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Volumn 440, Issue , 2015, Pages 79-86

PCSK9 and its modulation

Author keywords

Dyslipidemia; Low density lipoprotein cholesterol; Proprotein convertase subtilisin kexin type 9; Review

Indexed keywords

ALIROCUMAB; ANTISENSE OLIGONUCLEOTIDE; BERBERINE; CHINESE DRUG; COMPACTIN; ESTROGEN; EVOLOCUMAB; EZETIMIBE; FIBRIC ACID DERIVATIVE; FRUCTOSE; GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; PITAVASTATIN; PLACEBO; POLYUNSATURATED FATTY ACID; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; ROSUVASTATIN; SERINE PROTEINASE; SMALL INTERFERING RNA; STEROL; THIOCTIC ACID; THYROTROPIN; UNCLASSIFIED DRUG; XUEZHIKANG; AZETIDINE DERIVATIVE; CHOLESTEROL; HERBACEOUS AGENT; PCSK9 PROTEIN, HUMAN;

EID: 84913570284     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2014.10.044     Document Type: Review
Times cited : (31)

References (114)
  • 1
    • 82255173973 scopus 로고    scopus 로고
    • Inflammation in coronary artery diseases
    • Li J.J. Inflammation in coronary artery diseases. Chin Med J 2011, 124:3568-3575.
    • (2011) Chin Med J , vol.124 , pp. 3568-3575
    • Li, J.J.1
  • 2
    • 82955203309 scopus 로고    scopus 로고
    • Impact of 10mg rosuvastatin daily or alternate-day on lipid profile and inflammatory markers
    • Li J.J., Yang P., Liu J., et al. Impact of 10mg rosuvastatin daily or alternate-day on lipid profile and inflammatory markers. Clin Chim Acta 2012, 413(1-2):139-142.
    • (2012) Clin Chim Acta , vol.413 , Issue.1-2 , pp. 139-142
    • Li, J.J.1    Yang, P.2    Liu, J.3
  • 3
    • 0037417807 scopus 로고    scopus 로고
    • The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
    • Seidah N.G., Benjannet S., Wickham L., et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A 2003, 100:928-933.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wickham, L.3
  • 4
    • 84896694715 scopus 로고    scopus 로고
    • PCSK9 gene mutations and low-density lipoprotein cholesterol
    • Wu N.Q., Li J.J. PCSK9 gene mutations and low-density lipoprotein cholesterol. Clin Chim Acta 2014, 431:148-153.
    • (2014) Clin Chim Acta , vol.431 , pp. 148-153
    • Wu, N.Q.1    Li, J.J.2
  • 5
    • 84904872836 scopus 로고    scopus 로고
    • PCSK9 and lipid lowering drugs
    • Guo Y.L., Zhang W., Li J.J. PCSK9 and lipid lowering drugs. Clin Chim Acta 2014, 437C:66-71.
    • (2014) Clin Chim Acta , vol.437 C , pp. 66-71
    • Guo, Y.L.1    Zhang, W.2    Li, J.J.3
  • 6
    • 84897889156 scopus 로고    scopus 로고
    • PCSK9 a key modulator of cardiovascular health
    • Seidah N.G., Awan Z., Chretien M., Mbikay M. PCSK9 a key modulator of cardiovascular health. Circ Res 2014, 114:1022-1036.
    • (2014) Circ Res , vol.114 , pp. 1022-1036
    • Seidah, N.G.1    Awan, Z.2    Chretien, M.3    Mbikay, M.4
  • 7
    • 10344253854 scopus 로고    scopus 로고
    • NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    • Benjannet S., Rhainds D., Essalmani R., et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 2004, 279:48865-48875.
    • (2004) J Biol Chem , vol.279 , pp. 48865-48875
    • Benjannet, S.1    Rhainds, D.2    Essalmani, R.3
  • 8
    • 49649128629 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
    • Zaid A., Roubstsova A., Essalmani R., et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 2008, 48:646-654.
    • (2008) Hepatology , vol.48 , pp. 646-654
    • Zaid, A.1    Roubstsova, A.2    Essalmani, R.3
  • 9
    • 84900799894 scopus 로고    scopus 로고
    • PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day
    • Chen Y.Q., Troutt J.S., Konrad R.J. PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day. Lipids 2014, 49:445-455.
    • (2014) Lipids , vol.49 , pp. 445-455
    • Chen, Y.Q.1    Troutt, J.S.2    Konrad, R.J.3
  • 10
    • 84855964405 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels
    • Ferri N., Tibolla G., Pirillo A., et al. Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels. Atherosclerosis 2012, 220:381-386.
    • (2012) Atherosclerosis , vol.220 , pp. 381-386
    • Ferri, N.1    Tibolla, G.2    Pirillo, A.3
  • 12
    • 57649129016 scopus 로고    scopus 로고
    • Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels
    • Mayer G., Poirier S., Seidah N.G. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J Biol Chem 2008, 283:31791-31801.
    • (2008) J Biol Chem , vol.283 , pp. 31791-31801
    • Mayer, G.1    Poirier, S.2    Seidah, N.G.3
  • 13
    • 33750090075 scopus 로고    scopus 로고
    • The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications
    • Benjannet S., Rhainds D., Hamelin J., Nassoury N., Seidah N.G. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. J Biol Chem 2006, 281:30561-30572.
    • (2006) J Biol Chem , vol.281 , pp. 30561-30572
    • Benjannet, S.1    Rhainds, D.2    Hamelin, J.3    Nassoury, N.4    Seidah, N.G.5
  • 15
    • 79960270412 scopus 로고    scopus 로고
    • Regulation of proprotein convertase substilisin/kexin type 9: therapeutical perspectives
    • Chan D.C. Regulation of proprotein convertase substilisin/kexin type 9: therapeutical perspectives. Atherosclerosis 2011, 217:77-79.
