Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9409-9419

  Ciciani, Giovanna ^a   Coronnello, Marcella ^b   Guerrini, Gabriella ^a   Selleri, Silvia ^a   Cantore, Miriam ^b   Failli, Paola ^b   Mini, Enrico ^b   Costanzo, Annarella ^a  

^a Laboratorio di Progettazione   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antitumor activity; Pyrazole derivatives; Pyrazolo 51 c 1,2,4 benzotriazine; Pyrazolo 51 c pyrido 4,3 e 1,2,4 triazine; Tricyclic heteroaromatic system

Indexed keywords

8 (4 METHYLPIPERAZIN 1 YL) 3 NITROPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 8 (4 METHYLPIPERAZIN 1 YL) 3 PHENYLPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; CYTOTOXIC AGENT; PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE; PYRAZOLO[5,1 C]PYRIDO[4,3 E][1,2,4]TRIAZINE; REACTIVE OXYGEN METABOLITE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA; IC 50;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL HYPOXIA; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; OXYGEN; PYRAZOLES; REACTIVE OXYGEN SPECIES; TRIAZINES; TUMOR CELLS, CULTURED;

HUMAN ECHOVIRUS 1;

EID: 53749085954     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.055     Document Type: Article

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