11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 4, 2004, Pages 795-806

  Ruchelman, Alexander L ^a   Singh, Sudhir K ^a   Ray, Abhijit ^a   Wu, Xiaohua ^a,b   Yang, Jin Ming ^b   Zhou, Nai ^c   Liu, Angela ^c   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11 [(2 DIMETHYLAMINO)ETHYL] 2,3 DIMETHOXY 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 11 [(2 DIMETHYLAMINO)ETHYL] 2,3 DIMETHOXY 9 NITRO 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIBENZO[C,H]CINNOLINE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 (2 TETRAHYDROFURANYL)METHYL 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 BUTYL 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 [(2 DIETHYLAMINO)ETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 [(2 DIMETHYLAMINO) 1 METHYLETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 [(2 DIMETHYLAMINO)ETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 [2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 [2 (PIPERIDIN 1 YL)ETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXY 11 [2 (PYRROLIDIN 1 YL)ETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; 8,9 METHYLENEDIOXY 11 [2 (N,N DIMETHYLAMINO)ETHYL] 11H ISOQUINO[4,3 C]CINNOLIN 12 ONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; HYDROGEN; METHYL GROUP; NITRO DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CANCER INHIBITION; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; NUDE MOUSE; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

MUS MUSCULUS;

EID: 0842265849     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.061     Document Type: Article

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