    • (2011) Atherosclerosis , vol.217 , pp. 77-79
    • Chan, D.C.1
  • 16
    • 70449732531 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL apolipoprotein B-100 catabolism?
    • Chan D.C., Lambert G., Barrett P.H., Rye K.A., Ooi E.M., Watts G.F. Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL apolipoprotein B-100 catabolism?. Clin Chem 2009, 55:2049-2052.
    • (2009) Clin Chem , vol.55 , pp. 2049-2052
    • Chan, D.C.1    Lambert, G.2    Barrett, P.H.3    Rye, K.A.4    Ooi, E.M.5    Watts, G.F.6
  • 17
    • 73849114174 scopus 로고    scopus 로고
    • PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia
    • Cariou B., Ouguerram K., Zaïr Y., et al. PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia. Arterioscler Thromb Vasc Biol 2009, 29:2191-2197.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 2191-2197
    • Cariou, B.1    Ouguerram, K.2    Zaïr, Y.3
  • 18
    • 38949137409 scopus 로고    scopus 로고
    • Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression in sterol-regulatory element binding protein-2
    • Jeong H.J., Lee H.S., Kim K.S., Kim Y.K., Yoon D., Park S.W. Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression in sterol-regulatory element binding protein-2. J Lipid Res 2008, 49:399-409.
    • (2008) J Lipid Res , vol.49 , pp. 399-409
    • Jeong, H.J.1    Lee, H.S.2    Kim, K.S.3    Kim, Y.K.4    Yoon, D.5    Park, S.W.6
  • 19
    • 70350389729 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine
    • Li H., Dong B., Park S.W., Lee H.S., Chen W., Liu J. Hepatocyte nuclear factor 1 alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. J Biol Chem 2009, 284:28885-28895.
    • (2009) J Biol Chem , vol.284 , pp. 28885-28895
    • Li, H.1    Dong, B.2    Park, S.W.3    Lee, H.S.4    Chen, W.5    Liu, J.6
  • 20
    • 84860158835 scopus 로고    scopus 로고
    • The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells
    • Li H., Liu J. The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells. Biochem J 2012, 443:757-768.
    • (2012) Biochem J , vol.443 , pp. 757-768
    • Li, H.1    Liu, J.2
  • 21
    • 40349110828 scopus 로고    scopus 로고
    • Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes
    • Langhi C., Le May C., Kourimate S., et al. Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes. FEBS Lett 2008, 582:949-955.
    • (2008) FEBS Lett , vol.582 , pp. 949-955
    • Langhi, C.1    Le May, C.2    Kourimate, S.3
  • 22
    • 44349177547 scopus 로고    scopus 로고
    • Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9
    • Kourimate S., Le May C., Langhi C., et al. Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. J Biol Chem 2008, 283:9666-9673.
    • (2008) J Biol Chem , vol.283 , pp. 9666-9673
    • Kourimate, S.1    Le May, C.2    Langhi, C.3
  • 23
    • 33845955966 scopus 로고    scopus 로고
    • Activation of PPAR alpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2
    • König B., Koch A., Spielmann J., Hilgenfeld C., Stangl G.I., Eder K. Activation of PPAR alpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem Pharmacol 2007, 73:574-585.
    • (2007) Biochem Pharmacol , vol.73 , pp. 574-585
    • König, B.1    Koch, A.2    Spielmann, J.3    Hilgenfeld, C.4    Stangl, G.I.5    Eder, K.6
  • 24
    • 84863631048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression
    • Duan Y., Chen Y., Hu W., et al. Peroxisome proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. J Biol Chem 2012, 287:23667-23677.
    • (2012) J Biol Chem , vol.287 , pp. 23667-23677
    • Duan, Y.1    Chen, Y.2    Hu, W.3
  • 26
    • 63749121093 scopus 로고    scopus 로고
    • Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease
    • Abifadel M., Rabes J.P., Devillers M., et al. Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease. Hum Mutat 2009, 30:520-529.
    • (2009) Hum Mutat , vol.30 , pp. 520-529
    • Abifadel, M.1    Rabes, J.P.2    Devillers, M.3
  • 27
    • 29944443017 scopus 로고    scopus 로고
    • Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia
    • Allard D., Amsellem S., Abifadel M., et al. Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum Mutat 2005, 26:497.
    • (2005) Hum Mutat , vol.26 , pp. 497
    • Allard, D.1    Amsellem, S.2    Abifadel, M.3
  • 28
    • 80053432726 scopus 로고    scopus 로고
    • Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture
    • Mayne J., Dewpura T., Raymond A., et al. Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clin Chem 2011, 57:1415-1423.
    • (2011) Clin Chem , vol.57 , pp. 1415-1423
    • Mayne, J.1    Dewpura, T.2    Raymond, A.3
  • 29
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J., Pertsemlidis A., Kotowski I.K., Graham R., Garcia C.K., Hobbs H.H. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005, 37:161-165.
    • (2005) Nat Genet , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 30
    • 78651302317 scopus 로고    scopus 로고
    • The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    • Aung L.H., Yin R.X., Miao L., et al. The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis 2011, 10:5.
    • (2011) Lipids Health Dis , vol.10 , pp. 5
    • Aung, L.H.1    Yin, R.X.2    Miao, L.3
  • 31
    • 49949100564 scopus 로고    scopus 로고
    • Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
    • Polisecki E., Peter I., Robertson M., et al. Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis 2008, 200:95-101.
