Lanford RE, Guerra B, Chavez D. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology (7), 1508-1517,. 1517.e1-10 (2013).
    • (2013) Gastroenterology , Issue.7 , pp. 1508-1517
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.3


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