메뉴 건너뛰기




Volumn 22, Issue 2, 2016, Pages 96-100

Short- and long-term effects of Xuezhikang (血脂康), an extract of cholestin, on serum proprotein convertase subtilisin/kexin type 9 levels

Author keywords

Chinese medicine; lipid profile; proprotein convertase subtilisin kexin type 9; statin; Xuezhikang

Indexed keywords

KEXIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MEVINOLIN; SODIUM CHLORIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; SUBTILISIN; XUEZHIKANG; BIOLOGICAL PRODUCT; CHOLESTIN; HERBACEOUS AGENT; LIPID; PCSK9 PROTEIN, HUMAN; PCSK9 PROTEIN, RAT; PROPROTEIN CONVERTASE 9;

EID: 84958164039     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-014-1846-y     Document Type: Article
Times cited : (15)

References (23)
  • 2
    • 84922680162 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases
    • Ferri N. Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases. Scientifica 2012;2012:21.
    • (2012) Scientifica , vol.2012 , pp. 21
    • Ferri, N.1
  • 3
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
    • COI: 1:CAS:528:DC%2BD2sXmsVOksLc%3D, PID: 17452316
    • Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, et al. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem 2007;282:18602–18612.
    • (2007) J Biol Chem , vol.282 , pp. 18602-18612
    • Zhang, D.W.1    Lagace, T.A.2    Garuti, R.3    Zhao, Z.4    McDonald, M.5    Horton, J.D.6
  • 4
    • 59449095645 scopus 로고    scopus 로고
    • Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants
    • COI: 1:CAS:528:DC%2BD1MXhsV2iuw%3D%3D, PID: 19001363
    • Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, et al. Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants. J Biol Chem 2009;284:1313–1323.
    • (2009) J Biol Chem , vol.284 , pp. 1313-1323
    • Bottomley, M.J.1    Cirillo, A.2    Orsatti, L.3    Ruggeri, L.4    Fisher, T.S.5    Santoro, J.C.6
  • 5
    • 82555187008 scopus 로고    scopus 로고
    • Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
    • PID: 22081141
    • Lo Surdo P, Bottomley MJ, Calzetta A, Settembre EC, Cirillo A, Pandit S, et al. Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. EMBO Rep 2011;12:1300–1305.
    • (2011) EMBO Rep , vol.12 , pp. 1300-1305
    • Lo Surdo, P.1    Bottomley, M.J.2    Calzetta, A.3    Settembre, E.C.4    Cirillo, A.5    Pandit, S.6
  • 6
    • 22244478077 scopus 로고    scopus 로고
    • Structure and physiologic function of the low-density lipoprotein receptor
    • COI: 1:CAS:528:DC%2BD2MXpsVensLo%3D, PID: 15952897
    • Jeon H, Blacklow SC. Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 2005;74:535–562.
    • (2005) Annu Rev Biochem , vol.74 , pp. 535-562
    • Jeon, H.1    Blacklow, S.C.2
  • 7
    • 84871362850 scopus 로고    scopus 로고
    • PCSK9 inhibition and LDL cholesterol lowering: the biology of an attractive therapeutic target and critical review of the latest clinical trials
    • COI: 1:CAS:528:DC%2BC38XhvVClurbM
    • Rhainds D, Arsenault BJ, Tardif JC. PCSK9 inhibition and LDL cholesterol lowering: the biology of an attractive therapeutic target and critical review of the latest clinical trials. Clin Lipidol 2012;7:621–640.
    • (2012) Clin Lipidol , vol.7 , pp. 621-640
    • Rhainds, D.1    Arsenault, B.J.2    Tardif, J.C.3
  • 8
    • 2442670243 scopus 로고    scopus 로고
    • Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
    • COI: 1:STN:280:DC%2BD2c3ksFWrtw%3D%3D, PID: 15099351
    • Leren TP. Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. Clin Genet 2004;65:419–422.
    • (2004) Clin Genet , vol.65 , pp. 419-422
    • Leren, T.P.1
  • 9
    • 33644807009 scopus 로고    scopus 로고
    • Severe hypercholesterolemia in four british families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response
    • COI: 1:CAS:528:DC%2BD2MXht1Crt7vJ
    • Naoumova RP, Tosi I, Patel D, Neuwirth C, Horswell SD, Marais AD, et al. Severe hypercholesterolemia in four british families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response. Arterioscle Thromb Vasc Biol 2005;25:2654–2660.
    • (2005) Arterioscle Thromb Vasc Biol , vol.25 , pp. 2654-2660
    • Naoumova, R.P.1    Tosi, I.2    Patel, D.3    Neuwirth, C.4    Horswell, S.D.5    Marais, A.D.6
  • 10
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • COI: 1:CAS:528:DC%2BD28Xislequr8%3D, PID: 16554528
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006;354:1264–1272.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 11
    • 71849105837 scopus 로고    scopus 로고
    • Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: The coronary artery risk development in young adults study
    • COI: 1:CAS:528:DC%2BD1MXhtFCgtr7L, PID: 20031607
    • Huang CC, Fornage M, Lloyd-Jones DM, Wei GS, Boerwinkle E, Liu K. Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: The coronary artery risk development in young adults study. Circ Cardiovasc Genet 2009;2:354–361.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 354-361
    • Huang, C.C.1    Fornage, M.2    Lloyd-Jones, D.M.3    Wei, G.S.4    Boerwinkle, E.5    Liu, K.6
  • 12
    • 44749084870 scopus 로고    scopus 로고