    • (2008) Atherosclerosis , vol.200 , pp. 95-101
    • Polisecki, E.1    Peter, I.2    Robertson, M.3
  • 32
    • 33344464808 scopus 로고    scopus 로고
    • A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
    • Kotowski I.K., Pertsemlidis A., Luke A., et al. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet 2006, 78:410-422.
    • (2006) Am J Hum Genet , vol.78 , pp. 410-422
    • Kotowski, I.K.1    Pertsemlidis, A.2    Luke, A.3
  • 33
    • 40949104944 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke
    • Abboud S., Karhunen P.J., Lütjohann D., et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke. PLoS One 2007, 2:e1043.
    • (2007) PLoS One , vol.2 , pp. e1043
    • Abboud, S.1    Karhunen, P.J.2    Lütjohann, D.3
  • 34
    • 73449143804 scopus 로고    scopus 로고
    • Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles
    • Norata G.D., Garlaschelli K., Grigore L., et al. Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis 2010, 208:177-182.
    • (2010) Atherosclerosis , vol.208 , pp. 177-182
    • Norata, G.D.1    Garlaschelli, K.2    Grigore, L.3
  • 35
    • 84901452665 scopus 로고    scopus 로고
    • Effect of E670G polymorphism in PCSK9 gene on the risk and severity of coronary heart disease and ischemic stroke in a Tunisian cohort
    • Slimani A., Harira Y., Trabelsi I., et al. Effect of E670G polymorphism in PCSK9 gene on the risk and severity of coronary heart disease and ischemic stroke in a Tunisian cohort. J Mol Neurosci 2014, 53(2):150-157.
    • (2014) J Mol Neurosci , vol.53 , Issue.2 , pp. 150-157
    • Slimani, A.1    Harira, Y.2    Trabelsi, I.3
  • 36
    • 65549116032 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 null mice are protected from postprandial triglyceridemia
    • Le May C., Kourimate S., Langhi C., et al. Proprotein convertase subtilisin/kexin type 9 null mice are protected from postprandial triglyceridemia. Arterioscler Thromb Vasc Biol 2009, 29:684-690.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 684-690
    • Le May, C.1    Kourimate, S.2    Langhi, C.3
  • 37
    • 71849105837 scopus 로고    scopus 로고
    • Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the coronary artery risk development in young adults study
    • Huang C.C., Fornage M., Lloyd-Jones D.M., Wei G.S., Boerwinkle E., Liu K. Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the coronary artery risk development in young adults study. Circ Cardiovasc Genet 2009, 2:354-361.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 354-361
    • Huang, C.C.1    Fornage, M.2    Lloyd-Jones, D.M.3    Wei, G.S.4    Boerwinkle, E.5    Liu, K.6
  • 38
    • 43249106948 scopus 로고    scopus 로고
    • Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population
    • Kostrzewa G., Broda G., Kurjata P., Piotrowski W., Ploski R. Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population. Mol Genet Metab 2008, 94:259-262.
    • (2008) Mol Genet Metab , vol.94 , pp. 259-262
    • Kostrzewa, G.1    Broda, G.2    Kurjata, P.3    Piotrowski, W.4    Ploski, R.5
  • 39
    • 36849085368 scopus 로고    scopus 로고
    • The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men
    • Scartezini M., Hubbart C., Whittall R.A., Cooper J.A., Neil A.H., Humphries S.E. The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. Clin Sci (Lond) 2007, 113:435-441.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 435-441
    • Scartezini, M.1    Hubbart, C.2    Whittall, R.A.3    Cooper, J.A.4    Neil, A.H.5    Humphries, S.E.6
  • 40
    • 50649106826 scopus 로고    scopus 로고
    • Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population
    • Sirois F., Gbeha E., Sanni A., Chretien M., Labuda D., Mbikay M. Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population. Genet Test 2008, 12:377-380.
    • (2008) Genet Test , vol.12 , pp. 377-380
    • Sirois, F.1    Gbeha, E.2    Sanni, A.3    Chretien, M.4    Labuda, D.5    Mbikay, M.6
  • 41
    • 57649193160 scopus 로고    scopus 로고
    • Atherosclerosis Risk in Communities (ARIC) Study Investigators. Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease
    • Folsom A.R., Peacock J.M., Boerwinkle E. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease. Atherosclerosis 2009, 202:211-215.
    • (2009) Atherosclerosis , vol.202 , pp. 211-215
    • Folsom, A.R.1    Peacock, J.M.2    Boerwinkle, E.3
  • 42
    • 69549138572 scopus 로고    scopus 로고
    • Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
    • Baass A., Dubuc G., Tremblay M., et al. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem 2009, 55:1637-1645.
    • (2009) Clin Chem , vol.55 , pp. 1637-1645
    • Baass, A.1    Dubuc, G.2    Tremblay, M.3
  • 43
    • 78650419609 scopus 로고    scopus 로고
    • Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans
    • Persson L., Cao G., Ståhle L., et al. Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans. Arterioscler Thromb Vasc Biol 2010, 30:2666-2672.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2666-2672
    • Persson, L.1    Cao, G.2    Ståhle, L.3
  • 44
    • 34548419618 scopus 로고    scopus 로고
    • Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol
    • Gälman C., Matasconi M., Persson L., Parini P., Angelin B., Rudling M. Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol. Am J Physiol Endocrinol Metab 2007, 293:E737-E742.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E737-E742
    • Gälman, C.1    Matasconi, M.2    Persson, L.3    Parini, P.4    Angelin, B.5    Rudling, M.6
  • 46
    • 78649755606 scopus 로고    scopus 로고
    • Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population
    • Cui Q., Ju X., Yang T., et al. Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population. Atherosclerosis 2010, 213:632-636.
    • (2010) Atherosclerosis , vol.213 , pp. 632-636
    • Cui, Q.1    Ju, X.2    Yang, T.3
  • 48
    • 84897895116 scopus 로고    scopus 로고
    • Human serum PCSK9 is elevated at parturition in comparison to nonpregnant subjects while serum PCSK9 from umbilical cord blood is lower compared to maternal blood
    • Peticca P., Raymond A., Gruslin A., et al. Human serum PCSK9 is elevated at parturition in comparison to nonpregnant subjects while serum PCSK9 from umbilical cord blood is lower compared to maternal blood. ISRN Endocrinol 2013, 2013:341632.
    • (2013) ISRN Endocrinol , vol.2013 , pp. 341632
    • Peticca, P.1    Raymond, A.2    Gruslin, A.3
  • 49
    • 0037038239 scopus 로고    scopus 로고
    • Effects of the amount and intensity of exercise on plasma lipoproteins
    • Kraus W.E., Houmard J.A., Duscha B.D., et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002, 347:1483-1492.
    • (2002) N Engl J Med , vol.347 , pp. 1483-1492
    • Kraus, W.E.1    Houmard, J.A.2    Duscha, B.D.3
  • 50
    • 84899922338 scopus 로고    scopus 로고
    • Treadmill exercise training modulates hepatic cholesterol metabolism and circulating PCSK9 concentration in high-fat-fed mice
    • Wen S., Jadhav K.S., Williamson D.L., Rideout T.C. Treadmill exercise training modulates hepatic cholesterol metabolism and circulating PCSK9 concentration in high-fat-fed mice. J Lipid 2013, 2013:908048.
    • (2013) J Lipid , vol.2013 , pp. 908048
    • Wen, S.1    Jadhav, K.S.2    Williamson, D.L.3    Rideout, T.C.4
  • 51
    • 84904580075 scopus 로고    scopus 로고
    • LDL receptor and Pcsk9 transcripts are decreased in liver of ovariectomized rats: effects of exercise training
    • Ngo Sock E.T., Chapados N.A., Lavoie J.M. LDL receptor and Pcsk9 transcripts are decreased in liver of ovariectomized rats: effects of exercise training. Horm Metab Res 2014, 46:550-555.
    • (2014) Horm Metab Res , vol.46 , pp. 550-555
    • Ngo Sock, E.T.1    Chapados, N.A.2    Lavoie, J.M.3
  • 52
    • 80054113117 scopus 로고    scopus 로고
    • Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk
    • Calandra S., Tarugi P., Speedy H.E., Dean A.F., Bertolini S., Shoulders C.C. Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res 2011, 52:1885-1926.
    • (2011) J Lipid Res , vol.52 , pp. 1885-1926
    • Calandra, S.1    Tarugi, P.2    Speedy, H.E.3    Dean, A.F.4    Bertolini, S.5    Shoulders, C.C.6
  • 53
    • 33646547336 scopus 로고    scopus 로고
    • Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
    • Costet P., Cariou B., Lambert G., et al. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem 2006, 281:6211-6218.
    • (2006) J Biol Chem , vol.281 , pp. 6211-6218
    • Costet, P.1    Cariou, B.2    Lambert, G.3
  • 54
    • 84871942788 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets
    • Cariou B., Langhi C., Le Bras M., et al. Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets. Nutr Metab (Lond) 2013, 10(1):4.
    • (2013) Nutr Metab (Lond) , vol.10 , Issue.1 , pp. 4
    • Cariou, B.1    Langhi, C.2    Le Bras, M.3
  • 55
    • 84892732549 scopus 로고    scopus 로고
    • Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing
    • Jia Y.J., Liu J., Guo Y.L., Xu R.X., Sun J., Li J.J. Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing. J Geriatr Cardiol 2013, 10:361-368.
    • (2013) J Geriatr Cardiol , vol.10 , pp. 361-368
    • Jia, Y.J.1    Liu, J.2    Guo, Y.L.3    Xu, R.X.4    Sun, J.5    Li, J.J.6
  • 56
    • 84856764290 scopus 로고    scopus 로고
    • Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome
    • Richard C., Couture P., Desroches S., et al. Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome. Br J Nutr 2012, 107:705-711.
    • (2012) Br J Nutr , vol.107 , pp. 705-711
    • Richard, C.1    Couture, P.2    Desroches, S.3
  • 57
    • 84860297671 scopus 로고    scopus 로고
    • Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial
    • Bjermo H., Iggman D., Kullberg J., et al. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. Am J Clin Nutr 2012, 95:1003-1012.
    • (2012) Am J Clin Nutr , vol.95 , pp. 1003-1012
    • Bjermo, H.1    Iggman, D.2    Kullberg, J.3
  • 58
    • 78149300891 scopus 로고    scopus 로고
    • Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
    • Browning J.D., Horton J.D. Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans. J Lipid Res 2010, 51:3359-3363.
    • (2010) J Lipid Res , vol.51 , pp. 3359-3363
    • Browning, J.D.1    Horton, J.D.2
  • 59
    • 84866527165 scopus 로고    scopus 로고
    • Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters
    • Wu M., Dong B., Cao A., Li H., Liu J. Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters. Atherosclerosis 2012, 224:401-410.
    • (2012) Atherosclerosis , vol.224 , pp. 401-410
    • Wu, M.1    Dong, B.2    Cao, A.3    Li, H.4    Liu, J.5
  • 60
    • 3042606551 scopus 로고    scopus 로고
    • Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host
    • Khovidhunkit W., Kim M.S., Memon R.A., et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 2004, 45:1169-1196.