    • Effect of Xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction
    • PID: 18549841
    • Lu Z, Kou W, Du B, Wu Y, Zhao S, Brusco OA, et al. Effect of Xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction. Am J Cardiol 2008;101:1689–1693.
    • (2008) Am J Cardiol , vol.101 , pp. 1689-1693
    • Lu, Z.1    Kou, W.2    Du, B.3    Wu, Y.4    Zhao, S.5    Brusco, O.A.6
  • 13
    • 70349292926 scopus 로고    scopus 로고
    • Beneficial impact of Xuezhikang on cardiovascular events and mortality in elderly hypertensive patients with previous myocardial infarction from the China Coronary Secondary Prevention Study (CCSPS)
    • COI: 1:CAS:528:DC%2BD1MXhtVSqur%2FK, PID: 19602720
    • Li JJ, Lu ZL, Kou WR, Chen Z, Wu YF, Yu XH, et al. Beneficial impact of Xuezhikang on cardiovascular events and mortality in elderly hypertensive patients with previous myocardial infarction from the China Coronary Secondary Prevention Study (CCSPS). J Clin Pharmacol 2009;49:947–956.
    • (2009) J Clin Pharmacol , vol.49 , pp. 947-956
    • Li, J.J.1    Lu, Z.L.2    Kou, W.R.3    Chen, Z.4    Wu, Y.F.5    Yu, X.H.6
  • 14
    • 67249153214 scopus 로고    scopus 로고
    • Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial
    • PID: 19528562
    • Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med 2009;150:830–839, W147–W149.
    • (2009) Ann Intern Med , vol.150 , pp. 830-839
    • Becker, D.J.1    Gordon, R.Y.2    Halbert, S.C.3    French, B.4    Morris, P.B.5    Rader, D.J.6
  • 15
    • 73149101073 scopus 로고    scopus 로고
    • Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance
    • COI: 1:CAS:528:DC%2BC3cXosVai, PID: 20102918
    • Halbert SC, French B, Gordon RY, Farrar JT, Schmitz K, Morris PB, et al. Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. Am J Cardiol 2010;105:198–204.
    • (2010) Am J Cardiol , vol.105 , pp. 198-204
    • Halbert, S.C.1    French, B.2    Gordon, R.Y.3    Farrar, J.T.4    Schmitz, K.5    Morris, P.B.6
  • 16
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • COI: 1:CAS:528:DC%2BD1cXhsVaitbk%3D, PID: 18033751
    • Careskey HE, Davis RA, Alborn WE, Troutt JS, Cao G, Konrad RJ. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008;49:394–398.
    • (2008) J Lipid Res , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 17
    • 84856077137 scopus 로고    scopus 로고
    • Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial
    • COI: 1:CAS:528:DC%2BC38XnvFertQ%3D%3D, PID: 22065156
    • Awan Z, Seidah NG, MacFadyen JG, Benjannet S, Chasman DI, Ridker PM, et al. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clin Chem 2012;58:183–189.
    • (2012) Clin Chem , vol.58 , pp. 183-189
    • Awan, Z.1    Seidah, N.G.2    MacFadyen, J.G.3    Benjannet, S.4    Chasman, D.I.5    Ridker, P.M.6
  • 18
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143–3421
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 19
    • 77956797294 scopus 로고    scopus 로고
    • High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
    • COI: 1:CAS:528:DC%2BC3cXhtVOltr%2FM, PID: 20525997
    • Welder G, Zineh I, Pacanowski MA, Troutt JS, Cao G, Konrad RJ. High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol. J Lipid Res 2010;51:2714–2721.
    • (2010) J Lipid Res , vol.51 , pp. 2714-2721
    • Welder, G.1    Zineh, I.2    Pacanowski, M.A.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 20
    • 40949129205 scopus 로고    scopus 로고
    • Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: A randomized trial in healthy men
    • COI: 1:CAS:528:DC%2BD1cXktFClsro%3D, PID: 17980884
    • Gouni-Berthold I, Berthold HK, Gylling H, Hallikainen M, Giannakidou E, Stier S, et al. Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: A randomized trial in healthy men. Atherosclerosis 2008;198:198–207.
    • (2008) Atherosclerosis , vol.198 , pp. 198-207
    • Gouni-Berthold, I.1    Berthold, H.K.2    Gylling, H.3    Hallikainen, M.4    Giannakidou, E.5    Stier, S.6
  • 21
    • 77949525476 scopus 로고    scopus 로고
    • Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels
    • COI: 1:CAS:528:DC%2BC3cXptVWnsA%3D%3D, PID: 19738285
    • Troutt JS, Alborn WE, Cao G, Konrad RJ. Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels. J Lipid Res 2010;51:345–351.
    • (2010) J Lipid Res , vol.51 , pp. 345-351
    • Troutt, J.S.1    Alborn, W.E.2    Cao, G.3    Konrad, R.J.4
  • 22
    • 73449109571 scopus 로고    scopus 로고
    • Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
    • PID: 19768174
    • Davignon J, Dubuc G. Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels. Trans Am Clin Climatol Assoc 2009;120:163–173.
    • (2009) Trans Am Clin Climatol Assoc , vol.120 , pp. 163-173
    • Davignon, J.1    Dubuc, G.2
  • 23
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    • COI: 1:CAS:528:DC%2BD2cXmtValtLY%3D, PID: 15178557
    • Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2004;24:1454–1459.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3    Davignon, J.4    Seidah, N.G.5    Bernier, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.