    • (2004) J Lipid Res , vol.45 , pp. 1169-1196
    • Khovidhunkit, W.1    Kim, M.S.2    Memon, R.A.3
  • 61
    • 0034041239 scopus 로고    scopus 로고
    • Infection and inflammation induce LDL oxidation in vivo
    • Memon R.A., Staprans I., Noor M., et al. Infection and inflammation induce LDL oxidation in vivo. Arterioscler Thromb Vasc Biol 2000, 20:1536-1542.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1536-1542
    • Memon, R.A.1    Staprans, I.2    Noor, M.3
  • 62
    • 84863524541 scopus 로고    scopus 로고
    • Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner
    • Clark P.J., Thompson A.J., Vock D.M., et al. Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. Hepatology 2012, 56:49-56.
    • (2012) Hepatology , vol.56 , pp. 49-56
    • Clark, P.J.1    Thompson, A.J.2    Vock, D.M.3
  • 63
    • 0032582538 scopus 로고    scopus 로고
    • Binding of hepatitis C virus to CD81
    • Pileri P., Uematsu Y., Campagnoli S., et al. Binding of hepatitis C virus to CD81. Science 1998, 282:938-941.
    • (1998) Science , vol.282 , pp. 938-941
    • Pileri, P.1    Uematsu, Y.2    Campagnoli, S.3
  • 64
    • 18644378971 scopus 로고    scopus 로고
    • The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
    • Scarselli E., Ansuini H., Cerino R., et al. The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J 2002, 21:5017-5025.
    • (2002) EMBO J , vol.21 , pp. 5017-5025
    • Scarselli, E.1    Ansuini, H.2    Cerino, R.3
  • 65
    • 84896689449 scopus 로고    scopus 로고
    • Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation
    • Syed G.H., Tang H., Khan M., Hassanein T., Liu J., Siddiqui A. Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol 2014, 88:2519-2529.
    • (2014) J Virol , vol.88 , pp. 2519-2529
    • Syed, G.H.1    Tang, H.2    Khan, M.3    Hassanein, T.4    Liu, J.5    Siddiqui, A.6
  • 66
    • 41149117446 scopus 로고    scopus 로고
    • The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus
    • Meertens L., Bertaux C., Cukierman L., et al. The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus. J Virol 2008, 82:3555-3560.
    • (2008) J Virol , vol.82 , pp. 3555-3560
    • Meertens, L.1    Bertaux, C.2    Cukierman, L.3
  • 67
    • 67651160910 scopus 로고    scopus 로고
    • PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression
    • Labonté P., Begley S., Guévin C., et al. PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression. Hepatology 2009, 50:17-24.
    • (2009) Hepatology , vol.50 , pp. 17-24
    • Labonté, P.1    Begley, S.2    Guévin, C.3
  • 68
    • 84905752955 scopus 로고    scopus 로고
    • The effect of insulin on circulating PCSK9 in postmenopausal obese women
    • Awan Z., Dubuc G., Faraj M., et al. The effect of insulin on circulating PCSK9 in postmenopausal obese women. Clin Biochem 2014, 47:1033-1039.
    • (2014) Clin Biochem , vol.47 , pp. 1033-1039
    • Awan, Z.1    Dubuc, G.2    Faraj, M.3
  • 69
    • 38549113525 scopus 로고    scopus 로고
    • Diabetes alters LDL receptor and PCSK9 expression in rat liver
    • Niesen M., Bedi M., Lopez D. Diabetes alters LDL receptor and PCSK9 expression in rat liver. Arch Biochem Biophys 2008, 470:111-115.
    • (2008) Arch Biochem Biophys , vol.470 , pp. 111-115
    • Niesen, M.1    Bedi, M.2    Lopez, D.3
  • 70
    • 77149134008 scopus 로고    scopus 로고
    • Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus
    • Levy E., Lalonde G., Delvin E., et al. Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology 2010, 151:958-970.
    • (2010) Endocrinology , vol.151 , pp. 958-970
    • Levy, E.1    Lalonde, G.2    Delvin, E.3
  • 71
    • 84877054863 scopus 로고    scopus 로고
    • Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta
    • Dubé E., Ethier-Chiasson M., Lafond J. Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta. Biol Reprod 2013, 88:16.
    • (2013) Biol Reprod , vol.88 , pp. 16
    • Dubé, E.1    Ethier-Chiasson, M.2    Lafond, J.3
  • 72
    • 84894524906 scopus 로고    scopus 로고
    • Intestinal lipid handling: evidence and implication of insulin signaling abnormalities in human obese subjects
    • Veilleux A., Grenier E., Marceau P., Carpentier A.C., Richard D., Levy E. Intestinal lipid handling: evidence and implication of insulin signaling abnormalities in human obese subjects. Arterioscler Thromb Vasc Biol 2014, 34:644-653.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 644-653
    • Veilleux, A.1    Grenier, E.2    Marceau, P.3    Carpentier, A.C.4    Richard, D.5    Levy, E.6
  • 73
    • 84868302770 scopus 로고    scopus 로고
    • Relationship of proprotein convertase subtilisin-kexin type 9 levels with resistin in lean and obese subjects
    • Kwakernaak A.J., Lambert G., Dullaart R.P. Relationship of proprotein convertase subtilisin-kexin type 9 levels with resistin in lean and obese subjects. Clin Biochem 2012, 45:1522-1524.
    • (2012) Clin Biochem , vol.45 , pp. 1522-1524
    • Kwakernaak, A.J.1    Lambert, G.2    Dullaart, R.P.3
  • 74
    • 84860465539 scopus 로고    scopus 로고
    • Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9
    • Melone M., Wilsie L., Palyha O., Strack A., Rashid S. Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9. J Am Coll Cardiol 2012, 59:1697-1705.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1697-1705
    • Melone, M.1    Wilsie, L.2    Palyha, O.3    Strack, A.4    Rashid, S.5
  • 75
    • 84897077564 scopus 로고    scopus 로고
    • Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats
    • Carrier B., Wen S., Zigouras S., et al. Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. PLoS ONE 2014, 9:e90863.
    • (2014) PLoS ONE , vol.9 , pp. e90863
    • Carrier, B.1    Wen, S.2    Zigouras, S.3
  • 76
    • 84856800207 scopus 로고    scopus 로고
    • Update in lipid alterations in subclinical hypothyroidism
    • Pearce E.N. Update in lipid alterations in subclinical hypothyroidism. J Clin Endocrinol Metab 2012, 97:326-333.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 326-333
    • Pearce, E.N.1
  • 77
    • 84873663668 scopus 로고    scopus 로고
    • Adiposity blunts the positive relationship of thyrotropin with proprotein convertase subtilisin-kexin type 9 levels in euthyroid subjects
    • Kwakernaak A.J., Lambert G., Muller Kobold A.C., Dullaart R.P. Adiposity blunts the positive relationship of thyrotropin with proprotein convertase subtilisin-kexin type 9 levels in euthyroid subjects. Thyroid 2013, 23:166-172.
    • (2013) Thyroid , vol.23 , pp. 166-172
    • Kwakernaak, A.J.1    Lambert, G.2    Muller Kobold, A.C.3    Dullaart, R.P.4
  • 78
    • 84900466057 scopus 로고    scopus 로고
    • Acute TSH stimulation in vivo does not alter serum PCSK9 levels
    • Gagnon A., Mahzari M., Lochnan H.A., Sorisky A. Acute TSH stimulation in vivo does not alter serum PCSK9 levels. Thyroid Res 2014, 7:4.
    • (2014) Thyroid Res , vol.7 , pp. 4
    • Gagnon, A.1    Mahzari, M.2    Lochnan, H.A.3    Sorisky, A.4
  • 79
    • 84893863331 scopus 로고    scopus 로고
    • Chronic kidney disease on hemodialysis is associated with decreased serum PCSK9 levels
    • Abujrad H., Mayne J., Ruzicka M., et al. Chronic kidney disease on hemodialysis is associated with decreased serum PCSK9 levels. Atherosclerosis 2014, 233:123-129.
    • (2014) Atherosclerosis , vol.233 , pp. 123-129
    • Abujrad, H.1    Mayne, J.2    Ruzicka, M.3
  • 80
    • 33644854296 scopus 로고    scopus 로고
    • Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences
    • Vaziri N.D. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am J Physiol Renal Physiol 2006, 290:F262-F272.
    • (2006) Am J Physiol Renal Physiol , vol.290 , pp. F262-F272
    • Vaziri, N.D.1
  • 81
    • 84897112851 scopus 로고    scopus 로고
    • Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study
    • Jin K., Park B.S., Kim Y.W., Vaziri N.D. Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study. Am J Kidney Dis 2014, 63:584-589.
    • (2014) Am J Kidney Dis , vol.63 , pp. 584-589
    • Jin, K.1    Park, B.S.2    Kim, Y.W.3    Vaziri, N.D.4
  • 82
    • 84895749296 scopus 로고    scopus 로고
    • Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome
    • Liu S., Vaziri N.D. Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome. Nephrol Dial Transplant 2014, 29:538-543.
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 538-543
    • Liu, S.1    Vaziri, N.D.2
  • 83
    • 69449094509 scopus 로고    scopus 로고
    • Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice
    • Luo Y., Warren L., Xia D., et al. Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice. J Lipid Res 2009, 50:1581-1588.
    • (2009) J Lipid Res , vol.50 , pp. 1581-1588
    • Luo, Y.1    Warren, L.2    Xia, D.3
  • 84
    • 0037417807 scopus 로고    scopus 로고
    • The sectetory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
    • Seidah N.G., Benjannet S., Wichham L., et al. The sectetory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci USA 2003, 100(3):928-933.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.3 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wichham, L.3
  • 85
    • 0042510743 scopus 로고    scopus 로고
    • Inflammatory reactions in the pathogenesis of atherosclerosis
    • Fan J., Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. J Atheroscler Thromb 2003, 10:63-71.
    • (2003) J Atheroscler Thromb , vol.10 , pp. 63-71
    • Fan, J.1    Watanabe, T.2
  • 87
    • 84866499818 scopus 로고    scopus 로고
    • PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophages
    • Tang Z., Jiang L., Peng J., et al. PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophages. Int J Mol Med 2012, 30:931-938.
    • (2012) Int J Mol Med , vol.30 , pp. 931-938
    • Tang, Z.1    Jiang, L.2    Peng, J.3
  • 88
    • 51449103813 scopus 로고    scopus 로고
    • Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
    • Ranheim T., Mattingsdal M., Lindvall J.M., et al. Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9. J Cell Physiol 2008, 217:459-467.
    • (2008) J Cell Physiol , vol.217 , pp. 459-467
    • Ranheim, T.1    Mattingsdal, M.2    Lindvall, J.M.3
  • 89
    • 84883245777 scopus 로고    scopus 로고
    • Acute myocardial infarction in an 8-year old male child with homozygous familiar hypercholesterolemia: laboratory findings and response to lipid-lowering drugs
    • Wu N.Q., Guo Y.L., Xu R.X., et al. Acute myocardial infarction in an 8-year old male child with homozygous familiar hypercholesterolemia: laboratory findings and response to lipid-lowering drugs. Clin Lab 2013, 59:901-907.
    • (2013) Clin Lab , vol.59 , pp. 901-907
    • Wu, N.Q.1    Guo, Y.L.2    Xu, R.X.3
  • 90
    • 84900854191 scopus 로고    scopus 로고
    • Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease
    • Li S., Guo Y.L., Xu R.X., et al. Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease. Atherosclerosis 2014, 234:441-445.
    • (2014) Atherosclerosis , vol.234 , pp. 441-445
    • Li, S.1    Guo, Y.L.2    Xu, R.X.3
  • 91
    • 84913595062 scopus 로고    scopus 로고
    • The relationship between the plasma PCSK9 levels and platelet indices in patients with stable coronary artery disease
    • [xxx: xxx-xxx, in press]
    • Li S., Zhu C.G., Guo Y.L., et al. The relationship between the plasma PCSK9 levels and platelet indices in patients with stable coronary artery disease. J Atheroscler Thromb 2014, 21. [xxx: xxx-xxx, in press].
    • (2014) J Atheroscler Thromb , vol.21
    • Li, S.1    Zhu, C.G.2    Guo, Y.L.3
  • 92
    • 84908456695 scopus 로고    scopus 로고
    • Relation of circulating PCSK9 concentration to fibrinogen in patients with stable coronary artery disease
    • Zhang Y., Zhu C.G., Xu R.X., et al. Relation of circulating PCSK9 concentration to fibrinogen in patients with stable coronary artery disease. J Clin Lipidol 2014, 8(5):494-500.
    • (2014) J Clin Lipidol , vol.8 , Issue.5 , pp. 494-500
    • Zhang, Y.1    Zhu, C.G.2    Xu, R.X.3
  • 93
    • 84903301550 scopus 로고    scopus 로고
    • Plasma PCSK9 levels are associated with the severity of coronary stenosis in patients with atherosclerosis
    • Li S., Guo Y.L., Xu R.X., et al. Plasma PCSK9 levels are associated with the severity of coronary stenosis in patients with atherosclerosis. Int J Cardiol 2014, 174(3):863-864.
    • (2014) Int J Cardiol , vol.174 , Issue.3 , pp. 863-864
    • Li, S.1    Guo, Y.L.2    Xu, R.X.3
  • 94
    • 82955232910 scopus 로고    scopus 로고
    • Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration
    • Miyazawa H., Honda T., Miyauchi S., et al. Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration. Clin Chim Acta 2012, 413:154-159.
    • (2012) Clin Chim Acta , vol.413 , pp. 154-159
    • Miyazawa, H.1    Honda, T.2    Miyauchi, S.3
  • 95
    • 84884566227 scopus 로고    scopus 로고
    • Rapid effects of different lipid-lowering drugs on PCSK9 in humans
    • Liu J., Guo Y.L., Xu R.X., Li J.J. Rapid effects of different lipid-lowering drugs on PCSK9 in humans. Clin Lipid 2013, 8:519-524.
    • (2013) Clin Lipid , vol.8 , pp. 519-524
    • Liu, J.1    Guo, Y.L.2    Xu, R.X.3    Li, J.J.4
  • 96
    • 84890264853 scopus 로고    scopus 로고
    • Short-term impact of low-dose atorvastatin on serum proprotein convertase subtilisin/kexin type 9
    • Guo Y.L., Liu J., Xu R.X., Wu N.Q., Jiang L.X., Li J.J. Short-term impact of low-dose atorvastatin on serum proprotein convertase subtilisin/kexin type 9. Clin Drug Investig 2013, 33:877-883.
    • (2013) Clin Drug Investig , vol.33 , pp. 877-883
    • Guo, Y.L.1    Liu, J.2    Xu, R.X.3    Wu, N.Q.4    Jiang, L.X.5    Li, J.J.6
  • 97
    • 33646443979 scopus 로고    scopus 로고
    • Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    • Berge K.E., Ose L., Leren T.P. Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy. Arterioscler Thromb Vasc Biol 2006, 26:1094-1100.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1094-1100
    • Berge, K.E.1    Ose, L.2    Leren, T.P.3
  • 98
    • 69549111453 scopus 로고    scopus 로고
    • Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the treating to new targets (TNT) cohort
    • Thompson J.F., HydeCL WoodLS, Paciga S.A., et al. Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the treating to new targets (TNT) cohort. Circ Cardiovasc Genet 2009, 2:173-181.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 173-181
    • Thompson, J.F.1    Hydecl, W.2    Paciga, S.A.3
  • 99
    • 33644784875 scopus 로고    scopus 로고
    • Fibrates: therapeutic review
    • Chapman M.J. Fibrates: therapeutic review. Br J Diabetes Vasc Dis 2006, 6:11-18.
    • (2006) Br J Diabetes Vasc Dis , vol.6 , pp. 11-18
    • Chapman, M.J.1
  • 100
    • 84907979645 scopus 로고    scopus 로고
    • Combination therapy in dyslipidemia: where are we now?
    • Catapano A.L., Farnier M., Foody J.M., et al. Combination therapy in dyslipidemia: where are we now?. Atherosclerosis 2014, 237(1):319-335.
    • (2014) Atherosclerosis , vol.237 , Issue.1 , pp. 319-335
    • Catapano, A.L.1    Farnier, M.2    Foody, J.M.3
  • 101
    • 79953317222 scopus 로고    scopus 로고
    • Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9
    • Ason B., Tep S., Davis H.R., et al. Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9. J Lipid Res 2011, 52:679-687.
    • (2011) J Lipid Res , vol.52 , pp. 679-687
    • Ason, B.1    Tep, S.2    Davis, H.R.3
  • 102
    • 73449109571 scopus 로고    scopus 로고
    • Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
    • Davignon J., Dubuc G. Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels. Trans Am Clin Climatol Assoc 2009, 120:163-173.
    • (2009) Trans Am Clin Climatol Assoc , vol.120 , pp. 163-173
    • Davignon, J.1    Dubuc, G.2
  • 103
    • 84896697540 scopus 로고    scopus 로고
    • Impact of currently prescribed lipid-lowering drugs on plasma PCSK9 concentration: single or in combination study in rats
    • Zhang Y., Liu J., Li S., Xu R.X., Sun J., Li J.J. Impact of currently prescribed lipid-lowering drugs on plasma PCSK9 concentration: single or in combination study in rats. Lipids Health Dis 2014, 13:35-40.
    • (2014) Lipids Health Dis , vol.13 , pp. 35-40
    • Zhang, Y.1    Liu, J.2    Li, S.3    Xu, R.X.4    Sun, J.5    Li, J.J.6
  • 104
    • 84958164039 scopus 로고    scopus 로고
    • Short- and long-term effects of Xuezhikang, an extract of cholestin, on serum proprotein convertase subtilisin/kexin type 9 levels
    • Jia Y.J., Zhang Y., Liu J., Guo Y.L., Xu R.X., Li J.J. Short- and long-term effects of Xuezhikang, an extract of cholestin, on serum proprotein convertase subtilisin/kexin type 9 levels. Chin J Integr Med 2014, 10.1007/s11655-014-1846-y.
    • (2014) Chin J Integr Med
    • Jia, Y.J.1    Zhang, Y.2    Liu, J.3    Guo, Y.L.4    Xu, R.X.5    Li, J.J.6
  • 106
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky M., Grefhorst A., Anderson N.N., et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A 2008, 105:11915-11920.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11915-11920
    • Frank-Kamenetsky, M.1    Grefhorst, A.2    Anderson, N.N.3
  • 107
    • 84913536845 scopus 로고    scopus 로고
    • Novel regulators of low-density lipoprotein receptor and circulating LDL-C for the prevention and treatment of coronary artery disease
    • InTech, A. Squeri (Ed.)
    • Cao G.Q., Konrad R.J., Kowala M.C., Wang J. Novel regulators of low-density lipoprotein receptor and circulating LDL-C for the prevention and treatment of coronary artery disease. Coronary artery disease - new insights and novel approaches 2012, 225-242. InTech. A. Squeri (Ed.).
    • (2012) Coronary artery disease - new insights and novel approaches , pp. 225-242
    • Cao, G.Q.1    Konrad, R.J.2    Kowala, M.C.3    Wang, J.4
  • 108
    • 34147136507 scopus 로고    scopus 로고
    • Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    • Graham M.J., Lemonidis K.M., Whipple C.P., et al. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007, 48:763-767.
    • (2007) J Lipid Res , vol.48 , pp. 763-767
    • Graham, M.J.1    Lemonidis, K.M.2    Whipple, C.P.3
  • 109
    • 77956519356 scopus 로고    scopus 로고
    • A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo
    • Gupta N., Fisker N., Asselin M.C., et al. A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. PLos ONE 2010, 5:e10682.
    • (2010) PLos ONE , vol.5 , pp. e10682
    • Gupta, N.1    Fisker, N.2    Asselin, M.C.3
  • 110
    • 84947018549 scopus 로고    scopus 로고
    • PCSK9: the functional relevance of fenofibrate-stain combination therapy to reduce residual cardiovascular risk
    • Fruchart J.C. PCSK9: the functional relevance of fenofibrate-stain combination therapy to reduce residual cardiovascular risk. Int J Diab Mellit 2010, 10.1016/j.ijdm.2010.11.001.
    • (2010) Int J Diab Mellit
    • Fruchart, J.C.1
  • 111
    • 84913574803 scopus 로고    scopus 로고
    • PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
    • [pii: S0140-6736(14)61399-4], [Epub ahead of print]
    • Raal F.J., Stein E.A., Dufour R., et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet 2014, [pii: S0140-6736(14)61399-4], [Epub ahead of print].
    • (2014) Lancet
    • Raal, F.J.1    Stein, E.A.2    Dufour, R.3
  • 112
    • 84913574802 scopus 로고    scopus 로고
    • Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial
    • [pii: S0140-6736(14)61374-X], [Epub ahead of print]
    • Raal F.J., Honarpour N., Blom D.J., et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet 2014, [pii: S0140-6736(14)61374-X], [Epub ahead of print].
    • (2014) Lancet
    • Raal, F.J.1    Honarpour, N.2    Blom, D.J.3
  • 113
    • 84906323762 scopus 로고    scopus 로고
    • Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24week, double-blind, randomized phase 3 trial
    • Roth E.M., Taskinen M.R., Ginsberg H.N., et al. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24week, double-blind, randomized phase 3 trial. Int J Cardiol 2014, 176(1):55-61.
    • (2014) Int J Cardiol , vol.176 , Issue.1 , pp. 55-61
    • Roth, E.M.1    Taskinen, M.R.2    Ginsberg, H.N.3
  • 114
    • 81255188000 scopus 로고    scopus 로고
    • Familial hypercholesterohemia: present and future management
    • Sjouke B., Kusters D.M., Kastelein J.J.P. Familial hypercholesterohemia: present and future management. Curr Cardiol Rep 2011, 13:527-536.
    • (2011) Curr Cardiol Rep , vol.13 , pp. 527-536
    • Sjouke, B.1    Kusters, D.M.2    Kastelein, J.J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.